Listeria Cerebritis

Inflammation of the meninges caused by LISTERIA MONOCYTOGENES infection, usually occurring in individuals under the age of 3 years or over the age of 50 years. It may occur at any age in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES. Clinical manifestations include FEVER, altered mentation, HEADACHE, meningeal signs, focal neurologic signs, and SEIZURES. (From Medicine 1998 Sep;77(5):313-36)

Synonym
Listeria Cerebritis
Listeria Meningoencephalitis
Meningitis, Listeria
Listeria monocytogenes Meningitis
Meningoencephalitis, Listeria

Excerpt	Reference
"A case of recurrent Listeria monocytogenes meningitis is reported, the two episodes arising 4 months and 8 months after the patient had received a heart transplant."	( Conway, MA; Forfar, JC; Larner, AJ; Mitchell, RG, 1989)
"Listeria monocytogenes meningitis is very rare in immunocompetent children."	( Ben Shimol, S; Einhorn, M; Greenberg, D, 2012)
"Listeria meningoencephalitis is a rare condition, occurring mainly in immunocompromised patients."	( Carreazo, NY; Pinelo-Chumbe, E; Valdivia-Tapia, Mdel C, 2015)
"Although Listeria meningitis is rare in previously healthy immunocompetent children, it must be considered, especially in children who do not improve with first-line antibiotic treatment."	( Bosis, S; Castellazzi, ML; Marchisio, P, 2018)

Excerpt	Reference
"We present the case of a patient with Listeria monocytogenes meningitis who failed to respond clinically to standard therapy, and whose organism demonstrated tolerance to Ampicillin (MBC: MIC = 258:1) that successfully responded to trimethoprim-sulfamethoxazole (TMP-SMX)."	( Friedrich, LV; Reboli, AC; White, RL, 1990)
"A case of Listeria monocytogenes meningitis in a 3-year-old boy which relapsed after chloramphenicol treatment is described."	( Ponton, AW; Richards, J; Swann, RA, 1988)
"Another had Listeria monocytogenes meningitis which was difficult to eradicate and required prolonged maintenance antimicrobial therapy with oral trimethoprim-sulfamethoxazole and intrathecal gentamicin until death due to chronic graft-versus-host disease."	( Brincat, S; Catovsky, D; Iveson, T; Jameson, B; Mehta, J; Paul, B; Powles, R; Singhal, S; Treleaven, J; Zomas, A, 1994)
"An 82-year-old woman with Listeria monocytogenes meningitis, whose symptoms had been improving after the initiation of antibacterial therapy, fell into a coma on day 15 and developed generalized seizure."	( Hibino, T; Kobayashi, T; Odai, T; Tadokoro, H; Waki, K, 2015)
"Here, we report a rare case of Listeria meningitis and bacteremia in a 7-month-old immunocompetent girl, which was refractory to ampicillin plus gentamicin treatment and successfully treated by the addition of TMP/SMX."	( Çağlar, K; Derinöz, O; Kara, SS; Polat, M; Tapısız, A; Tezer, H, 2016)
"Although Listeria meningitis is rare in previously healthy immunocompetent children, it must be considered, especially in children who do not improve with first-line antibiotic treatment."	( Bosis, S; Castellazzi, ML; Marchisio, P, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	105 (50.48)	23.3326
1990's	30 (14.42)	12.5806
2000's	32 (15.38)	18.1394
2010's	31 (14.90)	28.8240
2020's	10 (4.81)	9.53

Drug	Relationship Strength	Studies
beta-alanine	low	1
bromide	low	1
pyridoxine	low	1
phenytoin	low	1
azathioprine	low	7
cefuroxime	low	3
chlorambucil	low	1
ciprofloxacin	low	1
foscarnet	low	1
gentamicin	low	36
isoniazid	low	3
isoproterenol	low	1
apnea	low	1
ofloxacin	low	1
phenobarbital	low	1
piracetam	low	1
pyrimethamine	low	1
sulfadiazine	low	4
sulfamerazine	low	1
sulfamethoxazole	low	3
sulfanilamide	low	1
sulfisoxazole	low	1
trimethoprim	low	4
prednisolone	low	3
cephaloridine	low	1
aldosterone	low	1
prednisone	low	8
penicillin g	low	7
chloramphenicol	low	26
aminopyrine	low	1
cephalothin	low	2
kanamycin a	low	4
methicillin	low	1
oxacillin	low	1
ampicillin	low	82
mannitol	low	1
methylprednisolone	low	3
framycetin	low	2
sulfalene	low	1
erythromycin	low	5
vancomycin	low	12
streptomycin	low	9
trolamine salicylate	low	1
transferrin	low	1
amoxicillin	low	8
zidovudine	low	1
tobramycin	low	2
amikacin	low	4
piperacillin	low	2
fenoxaprop ethyl	low	1
cephalosporin c	low	9
oxazolidin-2-one	low	3
fibrinogen	low	1
imipenem, anhydrous	low	1
panipenem-betamipron	low	1
imatinib mesylate	low	1
methotrexate	low	1
beta-lactams	low	3
levofloxacin	low	1
moxifloxacin	low	1
cortisone	low	1
trimethoprim, sulfamethoxazole drug combination	low	13
bortezomib	low	1
meropenem	low	9
linezolid	low	3
mycophenolic acid	low	1
mezlocillin	low	1
mercaptopurine	low	1
digoxin	low	1
amphotericin b	low	3
clavulanic acid	low	1
levetiracetam	low	1
morphine	low	2
cefotaxime	low	4
cilastatin	low	1
nitrofurantoin	low	1
amoxicillin-potassium clavulanate combination	low	1
ro13-9904	low	9
colistin	low	3
novobiocin	low	1
tetracycline	low	12
oxytetracycline, anhydrous	low	6
calca protein, human	low	1
transforming growth factor beta	low	1
muramidase	low	2
acyclovir	low	1
levoleucovorin	low	1
neopterin	low	1
rifampin	low	4
ganciclovir	low	1
gq1b ganglioside	low	1

Protein Targets (960)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	10	0	0	10
Chain B, HADH2 protein	10	0	0	10
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
Chain A, Ferritin light chain	6	0	0	6
Thymidine kinase	0	2	0	2
thioredoxin reductase	17	0	0	17
phosphopantetheinyl transferase	13	0	0	13
GLS protein	15	0	0	15
TDP1 protein	29	0	0	29
Smad3	3	0	0	3
thyroid stimulating hormone receptor	10	0	0	10
EWS/FLI fusion protein	18	0	0	18
arylsulfatase A	8	0	0	8
euchromatic histone-lysine N-methyltransferase 2	23	0	0	23
activating transcription factor 6	13	0	0	13
Histone H2A.x	13	0	0	13
Bloom syndrome protein isoform 1	10	0	0	10
hemoglobin subunit beta	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	5	0	0	5
lamin isoform A-delta10	19	0	0	19
Solute carrier family 22 member 1	0	3	0	5
ATP-binding cassette sub-family C member 3	0	32	0	32
Multidrug resistance-associated protein 4	0	32	0	33
Solute carrier family 22 member 6	0	5	0	7
Bile salt export pump	0	13	0	13
Bile salt export pump	0	48	0	48
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	2	0	4
POU domain, class 2, transcription factor 2	0	0	0	2
Cytochrome P450 2C9	0	10	0	11
Cytochrome P450 2J2	0	5	0	5
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	3	3
Solute carrier family 22 member 6	0	6	0	10
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	6	0	10
Canalicular multispecific organic anion transporter 1	0	31	0	31
Thymidine kinase	0	1	0	1
AR protein	33	0	0	33
glucocorticoid receptor [Homo sapiens]	22	0	0	22
thyroid hormone receptor beta isoform a	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
geminin	31	0	0	31
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	3	0	3
Mineralocorticoid receptor	0	3	3	6
Androgen receptor	0	4	0	4
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Guanine nucleotide-binding protein G	3	0	0	3
estrogen nuclear receptor alpha	37	0	0	37
peripheral myelin protein 22	12	0	0	12
histone acetyltransferase KAT2A isoform 1	9	0	0	9
Aminoglycoside 3'-phosphotransferase	0	0	0	2
ATP-dependent phosphofructokinase	10	0	0	10
Luciferase	6	0	0	6
interleukin 8	10	0	0	10
15-lipoxygenase, partial	3	0	0	3
RAR-related orphan receptor gamma	16	0	0	16
GLI family zinc finger 3	25	0	0	25
estrogen receptor 2 (ER beta)	13	0	0	13
nuclear receptor subfamily 1, group I, member 3	20	0	0	20
cytochrome P450 family 3 subfamily A polypeptide 4	13	0	0	13
retinoic acid nuclear receptor alpha variant 1	21	0	0	21
retinoid X nuclear receptor alpha	21	0	0	21
estrogen-related nuclear receptor alpha	28	0	0	28
pregnane X nuclear receptor	21	0	0	21
G	9	0	0	9
peroxisome proliferator-activated receptor delta	16	0	0	16
vitamin D (1,25- dihydroxyvitamin D3) receptor	18	0	0	18
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	18	0	0	18
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
chromobox protein homolog 1	13	0	0	13
thyroid hormone receptor beta isoform 2	21	0	0	21
histone deacetylase 9 isoform 3	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	27	0	0	27
Voltage-dependent calcium channel gamma-2 subunit	13	0	0	13
Interferon beta	13	0	0	13
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Glutamate receptor 2	13	1	0	14
Nicotinate phosphoribosyltransferase	0	1	0	1
Inositol hexakisphosphate kinase 1	9	0	0	9
cytochrome P450 2C9, partial	9	0	0	9
ORF73	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Chain A, Beta-lactamase	9	0	0	9
Chain A, 2-oxoglutarate Oxygenase	12	0	0	12
Beta-lactamase	0	1	0	5
Beta-lactamase	0	1	0	7
Beta-lactamase	0	0	0	7
Beta-lactamase	0	1	0	8
apical membrane antigen 1, AMA1	4	0	0	4
Beta-lactamase	0	0	0	5
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
DNA polymerase eta isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	12	0	0	12
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
DNA polymerase kappa isoform 1	8	0	0	8
Beta-lactamase SHV-1	0	1	0	6
Beta-lactamase SHV-1	0	2	0	10
Beta-lactamase	0	1	0	9
Kappa-type opioid receptor	0	2	0	8
Solute carrier family 15 member 1	0	10	0	10
Solute carrier family 15 member 1	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	7
Solute carrier family 15 member 2	0	7	0	7
Beta-lactamase	0	1	0	6
Beta-lactamase	0	1	0	6
Solute carrier family 15 member 2	0	8	0	8
Beta-lactamase	0	1	0	6
Beta-lactamase	0	0	0	6
Chain A, Cruzipain	5	0	0	5
farnesoid X nuclear receptor	17	0	0	17
tumor necrosis factor	2	0	0	2
vitamin D3 receptor isoform VDRA	10	0	0	10
Cytochrome P450 1A2	0	4	0	5
Cytochrome P450 3A4	0	11	1	14
Cytochrome P450 2D6	0	4	0	5
Cytochrome P450 2C19	0	4	0	5
Nuclear receptor ROR-gamma	7	1	1	9
Potassium voltage-gated channel subfamily H member 2	0	12	0	14
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	5
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Beta-lactamase	0	2	0	6
acid sphingomyelinase	3	0	0	3
Beta-lactamase	0	2	0	8
Beta-lactamase	0	0	0	7
Metallo-beta-lactamase type 2	0	0	1	8
Metallo-beta-lactamase VIM-11	0	0	0	6
Metallo-beta-lactamase VIM-2	0	0	0	6
Beta-lactamase	0	0	0	7
Metallo-beta-lactamase	0	0	0	6
Beta-lactamase	0	2	0	8
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
DNA polymerase beta	4	0	0	4
Carbonic anhydrase 1	0	7	0	9
Carbonic anhydrase 2	0	8	2	11
60 kDa heat shock protein, mitochondrial	0	4	0	4
Beta-lactamase OXA-7	0	0	0	4
Spike glycoprotein	14	0	0	14
10 kDa heat shock protein, mitochondrial	0	4	0	4
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	1	0	5
Beta-lactamase	0	1	0	5
Beta-lactamase	0	1	0	5
Thiosulfate sulfurtransferase	0	4	0	4
Metallo-beta-lactamase VIM-13	0	0	0	7
Efflux transporter	0	0	0	4
Beta-lactamase	0	0	0	6
Beta-lactamase Toho-1	0	0	0	5
Beta-lactamase	0	0	0	4
Class D beta-lactamase	0	1	0	5
60 kDa chaperonin	0	5	0	5
Metallo-beta-lactamase	0	0	0	5
Beta-lactamase	0	1	0	7
Beta-lactamase	0	0	1	5
10 kDa chaperonin	0	5	0	5
Metallo-b-lactamase	0	0	0	10
Carbapenem-hydrolyzing beta-lactamase KPC	0	2	0	10
Histamine H3 receptor	0	0	0	6
Beta-lactamase class B VIM-2	0	0	1	11
Beta-lactamase VIM-1	0	0	0	7
ATAD5 protein, partial	8	0	0	8
Microtubule-associated protein tau	13	0	0	13
D(1A) dopamine receptor	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	10	0	0	10
acetylcholinesterase	8	0	0	8
SMAD family member 2	8	0	0	8
Fumarate hydratase	6	0	0	6
SMAD family member 3	8	0	0	8
thioredoxin glutathione reductase	8	0	0	8
polyprotein	6	0	0	6
P53	1	0	0	1
peroxisome proliferator activated receptor gamma	15	0	0	15
IDH1	9	0	0	9
aryl hydrocarbon receptor	13	0	0	13
thyroid stimulating hormone receptor	9	0	0	9
peripheral myelin protein 22 isoform 1	4	0	0	4
cellular tumor antigen p53 isoform a	6	0	0	6
heat shock protein beta-1	6	0	0	6
survival motor neuron protein isoform d	9	0	0	9
cytochrome P450 3A4 isoform 1	8	0	0	8
M-phase phosphoprotein 8	4	0	0	4
muscleblind-like protein 1 isoform 1	6	0	0	6
muscarinic acetylcholine receptor M1	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	8	3	0	12
Cellular tumor antigen p53	20	0	0	20
Gamma-aminobutyric acid receptor subunit beta-1	8	3	0	12
Gamma-aminobutyric acid receptor subunit delta	8	3	0	12
Gamma-aminobutyric acid receptor subunit gamma-2	8	3	0	12
Gamma-aminobutyric acid receptor subunit alpha-5	8	3	0	12
Gamma-aminobutyric acid receptor subunit alpha-3	8	3	0	12
Gamma-aminobutyric acid receptor subunit gamma-1	8	3	0	12
Gamma-aminobutyric acid receptor subunit alpha-2	8	3	0	12
Gamma-aminobutyric acid receptor subunit alpha-4	8	3	0	12
Gamma-aminobutyric acid receptor subunit gamma-3	8	3	0	12
Gamma-aminobutyric acid receptor subunit alpha-6	8	3	0	12
Gamma-aminobutyric acid receptor subunit alpha-1	8	3	0	12
Gamma-aminobutyric acid receptor subunit beta-3	8	3	0	12
Gamma-aminobutyric acid receptor subunit beta-2	8	3	0	12
GABA theta subunit	8	3	0	12
ATPase family AAA domain-containing protein 5	13	0	0	13
Ataxin-2	13	0	0	13
Gamma-aminobutyric acid receptor subunit epsilon	8	3	0	12
Protein-arginine deiminase type-4	0	7	0	7
regulator of G-protein signaling 4	6	0	0	6
lethal factor (plasmid)	7	0	0	7
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	1	2
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	1	2
Glutamate receptor ionotropic, NMDA 2B	0	1	1	2
Glutamate receptor ionotropic, NMDA 2C	0	1	1	2
Glutamate receptor ionotropic, NMDA 2D	0	1	1	2
Proton-coupled amino acid transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	1	2
Chain H, Proteasome component PUP1	0	1	0	1
Chain I, Proteasome component PUP3	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Proteasome subunit beta type-11	0	1	0	1
PPM1D protein	3	0	0	3
caspase 7, apoptosis-related cysteine protease	3	0	0	3
progesterone receptor	15	0	0	15
caspase-3	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
26S proteasome non-ATPase regulatory subunit 11	0	1	0	1
26S proteasome non-ATPase regulatory subunit 12	0	1	0	1
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Histone deacetylase 3	0	1	0	1
26S proteasome non-ATPase regulatory subunit 3	0	1	0	1
Carbonic anhydrase 12	0	3	0	3
Prothrombin	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Carbonic anhydrase 3	0	2	0	2
Cathepsin B	0	1	0	1
Neutrophil elastase	0	2	0	2
Cathepsin G	0	2	0	2
Lysosomal protective protein	0	1	0	1
Chymotrypsinogen B	0	1	0	1
26S proteasome regulatory subunit 6A	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Proteasome subunit beta type-1	0	1	0	2
Carbonic anhydrase 4	0	4	0	4
Carbonic anhydrase 6	0	4	0	4
Chymase	0	1	0	1
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	3
Carbonic anhydrase 5A, mitochondrial	0	4	0	5
26S proteasome regulatory subunit 7	0	1	0	1
Lon protease homolog, mitochondrial	0	1	0	1
Proteasome subunit beta type-10	0	1	0	1
Carbonic anhydrase 7	0	2	0	2
26S proteasome regulatory subunit 6B	0	1	0	1
26S proteasome non-ATPase regulatory subunit 8	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	1	0	2
26S proteasome non-ATPase regulatory subunit 7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 4	0	1	0	1
26S proteasome complex subunit SEM1	0	1	0	1
Proteasome subunit alpha type-6	0	1	0	1
26S proteasome regulatory subunit 4	0	1	0	1
26S proteasome regulatory subunit 8	0	1	0	1
26S proteasome regulatory subunit 10B	0	1	0	1
Beta-carbonic anhydrase 1	0	2	0	2
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
26S proteasome non-ATPase regulatory subunit 2	0	1	0	1
Histone deacetylase 1	0	1	0	1
26S proteasome non-ATPase regulatory subunit 6	0	1	0	1
Proteasomal ubiquitin receptor ADRM1	0	1	0	1
Carbonic anhydrase 9	0	5	0	5
ATP-dependent Clp protease proteolytic subunit	0	1	1	2
Carbonic anhydrase 13	0	2	0	2
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Histone deacetylase 2	0	1	0	1
Proteasome subunit beta type-7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 1	0	1	0	1
Carbonic anhydrase 15	0	3	0	3
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Carbonic anhydrase 14	0	2	0	2
26S proteasome non-ATPase regulatory subunit 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	0	3
Carbonic anhydrase	0	2	0	2
Beta-lactamase	0	1	0	5
Beta-lactamase	0	2	0	5
Metallo-beta-lactamase VIM-19	0	0	0	5
Beta-lactamase	0	1	0	6
Albumin	0	0	8	8
Beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	6
Metallo-beta-lactamase VIM-2	0	0	0	6
Solute carrier family 22 member 7	0	3	0	4
BlaVIM-1	0	0	0	5
Beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	6
Solute carrier family 22 member 11	0	3	0	6
Solute carrier family 22 member 8	0	5	0	6
Solute carrier family 22 member 7	0	3	0	5
Beta-lactamase	0	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	8	0	0	8
Beta-lactamase	0	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Solute carrier family 22 member 5	0	1	0	1
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	6
Beta-lactamase OXA-10	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase TEM	0	3	0	9
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	4
Beta-lactamase	0	0	0	4
Beta-lactamase IMP-1	0	0	0	4
Beta-lactamase	0	0	0	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
endonuclease IV	5	0	0	5
WRN	2	0	0	2
DNA (cytosine-5)-methyltransferase 1 isoform b	0	1	0	1
importin subunit beta-1 isoform 1	3	0	0	3
flap endonuclease 1	7	0	0	7
serine/threonine-protein kinase PLK1	4	0	0	4
snurportin-1	3	0	0	3
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
Solute carrier family 22 member 8	0	4	0	6
Beta-lactamase OXA-1	0	1	0	2
Beta-lactamase	0	0	0	3
phosphoglycerate kinase	2	0	0	2
NFKB1 protein, partial	3	0	0	3
GALC protein	2	0	0	2
Thrombopoietin	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	18	0	0	18
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	5	0	7
cytochrome P450 2D6	8	0	0	8
streptokinase A precursor	0	0	9	9
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
30S ribosomal protein S6	0	6	1	7
30S ribosomal protein S7	0	6	1	7
50S ribosomal protein L15	0	6	1	7
50S ribosomal protein L10	0	6	1	7
50S ribosomal protein L11	0	6	1	7
50S ribosomal protein L7/L12	0	6	1	7
50S ribosomal protein L19	0	6	1	7
50S ribosomal protein L1	0	6	1	7
50S ribosomal protein L20	0	6	1	7
50S ribosomal protein L27	0	6	1	7
50S ribosomal protein L28	0	6	1	7
50S ribosomal protein L29	0	6	1	7
50S ribosomal protein L31	0	6	1	7
50S ribosomal protein L31 type B	0	6	1	7
50S ribosomal protein L32	0	6	1	7
50S ribosomal protein L33	0	6	1	7
50S ribosomal protein L34	0	6	1	7
50S ribosomal protein L35	0	6	1	7
50S ribosomal protein L36	0	6	1	7
30S ribosomal protein S10	0	6	1	7
30S ribosomal protein S11	0	6	1	7
30S ribosomal protein S12	0	6	1	7
30S ribosomal protein S13	0	6	1	7
30S ribosomal protein S16	0	6	1	7
30S ribosomal protein S18	0	6	1	7
30S ribosomal protein S19	0	6	1	7
30S ribosomal protein S20	0	6	1	7
30S ribosomal protein S2	0	6	1	7
30S ribosomal protein S3	0	6	1	7
30S ribosomal protein S4	0	6	1	7
30S ribosomal protein S5	0	6	1	7
30S ribosomal protein S8	0	6	1	7
30S ribosomal protein S9	0	6	1	7
50S ribosomal protein L13	0	6	1	7
50S ribosomal protein L14	0	6	1	7
50S ribosomal protein L16	0	6	1	7
50S ribosomal protein L23	0	6	1	7
30S ribosomal protein S15	0	6	1	7
50S ribosomal protein L17	0	6	1	7
50S ribosomal protein L21	0	6	1	7
50S ribosomal protein L30	0	6	1	7
50S ribosomal protein L6	0	6	1	7
30S ribosomal protein S14	0	6	1	7
30S ribosomal protein S17	0	6	1	7
30S ribosomal protein S1	0	6	1	7
50S ribosomal protein L18	0	6	1	7
50S ribosomal protein L2	0	6	1	7
50S ribosomal protein L3	0	6	1	7
50S ribosomal protein L24	0	6	1	7
50S ribosomal protein L4	0	6	1	7
50S ribosomal protein L22	0	6	1	7
50S ribosomal protein L5	0	6	1	7
30S ribosomal protein S21	0	6	1	7
50S ribosomal protein L25	0	6	1	7
50S ribosomal protein L36 2	0	6	1	7
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Beta-2 adrenergic receptor	0	3	1	4
Beta-1 adrenergic receptor	0	3	1	5
Dipeptidase 1	0	1	0	1
Beta-3 adrenergic receptor	0	2	1	3
cytochrome P450 2C9 precursor	4	0	0	4
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	4	0	6
DNA gyrase subunit A	0	7	0	12
DNA gyrase subunit B	0	7	1	12
DNA topoisomerase 4 subunit A	0	2	0	2
DNA topoisomerase 4 subunit B	0	2	0	3
DNA topoisomerase 4 subunit A	0	3	0	4
DNA topoisomerase 2-alpha	0	2	0	6
DNA gyrase subunit A	0	4	0	6
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	5	0	1	6
DNA gyrase subunit B	0	6	0	8
DNA gyrase subunit A	0	7	0	9
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	5
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Cytochrome P450 2B6	0	1	1	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
dopamine D1 receptor	3	0	0	3
pregnane X receptor	3	0	0	3
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	4	0	0	4
Multidrug and toxin extrusion protein 1	0	3	0	3
PAX8	0	0	0	1
STAT3, partial	0	1	0	1
67.9K protein	7	0	0	7
alpha-galactosidase	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
ras-related protein Rab-9A	1	0	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
nuclear receptor ROR-gamma isoform 1	5	0	0	5
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Integrin beta-3	5	0	0	5
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
ATP-dependent translocase ABCB1	0	4	0	4
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
ATP-dependent translocase ABCB1	0	4	0	6
Integrin alpha-IIb	5	0	0	5
Replicase polyprotein 1ab	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
ATP-dependent translocase ABCB1	0	4	0	4
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	4	0	5
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	2	0	2
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
60 kDa chaperonin	0	1	0	1
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	2	0	2
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Genome polyprotein	0	2	2	4
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
hypothetical protein, conserved	1	0	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
eyes absent homolog 2 isoform a	2	0	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
Chain A, probable fosfomycin resistance protein	0	0	1	1
Chain B, probable fosfomycin resistance protein	0	0	1	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
DNA polymerase delta catalytic subunit	0	1	0	1
Reverse transcriptase/RNaseH	0	2	4	9
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
Lethal factor	0	1	0	1
Protein Rev	0	0	2	2
Tyrosyl-DNA phosphodiesterase 1	0	2	0	2
ClpP	2	0	0	2
Transitional endoplasmic reticulum ATPase	0	1	0	1
glp-1 receptor, partial	5	0	0	5
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Tyrosine-protein kinase ABL1	0	1	2	3
Cytochrome P450 2C8	0	1	0	2
Mast/stem cell growth factor receptor Kit	0	1	1	2
Breakpoint cluster region protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Cytochrome P450 3A5	0	1	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	1	0	1
Myeloperoxidase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Endonuclease 8-like 1	0	1	0	1
NPYLR7B	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	2
beta-2 adrenergic receptor	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Beta-2 adrenergic receptor	0	2	2	5
Beta-1 adrenergic receptor	0	2	1	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Beta-3 adrenergic receptor	0	1	1	2
D(2) dopamine receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	4	0	4
Beta-2 adrenergic receptor	0	0	1	1
Alpha-2B adrenergic receptor	0	3	0	3
D(1A) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	4	0	4
Beta-adrenergic receptor kinase 1	0	0	1	1
Alpha-1D adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	1	1	2
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	1	1
D(3) dopamine receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	4	0	4
D(1A) dopamine receptor	1	0	0	1
Beta-2 adrenergic receptor	0	1	0	1
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Oxytocin receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	1	2
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	1	2	3
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
Hsf1 protein	0	0	2	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Capsid protein	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Synaptic vesicle glycoprotein 2A	0	2	0	2
Replicase polyprotein 1ab	0	1	0	1
CAAX prenyl protease 2 isoform 2	0	0	0	1
Tubulin beta-4A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
Tubulin alpha-3C chain	0	1	0	1
Tubulin alpha-1B chain	0	1	0	1
Tubulin alpha-4A chain	0	1	0	1
Tubulin beta-4B chain	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
DNA primase	0	1	0	1
Tubulin beta-3 chain	0	1	0	1
Tubulin beta-2A chain	0	1	0	1
Tubulin beta-8 chain	0	1	0	1
Tubulin alpha-3E chain	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Tubulin alpha-1C chain	0	1	0	1
Tubulin beta-6 chain	0	1	0	1
Tubulin beta-2B chain	0	1	0	1
Tubulin beta-1 chain	0	1	0	1
Estrogen receptor	0	0	3	3
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Estrogen receptor beta	0	0	3	3
Renin	0	1	0	1
USP1 protein, partial	5	0	0	5
transcriptional regulator ERG isoform 3	5	0	0	5
UDP-glucose 6-dehydrogenase	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	6	0	7
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	4	0	4
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	3	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	3
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	3	0	3
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	6	3	10
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	5	0	5
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	7	0	8
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	4	1	8
Kappa-type opioid receptor	0	3	1	5
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	2	0	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Pteridine reductase 1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	3	0	4
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
nonstructural protein 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	1	1	2
Muscarinic acetylcholine receptor M2	0	1	0	1
Translocator protein	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	3	0	3
Delta-type opioid receptor	0	2	0	3
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	4	0	4
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
DNA gyrase subunit B	0	2	0	2
Replicase polyprotein 1ab	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Alpha-synuclein	1	2	0	3
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
glucocerebrosidase	1	0	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Chain A, Gyrase	0	0	1	1
DNA gyrase subunit B	0	1	0	1
interferon gamma precursor	0	0	0	1
Heat shock protein HSP 90-alpha	0	0	2	2
Heat shock protein HSP 90-beta	0	1	2	4
DNA gyrase subunit B	0	1	0	1
Cell division inhibitor SulA	0	0	0	1
Heat shock protein HSP 90	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
DNA topoisomerase	0	1	0	1
Microtubule-associated proteins 1A/1B light chain 3B	0	2	1	3
Microtubule-associated proteins 1A/1B light chain 3A	0	2	1	3
STE24	0	0	0	1
CAAX prenyl protease	0	0	0	1
Trypsin	0	0	0	1
MecA	0	1	0	1
Vpr	1	0	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Valosin-containing protein	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Beta-lactamase 1	0	0	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Gamma-aminobutyric acid	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Pyridoxal kinase	0	0	0	1
dual specificity protein phosphatase 3	0	1	0	1
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Beta-hexosaminidase subunit alpha	0	1	0	2
Beta-hexosaminidase subunit beta	0	1	0	1
Substance-K receptor	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dipeptidyl peptidase 4	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Trace amine-associated receptor 5	0	0	2	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	2	0	2
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Aurora kinase A	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Endothelin-1 receptor	0	2	0	2
Protease	0	2	2	4
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2	0	1	1	2
Cholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Protein argonaute-2	0	0	1	1
cytochrome P450 2C19 precursor	2	0	0	2
Endothelin-1 receptor	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
Protein kinase C beta type	0	1	0	1
DNA polymerase beta	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
Thymidylate kinase	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(5)

Research Excerpts

Overview

Treatment

Research

Studies (208)

Protein Targets (960)

Listeria Cerebritis

Synonyms(5)

Research Excerpts

Overview

Treatment

Research

Studies (208)

Drugs Studied (102)

Protein Targets (960)