Compounds > em 201
Page last updated: 2024-12-07

em 201

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

8,9-anhydroerythromycin A 6,9-hemiketal: a motilin agonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID83954
CHEMBL ID300004
CHEBI ID184048
SCHEMBL ID12101978
MeSH IDM0246977

Synonyms (38)

Synonym
33396-29-1
(1r,2r,3s,4s,5r,8r,9s,10r,11r)-2-[(2s,3r,4s,6r)-4-dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-8-ethyl-9,10-dihydroxy-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-1,3,5,9,11,13-hexamethyl-7,15-dioxabicyclo[10.2.1]pentadec-12-en-6-one
me-4
em-a enolether
gtpl1448
em-201
CHEMBL300004
(2r,3r,4s,5r,8r,9s,10s,11r,12s)-5-ethyl-11-[(2s,3r,4s,6r)-4-[ethyl(methyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-3,4-dihydroxy-9-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec-1(14)
erythromycin a enol ether
CHEBI:184048
(2r,3r,4s,5r,8r,9s,10s,11r,12r)-11-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-5-ethyl-3,4-dihydroxy-9-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec-1(14)-en-7
unii-32b40i7v7b
brl 46357er
em 201
erythromycin enol ether
8,9-anhydroerythromycin a 6,9-hemiketal
me 4
32b40i7v7b ,
erythromycin-a enol ether
cas_33396-29-1
erythromycin a 6,9-enolether
bdbm85846
em523
me523
(2r,3r,4s,5r,8r,9s,10s,11r,12r)-9-((2,6-dideoxy-3-c-methyl-3-o-methyl-.alpha.-l-ribo-hexopyranosyl)oxy)-5-ethyl-3,4-dihydroxy-2,4,8,10,12,14-hexamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-.beta.-d-xylo-hexopyranosyl)oxy)-6,15-dioxabicyclo(10.2.1)pentade
erythromycin estolate impurity e [ep impurity]
erythromycin stearate impurity e [ep impurity]
erythromycin ethylsuccinate impurity e [ep impurity]
erythromycin impurity e [ep impurity]
brl-46357er
erythromycin lactobionate impurity e [ep impurity]
SCHEMBL12101978
JFVYXJKGJMUGRG-KJPZRSJGSA-N
em201
Q27083849
HY-122207
CS-0082649
AKOS040744877

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" ABT-229 was > 300,000 times more potent than erythromycin in vitro and had 39% oral bioavailability in dog compared to its 4",12-dihydroxy congener (EM-523), which was only 400 times more potent than erythromycin and had relatively low (1."( Synthesis of 4"-deoxy motilides: identification of a potent and orally active prokinetic drug candidate.
Edwards, CM; Faghih, R; Freiberg, L; Klein, LL; Lartey, PA; Marsh, K; Nellans, HN; Petersen, A; Plattner, JJ; Quigley, S, 1995)		0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
aminoglycoside
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID58287Evaluated for gastrointestinal motor stimulating (GMS) activity in dog estimated in vivo by 2 x 2 points parallel line assay. Activity of EM-A was assumed to be 11987Journal of medicinal chemistry, Nov, Volume: 30, Issue:11
Macrolides with gastrointestinal motor stimulating activity.
AID167709The compound was tested in vitro for prokinetic activity as smooth muscle contractility in isolated rabbit duodenum1995Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
Synthesis of 4"-deoxy motilides: identification of a potent and orally active prokinetic drug candidate.
AID69621Antibacterial activity against Escherichia coli NIHJ1987Journal of medicinal chemistry, Nov, Volume: 30, Issue:11
Macrolides with gastrointestinal motor stimulating activity.
AID234709Activity relative to erythromycin A1995Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
Synthesis of 4"-deoxy motilides: identification of a potent and orally active prokinetic drug candidate.
AID40647Antibacterial activity against Bacillus subtilis ATCC 66331987Journal of medicinal chemistry, Nov, Volume: 30, Issue:11
Macrolides with gastrointestinal motor stimulating activity.
AID206875Antibacterial activity against Staphylococcus aureus ATCC 6538P1987Journal of medicinal chemistry, Nov, Volume: 30, Issue:11
Macrolides with gastrointestinal motor stimulating activity.
AID40211Antibacterial activity against Bacillus cereus IFO 30011987Journal of medicinal chemistry, Nov, Volume: 30, Issue:11
Macrolides with gastrointestinal motor stimulating activity.
AID95914Antibacterial activity against Klebsiella pneumoniae ATCC 100311987Journal of medicinal chemistry, Nov, Volume: 30, Issue:11
Macrolides with gastrointestinal motor stimulating activity.
AID1346284Human motilin receptor (Motilin receptor)2005The Journal of pharmacology and experimental therapeutics, Jun, Volume: 313, Issue:3
Desensitization of the human motilin receptor by motilides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (9.09)18.7374
1990's3 (27.27)18.2507
2000's6 (54.55)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 37.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index37.47 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.86 (4.65)
Search Engine Demand Index93.48 (26.88)
Search Engine Supply Index3.86 (0.95)

This Compound (37.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
inositol
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.. inositol : Any cyclohexane-1,2,3,4,5,6-hexol.. 1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.. muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.		1.9810cyclitol;
hexol
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source		2.0210chromones;
morpholines;
organochlorine compound		autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector
pd 98059
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source. 2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.		2.0210aromatic amine;
monomethoxyflavone		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector
carbachol
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.		1.9810ammonium salt;
carbamate ester		cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic
erythromycin
Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.		3.8110cyclic ketone;
erythromycin
clarithromycin
Clarithromycin: A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.. clarithromycin : The 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis.		1.9910macrolide antibioticantibacterial drug;
environmental contaminant;
protein synthesis inhibitor;
xenobiotic
sirolimus
Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.. sirolimus : A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.		2.0210antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol		antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor
em 523
EM 523: structure given in first source		1.9810
alemcinal
[no description available]		2.4120
motilin
Motilin: A peptide of about 22-amino acids isolated from the DUODENUM. At low pH it inhibits gastric motor activity, whereas at high pH it has a stimulating effect.		2.420
interleukin-8
Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.		1.9910
em703
EM703: improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-beta signaling in lung fibroblasts; structure in first source		2.0410
guanosine triphosphate
Guanosine Triphosphate: Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.		1.9810guanosine 5'-phosphate;
purine ribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor
guanosine 5'-o-(3-thiotriphosphate)
Guanosine 5'-O-(3-Thiotriphosphate): Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes.		1.9810nucleoside triphosphate analogue
ConditionIndicatedRelationship StrengthStudiesTrials
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		02.3920
Diathesis
[description not available]		02.0410
Skin Aging
The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.		02.0510