pentoxifylline has been researched along with Shock, Septic in 59 studies
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effect of pentoxifylline on organ dysfunction, survival, and mediator response in patients with severe sepsis." | 9.08 | Effect of pentoxifylline in severe sepsis: results of a randomized, double-blind, placebo-controlled study. ( Gehrke, K; Schröder, J; Staubach, KH; Stüber, F; Traumann, E; Zabel, P, 1998) |
| "The influence of pentoxifylline (PTX) on mortality and some important mediators was studied in a model of cecal perforation with fulminant intra-abdominal sepsis in rats." | 7.69 | Pentoxifylline improves survival and reduces tumor necrosis factor, interleukin-6, and endothelin-1 in fulminant intra-abdominal sepsis in rats. ( Ekstrøm, P; Giercksky, KE; Lundblad, R, 1995) |
| "To determine the effects of pretreatment and posttreatment with pentoxifylline in a porcine model of gram-negative sepsis." | 7.69 | Beneficial cardiopulmonary effects of pentoxifylline in experimental sepsis are lost once septic shock is established. ( Blocher, CR; Fisher, BJ; Fowler, AA; Kennedy, E; Ridings, PC; Sholley, MM; Sugerman, HJ; Windsor, AC, 1994) |
| "Pentoxifylline (POF) was found to possess high protecting potential in murine endotoxin shock." | 7.68 | Pentoxifylline increases survival in murine endotoxin shock and decreases formation of tumor necrosis factor. ( Schade, UF, 1990) |
| "Pentoxifylline (PTX) is a derivative of methyl xanthine and has several beneficial effects in sepsis." | 5.31 | The effects of pentoxifylline on bacterial translocation after intestinal obstruction. ( Gokce, O; Gulay, Z; Kocdor, H; Kocdor, MA, 2002) |
| "Since fungal septic shock with acute disseminated candidiasis evolves prior to significant increases in circulating TNF, PTX also appears ineffective in its treatment." | 5.29 | Effects of pentoxifylline on tumor necrosis factor production and survival during lethal E. coli sepsis vs. disseminated candidiasis with fungal septic shock. ( Lechner, AJ; Matuschak, GM; Potthoff, LH; Rouben, LR; Tredway, TL, 1993) |
| "Isolated limb perfusion (ILP) with recombinant human tumor necrosis factor-alpha (rhTNF-alpha) and melphalan harbors the risk of septic shock-like syndrome." | 5.10 | Pentoxifyllin attenuates the systemic inflammatory response induced during isolated limb perfusion with recombinant human tumor necrosis factor-alpha and melphalan. ( Hohenberger, P; Kettelhack, C; Latz, E; Rezaei, AH; Schlag, PM; Schumann, R, 2003) |
| "To evaluate the effect of pentoxifylline on organ dysfunction, survival, and mediator response in patients with severe sepsis." | 5.08 | Effect of pentoxifylline in severe sepsis: results of a randomized, double-blind, placebo-controlled study. ( Gehrke, K; Schröder, J; Staubach, KH; Stüber, F; Traumann, E; Zabel, P, 1998) |
| "The influence of pentoxifylline (PTX) on mortality and some important mediators was studied in a model of cecal perforation with fulminant intra-abdominal sepsis in rats." | 3.69 | Pentoxifylline improves survival and reduces tumor necrosis factor, interleukin-6, and endothelin-1 in fulminant intra-abdominal sepsis in rats. ( Ekstrøm, P; Giercksky, KE; Lundblad, R, 1995) |
| "To determine the effects of pretreatment and posttreatment with pentoxifylline in a porcine model of gram-negative sepsis." | 3.69 | Beneficial cardiopulmonary effects of pentoxifylline in experimental sepsis are lost once septic shock is established. ( Blocher, CR; Fisher, BJ; Fowler, AA; Kennedy, E; Ridings, PC; Sholley, MM; Sugerman, HJ; Windsor, AC, 1994) |
| "The inhibitory effect of chlorpromazine (CPZ), pentoxifylline (PTX) and dexamethasone (DEX) was investigated in a model of endotoxin shock in Holstein calves following an intravenous administration of Esherichia coli endotoxin (LPS)." | 3.69 | Inhibitory effect on LPS-induced tumor necrosis factor in calves treated with chlorpromazine or pentoxifylline. ( Higuchi, T; Matsuzawa, H; Ohtsuka, H; Sato, H; Takahashi, J; Takahashi, K; Yoshino, TO, 1997) |
| "In an intensive care setting we studied the effects of pentoxifylline on hemodynamics, gas-exchange and platelet sequestration in multiple organs in three groups of sheep exposed to endotoxin shock (n = 7 in each)." | 3.68 | Effects of pentoxifylline on hemodynamics, gas exchange and multiple organ platelet sequestration in experimental endotoxic shock. ( Sigurdsson, GH; Youssef, H, 1993) |
| "To assess the role of tumor necrosis factor (TNF) in the appearance of soluble TNF receptors (sTNFRs), 20 consecutive patients with a clinical diagnosis of sepsis were studied as were 7 chimpanzees after administration of endotoxin (4 ng/kg) with or without pentoxifylline." | 3.68 | Release of soluble receptors for tumor necrosis factor in clinical sepsis and experimental endotoxemia. ( Gallati, H; Jansen, J; Levi, M; ten Cate, H; ten Cate, JW; van der Poll, T; van Deventer, SJ; van Leenen, D; von der Möhlen, M, 1993) |
| "Pentoxifylline (POF) was found to possess high protecting potential in murine endotoxin shock." | 3.68 | Pentoxifylline increases survival in murine endotoxin shock and decreases formation of tumor necrosis factor. ( Schade, UF, 1990) |
| "In pentoxifylline-treated patients, at 24 hrs, serum concentrations of TNF were significantly lower compared with controls (12 +/- 2 vs." | 2.68 | Effects of pentoxifylline on circulating cytokine concentrations and hemodynamics in patients with septic shock: results from a double-blind, randomized, placebo-controlled study. ( Bertrand, JC; Bertrand, M; Gay, JP; Gery, P; Page, D; Page, Y; Pain, P; Vermesch, R; Vindimian, M; Zeni, F, 1996) |
| "PTX does influence TNF levels in septic shock patients." | 2.68 | Influence of pentoxifylline on cytokine levels and inflammatory parameters in septic shock. ( Frass, M; Graninger, W; Klappacher, G; Knapp, S; Kordova, H; Laczika, K; Locker, GJ; Presterl, E; Staudinger, T; Stoiser, B; Tesinsky, P; Wagner, A, 1996) |
| " The reasons for these mixed results include differences in models, drug dosages, dosing methods and intervals and timing of administration relative to disease duration and severity." | 2.41 | Novel agents in the therapy of endotoxic shock. ( Howe, LM, 2000) |
| "Therefore, therapeutic strategies in septic shock may benefit from antagonism or inhibition of these mediators." | 2.38 | [Therapeutic strategies against mediators of septic shock]. ( Schade, FU; Zabel, P, 1993) |
| "Pentoxifylline (Trental) is a well-known vasoactive drug with proven clinical efficacy in various circulatory disorders." | 2.38 | The effect of pentoxifylline in septic shock--new pharmacologic aspects of an established drug. ( Schade, UF; Schönharting, MM, 1989) |
| "The problem of sepsis and septic shock (SSH) is known to be very actual due to peak-shaped growth of the number of such patients and unsatisfactory results of treatment." | 1.32 | [Septic shock]. ( Bagnenko, SF; Grinev, MV; Gromov, MI; Kulibaba, DM, 2004) |
| "Pentoxifylline (PTX) is a derivative of methyl xanthine and has several beneficial effects in sepsis." | 1.31 | The effects of pentoxifylline on bacterial translocation after intestinal obstruction. ( Gokce, O; Gulay, Z; Kocdor, H; Kocdor, MA, 2002) |
| "Pentoxifylline is a phosphodiesterase inhibitor, known to suppress tumour necrosis factor-alpha production and improve cardiopulmonary parameters and survival in animal models of sepsis." | 1.31 | Pentoxifylline fails to improve organ dysfunction and survival when used in the resuscitation of a porcine model of haemorrhage and abdominal sepsis. ( Brown, D; Kenward, CE; Parker, SJ; Watkins, PE, 2000) |
| "Therefore, IL-9 may be protective in septic shock via a rather unique mechanism involving a complex modulation of inflammatory and anti-inflammatory mediators." | 1.31 | IL-9 protects mice from Gram-negative bacterial shock: suppression of TNF-alpha, IL-12, and IFN-gamma, and induction of IL-10. ( Campanile, F; Fioretti, MC; Giampietri, A; Grohmann, U; Puccetti, P; Renauld, JC; Silla, S; Vacca, C; Van Snick, J, 2000) |
| "Treatment with pentoxifylline significantly decreased plasma biopterin and TNF levels at 2 to 8 hours after endotoxin challenge (P < 0." | 1.31 | [The effect of pentoxifylline on endotoxin-induced biopterin formation in rabbits]. ( Chang, G; Dong, N; Peng, Z; Sheng, Z; Yao, Y; Yu, Y, 2000) |
| "Mortality caused by septic shock in experimental animals is reduced by thalidomide, an inhibitor of tumour necrosis factor alpha." | 1.30 | Protective effect of pentoxifylline plus thalidomide against septic shock in mice. ( Arrieta, O; Calvillo, M; Ortiz-Reyes, A; Rembao, D; Rivera, E; Sotelo, J, 1999) |
| "Since fungal septic shock with acute disseminated candidiasis evolves prior to significant increases in circulating TNF, PTX also appears ineffective in its treatment." | 1.29 | Effects of pentoxifylline on tumor necrosis factor production and survival during lethal E. coli sepsis vs. disseminated candidiasis with fungal septic shock. ( Lechner, AJ; Matuschak, GM; Potthoff, LH; Rouben, LR; Tredway, TL, 1993) |
| "On the 7 samples of the 3 patients with septic shock no TNF alpha production has been detected." | 1.28 | Study of pentoxifylline induced modulation of TNF alpha and interleukin-6 secretion in healthy and septic patients by the use of an ex-vivo model on whole blood. ( Barbier, M; Barbier, Y; Bienvenu, J; Coulon, L; Doche, C; Guenounou, M; Lepape, A, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (6.78) | 18.7374 |
| 1990's | 44 (74.58) | 18.2507 |
| 2000's | 11 (18.64) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wyska, E | 1 |
| Bansal, S | 1 |
| Wang, W | 1 |
| Falk, S | 1 |
| Schrier, R | 1 |
| Kocdor, MA | 1 |
| Kocdor, H | 1 |
| Gulay, Z | 1 |
| Gokce, O | 1 |
| Cornélie, S | 1 |
| Wiel, E | 1 |
| Lund, N | 1 |
| Lebuffe, G | 1 |
| Vendeville, C | 1 |
| Riveau, G | 1 |
| Vallet, B | 1 |
| Ban, E | 1 |
| Hohenberger, P | 1 |
| Latz, E | 1 |
| Kettelhack, C | 1 |
| Rezaei, AH | 1 |
| Schumann, R | 1 |
| Schlag, PM | 1 |
| Schröder, J | 2 |
| Staubach, KH | 2 |
| Stüber, F | 2 |
| Zabel, P | 3 |
| Grinev, MV | 1 |
| Bagnenko, SF | 1 |
| Kulibaba, DM | 1 |
| Gromov, MI | 1 |
| Alexandre-Moreira, MS | 1 |
| Takiya, CM | 1 |
| de Arruda, LB | 1 |
| Pascarelli, B | 1 |
| Gomes, RN | 1 |
| Castro Faria Neto, HC | 1 |
| Lima, LM | 1 |
| Barreiro, EJ | 1 |
| Sugiura, Y | 1 |
| Kato, T | 1 |
| Goto, Y | 1 |
| Yamamoto, K | 1 |
| Aochi, O | 1 |
| Badger, AM | 1 |
| Olivera, DL | 1 |
| Esser, KM | 1 |
| Bursten, S | 3 |
| Weeks, R | 1 |
| West, J | 1 |
| Le, T | 1 |
| Wilson, T | 1 |
| Porubek, D | 1 |
| Bianco, JA | 2 |
| Singer, JW | 2 |
| Rice, GC | 2 |
| Zhang, H | 1 |
| Spapen, H | 1 |
| Benlabed, M | 1 |
| Nguyen, DN | 1 |
| Buurman, WA | 2 |
| Vincent, JL | 1 |
| Lerner, MR | 1 |
| Balla, AK | 1 |
| Wilson, MF | 1 |
| Brackett, DJ | 1 |
| Lundblad, R | 1 |
| Ekstrøm, P | 1 |
| Giercksky, KE | 1 |
| Netea, MG | 1 |
| Blok, WL | 1 |
| Kullberg, BJ | 1 |
| Bemelmans, M | 1 |
| Vogels, MT | 1 |
| van der Meer, JW | 1 |
| Matuschak, GM | 2 |
| Lamprech, KE | 1 |
| Lechner, AJ | 2 |
| Ridings, PC | 1 |
| Windsor, AC | 1 |
| Sugerman, HJ | 1 |
| Kennedy, E | 1 |
| Sholley, MM | 1 |
| Blocher, CR | 1 |
| Fisher, BJ | 1 |
| Fowler, AA | 1 |
| Brown, PA | 1 |
| Nelson, RJ | 1 |
| Sigurdsson, GH | 1 |
| Youssef, H | 1 |
| Schade, FU | 1 |
| van Leenen, D | 2 |
| van der Poll, T | 2 |
| Levi, M | 2 |
| ten Cate, H | 2 |
| van Deventer, SJ | 2 |
| Hack, CE | 1 |
| Aarden, LA | 1 |
| ten Cate, JW | 2 |
| Jansen, J | 1 |
| von der Möhlen, M | 1 |
| Gallati, H | 1 |
| Rouben, LR | 1 |
| Potthoff, LH | 1 |
| Tredway, TL | 1 |
| Hoffmann, H | 1 |
| Weis, M | 1 |
| Frank, G | 1 |
| Birg, A | 1 |
| Schönharting, MM | 2 |
| Jochum, M | 1 |
| Zeni, F | 1 |
| Pain, P | 1 |
| Vindimian, M | 1 |
| Gay, JP | 1 |
| Gery, P | 1 |
| Bertrand, M | 1 |
| Page, Y | 1 |
| Page, D | 1 |
| Vermesch, R | 1 |
| Bertrand, JC | 1 |
| Campanile, F | 2 |
| Giampietri, A | 2 |
| Grohmann, U | 2 |
| Belladonna, ML | 1 |
| Fioretti, MC | 2 |
| Puccetti, P | 2 |
| Staudinger, T | 1 |
| Presterl, E | 1 |
| Graninger, W | 1 |
| Locker, GJ | 1 |
| Knapp, S | 1 |
| Laczika, K | 1 |
| Klappacher, G | 1 |
| Stoiser, B | 1 |
| Wagner, A | 1 |
| Tesinsky, P | 1 |
| Kordova, H | 1 |
| Frass, M | 1 |
| Castanón-González, JA | 1 |
| Eid-Lidt, G | 1 |
| Wacher, N | 1 |
| Gallegos-Pérez, H | 1 |
| Miranda-Ruíz, R | 1 |
| Hasegawa, N | 1 |
| Oka, Y | 1 |
| Nakayama, M | 1 |
| Berry, GJ | 1 |
| Rice, G | 1 |
| Raffin, TA | 1 |
| Ohtsuka, H | 1 |
| Higuchi, T | 1 |
| Matsuzawa, H | 1 |
| Sato, H | 1 |
| Takahashi, K | 1 |
| Takahashi, J | 1 |
| Yoshino, TO | 1 |
| Ladny, JR | 1 |
| Dzienis, H | 1 |
| Dadan, J | 1 |
| Polaków, J | 1 |
| Venskutonis, D | 1 |
| Puchalski, Z | 1 |
| Gehrke, K | 1 |
| Traumann, E | 1 |
| Howe, LM | 2 |
| Quezado, ZM | 1 |
| Hoffman, WD | 1 |
| Banks, SM | 1 |
| Danner, RL | 1 |
| Eichacker, PQ | 1 |
| Susla, GM | 1 |
| Natanson, C | 1 |
| Arrieta, O | 1 |
| Ortiz-Reyes, A | 1 |
| Rembao, D | 1 |
| Calvillo, M | 1 |
| Rivera, E | 1 |
| Sotelo, J | 1 |
| Krakauer, T | 1 |
| Stiles, BG | 1 |
| Parker, SJ | 1 |
| Brown, D | 1 |
| Kenward, CE | 1 |
| Watkins, PE | 1 |
| Van Snick, J | 1 |
| Silla, S | 1 |
| Vacca, C | 1 |
| Renauld, JC | 1 |
| Yao, Y | 1 |
| Yu, Y | 1 |
| Peng, Z | 1 |
| Dong, N | 1 |
| Chang, G | 1 |
| Sheng, Z | 1 |
| Bienvenu, J | 1 |
| Coulon, L | 1 |
| Barbier, Y | 1 |
| Barbier, M | 1 |
| Doche, C | 1 |
| Lepape, A | 1 |
| Guenounou, M | 1 |
| Martich, GD | 1 |
| Parker, MM | 1 |
| Cunnion, RE | 1 |
| Suffredini, AF | 1 |
| Law, WR | 1 |
| Nadkarni, VM | 2 |
| Fletcher, MA | 2 |
| Nevola, JJ | 1 |
| Eckstein, JM | 1 |
| Quance, J | 1 |
| McKenna, TM | 2 |
| Lee, CH | 1 |
| Williams, TJ | 1 |
| Tuckey, JA | 1 |
| Parry, BR | 1 |
| McCall, JL | 1 |
| Owens, EH | 1 |
| Masouyé, P | 1 |
| Gunning, K | 1 |
| Pittet, JF | 1 |
| Suter, PM | 1 |
| Morel, DR | 1 |
| Giroir, BP | 1 |
| Beutler, B | 1 |
| Baumgartner, JD | 1 |
| Eggimann, P | 1 |
| Glauser, MP | 1 |
| Youn, YK | 1 |
| LaLonde, C | 1 |
| Demling, R | 1 |
| Sable, CA | 1 |
| Wispelwey, B | 1 |
| Chung, TW | 1 |
| O'Rear, EA | 2 |
| Whitsett, TL | 2 |
| Hinshaw, LB | 2 |
| Smith, MA | 1 |
| Ambrus, JL | 1 |
| Halpern, J | 1 |
| Mahafzah, M | 1 |
| Sayyid, S | 1 |
| Sarma, PS | 1 |
| Waxman, K | 1 |
| Schade, UF | 3 |
| Heath, MF | 1 |
| Tighe, D | 1 |
| Moss, R | 1 |
| Bennett, ED | 1 |
| von der Bosch, J | 1 |
| Schönharting, M | 1 |
| Puranapanda, V | 1 |
| Chang, AC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pentoxifylline Dose Optimization in Preterm Neonatal Late Onset Sepsis[NCT04152980] | Phase 3 | 40 participants (Anticipated) | Interventional | 2020-01-12 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for pentoxifylline and Shock, Septic
| Article | Year |
|---|---|
[Therapeutic strategies against mediators of septic shock].
Topics: Animals; Humans; Immunologic Techniques; Interleukin-1; Interleukin-6; Leukocyte Count; Mice; Pentox | 1993 |
Treatment of endotoxic shock: glucocorticoids, lazaroids, nonsteroidals, others.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Glucocorticoids; Nitric Oxide Syntha | 1998 |
Novel agents in the therapy of endotoxic shock.
Topics: Animals; Enzyme Inhibitors; Humans; Nitric Oxide Synthase; Pentoxifylline; Shock, Septic | 2000 |
Methylxanthines in surgery: a bright future?
Topics: Humans; Neoplasms; Pentoxifylline; Respiratory Distress Syndrome; Shock, Septic; Surgical Procedures | 1992 |
Management of septic shock: new approaches.
Topics: Animals; Antibodies, Monoclonal; Escherichia coli; Glucocorticoids; Humans; Immunization, Passive; I | 1992 |
Use of antioxidant therapy in shock and trauma.
Topics: Antioxidants; Dobutamine; Pentoxifylline; Pregnatrienes; Shock, Septic; Shock, Traumatic | 1991 |
Pharmacologic interventions aimed at preventing the biologic effects of endotoxin.
Topics: Animals; Cyclooxygenase Inhibitors; Endotoxins; Gram-Negative Bacteria; Gram-Negative Bacterial Infe | 1991 |
The effect of pentoxifylline in septic shock--new pharmacologic aspects of an established drug.
Topics: Animals; Disease Models, Animal; Mice; Pentoxifylline; Shock, Septic; Theobromine | 1989 |
7 trials available for pentoxifylline and Shock, Septic
| Article | Year |
|---|---|
Pentoxifyllin attenuates the systemic inflammatory response induced during isolated limb perfusion with recombinant human tumor necrosis factor-alpha and melphalan.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Chemothera | 2003 |
[Pentoxifylline as adjuvant therapy of multiple organ failure].
Topics: Combined Modality Therapy; Critical Care; Humans; Infusions, Intravenous; Multiple Organ Failure; Pe | 1998 |
Effects of pentoxifylline on circulating cytokine concentrations and hemodynamics in patients with septic shock: results from a double-blind, randomized, placebo-controlled study.
Topics: Adult; Aged; Aged, 80 and over; Cytokines; Double-Blind Method; Female; Hemodynamics; Humans; Infusi | 1996 |
Influence of pentoxifylline on cytokine levels and inflammatory parameters in septic shock.
Topics: Acute-Phase Proteins; Adult; Aged; APACHE; Cytokines; Female; Hemodynamics; Humans; Inflammation; Ma | 1996 |
Effect of pentoxifylline in severe sepsis: results of a randomized, double-blind, placebo-controlled study.
Topics: APACHE; Double-Blind Method; Female; Humans; Male; Middle Aged; Multiple Organ Failure; Pentoxifylli | 1998 |
Effects of ibuprofen and pentoxifylline on the cardiovascular response of normal humans to endotoxin.
Topics: Adult; Cardiovascular Physiological Phenomena; Cardiovascular System; Endotoxins; Female; Hemodynami | 1992 |
Pentoxifylline in septic shock.
Topics: Adult; Female; Humans; Male; Middle Aged; Pentoxifylline; Prospective Studies; Respiratory Distress | 1990 |
44 other studies available for pentoxifylline and Shock, Septic
| Article | Year |
|---|---|
Pretreatment with R(+)-verapamil significantly reduces mortality and cytokine expression in murine model of septic shock.
Topics: Animals; Anti-Inflammatory Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytokine | 2009 |
Combination therapy with albumin and pentoxifylline protects against acute kidney injury during endotoxemic shock in mice.
Topics: Acute Kidney Injury; Albumins; Animals; Disease Models, Animal; Drug Therapy, Combination; Male; Mic | 2009 |
The effects of pentoxifylline on bacterial translocation after intestinal obstruction.
Topics: Analysis of Variance; Animals; Bacterial Infections; Bacterial Translocation; Chi-Square Distributio | 2002 |
Cytosine-phosphate-guanine (CpG) motifs are sensitizing agents for lipopolysaccharide in toxic shock model.
Topics: Animals; Base Sequence; CpG Islands; DNA Primers; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mo | 2002 |
[Septic shock].
Topics: Abdominal Injuries; Adjuvants, Immunologic; Anti-Bacterial Agents; Blood Transfusion; Enzyme Inhibit | 2004 |
LASSBio-468: a new achiral thalidomide analogue which modulates TNF-alpha and NO production and inhibits endotoxic shock and arthritis in an animal model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Gene Expression; Indoles; Isoindoles; Li | 2005 |
[Experimental study on the effect of pentoxifylline on blood rheology and microcirculation--a study using an endotoxin shock model].
Topics: Animals; Blood Flow Velocity; Blood Viscosity; Disease Models, Animal; Microcirculation; Pentoxifyll | 1983 |
Beneficial effects of the phosphodiesterase inhibitors BRL 61063, pentoxifylline, and rolipram in a murine model of endotoxin shock.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, | 1994 |
Potential role for phosphatidic acid in mediating the inflammatory responses to TNF alpha and IL-1 beta.
Topics: Animals; Base Sequence; Chromatography, High Pressure Liquid; Diglycerides; Female; Inflammation; In | 1994 |
Pentoxifylline improves the tissue oxygen extraction capabilities during endotoxic shock.
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiac Output; Cardiac Tamponade; Dogs; Endotoxins; | 1994 |
Pentoxifylline interferes with potential sources of free radical generation during endotoxemia.
Topics: Animals; Blood Glucose; Cardiac Output; Endotoxins; Free Radicals; Heart Rate; Hemodynamics; Hemorrh | 1994 |
Pentoxifylline improves survival and reduces tumor necrosis factor, interleukin-6, and endothelin-1 in fulminant intra-abdominal sepsis in rats.
Topics: Abdomen; Animals; Cecal Diseases; Disease Models, Animal; Endothelins; Endotoxins; Interleukin-6; In | 1995 |
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice.
Topics: Animals; Candidiasis; Chlorpromazine; Female; Interleukin-1; Kidney; Klebsiella Infections; Klebsiel | 1995 |
Pentoxifylline inhibits tumor necrosis factor production in septic shock.
Topics: Animals; Pentoxifylline; Rats; Shock, Septic; Tumor Necrosis Factor-alpha | 1994 |
Beneficial cardiopulmonary effects of pentoxifylline in experimental sepsis are lost once septic shock is established.
Topics: Animals; Blood Gas Analysis; Bronchoalveolar Lavage Fluid; Cardiovascular System; Immunophenotyping; | 1994 |
Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid.
Topics: Acyltransferases; Animals; Female; Lysophospholipids; Membrane Lipids; Mice; Mice, Inbred BALB C; Pe | 1994 |
Effects of pentoxifylline on hemodynamics, gas exchange and multiple organ platelet sequestration in experimental endotoxic shock.
Topics: Animals; Blood Circulation; Blood Platelets; Blood Pressure; Cardiac Output; Endotoxins; Escherichia | 1993 |
Pentoxifylline attenuates neutrophil activation in experimental endotoxemia in chimpanzees.
Topics: Animals; Cell Degranulation; Complement Activation; Cytokines; Endotoxins; Escherichia coli; Leukocy | 1993 |
Release of soluble receptors for tumor necrosis factor in clinical sepsis and experimental endotoxemia.
Topics: Adult; Aged; Analysis of Variance; Animals; Endotoxins; Escherichia coli; Female; Humans; Kinetics; | 1993 |
Effects of pentoxifylline on tumor necrosis factor production and survival during lethal E. coli sepsis vs. disseminated candidiasis with fungal septic shock.
Topics: Animals; Bacteremia; Candidiasis; Escherichia coli Infections; Fungemia; Gene Expression; Male; Pent | 1993 |
Amelioration of endotoxin-induced acute lung injury in pigs by HWA 138 and A 80 2715: new analogs of pentoxifylline.
Topics: Animals; Bronchodilator Agents; Hemodynamics; Infusions, Intravenous; Leukocyte Count; Leukopenia; L | 1995 |
Evidence for tumor necrosis factor alpha as a mediator of the toxicity of a cyclooxygenase inhibitor in Gram-negative sepsis.
Topics: Animals; Cyclooxygenase Inhibitors; Female; Gene Amplification; Gene Expression; Indomethacin; Male; | 1996 |
Effects of pentoxifylline in patients with septic shock.
Topics: Humans; Middle Aged; Oxygen Consumption; Pentoxifylline; Shock, Septic | 1997 |
The effects of post-treatment with lisofylline, a phosphatidic acid generation inhibitor, on sepsis-induced acute lung injury in pigs.
Topics: Adjuvants, Immunologic; Animals; Disease Models, Animal; Female; Hemodynamics; Lung; Male; Pentoxify | 1997 |
Inhibitory effect on LPS-induced tumor necrosis factor in calves treated with chlorpromazine or pentoxifylline.
Topics: Animals; Cattle; Chlorpromazine; Dexamethasone; Endotoxins; Escherichia coli Infections; Female; Lip | 1997 |
[The effect of some drugs on the levels of selected cytokines in experimental septic shock].
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dexamethasone; Disease Models, Animal; Ibuprofen; Live | 1997 |
Increasing doses of pentoxifylline as a continuous infusion in canine septic shock.
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Body Temperature; Disease Models, Animal; Dogs | 1999 |
Protective effect of pentoxifylline plus thalidomide against septic shock in mice.
Topics: Animals; Drug Therapy, Combination; Immunosuppressive Agents; Kidney; Liver; Male; Mice; Mice, Inbre | 1999 |
Pentoxifylline inhibits superantigen-induced toxic shock and cytokine release.
Topics: Animals; Bacterial Toxins; Cytokines; Depression, Chemical; Enterotoxins; Humans; Leukocytes, Mononu | 1999 |
Pentoxifylline fails to improve organ dysfunction and survival when used in the resuscitation of a porcine model of haemorrhage and abdominal sepsis.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hemodynamics; Hemorrhage; | 2000 |
IL-9 protects mice from Gram-negative bacterial shock: suppression of TNF-alpha, IL-12, and IFN-gamma, and induction of IL-10.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Monoclonal; Drug Therapy, Combination; Female; Inflamma | 2000 |
[The effect of pentoxifylline on endotoxin-induced biopterin formation in rabbits].
Topics: Animals; Biopterins; Enzyme Inhibitors; GTP Cyclohydrolase; Male; Pentoxifylline; Rabbits; Shock, Se | 2000 |
Study of pentoxifylline induced modulation of TNF alpha and interleukin-6 secretion in healthy and septic patients by the use of an ex-vivo model on whole blood.
Topics: Blood; Depression, Chemical; Humans; Interleukin-6; Leukocytes, Mononuclear; Pentoxifylline; Sepsis; | 1992 |
Pentoxifylline treatment of sepsis in conscious Yucatan minipigs.
Topics: Animals; Creatine; Disease Models, Animal; Escherichia coli; Hemodynamics; Oxygen; Pentoxifylline; S | 1992 |
Effects of in vivo pentoxifylline treatment on survival and ex vivo vascular contractility in a rat lipopolysaccharide shock model.
Topics: Animals; In Vitro Techniques; Lipopolysaccharides; Male; Pentoxifylline; Rats; Rats, Inbred Strains; | 1992 |
Xanthine derivative HWA 138 attenuates hemodynamic and oxygen uptake dysfunction secondary to severe endotoxin shock in sheep.
Topics: Animals; Disease Models, Animal; Endotoxins; Escherichia coli; Female; Half-Life; Hemodynamics; Male | 1992 |
Effect of amrinone on tumor necrosis factor production in endotoxic shock.
Topics: Amrinone; Animals; Cell Line; Chloramphenicol O-Acetyltransferase; Chromatography; Dexamethasone; Di | 1992 |
Survival factors in a canine septic shock model.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Erythrocyte Deformability; Escherichia coli I | 1991 |
Platelet aggregation in septic shock. Effect of pentoxifylline.
Topics: Adult; Aged; Humans; Middle Aged; Pentoxifylline; Platelet Aggregation; Reference Values; Respirator | 1990 |
Pentoxifylline in septic shock.
Topics: Animals; Pentoxifylline; Shock, Septic; Swine; Theobromine | 1990 |
Pentoxifylline increases survival in murine endotoxin shock and decreases formation of tumor necrosis factor.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Galactosamine; Kinetics; Lipopolysacchari | 1990 |
Relevance of serum phospholipase A2 assays to the assessment of septic shock.
Topics: Animals; Models, Biological; Pentoxifylline; Peritonitis; Phospholipases; Phospholipases A; Phosphol | 1990 |
Pentoxifylline increases survival of mice in endotoxic shock.
Topics: Animals; Epoprostenol; Female; Indomethacin; Leukopenia; Lipopolysaccharides; Mice; Pentoxifylline; | 1989 |
Erythrocyte deformability in canine septic shock and the efficacy of pentoxifylline and a leukotriene antagonist.
Topics: Acetophenones; Animals; Azoles; Dogs; Erythrocyte Deformability; Escherichia coli Infections; Female | 1987 |