Compounds > amicetin
Page last updated: 2024-11-05

amicetin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Amicetin is a natural product antibiotic produced by the bacterium *Streptomyces vinaceus*. It is a cyclic peptide composed of seven amino acids, including the unusual amino acid amicetinol. Amicetin has been shown to exhibit potent antibacterial activity against Gram-positive bacteria, including *Staphylococcus aureus* and *Streptococcus pneumoniae*. It is also effective against some Gram-negative bacteria, such as *Escherichia coli*. The mechanism of action of amicetin is thought to involve inhibition of protein synthesis by binding to the 50S ribosomal subunit. Amicetin's complex structure makes its total synthesis challenging. Research on amicetin has focused on understanding its biosynthesis, its mechanism of action, and its potential as a lead compound for the development of new antibiotics. Its importance lies in its potential for treating bacterial infections, especially those resistant to conventional antibiotics.'

Cross-References

ID SourceID
PubMed CID28675
SCHEMBL ID692021
MeSH IDM0045475

Synonyms (19)

Synonym
amicetin (van)
hydracrylanilide, 2-amino-4'-((1,2-dihydro-2-oxo-1-(2,3,6-trideoxy-4-o-(4,6-dideoxy-4-(dimethylamino)-alpha-d-glucopyranosyl)-beta-d-erythro-hexopyranosyl)-4-pyrimidinyl)carbamoyl)-2-methyl- (van)
brn 0102092
ai3-50806
benzamide, 4-((2-amino-3-hydroxy-2-methyl-1-oxopropyl)amino)-n-(1-(5-((4,6-dideoxy-4-(dimethylamino)-alpha-d-glucopyranosyl)oxy)-tet
sacromycin (van)
allomycin (van)
amicetin
4-[[(2s)-2-amino-3-hydroxy-2-methylpropanoyl]amino]-n-[1-[(2r,5s,6r)-5-[(2r,3r,4s,5s,6r)-5-(dimethylamino)-3,4-dihydroxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]-2-oxopyrimidin-4-yl]benzamide
unii-0909x15c85
0909x15c85 ,
benzamide, 4-(((2s)-2-amino-3-hydroxy-2-methyl-1-oxopropyl)amino)-n-(1-((2r,5s,6r)-5-((4,6-dideoxy-4-(dimethylamino)-.alpha.-d-glucopyranosyl)oxy)tetrahydro-6-methyl-2h-pyran-2-yl)-1,2-dihydro-2-oxo-4-pyrimidinyl)-
amicetin [mi]
SCHEMBL692021
n-{1-[(2r,5s,6r)-5-{[4,6-dideoxy-4-(dimethylamino)-alpha-d-glucopyranosyl]oxy}-6-methyloxan-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl}-4-[(2-methyl-l-seryl)amino]benzamide
DTXSID801015583
Q27236433
HY-120383
CS-0077734
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (28)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (35.71)18.7374
1990's5 (17.86)18.2507
2000's5 (17.86)29.6817
2010's5 (17.86)24.3611
2020's3 (10.71)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.52

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.52 (24.57)
Research Supply Index3.43 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.52)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (6.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other28 (93.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cytosine
[no description available]		3.2110aminopyrimidine;
pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
2,2'-dipyridyl
2,2'-Dipyridyl: A reagent used for the determination of iron.. 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.		2.110bipyridinechelator;
ferroptosis inhibitor
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		7.8940C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
lysine
Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.		1.9710aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
cytidine
[no description available]		3.2110cytidinesEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
erythromycin
Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.		1.9810cyclic ketone;
erythromycin
tobramycin
Tobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.. tobramycin : A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.		2.3620amino cyclitol glycosideantibacterial agent;
antimicrobial agent;
toxin
gougerotin
[no description available]		3.5120
puromycin
[no description available]		2.6830puromycinsantiinfective agent;
antimicrobial agent;
antineoplastic agent;
EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor;
EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor;
nucleoside antibiotic;
protein synthesis inhibitor
nikkomycin
[no description available]		3.2110
mildiomycin
mildiomycin: antibiotic nucleoside produced by Streptoverticillium rimofaciens effective against powdery mildew; 5-hydroxymethyl cytosine found on acid hydrolysis; RN given refers to (S)-isomer		3.2110
thiostrepton
Thiostrepton: One of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastitis caused by gram-negative organisms and in dermatologic disorders.. thiostrepton : A heterodetic cyclic peptide, in which the cyclisation step involves a formal lactonisation between the carboxy group of a quinaldic acid-based residue and a secondary alcohol. An antibiotic that inhibits bacterial protein synthesis. Also acts as an antitumor agent.		1.9810
ningnanmycin
ningnanmycin: isolated from Strepcomces noursei		3.2110
blasticidin s
blasticidin S: RN given refers to (S)-isomer; structure. blasticidin S : A blasticidin that is an antibiotic obtained from Streptomyces griseochromogene.		4.0240
collismycin b
collismycin B: glucocorticoid receptor antagonist; structure in first source		2.110
ConditionIndicatedRelationship StrengthStudiesTrials
Bacterial Disease
[description not available]		01.9610
Bacterial Infections
Infections by bacteria, general or unspecified.		01.9610