A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
ChEBI ID: 167309
Member | Definition | Role |
---|---|---|
dextromethadone | A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (S)-configuration. It is the less active enantiomer of methadone and has very little activity on opioid receptors and mainly responsible for the inhibition of hERG K+ channels and thus for cardiac toxicity. The drug is currently under clinical development for the treatment of major depressive disorder. | dextromethadone |
levomethadone | A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (R)-configuration. It is the active enantiomer of methadone and its hydrochloride salt is used to treat adults who are addicted to drugs such as heroin and morphine. | levomethadone |
Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
---|---|---|
pre-1990 | 3 (30.00) | 18.7374 |
1990's | 1 (10.00) | 18.2507 |
2000's | 2 (20.00) | 29.6817 |
2010's | 2 (20.00) | 24.3611 |
2020's | 2 (20.00) | 2.80 |
Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
---|---|---|
Trials | 3 (20.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 12 (80.00%) | 84.16% |