Page last updated: 2024-12-08

a 195773

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID156417
CHEMBL ID3989904
MeSH IDM0460079

Synonyms (13)

Synonym
(3as,4r,7r,9r,10r,11r,13r,15r,15ar)-4-ethyl-3a,7,9,11,13,15-hexamethyl-11-((3-(quinolin-3-yl)prop-2-enyl)oxy)-10-((3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyranosyl)oxy)octahydro-2h-oxacyclotetradecino(4,3-d)oxazole-2,6,8,14(1h,7h,9h)-tetrone
2h-oxacyclotetradecino(4,3-d)oxazole-2,6,8,14(1h,7h,9h)-tetrone, 4-ethyloctahydro-3a,7,9,11,13,15-hexamethyl-11-((3-(3-quinolinyl)-2-propenyl)oxy)-10-((3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyranosyl)oxy)-, (3as,4r,7r,9r,10r,11r,13r,15r,15ar)-
abt 773
(3as,4r,7r,9r,10r,11r,13r,15r,15ar)-4-ethyl-3a,7,9,11,13,15 hexamethyl-11-((3-(quinolin-3-yl)prop-2-enyl)oxy)-10-((3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyranosyl)oxy)octahydro-2h-oxacyclotetradecino(4,3-d)oxazole-2,6,8,14(1h,7h,9h)-tetrone
a-195,773
cethromycin [usan:inn]
a 195773
2h-oxacyclotetradecino(4,3-d)oxazole-2,6,8,14(1h,7h,9h)-tetrone, 4-ethyloctahydro-3a,7,9,11,13,15-hexamethyl-11-((3-(3-quinolinyl)-2-propenyl)oxy)-10-((3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyranosyl)oxy)-, (3as,4r,7r,9r,10r,11r,13r,15r,15ar)
a 195,773
unii-j0086219x6
CHEMBL3989904
(1s,2r,5r,7r,8r,9r,11r,13r,14r)-8-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-1,5,7,9,11,13-hexamethyl-9-(3-quinolin-3-ylprop-2-enoxy)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone
DTXSID00870225
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
antibacterial drugA drug used to treat or prevent bacterial infections.
protein synthesis inhibitorA compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
macrolide antibioticA macrocyclic lactone with a ring of twelve or more members which exhibits antibiotic activity.
quinolinesA class of aromatic heterocyclic compounds each of which contains a benzene ring ortho fused to carbons 2 and 3 of a pyridine ring.
monosaccharide derivativeA carbohydrate derivative that is formally obtained from a monosaccharide.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Cytochrome P450 3A4Homo sapiens (human)IC50 (µMol)2.70000.00011.753610.0000AID1549405
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (19)

Processvia Protein(s)Taxonomy
lipid hydroxylationCytochrome P450 3A4Homo sapiens (human)
lipid metabolic processCytochrome P450 3A4Homo sapiens (human)
steroid catabolic processCytochrome P450 3A4Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 3A4Homo sapiens (human)
steroid metabolic processCytochrome P450 3A4Homo sapiens (human)
cholesterol metabolic processCytochrome P450 3A4Homo sapiens (human)
androgen metabolic processCytochrome P450 3A4Homo sapiens (human)
estrogen metabolic processCytochrome P450 3A4Homo sapiens (human)
alkaloid catabolic processCytochrome P450 3A4Homo sapiens (human)
monoterpenoid metabolic processCytochrome P450 3A4Homo sapiens (human)
calcitriol biosynthetic process from calciolCytochrome P450 3A4Homo sapiens (human)
xenobiotic catabolic processCytochrome P450 3A4Homo sapiens (human)
vitamin D metabolic processCytochrome P450 3A4Homo sapiens (human)
vitamin D catabolic processCytochrome P450 3A4Homo sapiens (human)
retinol metabolic processCytochrome P450 3A4Homo sapiens (human)
retinoic acid metabolic processCytochrome P450 3A4Homo sapiens (human)
long-chain fatty acid biosynthetic processCytochrome P450 3A4Homo sapiens (human)
aflatoxin metabolic processCytochrome P450 3A4Homo sapiens (human)
oxidative demethylationCytochrome P450 3A4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (23)

Processvia Protein(s)Taxonomy
monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
steroid bindingCytochrome P450 3A4Homo sapiens (human)
iron ion bindingCytochrome P450 3A4Homo sapiens (human)
protein bindingCytochrome P450 3A4Homo sapiens (human)
steroid hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
retinoic acid 4-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
oxidoreductase activityCytochrome P450 3A4Homo sapiens (human)
oxygen bindingCytochrome P450 3A4Homo sapiens (human)
enzyme bindingCytochrome P450 3A4Homo sapiens (human)
heme bindingCytochrome P450 3A4Homo sapiens (human)
vitamin D3 25-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
caffeine oxidase activityCytochrome P450 3A4Homo sapiens (human)
quinine 3-monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
testosterone 6-beta-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 8,9 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 11,12 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 14,15 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
aromatase activityCytochrome P450 3A4Homo sapiens (human)
vitamin D 24-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
estrogen 16-alpha-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
estrogen 2-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
1,8-cineole 2-exo-monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
cytoplasmCytochrome P450 3A4Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 3A4Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 3A4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (123)

Assay IDTitleYearJournalArticle
AID245079Minimum inhibitory concentration against Streptococcus pyogenes 930 (erythromycin-resistant strain)2005Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10
Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.
AID518962Induction of erm(C) expression in Escherichia coli JM109 harboring Staphylococcus aureus erm(C)-containing pERMZ7 lacking codons 2 to 4 with additional mutations leader peptide cistrons reporter plasmid at 25 mg/ml after 36 hrs at 37 degC by disc-based be2008Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
Induction of erm(C) expression by noninducing antibiotics.
AID206748In vitro antibacterial activity against Staphylococcus aureus strain A 5278.2000Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.
AID1169031Antibacterial activity against efflux-resistant Streptococcus pneumoniae by agar microdilution method2014ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics.
AID208288Minimum inhibitory concentration against Streptococcus pneumoniae 5649 efflux2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID1169029Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae by agar microdilution method2014ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics.
AID1169035Antibacterial activity against Haemophilus influenzae by agar microdilution method2014ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics.
AID1278826Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B resistant Streptococcus pneumoniae by agar microdilution method2016Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6
Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens.
AID499558Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes B0544 by agar microdilution method2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides.
AID1459110Antibacterial activity against inducibly macrolide/lincosamide/streptogramin B-resistant Staphylococcus aureus by agar microdilution method2017European journal of medicinal chemistry, Jan-05, Volume: 125Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity.
AID518966Induction of erm(C) expression in Escherichia coli JM109 harboring Staphylococcus aureus erm(C)-containing pERMZalpha reporter plasmid after 36 hrs at 37 degC by disc-based beta-galactosidase reporter gene assay2008Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
Induction of erm(C) expression by noninducing antibiotics.
AID499560Antibacterial activity against Moraxella catarrhalis B0324 by agar microdilution method2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides.
AID642863Antibacterial activity against efflux mediated macrolide resistant Streptococcus pyogenes by agar microdilution method2011ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
AID1278829Antibacterial activity against inducibly macrolide-lincosamide-streptogramin B resistant Streptococcus pyogenes by agar microdilution method2016Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6
Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens.
AID210221In vitro antibacterial activity against Streptococcus pneumoniae 5979 (MLSB resistant stain bearing an erm (B) gene)2004Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14
Synthesis and antibacterial activity of novel bifunctional macrolides.
AID210389In vitro antibacterial activity against Streptococcus pneumoniae strain ATCC 6303.2000Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.
AID642857Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae by agar microdilution method2011ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
AID209608In vitro antibacterial activity against Streptococcus pyogenes strain EES 61.2000Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.
AID499552Antibacterial activity against efflux-resistant Staphylococcus aureus B0331 by agar microdilution method2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides.
AID209609In vitro antibacterial activity against Streptococcus pyogenes strain PIU 2548.2000Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.
AID674452Antibacterial activity against macrolide-susceptible Staphylococcus aureus ATCC 292132012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Synthesis and antibacterial activity of desosamine-modified macrolide derivatives.
AID539514Antibacterial activity against Haemophilus influenzae B0529 by agar microdilution method2010Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials.
AID539504Antibacterial activity against efflux-resistant Streptococcus pneumoniae B0326 by agar microdilution method2010Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials.
AID674453Antibacterial activity against macrolide-resistant Staphylococcus aureus ATCC 33591 constitutively expressing ermA2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Synthesis and antibacterial activity of desosamine-modified macrolide derivatives.
AID1459107Antibacterial activity against constitutively macrolide/lincosamide/streptogramin B-resistant Streptococcus pyogenes by agar microdilution method2017European journal of medicinal chemistry, Jan-05, Volume: 125Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity.
AID539503Antibacterial activity against erythromycin A-susceptible Streptococcus pyogenes B0542 by agar microdilution method2010Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials.
AID1278828Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes by agar microdilution method2016Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6
Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens.
AID245078Minimum inhibitory concentration against Staphylococcus aureus A5177 (erythromycin-resistant strain2005Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10
Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.
AID86120In vitro antibacterial activity against Haemophilus influenzae strain DILL.2000Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.
AID642859Antibacterial activity against efflux mediated macrolide resistant Streptococcus pneumoniae by agar microdilution method2011ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
AID1169028Antibacterial activity against macrolide lincosamide- streptogramin B-resistant Staphylococcus aureus by agar microdilution method2014ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics.
AID539502Antibacterial activity against inducible macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes B0543 by agar microdilution method2010Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials.
AID1459115Antibacterial activity against Mef-mediated macrolide efflux resistant Streptococcus pyogenes by agar microdilution method2017European journal of medicinal chemistry, Jan-05, Volume: 125Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity.
AID206298In vitro antibacterial activity against Staphylococcus aureus NCTC 10649 (erythromycin-susceptible strain)2004Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14
Synthesis and antibacterial activity of novel bifunctional macrolides.
AID1549405Inhibition of CYP3A4 (unknown origin)2019European journal of medicinal chemistry, May-01, Volume: 169Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens.
AID499550Antibacterial activity against inducible macrolide-lincosamide-streptogramin B-resistant Staphylococcus aureus B0538 by agar microdilution method2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides.
AID210388In vitro antibacterial activity against Streptococcus pneumoniae strain 5737.2000Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.
AID499549Antibacterial activity against erythromycin A-resistant Staphylococcus aureus B0329 by agar microdilution method2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides.
AID1278823Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B resistant Staphylococcus aureus by agar microdilution method2016Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6
Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens.
AID155562Minimum inhibitory concentration against Streptococcus pyogenes PIU2548 efflux2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID1459116Antibacterial activity against Haemophilus influenzae by agar microdilution method2017European journal of medicinal chemistry, Jan-05, Volume: 125Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity.
AID642852Antibacterial activity against ciprofloxacin-resistant Staphylococcus aureus by agar microdilution method2011ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
AID206750In vitro antibacterial activity against Staphylococcus aureus strain ATCC 6538P.2000Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.
AID642855Antibacterial activity against constitutive MLS resistant Staphylococcus aureus by agar microdilution method2011ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
AID1459108Antibacterial activity against constitutively macrolide/lincosamide/streptogramin B-resistant Streptococcus pneumoniae by agar microdilution method2017European journal of medicinal chemistry, Jan-05, Volume: 125Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity.
AID1278822Antibacterial activity against inducibly macrolide-lincosamide-streptogramin B resistant Staphylococcus aureus by agar microdilution method2016Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6
Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens.
AID642858Antibacterial activity against constitutive MLS resistant Streptococcus pneumoniae by agar microdilution method2011ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
AID539510Antibacterial activity against erythromycin A-susceptible Staphylococcus aureus B0329 by agar microdilution method2010Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials.
AID642862Antibacterial activity against constitutive MLS resistant Streptococcus pyogenes by agar microdilution method2011ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
AID208290Minimum inhibitory concentration against Streptococcus pneumoniae ATCC 6303 Ery-S2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID53775Minimum inhibitory concentration against Haemophilus influenzae DILL Amp-R2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID1278821Antibacterial activity against erythromycin-susceptible Staphylococcus aureus by agar microdilution method2016Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6
Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens.
AID1278832Antibacterial activity against Haemophilus influenzae by agar microdilution method2016Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6
Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens.
AID1459111Antibacterial activity against constitutively macrolide/lincosamide/streptogramin B-resistant Staphylococcus aureus by agar microdilution method2017European journal of medicinal chemistry, Jan-05, Volume: 125Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity.
AID518975Induction of erm(C) expression in Escherichia coli ZK796 harboring Staphylococcus aureus erm(C)-containing pERMCT plasmid assessed as increase in A2058 dimethylation in 23S rRNA at 25% MIC after 4 hrs by primer extension assay2008Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
Induction of erm(C) expression by noninducing antibiotics.
AID539513Antibacterial activity against Moraxella catarrhalis B0324 by agar microdilution method2010Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials.
AID499561Antibacterial activity against Haemophilus influenzae B0529 by agar microdilution method2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides.
AID1169032Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes by agar microdilution method2014ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics.
AID210387In vitro antibacterial activity against Streptococcus pneumoniae strain 5649.2000Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.
AID674454Ratio of MIC for macrolide-resistant Staphylococcus aureus ATCC 33591 to MIC for macrolide-susceptible Staphylococcus aureus ATCC 292132012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Synthesis and antibacterial activity of desosamine-modified macrolide derivatives.
AID1169026Antibacterial activity against erythromycin-susceptible Staphylococcus aureus by agar microdilution method2014ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics.
AID245232Minimum inhibitory concentration against Streptococcus pneumoniae ATCC 6303 (erythromycin-susceptible strain)2005Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10
Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.
AID499553Antibacterial activity against erythromycin A-resistant Streptococcus pneumoniae B0541 by agar microdilution method2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides.
AID518973Antimicrobial activity against Escherichia coli ZK796 harboring empty plasmid2008Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
Induction of erm(C) expression by noninducing antibiotics.
AID539508Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B-resistant Staphylococcus aureus B0330 by agar microdilution method2010Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials.
AID1169033Antibacterial activity against macrolide lincosamide- streptogramin B inducibly-resistant Streptococcus pyogenes by agar microdilution method2014ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics.
AID131225Mouse protection tests for effective dose against Staphylococcus aureus 10649 ((erythromycin susceptible strain)) infected mice2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID8441Minimum inhibitory concentration against Streptococcus pyogenes 930MLSB2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID539512Antibacterial activity against efflux-resistant Streptococcus pyogenes B0545 by agar microdilution method2010Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials.
AID518974Antimicrobial activity against Escherichia coli ZK796 harboring Staphylococcus aureus erm(C)-containing pERMCT plasmid2008Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
Induction of erm(C) expression by noninducing antibiotics.
AID499559Antibacterial activity against efflux-resistant Streptococcus pyogenes B0545 by agar microdilution method2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides.
AID1278825Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae by agar microdilution method2016Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6
Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens.
AID210219In vitro antibacterial activity against Streptococcus pneumoniae 5649 (efflux-resistant strain bearing a mef (E) gene)2004Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14
Synthesis and antibacterial activity of novel bifunctional macrolides.
AID1459109Antibacterial activity against erythromycin susceptible Streptococcus pneumoniae by agar microdilution method2017European journal of medicinal chemistry, Jan-05, Volume: 125Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity.
AID1169034Antibacterial activity against efflux-resistant Streptococcus pyogenes by agar microdilution method2014ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics.
AID1278824Antibacterial activity against efflux mediated macrolide resistant Staphylococcus aureus by agar microdilution method2016Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6
Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens.
AID245131Minimum inhibitory concentration against Streptococcus pyogenes EES61 (erythromycin-susceptible strain)2005Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10
Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.
AID1278833Antibacterial activity against Moraxella catarrhalis by agar microdilution method2016Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6
Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens.
AID1459114Antibacterial activity against erythromycin susceptible Staphylococcus aureus by agar microdilution method2017European journal of medicinal chemistry, Jan-05, Volume: 125Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity.
AID642856Antibacterial activity against efflux mediated macrolide resistant Staphylococcus aureus by agar microdilution method2011ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
AID8627Minimum inhibitory concentration against Staphylococcus aureus A 5177 MLSB-i2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID539509Antibacterial activity against inducible macrolide-lincosamide-streptogramin B-resistant Staphylococcus aureus B0538 by agar microdilution method2010Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials.
AID208280Minimum inhibitory concentration against Streptococcus pneumoniae 6303 (erythromycin susceptible strain)2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID245097Minimum inhibitory concentration against Staphylococcus aureus 6538P (erythromycin-susceptible strain)2005Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10
Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.
AID642860Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes by agar microdilution method2011ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
AID209607In vitro antibacterial activity against Streptococcus pyogenes strain 930.2000Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.
AID1459113Antibacterial activity against Mef-mediated macrolide efflux resistant Streptococcus pneumoniae by agar microdilution method2017European journal of medicinal chemistry, Jan-05, Volume: 125Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity.
AID206747In vitro antibacterial activity against Staphylococcus aureus strain A 5177.2000Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.
AID499555Antibacterial activity against efflux-resistant Streptococcus pneumoniae B0326 by agar microdilution method2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides.
AID499557Antibacterial activity against inducible macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes B0543 by agar microdilution method2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides.
AID642853Antibacterial activity against erythromycin-susceptible Staphylococcus aureus by agar microdilution method2011ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
AID206282In vitro antibacterial activity against Staphylococcus aureus 1775 (methicillin-resistant strain(MRSA))2004Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14
Synthesis and antibacterial activity of novel bifunctional macrolides.
AID642865Antibacterial activity against Moraxella catarrhalis by agar microdilution method2011ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
AID1278831Antibacterial activity against efflux mediated macrolide resistant Streptococcus pyogenes by agar microdilution method2016Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6
Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens.
AID539511Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes B0544 by agar microdilution method2010Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials.
AID642864Antibacterial activity against Haemophilus influenzae B0529 by agar microdilution method2011ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
AID67271Minimum inhibitory concentration against Streptococcus pyogenes EES 61 Ery-S2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID642861Antibacterial activity against Streptococcus pyogenes with inducible resistance to MLS by agar microdilution method2011ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
AID85978In vitro antibacterial activity against Haemophilus influenzae GYR1435 (fully susceptible strain)2004Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14
Synthesis and antibacterial activity of novel bifunctional macrolides.
AID8629Minimum inhibitory concentration against Staphylococcus aureus A 5278 MLSB-c2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID539505Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B-resistant Streptococcus pneumoniae B0627 by agar microdilution method2010Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials.
AID539507Antibacterial activity against efflux-resistant Staphylococcus aureus B0331 by agar microdilution method2010Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials.
AID1169030Antibacterial activity against macrolide lincosamide- streptogramin B inducibly-resistant Streptococcus pneumoniae by agar microdilution method2014ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics.
AID197857Minimum inhibitory concentration against Staphylococcus aureus 10649 (erythromycin susceptible strain)2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID499551Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B-resistant Staphylococcus aureus B0330 by agar microdilution method2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides.
AID1278827Antibacterial activity against efflux mediated macrolide resistant Streptococcus pneumoniae by agar microdilution method2016Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6
Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens.
AID499554Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B-resistant Streptococcus pneumoniae B0627 by agar microdilution method2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides.
AID642854Antibacterial activity against Staphylococcus aureus with inducible resistance to MLS by agar microdilution method2011ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
AID539506Antibacterial activity against erythromycin A-susceptible Streptococcus pneumoniae B0541 by agar microdilution method2010Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials.
AID210222In vitro antibacterial activity against Streptococcus pneumoniae ATCC 6303 (an erythromycin-susceptible strain)2004Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14
Synthesis and antibacterial activity of novel bifunctional macrolides.
AID245166Minimum inhibitory concentration against Haemophilus influenzae GYR1435 (erythromycin susceptible strain)2005Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10
Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.
AID244850Minimum inhibitory concentration against Streptococcus pneumoniae 5649 strain2005Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10
Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.
AID1278830Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B resistant Streptococcus pyogenes by agar microdilution method2016Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6
Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens.
AID1459112Antibacterial activity against erythromycin susceptible Streptococcus pyogenes by agar microdilution method2017European journal of medicinal chemistry, Jan-05, Volume: 125Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity.
AID518970Induction of erm(C) expression in Escherichia coli JM109 harboring Staphylococcus aureus erm(C)-containing pERMZdelta2-4 mutant leader peptide cistrons reporter plasmid at 25 mg/ml after 36 hrs at 37 degC by disc-based beta-galactosidase reporter gene ass2008Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
Induction of erm(C) expression by noninducing antibiotics.
AID208289Minimum inhibitory concentration against Streptococcus pneumoniae 5737 MLSB2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID244851Minimum inhibitory concentration against Streptococcus pneumoniae 5979 strain2005Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10
Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.
AID499556Antibacterial activity against erythromycin A-resistant Streptococcus pyogenes B0542 by agar microdilution method2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides.
AID131226Mouse protection tests for effective dose against Streptococcus pneumoniae 6303 ((erythromycin susceptible strain)) infected mice2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID209881Cell free inhibiting activity against erythromycin-susceptible strain Streptococcus pneumoniae 1813 (Wild type ribosomes for transcription/translation assay)2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID31895Minimum inhibitory concentration against Staphylococcus aureus ATCC 6538PEry-S2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID209882Cell free inhibiting activity against erythromycin-susceptible strain Streptococcus pneumoniae 1813 (methylated ribosomes for transcription/translation assay)2001Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
AID1169027Antibacterial activity against macrolide lincosamide- streptogramin B inducibly-resistant Staphylococcus aureus by agar microdilution method2014ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (38.46)29.6817
2010's8 (61.54)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.48

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.48 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index5.12 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.48)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]