pimagedine has been researched along with Shock, Septic in 32 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The endotoxin shock was induced by intravenously injecting LPS (400 micro g/kg)." | 5.32 | [Effect of dexamethasone, aminoguanidin, amrinone on oxygen utilization in endotoxin shock rabbits]. ( Fan, XM; Tang, HX, 2003) |
| "Although septic shock is a highly complex pathophysiological state, the course of septic shock has different phases with different characteristics which need different (special) treatment strategy." | 2.42 | Effects of endothelin and nitric oxide on organ injury, mesenteric ischemia, and survival in experimental models of septic shock. ( Guc, O; Iskit, AB, 2003) |
| "Changes in vascular reactivity during endotoxic shock are organ-specific." | 1.48 | Organ-specific changes in vascular reactivity and roles of inducible nitric oxide synthase and endothelin-1 in a rabbit endotoxic shock model. ( Chen, W; Li, T; Liu, LM; Zhang, ZS, 2018) |
| "The endotoxin shock was induced by intravenously injecting LPS (400 micro g/kg)." | 1.32 | [Effect of dexamethasone, aminoguanidin, amrinone on oxygen utilization in endotoxin shock rabbits]. ( Fan, XM; Tang, HX, 2003) |
| "Edotoxic shock was diagnosed when the mean arterial pressure (MAP) decreased to 30%." | 1.32 | [Effects of aminoguanidine in different dosages on renal function in endotoxin induced rabbits shock model]. ( Fan, XM; Tang, HX; Wang, L, 2004) |
| "The model of endotoxin shock was induced by lipopolysaccharide (1." | 1.32 | [Influence of electro-acupuncture of Neiguan on plasmic concentrations of NO and TNFalpha in endotoxin shock rats]. ( Chen, DF; Du, SH; Li, C; Li, H; Li, YW, 2003) |
| "In a porcine model of endotoxic shock, we evaluated the circulatory and respiratory effects of NO synthase (NOS) blockade." | 1.31 | Effect of NO synthase inhibition on cardiovascular and pulmonary dysfunction in a porcine short-term model of endotoxic shock. ( Albertini, M; Clement, MG; Hussain, SN; Lafortuna, CL; Mazzola, S; Radice, S, 2002) |
| "2." | 1.31 | The lung is the major site that produces nitric oxide to induce acute pulmonary oedema in endotoxin shock. ( Chen, HI; Kao, SJ; Lee, RP; Wang, D, 2001) |
| "Septic shock is characterized by arteriolar vasodilation and hypotension." | 1.31 | Inducible nitric oxide synthase pathway in the central nervous system and vasopressin release during experimental septic shock. ( Antunes-Rodrigues, J; Carnio, EC; De Castro, M; Giusti-Paiva, A, 2002) |
| "Future clinical trials in treating septic shock should therefore consider the preferential inhibition of iNOS while maintaining the integrity of endothelial NOS." | 1.29 | Expression and preferential inhibition of inducible nitric oxide synthase in aortas of endotoxemic rats. ( Higa, EM; McMurtry, IF; Niederberger, M; Raynolds, M; Schrier, RW; Weigert, AL, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (34.38) | 18.2507 |
| 2000's | 19 (59.38) | 29.6817 |
| 2010's | 2 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Teng, P | 1 |
| Liu, HL | 1 |
| Zhang, L | 1 |
| Feng, LL | 1 |
| Huai, Y | 1 |
| Deng, ZS | 1 |
| Sun, Y | 1 |
| Xu, Q | 1 |
| Li, JX | 1 |
| Zhang, ZS | 1 |
| Chen, W | 1 |
| Li, T | 1 |
| Liu, LM | 1 |
| Albertini, M | 1 |
| Lafortuna, CL | 1 |
| Clement, MG | 1 |
| Mazzola, S | 1 |
| Radice, S | 1 |
| Hussain, SN | 1 |
| Iskit, AB | 4 |
| Guc, O | 1 |
| Tang, HX | 2 |
| Fan, XM | 2 |
| Guc, MO | 3 |
| Wang, L | 1 |
| Li, H | 1 |
| Li, C | 1 |
| Du, SH | 1 |
| Li, YW | 1 |
| Chen, DF | 1 |
| Mitaka, C | 1 |
| Lin, HC | 2 |
| Wan, FJ | 2 |
| Wu, CC | 3 |
| Tung, CS | 1 |
| Wu, TH | 1 |
| Stabile, AM | 1 |
| Moreto, V | 1 |
| Antunes-Rodrigues, J | 2 |
| Carnio, EC | 2 |
| Doursout, MF | 1 |
| Oguchi, T | 1 |
| Fischer, UM | 1 |
| Liang, Y | 1 |
| Chelly, B | 1 |
| Hartley, CJ | 1 |
| Chelly, JE | 1 |
| Koga, K | 1 |
| Sata, T | 1 |
| Nanri, H | 1 |
| Sano, H | 1 |
| Ikeda, M | 1 |
| Shigematsu, A | 1 |
| Klabunde, RE | 1 |
| Coston, AF | 1 |
| Chen, SJ | 2 |
| Szabó, C | 1 |
| Thiemermann, C | 3 |
| Vane, JR | 1 |
| Weigert, AL | 1 |
| Higa, EM | 1 |
| Niederberger, M | 1 |
| McMurtry, IF | 1 |
| Raynolds, M | 1 |
| Schrier, RW | 1 |
| Keller, RS | 1 |
| Jones, JJ | 1 |
| Kim, KF | 1 |
| Myers, PR | 1 |
| Adams, HR | 1 |
| Parker, JL | 1 |
| Rubin, LJ | 1 |
| Kengatharan, KM | 1 |
| De Kimpe, SJ | 1 |
| Gagnon, C | 1 |
| Leblond, FA | 1 |
| Filep, JG | 1 |
| Yen, MH | 1 |
| Pedoto, A | 1 |
| Tassiopoulos, AK | 1 |
| Oler, A | 1 |
| McGraw, DJ | 1 |
| Hoffmann, SP | 1 |
| Camporesi, EM | 1 |
| Hakim, TS | 1 |
| Bhagat, K | 1 |
| Hingorani, AD | 1 |
| Palacios, M | 1 |
| Charles, IG | 1 |
| Vallance, P | 1 |
| Chen, CC | 1 |
| Lin, YC | 1 |
| Chen, SA | 1 |
| Luk, HN | 1 |
| Ding, PY | 1 |
| Chang, MS | 1 |
| Chiang, CE | 1 |
| Shan, Q | 1 |
| Bourreau, J | 1 |
| Baykal, A | 1 |
| Kavuklu, B | 1 |
| Hascelik, G | 1 |
| Sayek, I | 1 |
| Lee, RP | 1 |
| Wang, D | 1 |
| Kao, SJ | 1 |
| Chen, HI | 1 |
| Piepot, HA | 1 |
| Groeneveld, AB | 1 |
| van Lambalgen, AA | 1 |
| Sipkema, P | 1 |
| Giusti-Paiva, A | 1 |
| De Castro, M | 1 |
| Sheehan, M | 1 |
| Wong, HR | 1 |
3 reviews available for pimagedine and Shock, Septic
| Article | Year |
|---|---|
Effects of endothelin and nitric oxide on organ injury, mesenteric ischemia, and survival in experimental models of septic shock.
Topics: Animals; Bacterial Translocation; Bosentan; Endothelin Receptor Antagonists; Endothelins; Guanidines | 2003 |
[Septic shock and NO].
Topics: Animals; Biomarkers; Guanidines; Guanylate Cyclase; Hemodynamics; Humans; Methylene Blue; Nitrates; | 2004 |
Selective inhibition of the activity of inducible nitric oxide synthase in septic shock.
Topics: Animals; Arginine; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Guanidines; Humans; | 1995 |
29 other studies available for pimagedine and Shock, Septic
| Article | Year |
|---|---|
Synthesis and biological evaluation of novel sinomenine derivatives as anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Proliferation; Cells, Cultured; Enzyme-Li | 2012 |
Organ-specific changes in vascular reactivity and roles of inducible nitric oxide synthase and endothelin-1 in a rabbit endotoxic shock model.
Topics: Acetylcholine; Animals; Celiac Artery; Disease Models, Animal; Endothelin A Receptor Antagonists; En | 2018 |
Effect of NO synthase inhibition on cardiovascular and pulmonary dysfunction in a porcine short-term model of endotoxic shock.
Topics: Animals; Blood Pressure; Cardiac Output; Cardiovascular System; Central Venous Pressure; Disease Mod | 2002 |
[Effect of dexamethasone, aminoguanidin, amrinone on oxygen utilization in endotoxin shock rabbits].
Topics: Amrinone; Animals; Anti-Inflammatory Agents; Dexamethasone; Enzyme Inhibitors; Female; Guanidines; M | 2003 |
A new therapeutic approach for the treatment of sepsis.
Topics: Endothelins; Endothelium; Guanidines; Humans; Nitric Oxide; Nitric Oxide Synthase; Shock, Septic | 2004 |
[Effects of aminoguanidine in different dosages on renal function in endotoxin induced rabbits shock model].
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanidines; Kidney Function Te | 2004 |
[Influence of electro-acupuncture of Neiguan on plasmic concentrations of NO and TNFalpha in endotoxin shock rats].
Topics: Acupuncture Points; Animals; Blood Pressure; Electroacupuncture; Female; Guanidines; Male; Nitric Ox | 2003 |
Hyperbaric oxygen protects against lipopolysaccharide-stimulated oxidative stress and mortality in rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanid | 2005 |
Participation of the inducible nitric oxide synthase on atrial natriuretic peptide plasma concentration during endotoxemic shock.
Topics: Animals; Atrial Natriuretic Factor; Enzyme Inhibitors; Guanidines; Lipopolysaccharides; Male; Nitric | 2007 |
Distribution of NOS isoforms in a porcine endotoxin shock model.
Topics: Animals; Cardiomyopathies; Coronary Circulation; Disease Models, Animal; Enzyme Activation; Enzyme I | 2008 |
Hyperbaric oxygenation reduces overexpression of c-Fos and oxidative stress in the brain stem of experimental endotoxemic rats.
Topics: Analysis of Variance; Animals; Brain Stem; Guanidines; Hydralazine; Hyperbaric Oxygenation; Hypotens | 2008 |
Role of nitric oxide during carrageenan-sensitized endotoxin shock in mice.
Topics: Animals; Arginine; Carrageenan; Dose-Response Relationship, Drug; Guanidines; Lipopolysaccharides; M | 1995 |
Nitric oxide synthase inhibition does not prevent cardiac depression in endotoxic shock.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cardiac Output, Low; Dexamethasone; Guanidines; Heart | 1995 |
Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Disease Models, Animal; Dose-Response | 1995 |
Expression and preferential inhibition of inducible nitric oxide synthase in aortas of endotoxemic rats.
Topics: Animals; Aorta, Thoracic; DNA, Complementary; Enzyme Induction; Guanidines; Lipopolysaccharides; Mal | 1995 |
Endotoxin-induced myocardial dysfunction: is there a role for nitric oxide?
Topics: Animals; Arginine; Enzyme Inhibitors; Guanidines; Guinea Pigs; Heart Atria; Immunoenzyme Techniques; | 1995 |
Role of nitric oxide in the circulatory failure and organ injury in a rodent model of gram-positive shock.
Topics: Acid-Base Equilibrium; Animals; Anti-Inflammatory Agents; Blotting, Western; Dexamethasone; Enzyme I | 1996 |
Peroxynitrite production by human neutrophils, monocytes and lymphocytes challenged with lipopolysaccharide.
Topics: Adult; Enzyme Inhibitors; Female; Guanidines; Humans; Lipopolysaccharides; Lymphocytes; Male; Middle | 1998 |
Nitric oxide-independent activation of soluble guanylyl cyclase contributes to endotoxin shock in rats.
Topics: Animals; Aorta; Blood Pressure; Charybdotoxin; Dexamethasone; Endothelium, Vascular; Enzyme Activati | 1998 |
Treatment of septic shock in rats with nitric oxide synthase inhibitors and inhaled nitric oxide.
Topics: Administration, Inhalation; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Ther | 1998 |
Cytokine-induced venodilatation in humans in vivo: eNOS masquerading as iNOS.
Topics: Adult; Arginine; Biopterins; Bradykinin; Endothelium, Vascular; Enzyme Inhibitors; Female; Gene Expr | 1999 |
Shortening of cardiac action potentials in endotoxic shock in guinea pigs is caused by an increase in nitric oxide activity and activation of the adenosine triphosphate-sensitive potassium channel.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Cyclic GMP; Enzyme Inhibitors; Glyburide; Guanid | 2000 |
Cardiac and vascular effects of nitric oxide synthase inhibition in lipopolysaccharide-treated rats.
Topics: Animals; Aorta; Calcium; Enzyme Inhibitors; Guanidines; Heart; In Vitro Techniques; Lipopolysacchari | 2000 |
Experimental study of the effect of nitric oxide inhibition on mesenteric blood flow and interleukin-10 levels with a lipopolysaccharide challenge.
Topics: Animals; Female; Guanidines; Interleukin-10; Lipopolysaccharides; Mesentery; Mice; Mice, Inbred Stra | 2000 |
The timing of endothelin and nitric oxide inhibition affects survival in a mice model of septic shock.
Topics: Animals; Antihypertensive Agents; Bosentan; Canavanine; Disease Models, Animal; Endothelin Receptor | 2001 |
The lung is the major site that produces nitric oxide to induce acute pulmonary oedema in endotoxin shock.
Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Body Weight; Dexamethasone; Enzyme Inhibitors; Es | 2001 |
The role of inducible nitric oxide synthase in lipopolysaccharide-mediated hyporeactivity to vasoconstrictors differs among isolated rat arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Analysis of Variance; Animals; A | 2002 |
Inducible nitric oxide synthase pathway in the central nervous system and vasopressin release during experimental septic shock.
Topics: Animals; Central Nervous System; Enzyme Inhibitors; Guanidines; Hemodynamics; Hypotension; Lipopolys | 2002 |
Yet another potential role for nitric oxide in the pathophysiology of septic shock.
Topics: Animals; Enzyme Inhibitors; Guanidines; Humans; Nitric Oxide; Nitric Oxide Synthase; Rats; Shock, Se | 2002 |