Compounds > thiazomycin
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thiazomycin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

thiazomycin: isolated from Amycolatopsis fastidiosa; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

thiazomycin : A heterodetic cyclic peptide isolated from Amycolatopsis fastidiosa. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID16156566
CHEMBL ID506017
CHEBI ID66219
SCHEMBL ID14192134
MeSH IDM0516892

Synonyms (6)

Synonym
chebi:66219 ,
CHEMBL506017
thiazomycin
SCHEMBL14192134
Q27134757
2-[(e)-[(3ar,4s,6s,7as)-3,4,7a-trimethyl-3a,4,6,7-tetrahydro-2h-pyrano[3,4-d]oxazol-6-yl]oxy-dihydroxy-[(1r)-1-hydroxyethyl]-(1-methoxyethylidene)-hexaoxo-[?]yl]-n-(1-carbamoylvinyl)thiazole-4-carboxamide

Research Excerpts

Overview

Thiazomycin is a novel thiazolyl peptide closely related to nocathiacin I. It is a Gram-positive antibacterial agent with minimum inhibitory concentration (MIC) ranging 0.002-0.25 microg/mL.

ExcerptReferenceRelevance
"Thiazomycin A is a specific inhibitor of protein synthesis (IC(50) 0.7 microg/mL) and a potent Gram-positive antibacterial agent with minimum inhibitory concentration (MIC) ranging 0.002-0.25 microg/mL."( Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
Barrett, JF; Burgess, B; Masurekar, P; Onishi, R; Singh, SB; Ushio, M; Zhang, C; Zink, DL, 2008)		1.32
"Thiazomycin is a novel thiazolyl peptide closely related to nocathiacin I. "( Antibacterial evaluations of thiazomycin- a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
Barrett, JF; Dorso, K; Gill, C; Herath, K; Hickey, E; Jayasuriya, H; Masurekar, P; Motyl, M; Occi, J; Overbye, KM; Singh, SB, 2007)		2.07
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
antibacterial agentA substance (or active part thereof) that kills or slows the growth of bacteria.
antimicrobial agentA substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
bacterial metaboliteAny prokaryotic metabolite produced during a metabolic reaction in bacteria.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
heterodetic cyclic peptideA heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (27)

Assay IDTitleYearJournalArticle
AID424759Antibacterial activity against macrolide-sensitive, Linezolid, methicillin-resistant Staphylococcus aureus CL5814 after 20 hrs by twofold serial broth dilution method2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID388044Antibacterial activity against methicillin-resistant Staphylococcus aureus MB5393 containing COL plasmid after 18 to 20 hrs by serial dilution method2008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
AID424760Antibacterial activity against macrolide, methicillin-resistant Staphylococcus aureus CL5705 after 20 hrs by twofold serial broth dilution method2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID388041Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae CL2883 after 18 to 20 hrs by serial dilution method2008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
AID424765Antibacterial activity against vancomycin, macrolide-resistant, linezolid-sensitive Enterococcus faecalis CL5246 after 20 hrs by twofold serial broth dilution method2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID388048Antimicrobial activity against Candida albicans MY1055 after 18 to 20 hrs by serial dilution method2008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
AID424771Antifungal activity against Candida albicans MY1055 after 20 hrs by twofold serial broth dilution method2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID388046Antibacterial activity against Haemophilus influenzae MSD2261 after 18 to 20 hrs by serial dilution method2008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
AID424756Antibacterial activity against macrolide, imipenem, methicillin-resistant Staphylococcus aureus MB5393 after 20 hrs by twofold serial broth dilution method2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID1867109Selectivity ratio of MIC for Bacteroides fragilis ATCC 25285 to MIC for Clostridioides difficile
AID388047Antibacterial activity against Escherichia coli MB2884 after 18 to 20 hrs by serial dilution method2008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
AID388045Antibacterial activity against Staphylococcus aureus EP167 after 18 to 20 hrs by serial dilution method2008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
AID424762Antibacterial activity against ampicillin-sensitive Staphylococcus haemolyticus CL8544 after 20 hrs by twofold serial broth dilution method2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID424764Antibacterial activity against vancomycin-sensitive Enterococcus faecalis CL8516 after 20 hrs by twofold serial broth dilution method2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID424763Antibacterial activity against Staphylococcus epidermidis CL8040 after 20 hrs by twofold serial broth dilution method2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID424769Antibacterial activity against penicillin-resistant Streptococcus pneumoniae CL5771 after 20 hrs by twofold serial broth dilution method2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID424758Antibacterial activity against methicillin-sensitive Staphylococcus aureus MB2865 after 20 hrs by twofold serial broth dilution method in presence of 50% human serum2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID424757Antibacterial activity against methicillin-sensitive Staphylococcus aureus MB2865 after 20 hrs by twofold serial broth dilution method2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID424770Antibacterial activity against Streptococcus pyogenes CL10440 after 20 hrs by twofold serial broth dilution method2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID424768Antibacterial activity against penicillin-sensitive Streptococcus pneumoniae CL8002 after 20 hrs by twofold serial broth dilution method2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID1867111Antibacterial activity against Bacteroides fragilis ATCC 25285 assessed as inhibition of bacterial growth by CLSI based agar dilution susceptibility analysis
AID424766Antibacterial activity against vancomycin, linezolid-resistant Enterococcus faecium CL5791 after 20 hrs by twofold serial broth dilution method2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID388043Antibacterial activity against methicillin-susceptible Staphylococcus aureus MB2865 after 18 to 20 hrs by serial dilution method2008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
AID424767Antibacterial activity against vancomycin, linezolid-resistant Enterococcus faecium CL5791 after 20 hrs by twofold serial broth dilution method in presence of 50% human serum2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID1867110Antibacterial activity against Clostridioides difficile assessed as inhibition of bacterial growth by CLSI based agar dilution susceptibility analysis
AID424761Antibacterial activity against vancomycin-intermediate, macrolide, methicillin-resistant Staphylococcus aureus CL5706 after 20 hrs by twofold serial broth dilution method2009Journal of natural products, May-22, Volume: 72, Issue:5
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa.
AID388042Antibacterial activity against vancomycin-susceptible Enterococcus faecalis CL8516 after 18 to 20 hrs by serial dilution method2008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (62.50)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.15 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.34 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.15)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		2.1510carbohydrazideantitubercular agent;
drug allergen
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		2.04101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
thiazoles
[no description available]		3.44701,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
erythromycin
Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.		2.0510cyclic ketone;
erythromycin
moxifloxacin
Moxifloxacin: A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent.. moxifloxacin : A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents.		2.1510aromatic ether;
cyclopropanes;
fluoroquinolone antibiotic;
pyrrolidinopiperidine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antibacterial drug
linezolid
[no description available]		2.4520acetamides;
morpholines;
organofluorine compound;
oxazolidinone		antibacterial drug;
protein synthesis inhibitor
oxazolidine
oxazolidine: structure given in first source		2.0410oxazolidine
glycosides
[no description available]		2.0410
nocathiacin i
nocathiacin I: structure in first source		2.4820
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		2.1510cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Staphylococcal
[description not available]		02.0310
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.0310