Ubiquitin carboxyl-terminal hydrolase 5

A ubiquitin carboxyl-terminal hydrolase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P45974]

EC 3.4.19.12;
Deubiquitinating enzyme 5;
Isopeptidase T;
Ubiquitin thioesterase 5;
Ubiquitin-specific-processing protease 5

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
degrasyn	Homo sapiens (human)	IC50	3.0000	1	1
vialinin a	Homo sapiens (human)	IC50	5.9000	1	1
vialinin a	Homo sapiens (human)	Ki	8.2500	2	2

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
benzoylpropionic acid	Homo sapiens (human)	Kd	680.0000	1	1

This protein enables 6 target(s):

Target	Category	Definition
cysteine-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
cysteine-type deubiquitinase activity	molecular function	An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:jh2, PMID:30783221]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
ubiquitin binding	molecular function	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. [GOC:ecd]
deubiquitinase activity	molecular function	An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:mec, PMID:30783221]

This protein is located in 2 target(s):

Target	Category	Definition
lysosome	cellular component	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is active in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 6 target(s):

Target	Category	Definition
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
protein ubiquitination	biological process	The process in which one or more ubiquitin groups are added to a protein. [GOC:ai]
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	biological process	Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:mah]
protein K48-linked deubiquitination	biological process	A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. [GOC:mah]
negative regulation of ubiquitin-dependent protein catabolic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process. [GOC:BHF]
protein deubiquitination	biological process	The removal of one or more ubiquitin groups from a protein. [GOC:ai]