Page last updated: 2024-09-28

Peliosis Hepatis

A vascular disease of the LIVER characterized by the occurrence of multiple blood-filled CYSTS or cavities. The cysts are lined with ENDOTHELIAL CELLS; the cavities lined with hepatic parenchymal cells (HEPATOCYTES). Peliosis hepatis has been associated with use of anabolic steroids (ANABOLIC AGENTS) and certain drugs.

Synonyms(1)

Synonym
Peliosis Hepatis

Research Excerpts

Overview

ExcerptReference
"Peliosis hepatis is described in a renal transplant recipient and in a patient who was receiving long-term haemodialysis."( Hankey, GJ; Saker, BM, 1987)
"Peliosis hepatis is a recognized, but rare, complication of androgen replacement therapy."( Manz, HJ; Maxted, WC; Nuzzo, JL, 1985)
"Peliosis hepatis is pathologically characterized by blood-filled cystic spaces in the liver associated with the administration of anabolic androgenic steroids or oral contraceptive agents, particularly those with large components of estrogen."( Balfe, DM; Heiken, JP; Lee, JK; Press, GA; Smathers, RL, 1984)
"Peliosis hepatis is a rare condition, recognizable by macroscopical view."( Liehr, H; Spech, HJ, 1982)
"Peliosis hepatis is a rare condition, recognizable macroscopically."( Liehr, H; Spech, HJ, 1982)
"Regressive cases of peliosis hepatis are rare, and 4 out of 7 have been reported after antibiotic treatment."( Abdelli, N; Bouhnik, Y; Galian, A; Lavergne-Slove, A; Messing, B; Rambaud, JC, 1995)
"Bacillary peliosis hepatis is an uncommon but well recognized disease due to disseminated Bartonella infections occurring predominantly in immunocompromised individuals infected with human immunodeficiency virus, type 1."( Abendroth, CS; Ahsan, N; Holman, MJ; Langhoff, EG; Riley, TR; Yang, HC, 1998)
"Peliosis hepatis is an unusual disorder associated with a variety of diseases and treatments."( Gushiken, FC, 2000)
"Peliosis hepatis is associated with numerous infectious and neoplastic diseases, but also occurs as a result of toxic liver damage."( Adler, G; Bommer, M; Dikopoulos, N; Klaus, J; Kleger, A; Kunze, M; Leithaeuser, F; Wegener, M, 2009)
"Bacillary peliosis hepatis is a well recognised manifestation of disseminated Bartonella henselae infection that can occur in immunocompromised individuals."( Collins, J; Doane, T; Farris, AB; Friedman-Moraco, R; Guarner, J; Marshall Lyon, G; Pouch, S; Steed, D; Woodworth, MH; Yarar, D, 2022)

Context

ExcerptReference
"Peliosis hepatis has been induced immunologically with anti-rat glomerular basal membrane rabbit serum in rats pre-sensitized with a rare earth metal complex, neodymium pyrocatechin disulphonate (NPD)."( Husztik, E; Lázár, G; Szabó, E, 1984)
"Peliosis hepatis has been described as a rare consequence of taking estrogens and contraceptive."( Janicki, K; Maciejewski, R; Madej, B; Radzikowska, E; Wójtowicz, Z, 2001)

Research

Studies (76)

TimeframeStudies, This Condition (%)All Conditions %
pre-199029 (38.16)23.3326
1990's21 (27.63)12.5806
2000's13 (17.11)18.1394
2010's11 (14.47)28.8240
2020's2 (2.63)9.53
DrugIndicatedRelationship StrengthStudiesTrials
putrescine0low20
phenytoin0low10
acetaminophen0low10
aspirin0low10
azathioprine0low70
verapamil0low10
chlorambucil0low10
cimetidine0low20
clenbuterol0low10
pentetic acid0low10
valproic acid0low10
fenvalerate0low10
furosemide0low10
ketoconazole0low10
procarbazine0low10
tolazoline0low10
urethane0low10
prednisolone0low30
lynestrenol0low20
norethandrolone0low20
prednisone0low40
diethylnitrosamine0low10
ethinyl estradiol0low30
methyltestosterone0low10
ampicillin0low10
mestranol0low10
methandrostenolone0low10
vinyl chloride0low10
fluoxymesterone0low20
2-chloroadenosine0low10
ephedrine0low10
testosterone enanthate0low20
chenodeoxycholic acid0low10
erythromycin0low10
levonorgestrel0low20
thorium dioxide0low20
neodymium0low10
technetium0low10
cadmium0low40
gadolinium0low10
danazol0low60
ursodeoxycholic acid0low10
zidovudine0low10
etoposide0low10
methyldopa0low10
gadolinium chloride0low10
fluorodeoxyglucose f180low10
noracycline0low10
clarithromycin0low10
d-4-chloro-17 beta-hydroxy-3-oxo-17 alpha-methylandrosta-1,4-diene0low10
mizoribine0low10
methotrexate0low10
sulbactam0low10
neodymium pyrocatechin disulfonate0low10
methenolone acetate0low10
retinol0low10
zithromax0low10
diethylstilbestrol0low10
dactinomycin0low10
thioguanine anhydrous0low10
tamoxifen0low10
2-chloro-3'-deoxyadenosine0low10
methenolone0low10
bilirubin0low20
oxymetholone0low30
biliverdine0low10
nitrofurantoin0low10
gadolinium dtpa0low30
shu 5080low10
indocyanine green0low10
pyrethrins0low10
gadoxetic acid disodium0low10
norgestrel0low20
cyclosporine0low20
allopurinol0low10

Protein Targets (808)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE110011
Chain A, Beta-lactamase7007
glp-1 receptor, partial6006
TDP1 protein300030
Smad36006
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
NPYLR7B0011
67.9K protein8008
IDH1110011
cellular tumor antigen p53 isoform a7007
vasopressin V1b receptor1001
nuclear factor erythroid 2-related factor 2 isoform 27007
glycogen synthase kinase-3 beta isoform 10022
mitogen-activated protein kinase 14004
flap endonuclease 15005
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor0011
DNA polymerase iota isoform a (long)120012
urokinase-type plasminogen activator precursor7007
plasminogen precursor7007
urokinase plasminogen activator surface receptor precursor7007
geminin280028
survival motor neuron protein isoform d110011
relaxin receptor 1 isoform 11001
high affinity choline transporter 1 isoform a0202
relaxin receptor 2 isoform 11001
lamin isoform A-delta10200020
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Renin0101
Integrin beta-35106
Heat shock protein HSP 90-alpha0213
Integrin alpha-IIb5106
Adenosine receptor A3011112
Endoplasmin0112
Adenosine receptor A10304
Adenosine receptor A10101
5-hydroxytryptamine receptor 2A0909
Adenosine receptor A30101
Adenosine receptor A2a07210
Adenosine receptor A2b0113
Adenosine receptor A2b0204
Adenosine receptor A10506
Adenosine receptor A2a0305
Adenosine receptor A2a0011
Adenosine receptor A10112
Adenosine deaminase 0101
Adenylate cyclase type 50101
Ataxin-2170017
RAR-related orphan receptor gamma230023
ATAD5 protein, partial6006
GLS protein110011
Microtubule-associated protein tau140014
aldehyde dehydrogenase 1 family, member A1170017
thyroid stimulating hormone receptor130013
nuclear receptor subfamily 1, group I, member 3250025
progesterone receptor220022
EWS/FLI fusion protein9009
retinoic acid nuclear receptor alpha variant 1290029
retinoid X nuclear receptor alpha250025
estrogen-related nuclear receptor alpha350035
estrogen nuclear receptor alpha400040
peroxisome proliferator activated receptor gamma200020
aryl hydrocarbon receptor8008
chromobox protein homolog 1150015
thyroid hormone receptor beta isoform 2270027
peripheral myelin protein 22170017
cytochrome P450 3A4 isoform 1120012
Gamma-aminobutyric acid receptor subunit pi121013
ATP-binding cassette sub-family C member 3024024
Multidrug resistance-associated protein 4024025
Solute carrier family 22 member 60506
Carbonic anhydrase 120304
UDP-glucuronosyltransferase 1A90002
Bile salt export pump0909
Voltage-dependent calcium channel gamma-2 subunit160016
Bile salt export pump030030
Cytochrome P450 2B10102
Cytochrome P450 1A10001
Carbonic anhydrase 10708
Carbonic anhydrase 20719
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20102
Prostaglandin G/H synthase 10202
Carbonic anhydrase 30202
Cytochrome P450 3A4011012
Cytochrome P450 2D60303
Cytochrome P450 2C9 0909
Polyunsaturated fatty acid lipoxygenase ALOX150707
Gamma-aminobutyric acid receptor subunit beta-1121013
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta121013
Gamma-aminobutyric acid receptor subunit gamma-2121013
UDP-glucuronosyltransferase 1-60002
Glutamate receptor 2160016
Gamma-aminobutyric acid receptor subunit alpha-5121013
Gamma-aminobutyric acid receptor subunit alpha-3121013
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0205
Carbonic anhydrase 40203
Prostaglandin G/H synthase 10606
Carbonic anhydrase 60203
Gamma-aminobutyric acid receptor subunit gamma-1121013
Gamma-aminobutyric acid receptor subunit alpha-2121013
Gamma-aminobutyric acid receptor subunit alpha-4121013
Gamma-aminobutyric acid receptor subunit gamma-3121013
Gamma-aminobutyric acid receptor subunit alpha-6121013
Carbonic anhydrase 5A, mitochondrial0203
Prostaglandin G/H synthase 20304
Carbonic anhydrase 70203
Nuclear receptor ROR-gamma160016
Cytochrome P450 2J20808
Gamma-aminobutyric acid receptor subunit alpha-1122014
Gamma-aminobutyric acid receptor subunit beta-3121013
Gamma-aminobutyric acid receptor subunit beta-2121013
Carbonic anhydrase 90304
GABA theta subunit121013
Canalicular multispecific organic anion transporter 1025026
Carbonic anhydrase 150101
Carbonic anhydrase 130203
Gamma-aminobutyric acid receptor subunit epsilon121013
Carbonic anhydrase 140203
Carbonic anhydrase 5B, mitochondrial0203
toxin B0001
interleukin 8100010
AR protein300030
estrogen receptor 2 (ER beta)200020
glucocorticoid receptor [Homo sapiens]260026
euchromatic histone-lysine N-methyltransferase 2170017
Bloom syndrome protein isoform 1100010
transcriptional regulator ERG isoform 38008
ras-related protein Rab-9A2002
nuclear factor erythroid 2-related factor 2 isoform 1300030
Polyphenol oxidase 20101
Hypoxanthine-guanine phosphoribosyltransferase0002
Cellular tumor antigen p53270027
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase 0101
Xanthine dehydrogenase/oxidase0303
Nuclear receptor ROR-gamma0101
Xanthine dehydrogenase/oxidase0214
Purine nucleoside phosphorylase0011
TAR DNA-binding protein 438008
Shiga toxin subunit A0101
Histamine H3 receptor0102
Chain A, Mutant Al2 6e7p9g0011
Chain A, 2-oxoglutarate Oxygenase8008
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
Chain A, Cruzipain4004
Beta-lactamase 0001
acid sphingomyelinase3003
GLI family zinc finger 3300030
apical membrane antigen 1, AMA14004
farnesoid X nuclear receptor190019
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0102
Metallo-beta-lactamase0001
Beta-lactamase 0001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
DNA polymerase beta4004
DNA polymerase eta isoform 13003
DNA polymerase kappa isoform 18008
60 kDa heat shock protein, mitochondrial0202
Beta-lactamase OXA-70001
Solute carrier family 15 member 10303
Solute carrier family 15 member 10101
Spike glycoprotein120113
10 kDa heat shock protein, mitochondrial0202
Angiopoietin-1 receptor0011
Beta-lactamase 0102
Beta-lactamase 0102
Beta-lactamase 0102
Solute carrier family 15 member 20101
Thiosulfate sulfurtransferase0202
Metallo-beta-lactamase VIM-130001
Efflux transporter 0001
Beta-lactamase 0001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Class D beta-lactamase0102
60 kDa chaperonin 0303
Metallo-beta-lactamase0001
Solute carrier family 15 member 20101
Beta-lactamase 0102
Beta-lactamase 0001
10 kDa chaperonin 0303
Metallo-b-lactamase 0002
Carbapenem-hydrolyzing beta-lactamase KPC0102
Beta-lactamase class B VIM-2 0002
Beta-lactamase VIM-1 0001
ATP-dependent phosphofructokinase110011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE100010
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein9009
Chain B, HADH2 protein9009
GTP-binding protein (rab7)0011
ras protein, partial0011
thioredoxin reductase100010
hypothetical protein, conserved3003
cytochrome P450 family 3 subfamily A polypeptide 4200020
cytochrome P450 2D69009
glucocerebrosidase5005
peroxisome proliferator-activated receptor delta220022
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
muscarinic acetylcholine receptor M15005
lethal factor (plasmid)7007
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0202
Prostaglandin G/H synthase 2 0202
Epidermal growth factor receptor0303
Fatty acid-binding protein, liver0202
Myeloperoxidase0101
Seed linoleate 13S-lipoxygenase-10101
Glutathione hydrolase 1 proenzyme0101
Substance-P receptor0101
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Sigma non-opioid intracellular receptor 10213
Sigma non-opioid intracellular receptor 10011
Chain A, Ferritin light chain5005
acetylcholinesterase9009
phosphopantetheinyl transferase9009
SMAD family member 2110011
Fumarate hydratase3003
SMAD family member 3110011
thioredoxin glutathione reductase5005
pregnane X nuclear receptor240024
G120012
polyprotein3003
P531001
arylsulfatase A7007
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a180018
thyroid stimulating hormone receptor130013
activating transcription factor 6130013
v-jun sarcoma virus 17 oncogene homolog (avian)190019
Histone H2A.x140014
peripheral myelin protein 22 isoform 15005
hemoglobin subunit beta2002
heat shock protein beta-19009
M-phase phosphoprotein 86006
muscleblind-like protein 1 isoform 15005
Interferon beta160016
HLA class I histocompatibility antigen, B alpha chain 120012
Inositol hexakisphosphate kinase 1120012
ATPase family AAA domain-containing protein 5140014
Protein-arginine deiminase type-40303
cytochrome P450 2C9, partial120012
Chain A, Putative fructose-1,6-bisphosphate aldolase7007
USP1 protein, partial110011
vitamin D3 receptor isoform VDRA100010
caspase-1 isoform alpha precursor3003
Caspase-74004
Inositol monophosphatase 13003
Solute carrier organic anion transporter family member 1B30709
Solute carrier organic anion transporter family member 1B10506
Luciferase6006
caspase 7, apoptosis-related cysteine protease9009
vitamin D (1,25- dihydroxyvitamin D3) receptor210021
caspase-39009
Caspase-75005
caspase-35005
Alpha-2A adrenergic receptor010111
Vitamin D3 receptor0224
Alpha-2B adrenergic receptor0819
Alpha-2C adrenergic receptor0415
Retinoic acid receptor RXR-alpha0011
Guanine nucleotide-binding protein G2002
Ileal sodium/bile acid cotransporter0202
Bile acid receptor0011
G-protein coupled bile acid receptor 10022
Bile acid receptor0022
NFKB1 protein, partial2002
GALC protein2002
Thrombopoietin1001
bromodomain adjacent to zinc finger domain 2B3003
potassium voltage-gated channel subfamily H member 2 isoform d7007
FAD-linked sulfhydryl oxidase ALR0001
alpha-galactosidase2002
cytochrome P450 2C19 precursor3003
Solute carrier family 22 member 10101
Solute carrier family 22 member 20304
Solute carrier family 22 member 1 0505
Solute carrier family 22 member 20101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
ATP-dependent translocase ABCB10707
ATP-dependent translocase ABCB1012223
Potassium-transporting ATPase alpha chain 10101
ATP-dependent translocase ABCB10708
Histamine H2 receptor0808
Histamine H1 receptor0022
Histamine H2 receptor4217
Potassium-transporting ATPase subunit beta0101
Aldehyde oxidase0303
Solute carrier family 22 member 60103
Solute carrier family 22 member 10202
Multidrug and toxin extrusion protein 20202
Solute carrier family 22 member 80205
Multidrug and toxin extrusion protein 10404
Histamine H4 receptor0101
Solute carrier family 22 member 110103
Solute carrier family 22 member 20202
Solute carrier family 22 member 40101
Solute carrier family 22 member 80202
importin subunit beta-1 isoform 13003
snurportin-13003
GTP-binding nuclear protein Ran isoform 11001
streptokinase A precursor0055
Potassium voltage-gated channel subfamily H member 20707
regulator of G-protein signaling 49009
histone acetyltransferase KAT2A isoform 15005
Beta-2 adrenergic receptor0213
Beta-1 adrenergic receptor0606
5-hydroxytryptamine receptor 1A0808
5-hydroxytryptamine receptor 1B0606
Delta-type opioid receptor0112
Beta-2 adrenergic receptor 0013
Beta-2 adrenergic receptor0011
15-lipoxygenase, partial8008
hypoxia-inducible factor 1 alpha subunit120012
RAD510101
thyroid hormone receptor beta isoform a9009
huntingtin isoform 23003
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
nuclear receptor ROR-gamma isoform 18008
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Growth factor receptor-bound protein 20101
Pantothenate synthetase0101
Discoidin domain-containing receptor 20101
Growth factor receptor-bound protein 2 0101
Reverse transcriptase/RNaseH 0227
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
pregnane X receptor8008
nuclear receptor subfamily 1, group I, member 24004
parathyroid hormone/parathyroid hormone-related peptide receptor precursor6006
Rap guanine nucleotide exchange factor 33003
Estrogen receptor012316
Glucocorticoid receptor012320
Sex hormone-binding globulin0033
Glycine receptor subunit alpha-1012012
Aldo-keto reductase family 1 member B1013013
Beta-3 adrenergic receptor0404
Androgen receptor014014
Alpha-1B adrenergic receptor011112
Muscarinic acetylcholine receptor M30606
Glycine receptor subunit beta012012
Substance-K receptor0808
D(1A) dopamine receptor0606
Glycine receptor subunit alpha-2012012
Sodium-dependent noradrenaline transporter 012012
Glycine receptor subunit alpha-3012012
Sodium-dependent serotonin transporter014014
Mu-type opioid receptor0808
D(3) dopamine receptor0808
Kappa-type opioid receptor0808
Alpha-1A adrenergic receptor011112
Sodium-dependent dopamine transporter 010010
Chain A, JmjC domain-containing histone demethylation protein 3A5005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a8008
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
serine/threonine-protein kinase PLK13003
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
neuropeptide S receptor isoform A1001
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
5-hydroxytryptamine receptor 40606
Nuclear receptor subfamily 1 group I member 20101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Tyrosine-protein kinase Fyn0303
Polyunsaturated fatty acid 5-lipoxygenase0202
Muscarinic acetylcholine receptor M10404
D(2) dopamine receptor0404
Acetylcholinesterase0101
Thromboxane-A synthase 0303
Alpha-1D adrenergic receptor0404
5-hydroxytryptamine receptor 2C0606
Vasopressin V1a receptor0202
Alpha-synuclein3104
Delta-type opioid receptor0606
5-hydroxytryptamine receptor 2B0606
5-hydroxytryptamine receptor 60404
Estrogen-related receptor gamma0112
Disintegrin and metalloproteinase domain-containing protein 172002
UDP-glucose 4-epimerase0101
Mitogen-activated protein kinase 140101
Estrogen receptor beta07310
Broad substrate specificity ATP-binding cassette transporter ABCG20315
Cysteinyl leukotriene receptor 10202
Motilin receptor0011
low molecular weight phosphotyrosine protein phosphatase isoform c0101
Motilin receptor0112
30S ribosomal protein S60213
30S ribosomal protein S70213
50S ribosomal protein L150213
Albumin0134
60 kDa chaperonin0101
50S ribosomal protein L100213
50S ribosomal protein L110213
50S ribosomal protein L7/L120213
50S ribosomal protein L190213
50S ribosomal protein L10213
50S ribosomal protein L200213
50S ribosomal protein L270213
50S ribosomal protein L280213
50S ribosomal protein L290213
50S ribosomal protein L310213
50S ribosomal protein L31 type B0213
50S ribosomal protein L320213
50S ribosomal protein L330213
50S ribosomal protein L340213
50S ribosomal protein L350213
50S ribosomal protein L360213
30S ribosomal protein S100213
30S ribosomal protein S110213
30S ribosomal protein S120213
30S ribosomal protein S130213
30S ribosomal protein S160213
30S ribosomal protein S180213
30S ribosomal protein S190213
30S ribosomal protein S200213
30S ribosomal protein S20213
30S ribosomal protein S30213
30S ribosomal protein S40213
30S ribosomal protein S50213
30S ribosomal protein S80213
30S ribosomal protein S90213
50S ribosomal protein L130213
50S ribosomal protein L140213
50S ribosomal protein L160213
50S ribosomal protein L230213
30S ribosomal protein S150213
50S ribosomal protein L170213
50S ribosomal protein L210213
50S ribosomal protein L300213
50S ribosomal protein L60213
30S ribosomal protein S140213
30S ribosomal protein S170213
30S ribosomal protein S10213
50S ribosomal protein L180213
Chitinase B0101
Low molecular weight phosphotyrosine protein phosphatase0101
50S ribosomal protein L20213
50S ribosomal protein L30213
50S ribosomal protein L240213
50S ribosomal protein L40213
50S ribosomal protein L220213
50S ribosomal protein L50213
30S ribosomal protein S210213
50S ribosomal protein L250213
Cytochrome P450 1B10101
Lanosterol 14-alpha demethylase0314
50S ribosomal protein L36 20213
PPM1D protein3003
lysosomal alpha-glucosidase preproprotein4004
Vpr1001
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Cytochrome P450 2B60202
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Sulfotransferase 1A10214
Nuclear receptor subfamily 1 group I member 3 0101
LMP1 [Human herpesvirus 4]0001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0202
transactivating tegument protein VP16 [Human herpesvirus 1]0202
nuclear receptor coactivator 3 isoform a0202
Prothrombin0001
Regulatory protein E20011
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0117
DNA topoisomerase 20001
Serum paraoxonase/arylesterase 10202
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0001
Glutamate receptor ionotropic, NMDA 3A0001
nuclear factor NF-kappa-B p105 subunit isoform 11001
Androgen receptor0415
thyrotropin-releasing hormone receptor2002
Glucose-6-phosphate 1-dehydrogenase0202
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
6-phosphogluconate dehydrogenase, decarboxylating0202
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0303
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10606
Estrogen receptor beta0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0202
Cytochrome P450 26A10101
3',5'-cyclic-AMP phosphodiesterase 0101
Camphor 5-monooxygenase0001
Phospholipase A2, major isoenzyme0101
Chymotrypsinogen A0101
Beta-lactamase0202
Steroid 17-alpha-hydroxylase/17,20 lyase0202
Epoxide hydrolase 10001
Muscarinic acetylcholine receptor M20404
Cytochrome P450 2C11 0101
Steroid 21-hydroxylase0101
Cytochrome P450 2C80202
Aromatase0202
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
5-hydroxytryptamine receptor 2A0202
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2A20101
Cytochrome P450 11B1, mitochondrial 0202
Cytochrome P450 11B1, mitochondrial0101
Translocator protein0101
Cytochrome P450 7A1 0101
Cytochrome P450 11B2, mitochondrial0101
Estrogen receptor0101
Gonadotropin-releasing hormone receptor0112
Type-1 angiotensin II receptor0101
Malate dehydrogenase, cytoplasmic0101
Cytochrome P450 4F20101
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0202
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0101
Cytochrome P450 7A10101
Lanosterol 14-alpha demethylase 0202
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Progesterone receptor0315
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 70001
Cannabinoid receptor 10202
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
dopamine D1 receptor1001
ClpP1001
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0202
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0215
Mu-type opioid receptor0202
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
Solute carrier organic anion transporter family member 1A30002
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
endonuclease IV3003
Caspase 6, apoptosis-related cysteine peptidase0001
pyruvate kinase1001
estrogen receptor beta isoform 10101
serine/threonine-protein kinase mTOR isoform 13003
Cystathionine gamma-lyase0101
D(1A) dopamine receptor2002
phosphoglycerate kinase1001
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
Estrogen receptor0023
Estrogen receptor beta0023
nonstructural protein 11001
Gamma-aminobutyric acid 0101
cytochrome P450 2C9 precursor1001
atrial natriuretic peptide receptor 1 precursor1001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Sodium channel protein type 2 subunit alpha0101
Gamma-aminobutyric acid receptor subunit alpha-10101
Aldo-keto reductase family 1 member B10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0102
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit epsilon0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 9 subunit alpha0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0101
Sodium channel protein type 2 subunit alpha0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Sodium channel protein type 3 subunit alpha0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit theta0101
luciferase0001
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Nociceptin receptor0011
Chain A, PUTRESCINE-BINDING PROTEIN0011
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN0101
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN0101
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN0101
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN0101
Ornithine decarboxylase0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0101
S-adenosylmethionine decarboxylase proenzyme0001
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Retinol-binding protein 40011
Beta-lactoglobulin0011
Amyloid-beta precursor protein0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase0101
Beta-lactamase0101
Beta-lactamase SHV-10101
Replicase polyprotein 1ab0213
Beta-lactamase OXA-10101
Beta-lactamase0101
Metallo-beta-lactamase type 20101
Angiotensin-converting enzyme0101
Beta-lactamase TEM0202
Beta-lactamase 0101
Beta-lactamase 0101
Chain A, CES1 protein0101
DNA polymerase III, partial1001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
cytochrome P450 2D6 isoform 12002
NPC intracellular cholesterol transporter 1 precursor1001
interferon gamma precursor0001
D(1A) dopamine receptor1001
ubiquitin-conjugating enzyme E2 N0101
Transmembrane protease serine 20011
Serine/threonine-protein kinase D30101
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0202
Tyrosine-protein kinase Lck0101
Procathepsin L0011
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Protein kinase C alpha type0101
D(4) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Protein kinase C eta type0101
Substance-P receptor0202
B2 bradykinin receptor0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Protein kinase C iota type0101
Melanocortin receptor 30202
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0202
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
PAX80001
Apoptosis regulator Bcl-20101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Mitogen-activated protein kinase 3 0101
Bcl-2-like protein 10101
Alpha-2B adrenergic receptor0112
Alpha-2C adrenergic receptor0112
Alpha-2A adrenergic receptor0112
Alpha-1D adrenergic receptor0112
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1B0101
Trace amine-associated receptor 10101
Ubiquitin carboxyl-terminal hydrolase 20101
M1-family alanyl aminopeptidase0101
Cocaine esterase0101
Histone deacetylase 30202
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 2B70103
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Sigma non-opioid intracellular receptor 10101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
Glycoprotein0101
Muscarinic acetylcholine receptor M20011
Catechol O-methyltransferase0101
Potassium voltage-gated channel subfamily A member 30101
Delta-type opioid receptor0101
Kappa-type opioid receptor0101
5-hydroxytryptamine receptor 70101
D(2) dopamine receptor0101
Chloroquine resistance transporter0101
pyruvate kinase PKM isoform a1001
tyrosine-protein kinase Yes1001
Ectonucleoside triphosphate diphosphohydrolase 10001
Thymidine kinase, cytosolic0203
DNA polymerase beta0101
Thymidine kinase, cytosolic 0001
Thymidylate kinase0101
Thymidine kinase 0102
Solute carrier family 22 member 70001
Protease 0112
Thymidine kinase0102
Solute carrier family 22 member 70001
twin arginine protein translocation system - TatA protein0001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]