uric acid has been researched along with Shock, Septic in 6 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "LPS-induced septic shock and monosodium urate (MSU)-induced murine peritonitis models were employed for in vivo evaluations." | 1.56 | Ginsenoside metabolite 20(S)-protopanaxatriol from Panax ginseng attenuates inflammation-mediated NLRP3 inflammasome activation. ( Akther, M; Han, JH; Jiang, J; Kang, TB; Kopalli, SR; Koppula, S; Lee, KH; Lian, ML; Quan, LH; Sun, X, 2020) |
| "TAC, unable to distinguish severe sepsis and septic shock, is unlikely to be a particularly useful outcome measure." | 1.35 | Plasma antioxidant status in septic critically ill patients: a decrease over time. ( Aho, LS; Aube, H; Blettery, B; Doise, JM; Guilland, JC; Quenot, JP; Rochette, L; Vergely, C; Zeller, M, 2008) |
| "Patients with sepsis or acute pancreatitis had drastically reduced levels of total muscular free AA, mainly due to a fall in muscle glutamine." | 1.27 | [Amino acid and protein metabolism in critically ill patients]. ( Roth, E, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, J | 1 |
| Sun, X | 1 |
| Akther, M | 1 |
| Lian, ML | 1 |
| Quan, LH | 1 |
| Koppula, S | 1 |
| Han, JH | 1 |
| Kopalli, SR | 1 |
| Kang, TB | 1 |
| Lee, KH | 1 |
| Yue, H | 1 |
| Yang, Z | 1 |
| Ou, Y | 1 |
| Liang, S | 1 |
| Deng, W | 1 |
| Chen, H | 1 |
| Zhang, C | 1 |
| Hua, L | 1 |
| Hu, W | 1 |
| Sun, P | 1 |
| BODA, D | 1 |
| Doise, JM | 1 |
| Aho, LS | 1 |
| Quenot, JP | 1 |
| Guilland, JC | 1 |
| Zeller, M | 1 |
| Vergely, C | 1 |
| Aube, H | 1 |
| Blettery, B | 1 |
| Rochette, L | 1 |
| Szabó, C | 1 |
| Zingarelli, B | 1 |
| Salzman, AL | 1 |
| Roth, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock[NCT03380507] | Phase 2/Phase 3 | 106 participants (Actual) | Interventional | 2018-03-17 | Terminated (stopped due to The research is no longer funded and terminated due to futility) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for uric acid and Shock, Septic
| Article | Year |
|---|---|
Ginsenoside metabolite 20(S)-protopanaxatriol from Panax ginseng attenuates inflammation-mediated NLRP3 inflammasome activation.
Topics: Animals; Anti-Inflammatory Agents; Ginsenosides; Inflammasomes; Interleukin-1beta; Lipopolysaccharid | 2020 |
Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation.
Topics: Abietanes; AMP-Activated Protein Kinases; Animals; Autophagy; Disease Models, Animal; Female; Furans | 2021 |
[DISEASES OF THE INTRACELLULAR SYSTEM IN THE COURSE OF ACUTE METABOLIC DISTURBANCES].
Topics: Blood Chemical Analysis; Cell Biology; Hypernatremia; Hypokalemia; Metabolic Diseases; Nitrogen; Sep | 1964 |
Plasma antioxidant status in septic critically ill patients: a decrease over time.
Topics: Adult; Aged; Analysis of Variance; Antioxidants; Ascorbic Acid; Bilirubin; Biomarkers; Chromatograph | 2008 |
Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite.
Topics: Animals; Interferon-gamma; Lipopolysaccharides; Male; Mice; Mitochondria; Nitrates; Nitric Oxide; Ox | 1996 |
[Amino acid and protein metabolism in critically ill patients].
Topics: Adult; Aged; Amino Acids; Animals; Blood Proteins; Cholecystectomy; Critical Care; Dogs; Female; Hum | 1985 |