Page last updated: 2024-09-28

Erythema Chronicum Migrans

A deep type of gyrate erythema that follows a bite by an ixodid tick; it is a stage-1 manifestation of LYME DISEASE. The site of the bite is characterized by a red papule that expands peripherally as a nonscaling, palpable band that clears centrally. This condition is often associated with systemic symptoms such as chills, fever, headache, malaise, nausea, vomiting, fatigue, backache, and stiff neck.

Synonyms(1)

Synonym
Erythema Chronicum Migrans

Research

Studies (117)

TimeframeStudies, This Condition (%)All Conditions %
pre-19905 (4.27)23.3326
1990's38 (32.48)12.5806
2000's42 (35.90)18.1394
2010's23 (19.66)28.8240
2020's9 (7.69)9.53
DrugIndicatedRelationship StrengthStudiesTrials
cefuroxime0medium114
aminosalicylic acid0low10
probenecid0medium21
prednisolone0low10
penicillin g0low40
methylprednisolone0low10
penicillin v0medium145
erythromycin0medium43
zinc sulfate0low10
trolamine salicylate0low80
amoxicillin0medium415
fenoxycarb0low10
cephalosporin c0medium71
atovaquone0low10
beta-lactams0low10
biotin0low10
zithromax0medium135
ovalbumin0low10
clavulanic acid0low10
cefotaxime0low30
amoxicillin-potassium clavulanate combination0low10
ro13-99040medium333
interleukin-80low20
tetracycline0low60
minocycline0low40
calca protein, human0low10
transforming growth factor beta0low10
cefuroxime axetil0medium84
agar0low10

Protein Targets (395)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, 2-oxoglutarate Oxygenase2002
Microtubule-associated protein tau2002
thioredoxin glutathione reductase1001
Smad31001
euchromatic histone-lysine N-methyltransferase 22002
microphthalmia-associated transcription factor isoform 90101
Carbonic anhydrase 10303
Carbonic anhydrase 20303
Tyrosine-protein phosphatase non-receptor type 10011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Beta-lactamase2002
Beta-lactamase 0103
Beta-lactamase 0104
Beta-lactamase 0003
Beta-lactamase 0104
AR protein6006
apical membrane antigen 1, AMA12002
estrogen nuclear receptor alpha100010
Beta-lactamase 0003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
DNA polymerase kappa isoform 11001
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40707
Bile salt export pump0303
Bile salt export pump0909
Beta-lactamase SHV-10104
Beta-lactamase SHV-10205
Cytochrome P450 2C9 0404
Beta-lactamase0104
Kappa-type opioid receptor0003
Solute carrier family 15 member 10404
Solute carrier family 15 member 10101
Cytochrome P450 2J20404
B2 metallo-beta-lactamase 0003
Solute carrier family 15 member 20303
Beta-lactamase 0104
Beta-lactamase 0104
Solute carrier family 15 member 20303
Beta-lactamase 0104
Beta-lactamase 0003
Canalicular multispecific organic anion transporter 10808
phosphopantetheinyl transferase1001
RAR-related orphan receptor gamma6006
SMAD family member 21001
USP1 protein, partial2002
SMAD family member 31001
TDP1 protein5005
GLI family zinc finger 37007
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
thyroid stimulating hormone receptor2002
cytochrome P450 family 3 subfamily A polypeptide 43003
retinoid X nuclear receptor alpha5005
estrogen-related nuclear receptor alpha7007
pregnane X nuclear receptor4004
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma3003
IDH13003
aryl hydrocarbon receptor2002
activating transcription factor 61001
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Dihydroorotate dehydrogenase 0101
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C9 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
potassium voltage-gated channel subfamily H member 2 isoform d1001
transcriptional regulator ERG isoform 31001
thyroid hormone receptor beta isoform 25005
heat shock protein beta-12002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
nuclear factor erythroid 2-related factor 2 isoform 14004
nuclear receptor ROR-gamma isoform 13003
geminin5005
Vpr1001
peripheral myelin protein 221001
histone acetyltransferase KAT2A isoform 11001
lamin isoform A-delta102002
Voltage-dependent calcium channel gamma-2 subunit4004
Cytochrome b0101
Cellular tumor antigen p533003
Integrin beta-31001
Integrin alpha-IIb1001
Glutamate receptor 24004
Dihydroorotate dehydrogenase (fumarate)0101
Histamine H2 receptor1001
Spike glycoprotein1001
Guanine nucleotide-binding protein G2002
Disintegrin and metalloproteinase domain-containing protein 171001
Dihydroorotate dehydrogenase (quinone), mitochondrial0102
TAR DNA-binding protein 432002
Dihydroorotate dehydrogenase 0202
Dihydroorotate dehydrogenase (quinone), mitochondrial0102
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Chain A, Avidin0011
Chain A, Protein (streptavidin)0011
Chain B, Protein (streptavidin)0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin Complex With Biotin0011
Chain D, Circularly Permuted Core-streptavidin E51/a460011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Avidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, JmjC domain-containing histone demethylation protein 3A1001
nonstructural protein 10101
green fluorescent protein, partial0101
vitamin D3 receptor isoform VDRA1001
insulin-degrading enzyme isoform 10011
Streptavidin0011
Receptor-type tyrosine-protein phosphatase beta0001
Beta-lactamase 0002
Beta-lactamase 0103
Beta-lactamase 0203
Beta-lactamase 0002
Metallo-beta-lactamase type 20002
Metallo-beta-lactamase VIM-11 0002
Metallo-beta-lactamase VIM-20002
Beta-lactamase 0103
Metallo-beta-lactamase VIM-19 0002
Beta-lactamase 0103
Beta-lactamase 0002
Metallo-beta-lactamase0002
Beta-lactamase 0203
Solute carrier family 22 member 60303
Albumin0033
Beta-lactamase 0102
Beta-lactamase 0102
Beta-lactamase 0102
Metallo-beta-lactamase VIM-130002
Beta-lactamase 0002
Beta-lactamase 0103
Metallo-beta-lactamase VIM-20002
Beta-lactamase 0001
Beta-lactamase Toho-10002
Solute carrier family 22 member 60303
Solute carrier family 22 member 70202
Metallo-beta-lactamase0001
Beta-lactamase 0102
Metallo-b-lactamase 0003
BlaVIM-1 0002
Beta-lactamase 0002
Solute carrier family 22 member 80405
Beta-lactamase 0103
Carbapenem-hydrolyzing beta-lactamase KPC0204
Histamine H3 receptor0001
Beta-lactamase class B VIM-2 0003
Solute carrier family 22 member 110304
Solute carrier family 22 member 80405
Beta-lactamase VIM-1 0002
Solute carrier family 22 member 70304
Beta-lactamase 0101
Beta-lactamase0102
Beta-lactamase0101
Beta-lactamase0102
Neutrophil elastase0101
Beta-lactamase OXA-10101
Cytochrome P450 2B60101
Beta-lactamase TEM0305
Beta-lactamase0101
Class D beta-lactamase0102
Beta-lactamase 0101
Beta-lactamase 0101
Motilin receptor0011
acid sphingomyelinase1001
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK11001
streptokinase A precursor0033
Motilin receptor0112
Rap guanine nucleotide exchange factor 31001
30S ribosomal protein S60314
30S ribosomal protein S70314
50S ribosomal protein L150314
ATP-dependent translocase ABCB10202
ATP-dependent translocase ABCB10202
Cytochrome P450 3A40202
60 kDa chaperonin0101
50S ribosomal protein L100314
50S ribosomal protein L110314
50S ribosomal protein L7/L120314
50S ribosomal protein L190314
50S ribosomal protein L10314
50S ribosomal protein L200314
50S ribosomal protein L270314
50S ribosomal protein L280314
50S ribosomal protein L290314
50S ribosomal protein L310314
50S ribosomal protein L31 type B0314
50S ribosomal protein L320314
50S ribosomal protein L330314
50S ribosomal protein L340314
50S ribosomal protein L350314
50S ribosomal protein L360314
30S ribosomal protein S100314
30S ribosomal protein S110314
30S ribosomal protein S120314
30S ribosomal protein S130314
30S ribosomal protein S160314
30S ribosomal protein S180314
30S ribosomal protein S190314
30S ribosomal protein S200314
30S ribosomal protein S20314
30S ribosomal protein S30314
30S ribosomal protein S40314
30S ribosomal protein S50314
30S ribosomal protein S80314
30S ribosomal protein S90314
50S ribosomal protein L130314
50S ribosomal protein L140314
50S ribosomal protein L160314
50S ribosomal protein L230314
30S ribosomal protein S150314
50S ribosomal protein L170314
50S ribosomal protein L210314
50S ribosomal protein L300314
50S ribosomal protein L60314
30S ribosomal protein S140314
30S ribosomal protein S170314
30S ribosomal protein S10314
50S ribosomal protein L180314
60 kDa heat shock protein, mitochondrial0101
Chitinase B0101
ATP-dependent translocase ABCB10202
Low molecular weight phosphotyrosine protein phosphatase0101
50S ribosomal protein L20314
50S ribosomal protein L30314
50S ribosomal protein L240314
50S ribosomal protein L40314
50S ribosomal protein L220314
10 kDa heat shock protein, mitochondrial0101
50S ribosomal protein L50314
30S ribosomal protein S210314
50S ribosomal protein L250314
Potassium voltage-gated channel subfamily H member 20101
Cytochrome P450 1B10101
Thiosulfate sulfurtransferase0101
Lanosterol 14-alpha demethylase0101
50S ribosomal protein L36 20314
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Multidrug and toxin extrusion protein 10101
Luciferase1001
pregnane X receptor1001
hypoxia-inducible factor 1 alpha subunit3003
estrogen receptor 2 (ER beta)1001
nuclear receptor subfamily 1, group I, member 31001
progesterone receptor4004
retinoic acid nuclear receptor alpha variant 13003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
acetylcholinesterase1001
PPM1D protein2002
nonstructural protein 11001
glucocorticoid receptor [Homo sapiens]4004
G1001
bromodomain adjacent to zinc finger domain 2B1001
nuclear receptor subfamily 1, group I, member 23003
nuclear factor erythroid 2-related factor 2 isoform 22002
muscleblind-like protein 1 isoform 11001
Nuclear receptor subfamily 1 group I member 20011
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 1001
Glucocorticoid receptor04110
Glycine receptor subunit alpha-10404
Androgen receptor0303
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Inositol hexakisphosphate kinase 11001
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2C9, partial1001
ATP-dependent phosphofructokinase1001
GLS protein1001
EWS/FLI fusion protein2002
Stromelysin-10202
Matrilysin0101
Multidrug transporter MdfA0202
Matrix metalloproteinase-90101
Protein mono-ADP-ribosyltransferase PARP150101
Protein-arginine deiminase type-40404
Beta-lactamase 0001
Beta-lactamase0001
Solute carrier family 22 member 80304
Beta-lactamase 10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Efflux transporter 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase IMP-1 0001
Beta-lactamase 0001
Replicase polyprotein 1ab0101
Beta-lactamase OXA-70001
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Estrogen receptor beta0202
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
alpha-galactosidase1001
chromobox protein homolog 12002
ras-related protein Rab-9A1001
survival motor neuron protein isoform d1001
Solute carrier organic anion transporter family member 1A40101
Carbonic anhydrase 120101
UDP-glucuronosyltransferase 1A90101
Transient receptor potential cation channel subfamily A member 10011
UDP-glucuronosyltransferase 1-60101
UDP-glucuronosyltransferase 1A1 0101
Solute carrier organic anion transporter family member 1A10101
Carbonic anhydrase 90101
Solute carrier family 22 member 10101
Canalicular multispecific organic anion transporter 10101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Pannexin-10101
Solute carrier family 22 member 120101
Solute carrier organic anion transporter family member 1C10101
UDP-glucuronosyltransferase 1A70101
UDP-glucuronosyltransferase 1A100101
Pannexin-10101
Solute carrier family 22 member 20101
90-kda heat shock protein beta HSP90 beta, partial0101
Histone H2A.x1001
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
Tetracycline resistance protein, class B0001
Muscarinic acetylcholine receptor M20101
72 kDa type IV collagenase0101
Alpha-1B adrenergic receptor0101
Neutrophil collagenase0101
Alpha-1D adrenergic receptor0101
Alpha-synuclein0101
Alpha-1A adrenergic receptor0101
Collagenase 30101
Cannabinoid receptor 10101
Integrase 0101
P2Y purinoceptor 120101
interleukin 81001
glp-1 receptor, partial1001
thyroid stimulating hormone receptor1001
cytochrome P450 3A4 isoform 11001
twin arginine protein translocation system - TatA protein0001
Gamma-aminobutyric acid receptor subunit pi1001
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Nuclear receptor ROR-gamma1001
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
GABA theta subunit1001
Gamma-aminobutyric acid receptor subunit epsilon1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]