Page last updated: 2024-09-28

Benign Hyperglobulinemic Purpura of Waldenstru00F6m

Purplish or brownish red discoloration of the skin associated with increase in circulating polyclonal globulins, usually GAMMA-GLOBULINS. This syndrome often occurs on the legs of women aged 20 to 40 years.

Synonyms(6)

Synonym
Hyperglobulinemic Purpura of Waldenstru00F6m
Waldenstrom Hyperglobulinemic Purpura
Purpura, Hyperglobulinemic
Hyperglobulinemic Purpura
Benign Hyperglobulinemic Purpura of Waldenstru00F6m
Hypergammaglobulinemic Purpura of Waldenstrom

Research Excerpts

Research

Studies (58)

TimeframeStudies, This Condition (%)All Conditions %
pre-199046 (79.31)23.3326
1990's6 (10.34)12.5806
2000's5 (8.62)18.1394
2010's1 (1.72)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
ammonium hydroxide0low10
glycine0low10
uric acid0low10
mercaptoethanol0low20
azathioprine0low20
chlorambucil0low60
guanethidine0low10
hydroxychloroquine0low30
indomethacin0low10
phenylbutazone0low10
prednisolone0low50
penicillamine0low20
prednisone0low120
chloramphenicol0low20
colchicine0low10
reticulin0low10
erythromycin0low10
d-alpha tocopherol0low10
ethamsylate0low10
trolamine salicylate0low50
ammonium chloride0low10
fibrinogen0low20
mizoribine0low10
tartrazine0low10
mycophenolic acid0low10
melphalan0low30
mercaptopurine0low10
thioguanine anhydrous0low20
amphotericin b0low10
beryllium0low10
phosphorus0low10
allopurinol0low10
concanavalin a0low10

Protein Targets (472)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
interleukin 87007
TDP1 protein140014
AR protein150015
thyroid stimulating hormone receptor3003
estrogen receptor 2 (ER beta)7007
progesterone receptor7007
glucocorticoid receptor [Homo sapiens]120012
estrogen-related nuclear receptor alpha150015
estrogen nuclear receptor alpha160016
IDH15005
euchromatic histone-lysine N-methyltransferase 2130013
Bloom syndrome protein isoform 15005
transcriptional regulator ERG isoform 33003
thyroid hormone receptor beta isoform 2100010
ras-related protein Rab-9A3003
nuclear factor erythroid 2-related factor 2 isoform 1120012
geminin100010
survival motor neuron protein isoform d9009
lamin isoform A-delta10120012
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010010
Polyphenol oxidase 20101
Voltage-dependent calcium channel gamma-2 subunit9009
Bile salt export pump013013
Hypoxanthine-guanine phosphoribosyltransferase0003
Cellular tumor antigen p53140014
Glutamate receptor 291010
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase 0101
Adenosine receptor A2a0011
Xanthine dehydrogenase/oxidase0303
Nuclear receptor ROR-gamma0101
Xanthine dehydrogenase/oxidase0214
Purine nucleoside phosphorylase0022
TAR DNA-binding protein 434004
Canalicular multispecific organic anion transporter 10909
Shiga toxin subunit A0101
Histamine H3 receptor0101
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
Chain A, Cruzipain2002
phosphopantetheinyl transferase6006
GLS protein6006
farnesoid X nuclear receptor9009
peroxisome proliferator-activated receptor delta7007
vitamin D (1,25- dihydroxyvitamin D3) receptor110011
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA6006
peripheral myelin protein 227007
Cytochrome P450 1A20101
Cytochrome P450 3A40404
Cytochrome P450 2D60202
Cytochrome P450 2C9 0404
Cytochrome P450 2C190101
Nuclear receptor ROR-gamma7007
Potassium voltage-gated channel subfamily H member 20404
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, Ferritin light chain2002
acetylcholinesterase4004
thioredoxin reductase4004
RAR-related orphan receptor gamma100010
SMAD family member 23003
ATAD5 protein, partial2002
Fumarate hydratase4004
SMAD family member 33003
GLI family zinc finger 3120012
Microtubule-associated protein tau6006
thioredoxin glutathione reductase5005
nuclear receptor subfamily 1, group I, member 39009
EWS/FLI fusion protein8008
retinoic acid nuclear receptor alpha variant 1110011
retinoid X nuclear receptor alpha9009
pregnane X nuclear receptor100010
G7007
polyprotein4004
P531001
peroxisome proliferator activated receptor gamma8008
arylsulfatase A2002
aryl hydrocarbon receptor9009
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
thyroid stimulating hormone receptor2002
activating transcription factor 67007
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x6006
peripheral myelin protein 22 isoform 13003
hemoglobin subunit beta3003
cellular tumor antigen p53 isoform a4004
heat shock protein beta-14004
DNA polymerase iota isoform a (long)5005
cytochrome P450 3A4 isoform 15005
M-phase phosphoprotein 83003
muscleblind-like protein 1 isoform 14004
muscarinic acetylcholine receptor M13003
Gamma-aminobutyric acid receptor subunit pi5005
Bile salt export pump0202
Interferon beta9009
HLA class I histocompatibility antigen, B alpha chain 7007
Gamma-aminobutyric acid receptor subunit beta-15005
Gamma-aminobutyric acid receptor subunit delta5005
Gamma-aminobutyric acid receptor subunit gamma-25005
Gamma-aminobutyric acid receptor subunit alpha-55005
Gamma-aminobutyric acid receptor subunit alpha-35005
Gamma-aminobutyric acid receptor subunit gamma-15005
Gamma-aminobutyric acid receptor subunit alpha-25005
Gamma-aminobutyric acid receptor subunit alpha-45005
Gamma-aminobutyric acid receptor subunit gamma-35005
Gamma-aminobutyric acid receptor subunit alpha-65005
Gamma-aminobutyric acid receptor subunit alpha-15005
Gamma-aminobutyric acid receptor subunit beta-35005
Gamma-aminobutyric acid receptor subunit beta-25005
GABA theta subunit5005
Inositol hexakisphosphate kinase 17007
ATPase family AAA domain-containing protein 57007
Ataxin-27007
Gamma-aminobutyric acid receptor subunit epsilon5005
Protein-arginine deiminase type-40101
cytochrome P450 2C9, partial7007
Luciferase5005
NFKB1 protein, partial1001
GALC protein1001
Thrombopoietin2002
caspase 7, apoptosis-related cysteine protease2002
aldehyde dehydrogenase 1 family, member A1100010
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
bromodomain adjacent to zinc finger domain 2B3003
caspase-32002
chromobox protein homolog 13003
potassium voltage-gated channel subfamily H member 2 isoform d2002
FAD-linked sulfhydryl oxidase ALR0001
urokinase-type plasminogen activator precursor5005
plasminogen precursor5005
urokinase plasminogen activator surface receptor precursor5005
Carbonic anhydrase 120101
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Spike glycoprotein4015
Carbonic anhydrase 90101
Solute carrier organic anion transporter family member 1B30404
ATP-dependent phosphofructokinase5005
cytochrome P450 2D63003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
streptokinase A precursor0022
lethal factor (plasmid)3003
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60213
30S ribosomal protein S70213
50S ribosomal protein L150213
50S ribosomal protein L100213
50S ribosomal protein L110213
50S ribosomal protein L7/L120213
50S ribosomal protein L190213
50S ribosomal protein L10213
50S ribosomal protein L200213
50S ribosomal protein L270213
50S ribosomal protein L280213
50S ribosomal protein L290213
50S ribosomal protein L310213
50S ribosomal protein L31 type B0213
50S ribosomal protein L320213
50S ribosomal protein L330213
50S ribosomal protein L340213
50S ribosomal protein L350213
50S ribosomal protein L360213
30S ribosomal protein S100213
30S ribosomal protein S110213
30S ribosomal protein S120213
30S ribosomal protein S130213
30S ribosomal protein S160213
30S ribosomal protein S180213
30S ribosomal protein S190213
30S ribosomal protein S200213
30S ribosomal protein S20213
30S ribosomal protein S30213
30S ribosomal protein S40213
30S ribosomal protein S50213
30S ribosomal protein S80213
30S ribosomal protein S90213
50S ribosomal protein L130213
50S ribosomal protein L140213
50S ribosomal protein L160213
50S ribosomal protein L230213
30S ribosomal protein S150213
50S ribosomal protein L170213
50S ribosomal protein L210213
50S ribosomal protein L300213
50S ribosomal protein L60213
30S ribosomal protein S140213
30S ribosomal protein S170213
30S ribosomal protein S10213
50S ribosomal protein L180213
50S ribosomal protein L20213
50S ribosomal protein L30213
50S ribosomal protein L240213
50S ribosomal protein L40213
50S ribosomal protein L220213
50S ribosomal protein L50213
30S ribosomal protein S210213
50S ribosomal protein L250213
50S ribosomal protein L36 20213
Methionine--tRNA ligase, mitochondrial0011
Chain A, Beta-lactamase3003
endonuclease IV1001
PAX80002
pregnane X receptor3003
hypoxia-inducible factor 1 alpha subunit4004
USP1 protein, partial5005
PPM1D protein1001
Smad33003
cytochrome P450 family 3 subfamily A polypeptide 49009
67.9K protein4004
glucocerebrosidase3003
nuclear receptor subfamily 1, group I, member 23003
cytochrome P450 2D6 isoform 12002
nuclear receptor subfamily 0 group B member 10101
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor3003
thyroid hormone receptor beta isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 25005
atrial natriuretic peptide receptor 2 precursor1001
flap endonuclease 11001
steroidogenic factor 10101
caspase-1 isoform alpha precursor1001
neuropeptide S receptor isoform A3003
Solute carrier family 22 member 30101
Tubulin alpha-1A chain0213
Tubulin beta chain0213
Plasma kallikrein0001
Tubulin beta-4A chain0225
ATP-dependent translocase ABCB10303
Tubulin beta chain0225
ATP-dependent translocase ABCB10405
Tubulin alpha-3C chain0225
Serine/threonine-protein kinase pim-10101
ATP-dependent translocase ABCB10303
Histamine H2 receptor3003
Tubulin alpha-1B chain0225
Tubulin alpha-4A chain0225
Tubulin beta-4B chain0225
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain0225
Tubulin beta-2A chain0225
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain0225
Tubulin beta-2B chain0202
Tubulin alpha-3E chain0225
Tubulin alpha-1A chain0225
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
CREB-binding protein1001
Tubulin alpha-1C chain0225
Tubulin beta-6 chain0225
Tubulin beta-2B chain0225
Tubulin beta-1 chain0225
importin subunit beta-1 isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 11001
Rap guanine nucleotide exchange factor 32002
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
Motilin receptor0011
acid sphingomyelinase1001
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK11001
Motilin receptor0112
Albumin0123
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Chitinase B0101
Low molecular weight phosphotyrosine protein phosphatase0101
Cytochrome P450 2J20202
10 kDa heat shock protein, mitochondrial0101
Cytochrome P450 1B10101
Thiosulfate sulfurtransferase0101
Lanosterol 14-alpha demethylase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Multidrug and toxin extrusion protein 10202
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Glutamate receptor ionotropic, NMDA 1 0213
Sodium- and chloride-dependent glycine transporter 10101
Glutamate receptor ionotropic, NMDA 2A 0213
Glutamate receptor ionotropic, NMDA 2B0213
Glutamate receptor ionotropic, NMDA 2C0213
Large neutral amino acids transporter small subunit 10101
Glutamate receptor ionotropic, NMDA 2D0213
Proton-coupled amino acid transporter 10101
Glutamate receptor ionotropic, NMDA 3B0213
Serine racemase0101
Olfactory receptor 51E20011
Glutamate receptor ionotropic, NMDA 3A0213
Sodium- and chloride-dependent glycine transporter 20101
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Genome polyprotein 0101
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Procathepsin L0112
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0213
Muscarinic acetylcholine receptor M10101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Muscarinic acetylcholine receptor M30101
Alpha-1D adrenergic receptor0202
Sigma intracellular receptor 20101
Cyclic GMP-AMP synthase0101
Sigma non-opioid intracellular receptor 10101
Angiotensin-converting enzyme 2 0011
Toll-like receptor 90101
Toll-like receptor 70101
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
Chain A, 2-oxoglutarate Oxygenase4004
Parkin2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
serine/threonine-protein kinase mTOR isoform 11001
nuclear receptor ROR-gamma isoform 12002
DNA polymerase kappa isoform 11001
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0102
Prostaglandin G/H synthase 2 0102
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Epidermal growth factor receptor0101
Phospholipase A2, major isoenzyme0101
Prostaglandin G/H synthase 10304
Neuronal acetylcholine receptor subunit alpha-40101
Interleukin-80101
Androgen receptor0213
Neuronal acetylcholine receptor subunit beta-20101
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 10303
Sodium-dependent dopamine transporter0101
Sodium- and chloride-dependent GABA transporter 10101
Thromboxane-A synthase 0101
Adenosine receptor A10101
Serum paraoxonase/arylesterase 10101
Indoleamine 2,3-dioxygenase 10101
Caspase-10001
Nitric oxide synthase, inducible0101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin E2 receptor EP3 subtype0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 20415
Prostaglandin G/H synthase 2 0202
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0022
Aldo-keto reductase family 1 member C30202
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G1001
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30101
Prostaglandin G/H synthase 20202
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 60102
Solute carrier family 22 member 70001
Sigma intracellular receptor 20101
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Prostaglandin G/H synthase 1 0202
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 80303
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10202
glp-1 receptor, partial2002
15-lipoxygenase, partial1001
Caspase-71001
caspase-31001
Large neutral amino acids transporter small subunit 1 0101
Glutaminyl-peptide cyclotransferase0101
Chain A, JmjC domain-containing histone demethylation protein 3A2002
apical membrane antigen 1, AMA12002
histone acetyltransferase KAT2A isoform 12002
UDP-glucose 6-dehydrogenase0101
Solute carrier family 22 member 80001
Integrin beta-32002
Integrin alpha-IIb2002
UDP-glucose 6-dehydrogenase0101
UDP-glucuronosyltransferase 1A1 0101
regulator of G-protein signaling 43003
lysosomal alpha-glucosidase preproprotein1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
glycogen synthase kinase-3 beta isoform 10011
huntingtin isoform 21001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Chain A, Inosine-5'-Monophosphate Dehydrogenase 20101
UDP-glucuronosyltransferase 1A90001
Inosine-5'-monophosphate dehydrogenase 20202
Glutamate receptor 10101
Glutamate receptor 30101
Glutamate receptor 40101
Inosine-5'-monophosphate dehydrogenase 1 0202
UDP-glucuronosyltransferase 1A1 0001
Sodium-dependent serotonin transporter0101
Alpha-synuclein1001
Inosine-5'-monophosphate dehydrogenase0102
UDP-glucuronosyltransferase 1A70001
UDP-glucuronosyltransferase 1A100001
UDP-glucuronosyltransferase 1A80001
Cystathionine gamma-lyase0101
Succinyl-diaminopimelate desuccinylase0101
Estrogen receptor 10101
nonstructural protein 11001
D(1A) dopamine receptor1001
fMet-Leu-Phe receptor0101
mitogen-activated protein kinase 11001
Cyclooxygenase-2 0101
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor04211
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
hypothetical protein, conserved1001
Adenosine receptor A30202
Apoptosis regulator Bcl-20101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Alpha-1B adrenergic receptor0202
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Mitogen-activated protein kinase 3 0101
Alpha-1A adrenergic receptor0202
Bcl-2-like protein 10101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]