Page last updated: 2024-09-28

Chondrodysplasia Punctata

A heterogeneous group of bone dysplasias, the common character of which is stippling of the epiphyses in infancy. The group includes a severe autosomal recessive form (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC), an autosomal dominant form (Conradi-Hunermann syndrome), and a milder X-linked form. Metabolic defects associated with impaired peroxisomes are present only in the rhizomelic form.

Synonyms(16)

Synonym
X-Linked Chondrodysplasia Punctata 2
Hunermann-Conradi Syndrome
Chondrodystrophia Calcificans Congenita
Conradi-Hunermann Syndrome
Conradi-Hunermann-Happle Syndrome
Conradi-Hu00FCnermann-Happle Syndrome
Conradi-Hu00FCnermann Syndrome
Conradi Hunermann Happle Syndrome
Epiphyses, Stippled
Chondrodysplasia Punctata
Chondrodysplasia Punctata 2, X-Linked
Chondrodysplasia Punctata 2, X-Linked Dominant
Dysplasia Epiphysialis Punctata
Happle Syndrome
X-Linked Dominant Chondrodysplasia Punctata
Stippled Epiphyses

Research Excerpts

Overview

ExcerptReference
"A case of congenital stippled epiphyses is presented, and attention is drawn to the possibility that this condition was caused by maternal ingestion of warfarin during early pregnancy."( Fourie, DT; Hay, IT, 1975)
"Chondrodysplasia punctata is an uncommon group of congenital bone dysplasias."( Marshall, DR; Webster, HR, 1991)
"Chondrodysplasia punctata is a heterogeneous skeletal dysplasia characterized by small focal calcifications in articular and other cartilages in infancy, referred to as stippled epiphyses, with subsequent epiphysial dysplasia and associated anomalies of the face, eyes and skin."( Baugh, RF; McIntee, RA; Seguin, JH, 1993)
"Chondrodysplasia punctata is abnormal calcification in the cartilage of developing bones and has been seen in association with deranged vitamin K metabolism."( Ghimire, RK; Panta, OB; Paudel, SS; Songmen, S, 2017)
"Chondrodysplasia punctata is a skeletal dysplasia caused by a diverse spectrum of etiologies, with outcomes ranging from antenatal demise to a normal life span."( Blask, AR; Bulas, DI; Chapman, KA; Lawrence, AK; Rubio, EI, 2018)

Treatment

ExcerptReference
"Nasal hypoplasia with or without stippled epiphyses has now been reported in 11 infants born to mothers treated with warfarin during the first trimester, and a causal association is probable."( Ikonen, E; Raivio, KO; Saarikoski, S, 1977)

Research

Studies (150)

TimeframeStudies, This Condition (%)All Conditions %
pre-199060 (40.00)23.3326
1990's33 (22.00)12.5806
2000's28 (18.67)18.1394
2010's26 (17.33)28.8240
2020's3 (2.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
chlorine0low10
coumarin0low20
salicylic acid0low10
iodine0low10
pipecolic acid0low20
palmitic acid0low10
picolinic acid0low10
phenytoin0low20
adrenic acid0low10
baclofen0low10
verapamil0low10
carbamazepine0low10
cetyl alcohol0low10
diazepam0low20
erythrosine0low10
fentanyl0low10
furosemide0low10
iohexol0low10
2-propanol0low50
leflunomide0low10
midazolam0low10
propofol0low10
stearic acid0low10
sulfisoxazole0low20
dehydroepiandrosterone0low10
pilocarpine0low10
tyrosine0low10
3,3'-diaminobenzidine0low10
trehalose0low10
isoxazoles0low10
lignoceric acid0low10
erythromycin0low10
fluorescein0low10
ferric chloride0low10
phytanic acid0low130
vecuronium bromide0low10
ethyl 2-(5-(4-chlorophenyl)pentyl)oxiran-2-carboxylate0low10
remifentanil0low10
cholesteryl sulfate0low10
lathosterol0low10
emopamil0low10
clarithromycin0low10
zymostenol0low20
trehalose-6-phosphate0low10
technetium tc 99m hydroxymethylene diphosphonate0low10
pristanic acid0low30
cholesta-5,8-dien-3 beta-ol0low50
atropine0low10
lanosterol0low10
mevalonic acid0low20
desmosterol0low20
digitoxin0low10
arachidonic acid0low10
eicosapentaenoic acid0low10
bromochloroacetic acid0low20
squalene0low20
digoxin0low10
tamoxifen0low10
thiopental0low10
lithium0low10
cytellin0low10
dinoprostone0low20
vitamin k semiquinone radical0low70
leukotriene b40low10
leukotriene e40low10
6-ketoprostaglandin f1 alpha0low10
erucic acid0low10
phenylephrine hydrochloride0low150
vitamin k 10low10
sulfur0low10
diphenylhexatriene0low20
u 18666a0low10
natriuretic peptide, c-type0low10
phosphatidylcholines0low10
1-palmitoyl-2-(6-(n-(7-nitrobenz)-2-oxa-1,3-diazol-4-yl)aminocaproyl)phosphatidylcholine0low10
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene0low10
piperidines0low10
chondroitin0low20
heparitin sulfate0low10
acenocoumarol0low30
warfarin0low310
phenprocoumon0low30
digitonin0low10
technetium tc 99m medronate0low10
eye0low40
ego0low10

Protein Targets (740)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit6006
RAR-related orphan receptor gamma170017
GLI family zinc finger 3240024
AR protein260026
aldehyde dehydrogenase 1 family, member A1100010
retinoic acid nuclear receptor alpha variant 1210021
retinoid X nuclear receptor alpha160016
estrogen nuclear receptor alpha330033
peroxisome proliferator-activated receptor delta100010
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a130013
activating transcription factor 6130013
v-jun sarcoma virus 17 oncogene homolog (avian)110011
Histone H2A.x5005
thyroid hormone receptor beta isoform a110011
heat shock protein beta-17007
nuclear factor erythroid 2-related factor 2 isoform 1180018
lamin isoform A-delta10160016
Voltage-dependent calcium channel gamma-2 subunit9009
Glutamate receptor 29009
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Luciferase6006
nuclear receptor subfamily 1, group I, member 3110011
progesterone receptor120012
glucocorticoid receptor [Homo sapiens]210021
estrogen-related nuclear receptor alpha220022
farnesoid X nuclear receptor150015
pregnane X nuclear receptor190019
vitamin D (1,25- dihydroxyvitamin D3) receptor120012
aryl hydrocarbon receptor9009
thyroid stimulating hormone receptor110011
histone deacetylase 9 isoform 33003
Cellular tumor antigen p53180018
Solute carrier organic anion transporter family member 2A10104
Vitamin D3 receptor0001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE100010
G9009
peroxisome proliferator activated receptor gamma130013
euchromatic histone-lysine N-methyltransferase 2190019
chromobox protein homolog 17007
parathyroid hormone/parathyroid hormone-related peptide receptor precursor4004
geminin200020
muscleblind-like protein 1 isoform 12002
Interferon beta130013
HLA class I histocompatibility antigen, B alpha chain 9009
Guanine nucleotide-binding protein G1001
Inositol hexakisphosphate kinase 19009
cytochrome P450 2C9, partial9009
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN0011
Chain A, SERUM ALBUMIN0011
Chain A, SERUM ALBUMIN0011
Chain A, Beta-lactamase110011
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, 2-oxoglutarate Oxygenase6006
Chain A, ATP-DEPENDENT DNA HELICASE Q14004
Chain A, Cruzipain4004
15-lipoxygenase, partial2002
phosphopantetheinyl transferase7007
USP1 protein, partial110011
TDP1 protein190019
Microtubule-associated protein tau5005
thioredoxin glutathione reductase4004
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Bloom syndrome protein isoform 1100010
cellular tumor antigen p53 isoform a4004
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
vitamin D3 receptor isoform VDRA9009
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
nuclear receptor ROR-gamma isoform 16006
lethal(3)malignant brain tumor-like protein 1 isoform I3003
DNA polymerase kappa isoform 17007
cytochrome P450 3A4 isoform 16006
histone acetyltransferase KAT2A isoform 1100010
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
caspase-1 isoform alpha precursor1001
Fatty-acid amide hydrolase 10202
Gamma-aminobutyric acid receptor subunit pi66214
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Prostaglandin G/H synthase 1 0405
Trypsin0202
Coagulation factor VII0202
60 kDa chaperonin0202
60 kDa heat shock protein, mitochondrial0202
Aromatase0202
Tissue factor0202
Fatty acid-binding protein, adipocyte0336
Gamma-aminobutyric acid receptor subunit beta-166214
Gamma-aminobutyric acid receptor subunit delta66214
Gamma-aminobutyric acid receptor subunit gamma-266315
Gamma-aminobutyric acid receptor subunit alpha-566214
Gamma-aminobutyric acid receptor subunit alpha-366214
Gamma-aminobutyric acid receptor subunit gamma-166214
Gamma-aminobutyric acid receptor subunit alpha-266214
Gamma-aminobutyric acid receptor subunit alpha-466214
Gamma-aminobutyric acid receptor subunit gamma-366214
Gamma-aminobutyric acid receptor subunit alpha-666214
Prostaglandin G/H synthase 20315
Nuclear receptor subfamily 4 group A member 20011
Histamine H2 receptor6007
10 kDa heat shock protein, mitochondrial0202
Calmodulin 0001
Gamma-aminobutyric acid receptor subunit alpha-167316
Gamma-aminobutyric acid receptor subunit beta-366214
Gamma-aminobutyric acid receptor subunit beta-266315
Disintegrin and metalloproteinase domain-containing protein 171001
Prostaglandin G/H synthase 20405
Fatty acid-binding protein 50314
Fatty acid-binding protein 50011
Thiosulfate sulfurtransferase0202
Lanosterol 14-alpha demethylase0203
60 kDa chaperonin 0202
10 kDa chaperonin 0202
GABA theta subunit66214
Gamma-aminobutyric acid receptor subunit epsilon66214
Solute carrier organic anion transporter family member 1B30404
Cytosolic phospholipase A2 gamma0101
Transient receptor potential cation channel subfamily V member 20303
Solute carrier organic anion transporter family member 1B10606
Chain A, Phospholipase A2 isoform 30011
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 83003
thioredoxin reductase9009
GLS protein6006
thyroid stimulating hormone receptor6006
hypothetical protein, conserved2002
cytochrome P450 family 3 subfamily A polypeptide 4150015
EWS/FLI fusion protein5005
cytochrome P450 2D65005
glucocerebrosidase3003
Rac1 protein0011
IDH17007
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
DNA polymerase iota isoform a (long)7007
muscarinic acetylcholine receptor M14004
lethal factor (plasmid)3003
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 3015015
Multidrug resistance-associated protein 4015016
Solute carrier family 22 member 60303
Prostaglandin G/H synthase 2 0101
Bile salt export pump022022
Epidermal growth factor receptor0202
Carbonic anhydrase 108011
Carbonic anhydrase 208011
Fatty acid-binding protein, liver0303
Integrin beta-33104
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb3104
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10505
Adenosine receptor A10102
Adenosine receptor A2a0102
Substance-P receptor0102
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma3126
Ras-related protein Rab-2A0011
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0303
Solute carrier family 22 member 200303
Solute carrier family 22 member 60303
Canalicular multispecific organic anion transporter 1014014
Sigma non-opioid intracellular receptor 10415
Sigma non-opioid intracellular receptor 10112
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta1001
short transient receptor potential channel 6 isoform 10011
Solute carrier family 22 member 1 0506
5-hydroxytryptamine receptor 40808
Muscarinic acetylcholine receptor M205210
Muscarinic acetylcholine receptor M40417
Muscarinic acetylcholine receptor M10418
Muscarinic acetylcholine receptor M30418
Muscarinic acetylcholine receptor M40418
Muscarinic acetylcholine receptor M50418
Muscarinic acetylcholine receptor M50518
Muscarinic acetylcholine receptor M20419
Muscarinic acetylcholine receptor M105311
Muscarinic acetylcholine receptor M10012
Muscarinic acetylcholine receptor M30417
Alpha-1D adrenergic receptor0404
5-hydroxytryptamine receptor 2C0808
Muscarinic acetylcholine receptor M40101
5-hydroxytryptamine receptor 70202
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0112
ATAD5 protein, partial6006
NFKB1 protein, partial1001
regulator of G-protein signaling 48008
67.9K protein5005
D(1A) dopamine receptor3003
Gamma-aminobutyric acid type B receptor subunit 20213
Gamma-aminobutyric acid type B receptor subunit 20202
Gamma-aminobutyric acid type B receptor subunit 10213
Gamma-aminobutyric acid type B receptor subunit 10101
ATP-dependent phosphofructokinase3003
acetylcholinesterase9009
nuclear factor erythroid 2-related factor 2 isoform 24004
mitogen-activated protein kinase 13003
Vpr2002
Bile salt export pump0505
Albumin0033
Major prion protein0011
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2C9 0606
UDP-glucuronosyltransferase 2B70203
Cytochrome P450 2B60112
Sodium channel protein type 4 subunit alpha0204
Cytochrome P450 2J20404
Potassium voltage-gated channel subfamily H member 20808
Sodium channel protein type 9 subunit alpha0303
Frizzled-80011
P2X purinoceptor 40101
Carbonic anhydrase 40406
Carbonic anhydrase0102
Carbonic anhydrase 150304
Cholesterol 24-hydroxylase0011
thyroid hormone receptor beta isoform 2200020
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
streptokinase A precursor0033
ATP-dependent translocase ABCB1010221
Cytochrome P450 3A40617
pregnane X receptor1001
GALC protein2002
nuclear receptor subfamily 1, group I, member 24004
peripheral myelin protein 227007
glycogen synthase kinase-3 alpha0001
Exportin-10101
Carbonic anhydrase 120306
Glyceraldehyde-3-phosphate dehydrogenase0101
NAD-dependent histone deacetylase SIR20103
Carbonic anhydrase 30304
Cytochrome P450 2A60113
Aldo-keto reductase family 1 member B10202
UDP-glucuronosyltransferase 1-60202
Amine oxidase [flavin-containing] B0101
Cytochrome P450 2A50001
Amine oxidase [flavin-containing] A 0101
Acetylcholinesterase0101
Acetylcholinesterase0202
UDP-glucuronosyltransferase 1A1 0202
UDP-glucuronosyltransferase 1A40203
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal0101
Carbonic anhydrase 60305
Carbonic anhydrase 5A, mitochondrial0305
UDP-glucuronosyltransferase 2B10 0202
Carbonic anhydrase 70305
Quinone oxidoreductase0001
Beta-secretase 10101
Sorbitol dehydrogenase0101
Induced myeloid leukemia cell differentiation protein Mcl-10202
Carbonic anhydrase 90306
Zn finger protein 0101
Dihydroorotate dehydrogenase 0101
Carbonic anhydrase 130101
Carbonic anhydrase 130304
Carbonic anhydrase 140305
Carbonic anhydrase 5B, mitochondrial0305
SMAD family member 27007
SMAD family member 37007
estrogen receptor 2 (ER beta)8008
Sex hormone-binding globulin0011
Beta-glucuronidase0101
Corticosteroid-binding globulin0101
Beta-glucuronidase0101
Glucose-6-phosphate 1-dehydrogenase0303
Alpha-synuclein2103
TAR DNA-binding protein 431001
G-protein coupled bile acid receptor 10011
Glucose-6-phosphate 1-dehydrogenase 0101
NPC1-like intracellular cholesterol transporter 10011
Gamma-aminobutyric acid 0202
glp-1 receptor, partial4004
Gamma-aminobutyric acid receptor subunit pi0303
Gamma-aminobutyric acid receptor subunit delta0303
Voltage-dependent L-type calcium channel subunit alpha-1F0303
Alpha-1-acid glycoprotein 10001
Albumin0247
Gamma-aminobutyric acid receptor subunit alpha-10204
Gamma-aminobutyric acid receptor subunit beta-10204
Neuronal acetylcholine receptor subunit alpha-41102
Gamma-aminobutyric acid receptor subunit alpha-20204
Gamma-aminobutyric acid receptor subunit alpha-30204
Neuronal acetylcholine receptor subunit beta-21102
Gamma-aminobutyric acid receptor subunit alpha-10437
Translocator protein0214
Gamma-aminobutyric acid receptor subunit alpha-60202
Gamma-aminobutyric acid receptor subunit beta-10314
Gamma-aminobutyric acid receptor subunit gamma-20426
5-hydroxytryptamine receptor 1A0718
Gamma-aminobutyric acid receptor subunit alpha-40204
Gamma-aminobutyric acid receptor subunit gamma-20204
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit delta0202
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit beta-30426
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50336
Gamma-aminobutyric acid receptor subunit alpha-30325
Gamma-aminobutyric acid receptor subunit alpha-20325
Gamma-aminobutyric acid receptor subunit beta-20325
Gamma-aminobutyric acid receptor subunit alpha-40314
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-30202
Gamma-aminobutyric acid receptor subunit epsilon0303
Voltage-dependent L-type calcium channel subunit alpha-1D 0303
Neuronal acetylcholine receptor subunit alpha-70101
Voltage-dependent L-type calcium channel subunit alpha-1S0303
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Gamma-aminobutyric acid receptor subunit alpha-60314
Gamma-aminobutyric acid receptor subunit alpha-50202
Gamma-aminobutyric acid receptor subunit gamma-10303
Gamma-aminobutyric acid receptor subunit pi0202
Sphingosine-1-phosphate lyase 10101
ATPase family AAA domain-containing protein 55005
Ataxin-26006
Gamma-aminobutyric acid receptor subunit gamma-30303
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit theta0202
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit theta0303
STAT3, partial0202
Smad32002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
NPC intracellular cholesterol transporter 1 precursor4004
potassium voltage-gated channel subfamily H member 2 isoform d3003
ras-related protein Rab-9A4004
signal transducer and activator of transcription 1-alpha/beta isoform alpha0202
Sodium/potassium-transporting ATPase subunit alpha-1 0303
Sodium/potassium-transporting ATPase subunit beta-10303
Replicase polyprotein 1ab0213
Sodium/potassium-transporting ATPase subunit alpha-30202
Sodium/potassium-transporting ATPase subunit beta-20202
Sodium/potassium-transporting ATPase subunit alpha-20303
Sodium/potassium-transporting ATPase subunit alpha-10202
Sodium/potassium-transporting ATPase subunit beta-30202
Sodium/potassium-transporting ATPase subunit gamma0202
Sodium/potassium-transporting ATPase subunit alpha-40202
Solute carrier organic anion transporter family member 4C10102
PAX80001
PPM1D protein4004
alpha-galactosidase1001
tumor necrosis factor1001
Solute carrier organic anion transporter family member 1A40102
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
ATP-dependent translocase ABCB10505
Sodium/potassium-transporting ATPase subunit beta-1 0101
ATP-dependent translocase ABCB10506
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 1A40001
prostaglandin E2 receptor EP2 subtype1001
Solute carrier family 22 member 20102
Solute carrier organic anion transporter family member 1A50001
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Prostaglandin E2 receptor EP1 subtype0213
Prostaglandin E2 receptor EP1 subtype0101
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin F2-alpha receptor0011
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP3 subtype0213
Prostaglandin E2 receptor EP2 subtype0213
Prostacyclin receptor0213
Solute carrier family 22 member 60102
Solute carrier family 22 member 70002
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 80102
Solute carrier family 22 member 70001
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1B20001
Solute carrier family 22 member 70001
Chain A, Protein (peroxisome Proliferator Activated Receptor (ppar-delta))0101
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
Cytochrome P450 1A20202
Retinoic acid receptor RXR-alpha0101
Peroxisome proliferator-activated receptor gamma0011
Oxoeicosanoid receptor 10101
Motilin receptor0011
acid sphingomyelinase1001
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK11001
Motilin receptor0112
Rap guanine nucleotide exchange factor 33003
30S ribosomal protein S60112
30S ribosomal protein S70112
50S ribosomal protein L150112
50S ribosomal protein L100112
50S ribosomal protein L110112
50S ribosomal protein L7/L120112
50S ribosomal protein L190112
50S ribosomal protein L10112
50S ribosomal protein L200112
50S ribosomal protein L270112
50S ribosomal protein L280112
50S ribosomal protein L290112
50S ribosomal protein L310112
50S ribosomal protein L31 type B0112
50S ribosomal protein L320112
50S ribosomal protein L330112
50S ribosomal protein L340112
50S ribosomal protein L350112
50S ribosomal protein L360112
30S ribosomal protein S100112
30S ribosomal protein S110112
30S ribosomal protein S120112
30S ribosomal protein S130112
30S ribosomal protein S160112
30S ribosomal protein S180112
30S ribosomal protein S190112
30S ribosomal protein S200112
30S ribosomal protein S20112
30S ribosomal protein S30112
30S ribosomal protein S40112
30S ribosomal protein S50112
30S ribosomal protein S80112
30S ribosomal protein S90112
50S ribosomal protein L130112
50S ribosomal protein L140112
50S ribosomal protein L160112
50S ribosomal protein L230112
30S ribosomal protein S150112
50S ribosomal protein L170112
50S ribosomal protein L210112
50S ribosomal protein L300112
50S ribosomal protein L60112
30S ribosomal protein S140112
30S ribosomal protein S170112
30S ribosomal protein S10112
50S ribosomal protein L180112
Chitinase B0101
Low molecular weight phosphotyrosine protein phosphatase0101
50S ribosomal protein L20112
50S ribosomal protein L30112
50S ribosomal protein L240112
50S ribosomal protein L40112
50S ribosomal protein L220112
50S ribosomal protein L50112
30S ribosomal protein S210112
50S ribosomal protein L250112
Cytochrome P450 1B10101
50S ribosomal protein L36 20112
Multidrug and toxin extrusion protein 10303
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Genome polyprotein 0112
chaperonin-containing TCP-1 beta subunit homolog2002
Fumarate hydratase3003
polyprotein3003
bromodomain adjacent to zinc finger domain 2B3003
thyrotropin-releasing hormone receptor4004
eyes absent homolog 2 isoform a1001
relaxin receptor 1 isoform 11001
Flavin reductase (NADPH)0011
large T antigen0101
Nuclear receptor subfamily 1 group I member 20011
D(2) dopamine receptor0303
Amine oxidase [flavin-containing] A0202
D(4) dopamine receptor0303
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0303
Delta-type opioid receptor0202
Mu-type opioid receptor0415
Kappa-type opioid receptor0101
Histamine H1 receptor0101
Mu-type opioid receptor0415
D(3) dopamine receptor0505
Delta-type opioid receptor0404
Kappa-type opioid receptor0303
Kappa-type opioid receptor0404
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Sigma non-opioid intracellular receptor 10303
Chain A, Ferritin light chain5005
Serum paraoxonase/arylesterase 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
6-phosphogluconate dehydrogenase, decarboxylating0101
Spike glycoprotein6017
Holo-[acyl-carrier-protein] synthase0101
Sodium/bile acid cotransporter0101
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Broad substrate specificity ATP-binding cassette transporter ABCG20213
Alpha-crystallin B chain0011
Lanosterol 14-alpha demethylase0001
Peroxisome proliferator-activated receptor alpha2024
14-alpha sterol demethylase 0001
matrix metalloproteinase 1, partial0011
Thrombopoietin1001
caspase 7, apoptosis-related cysteine protease3003
nonstructural protein 11001
Parkin1001
P531001
arylsulfatase A4004
pyruvate kinase1001
caspase-33003
peripheral myelin protein 22 isoform 12002
cytochrome P450 2C19 precursor3003
cytochrome P450 2C9 precursor4004
huntingtin isoform 22002
survival motor neuron protein isoform d2002
neuropeptide S receptor isoform A1001
Dihydroorotate dehydrogenase (quinone), mitochondrial0101
Aldo-keto reductase family 1 member B10606
Endothelin receptor type B1001
Sodium-dependent noradrenaline transporter 0606
Endothelin-1 receptor1102
Sodium-dependent dopamine transporter 0404
Dihydroorotate dehydrogenase (quinone), mitochondrial0101
Dihydroorotate dehydrogenase (quinone), mitochondrial0101
Protein-arginine deiminase type-40101
Leukotriene B4 receptor 10202
Leukotriene B4 receptor 20101
Canalicular multispecific organic anion transporter 10101
P2Y purinoceptor 120011
Cysteinyl leukotriene receptor 20011
Cysteinyl leukotriene receptor 10011
Chain A, Fatty acid-binding protein, adipocyte0101
Acetylcholinesterase0303
Toll-like receptor 20101
Fatty acid-binding protein, intestinal0101
Tyrosine-protein phosphatase non-receptor type 10305
Olfactory receptor 51E20011
Gag-Pol polyprotein0101
Cytochrome P450 2D60101
Gag-Pol polyprotein0101
Protease 0303
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein2002
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
endonuclease IV1001
atrial natriuretic peptide receptor 1 precursor1001
transcriptional regulator ERG isoform 32002
flap endonuclease 12002
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Dihydrofolate reductase 0101
Aldo-keto reductase family 1 member B10101
Sodium channel protein type 1 subunit alpha0101
Inositol monophosphatase 11001
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Fatty acid-binding protein, liver0101
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Beta-lactamase 0101
Beta-lactamase 0112
Proton-coupled amino acid transporter 10101
Transmembrane prolyl 4-hydroxylase0101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Muscarinic acetylcholine receptor DM10101
Cytochrome P450 2A130112
Peroxisomal sarcosine oxidase0001
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
UDP-glucuronosyltransferase 1A90001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Sodium- and chloride-dependent GABA transporter 10202
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
5-hydroxytryptamine receptor 2B0606
Sodium- and chloride-dependent betaine transporter0202
Fatty-acid amide hydrolase 10202
UDP-glucuronosyltransferase 1A80001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20103
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Prolyl 4-hydroxylase subunit alpha-10101
Estrogen receptor0001
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
Squalene monooxygenase 0001
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0011
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0011
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0011
nuclear factor NF-kappa-B p105 subunit isoform 11001
Endothelin-1 receptor0202
Chain A, CES1 protein0101
apical membrane antigen 1, AMA11001
DNA polymerase III, partial1001
Caspase-71001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
cytochrome P450 2D6 isoform 11001
interferon gamma precursor0001
caspase-31001
ubiquitin-conjugating enzyme E2 N0101
serine/threonine-protein kinase mTOR isoform 11001
M-phase phosphoprotein 81001
Transmembrane protease serine 20011
Serine/threonine-protein kinase D30101
Estrogen receptor0214
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Estrogen receptor0012
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Progesterone receptor0101
Procathepsin L0011
Beta-1 adrenergic receptor0202
Alpha-2A adrenergic receptor0404
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Adenosine receptor A30202
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Beta-3 adrenergic receptor0202
Androgen receptor0202
Alpha-1B adrenergic receptor0202
Protein kinase C alpha type0101
Alpha-2B adrenergic receptor0202
Substance-K receptor0202
D(1A) dopamine receptor0202
Thromboxane-A synthase 0101
Protein kinase C eta type0101
Histamine H2 receptor0404
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 1B0404
Adenosine receptor A2a0202
B2 bradykinin receptor0202
Adenosine receptor A10202
Sodium-dependent serotonin transporter0404
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Protein kinase C iota type0101
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0202
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Estrogen receptor beta0213
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with trehalose0101
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with cellobiose0101
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with maltose0101
Trehalose-phosphatase0101
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Plasma kallikrein0001
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Tubulin--tyrosine ligase0101
Glutamate receptor ionotropic, NMDA 3B0001
Monocarboxylate transporter 100001
Taste receptor type 2 member 140001
Glutamate receptor ionotropic, NMDA 3A0001
Multidrug and toxin extrusion protein 20101
Glycoprotein0101
Muscarinic acetylcholine receptor M20011
Cytochrome P450 2C80101
Catechol O-methyltransferase0101
Potassium voltage-gated channel subfamily A member 30101
Multidrug resistance-associated protein 1 0214
D(2) dopamine receptor0101
Chloroquine resistance transporter0101
DNA polymerase eta isoform 11001
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]