Compounds > 4'-phosphopantetheine
Page last updated: 2024-09-24

4'-phosphopantetheine

Description

D-pantetheine 4'-phosphate : Pantetheine 4'-phosphate with D (R) configuration at the 2' position. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID115254
CHEBI ID4222
SCHEMBL ID106050
MeSH IDM0044102

Synonyms (36)

Synonym
2226-71-3
psh-4'-p
pantotheine-4'-phosphate
PNS ,
C01134
pantetheine 4'-phosphate
phosphopantetheine
d-pantetheine 4'-phosphate
4'-phosphopantetheine
DB03912
(2r)-2-hydroxy-n-(3-((2-mercaptoethyl)amino)-3-oxopropyl)-3,3-dimethyl-4-(phosphonooxy)butanamide
pantetheine-4'-phosphate
[(3r)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] dihydrogen phosphate
CHEBI:4222
n(3)-[(2r)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-n-(2-sulfanylethyl)-beta-alaninamide
o(4)-phosphono-d-pantethein
nm39wu8ofm ,
butanamide, 2-hydroxy-n-(3-((2-mercaptoethyl)amino)-3-oxopropyl)-3,3-dimethyl-4-(phosphonooxy)-, (r)-
unii-nm39wu8ofm
pantetheine phosphate
butyramide, 2,4-dihydroxy-n-(2-(2-mercaptoethylcarbamoyl)ethyl)-3,3-dimethyl-, 4-phosphate
butanamide, 2-hydroxy-n-(3-((2-mercaptoethyl)amino)-3-oxopropyl)-3,3-dimethyl-4-(phosphonooxy)-, (2r)-
SCHEMBL106050
5pd ,
phospho-pantotheine
4'-phosphopantotheine
n~3~-[(2r)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-n-(2-sulfanylethyl)-beta-alaninamide
DTXSID30897420
(3r)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl dihydrogen phosphate
[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphonicacid
JDMUPRLRUUMCTL-VIFPVBQESA-N
Q6590391
[(3r)-3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphonic acid
STR08840
AMY480
[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphonic acid

Roles (1)

RoleDescription
prosthetic groupA tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
pantetheine 4'-phosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

4'-phosphopantetheine is involved in 1 pathway(s), involving a total of 0 unique proteins and 466 unique compounds

PathwayProteinsCompounds
Biochemical pathways: part I0466

Research

Studies (129)

TimeframeStudies, This Drug (%)All Drugs %
pre-199019 (14.73)18.7374
1990's24 (18.60)18.2507
2000's51 (39.53)29.6817
2010's27 (20.93)24.3611
2020's8 (6.20)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (3.10%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other125 (96.90%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
pantetheine[no description available]medium1290pantetheines;
thiol		human metabolite;
metabolite;
mouse metabolite
coenzyme a[no description available]medium350adenosine 3',5'-bisphosphatecoenzyme;
Escherichia coli metabolite;
mouse metabolite
thioctic acid[no description available]medium10dithiolanes;
heterocyclic fatty acid;
thia fatty acid		fundamental metabolite;
geroprotector
serine[no description available]medium70L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
aspartic acid[no description available]medium10aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
glycine[no description available]medium10alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
alanine[no description available]medium50alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
threonine[no description available]medium10amino acid zwitterion;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
threonine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
perfluorobutane sulfonate[no description available]medium10perfluoroalkanesulfonic acidsurfactant
phenylalanine[no description available]medium40amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
adenosine monophosphate[no description available]medium30adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
cysteine[no description available]medium140cysteiniumfundamental metabolite
methotrexate[no description available]medium10dicarboxylic acid;
monocarboxylic acid amide;
pteridines		abortifacient;
antimetabolite;
antineoplastic agent;
antirheumatic drug;
dermatologic drug;
DNA synthesis inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
immunosuppressive agent
dephosphocoenzyme a[no description available]medium50adenosine 5'-phosphateEscherichia coli metabolite;
human metabolite;
mouse metabolite
bacillaene[no description available]medium10enamine;
monocarboxylic acid amide;
polyene antibiotic;
polyketide;
secondary alcohol		antibacterial agent;
antimicrobial agent;
bacterial metabolite
1-anilino-8-naphthalenesulfonate[no description available]medium10aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
gramicidin a[no description available]medium30
nadp[no description available]medium20
norsolorinic acid[no description available]medium10polyketide;
tetrahydroxyanthraquinone		fungal metabolite
cysteamine[no description available]medium20amine;
thiol		geroprotector;
human metabolite;
mouse metabolite;
radiation protective agent
dimethyl sulfoxide[no description available]medium10sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
lovastatin[no description available]medium10delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
polyketide;
statin (naturally occurring)		anticholesteremic drug;
antineoplastic agent;
Aspergillus metabolite;
prodrug
aflatoxin b1[no description available]medium10aflatoxin;
aromatic ether;
aromatic ketone		carcinogenic agent;
human metabolite
alpha,beta-methyleneadenosine 5'-triphosphate[no description available]medium10nucleoside triphosphate analogue
palmitoyl coenzyme a[no description available]medium1011,12-saturated fatty acyl-CoA;
3-substituted propionyl-CoA;
long-chain fatty acyl-CoA;
palmitoyl bioconjugate		Escherichia coli metabolite;
mouse metabolite
beta-lactams[no description available]medium10beta-lactam antibiotic allergen;
beta-lactam
fluorescein-5-isothiocyanate[no description available]medium10fluorescein isothiocyanate
naphthoquinones[no description available]medium10
frenolicin b[no description available]medium10benzoisochromanequinone;
p-quinones		metabolite
pantothenic acid[no description available]medium110pantothenic acid;
vitamin B5		antidote to curare poisoning;
geroprotector;
human blood serum metabolite
flavin mononucleotide[no description available]medium30
pantothenylcysteine 4'-phosphate[no description available]medium40L-cysteine derivativeEscherichia coli metabolite;
mouse metabolite
histidine[no description available]medium30amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
stearates[no description available]medium10
10-formyltetrahydrofolate[no description available]medium10formyltetrahydrofolic acidEscherichia coli metabolite;
mouse metabolite
levoleucovorin[no description available]medium105-formyltetrahydrofolic acidantineoplastic agent;
metabolite
5,6,7,8-tetrahydrofolic acid[no description available]medium10tetrahydrofolic acid
pantethine[no description available]medium30organic disulfidecoenzyme;
nutraceutical
beta-alanine[no description available]medium20amino acid zwitterion;
beta-amino acid		agonist;
fundamental metabolite;
human metabolite;
inhibitor;
neurotransmitter
phosphopantothenic acid[no description available]medium10amidoalkyl phosphateEscherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
iodoacetamide[no description available]medium20
s-adenosylmethionine[no description available]medium20organic cation;
sulfonium compound		coenzyme;
cofactor;
human metabolite;
micronutrient;
Mycoplasma genitalium metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
4-bromo-2,3-dioxobutyl-coenzyme a[no description available]medium10
valine[no description available]medium20L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
1,5-i-aedans[no description available]medium10aminonaphthalenesulfonic acidfluorescent probe
pyridoxal phosphate[no description available]medium10methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6 phosphate		coenzyme;
cofactor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
2,3-dihydroxybenzoic acid[no description available]medium10dihydroxybenzoic acidhuman xenobiotic metabolite;
plant metabolite
salicylic acid[no description available]medium20monohydroxybenzoic acidalgal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite
enterobactin[no description available]medium20catechols;
crown compound;
macrotriolide;
polyphenol		bacterial metabolite;
siderophore
salicylates[no description available]medium10monohydroxybenzoateplant metabolite
surfactin peptide[no description available]medium20
proline[no description available]medium10amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid		algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
phenylalanylproline[no description available]medium10dipeptidemetabolite
1,3-dibromo-2-propanone[no description available]medium20
acetone[no description available]medium20ketone body;
methyl ketone;
propanones;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
human metabolite;
polar aprotic solvent
lysine[no description available]medium20aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
tetracycline[no description available]medium10
concanavalin a[no description available]medium10
pyrophosphate[no description available]medium10diphosphate ion
flavin-adenine dinucleotide[no description available]medium10flavin adenine dinucleotide;
vitamin B2		cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prosthetic group
nicotinamide mononucleotide[no description available]medium10nicotinamide mononucleotideEscherichia coli metabolite;
mouse metabolite
nad[no description available]medium10organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
malonyl coenzyme a[no description available]medium20malonyl-CoAsEC 2.3.1.21 (carnitine O-palmitoyltransferase) inhibitor;
Escherichia coli metabolite;
metabolite;
mouse metabolite
yersiniabactin[no description available]medium10monocarboxylic acid;
phenols;
secondary alcohol;
thiazolidines		bacterial metabolite;
siderophore
thiazoles[no description available]medium101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
methylmalonyl-coenzyme a[no description available]medium10
erythromycin[no description available]medium10cyclic ketone;
erythromycin
propionyl-coenzyme a[no description available]medium10acyl-CoAEscherichia coli metabolite;
metabolite;
mouse metabolite
6-deoxyerythronolide b[no description available]medium10erythronolide
cytidine monophosphate[no description available]medium10cytidine 5'-phosphate;
pyrimidine ribonucleoside 5'-monophosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite
cytidine triphosphate[no description available]medium10cytidine 5'-phosphate;
pyrimidine ribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite
4-chlorobenzoyl coenzyme a[no description available]medium10chlorobenzoyl-CoA;
monochlorobenzenes
cephalosporin c[no description available]medium10cephalosporinfungal metabolite
dithiothreitol[no description available]medium101,4-dimercaptobutane-2,3-diol;
butanediols;
dithiol;
glycol;
thiol		chelator;
human metabolite;
reducing agent
mercaptoethanol[no description available]medium10alkanethiol;
primary alcohol		geroprotector
hydroxylamine[no description available]medium10hydroxylaminesalgal metabolite;
bacterial xenobiotic metabolite;
EC 1.1.3.13 (alcohol oxidase) inhibitor;
EC 4.2.1.22 (cystathionine beta-synthase) inhibitor;
EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor;
nitric oxide donor;
nucleophilic reagent
carboxyatractyloside[no description available]medium10
atractyloside[no description available]medium10
ethylmaleimide[no description available]medium10maleimidesanticoronaviral agent;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.1.1 (hexokinase) inhibitor
phenyl acetate[no description available]medium10benzenes;
phenyl acetates
acetic acid[no description available]medium10monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
acetyl coenzyme a[no description available]medium10acyl-CoAacyl donor;
coenzyme;
effector;
fundamental metabolite
malonic acid[no description available]medium10alpha,omega-dicarboxylic acidhuman metabolite
berlition[no description available]low00dithiolanes;
heterocyclic fatty acid;
lipoic acid;
thia fatty acid		cofactor;
nutraceutical;
prosthetic group
biotin[no description available]low00biotins;
vitamin B7		coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Bacterial Pneumonia0low10
Blood Pressure, High0low10
Body Weight0low10
Brain Hemorrhage, Cerebral0low10
Cancer of Liver0low10
Cancer of the Liver0low10
Cancer, Hepatocellular0low10
Carcinoma, Hepatocellular0low10
Cerebral Hemorrhage0low10
Cerebral Parenchymal Hemorrhage0low10
Degenerative Disease, Nervous System, Hereditary0low10
Degenerative Hereditary Diseases, Nervous System0low10
Degenerative Hereditary Disorders, Nervous System0low10
Disease Models, Animal0low10
Hallervorden-Spatz Disease0low10
Hallervorden-Spatz Syndrome0low10
Hemorrhage, Cerebral0low10
Hemorrhage, Cerebrum0low10
Hepatic Cancer0low10
Hepatic Neoplasms0low10
Hepatocellular Cancer0low10
Hepatocellular Carcinoma0low10
Hepatoma0low10
Hereditary Diseases, Neurodegenerative0low10
Hereditary Neurodegenerative Diseases0low10
Hereditary-Degenerative Disorders, Nervous System0low10
Heredodegenerative Disorders, Nervous System0low10
Hypertension0low10
Infections, Pneumococcal0low10
Infections, Streptococcus pneumoniae0low10
Intracerebral Hemorrhage0low10
Koch's Disease0low10
Kochs Disease0low10
Liver Cancer0low10
Liver Cancer, Adult0low10
Liver Cell Carcinoma0low10
Liver Cell Carcinoma, Adult0low10
Liver Neoplasms0low10
Mycobacterium tuberculosis Infection0low10
Neoplasms, Hepatic0low10
Neoplasms, Liver0low10
Nerve Degeneration0low10
Nervous System Degenerative Hereditary Diseases0low10
Nervous System Diseases, Degenerative, Hereditary0low10
Nervous System Hereditary Degenerative Diseases0low10
Neuroaxonal Dystrophy, Juvenile-Onset0low10
Neurodegeneration With Brain Iron Accumulation 10low10
Neurodegeneration with Brain Iron Accumulation Type 10low10
Neurodegenerative Diseases, Hereditary0low10
Neuron Degeneration0low10
Pantothenate Kinase-Associated Neurodegeneration0low10
Pigmentary Pallidal Atrophy0low10
Pigmentary Pallidal Degeneration0low10
PKAN Neuroaxonal Dystrophy, Juvenile-Onset0low10
Pneumococcal Diseases0low10
Pneumococcal Infections0low10
Pneumonia, Bacterial0low10
Pregnancy0low20
Starvation0low10
Streptococcus pneumoniae Infections0low10
Tuberculosis0low10

Research Highlights

Dosage (1)

ArticleYear
Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.
Antimicrobial agents and chemotherapy, Volume: 57, Issue: 12		2013
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]