ornithine decarboxylase inhibitor activity

Definition

Target type: molecularfunction

Binds to and stops, prevents or reduces the activity of ornithine decarboxylase. [GOC:jl]

Ornithine decarboxylase (ODC) inhibitor activity refers to the ability of a molecule to inhibit the enzyme ornithine decarboxylase. ODC is a key enzyme in the biosynthesis of polyamines, which are essential for cell growth, proliferation, and differentiation. It catalyzes the decarboxylation of ornithine to putrescine, the first committed step in polyamine biosynthesis. ODC inhibitors block this step, preventing the production of polyamines. This inhibition can have several downstream effects on cellular processes.

**Mechanism of action:**

* **Direct inhibition:** ODC inhibitors can directly bind to the active site of the enzyme, preventing the binding of ornithine and inhibiting its decarboxylation.
* **Indirect inhibition:** Some inhibitors can indirectly affect ODC activity by influencing its expression or stability. For instance, they may induce the degradation of ODC or block its synthesis.

**Biological consequences of ODC inhibition:**

* **Anti-proliferative effects:** ODC inhibition can suppress cell growth and proliferation by limiting the supply of polyamines necessary for these processes.
* **Anti-tumor activity:** Several ODC inhibitors have shown promise as potential cancer treatments. They can slow tumor growth and induce tumor regression.
* **Anti-inflammatory effects:** Polyamines play a role in inflammation, and ODC inhibitors can reduce inflammatory responses.
* **Neuroprotective effects:** ODC inhibitors may protect neurons from damage and death in various neurological conditions.

**Clinical applications:**

* **Cancer therapy:** ODC inhibitors are currently being investigated as potential treatments for various types of cancer.
* **Other medical conditions:** ODC inhibitors may be beneficial in treating conditions such as inflammatory bowel disease, arthritis, and neurodegenerative disorders.

**Examples of ODC inhibitors:**

* **Difluoromethylornithine (DFMO):** This is a widely studied and potent ODC inhibitor with potential applications in cancer therapy.
* **Eflornithine:** This drug is approved for the treatment of African trypanosomiasis, a parasitic disease. It also exhibits ODC inhibitory activity.
* **α-difluoromethylornithine (α-DFMO):** This is another potent ODC inhibitor with potential applications in cancer treatment.

**Note:** The specific mechanisms of action and biological effects of ODC inhibitors can vary depending on the inhibitor and the cell type being studied.'
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Proteins (1)

Compounds (21)