verapamil has been researched along with Shock, Septic in 11 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Septic shock has a high mortality rate due to the hypotension and circulatory disorder that occurs during its pathogenesis." | 1.33 | Effects of verapamil and nifedipine on different parameters in lipopolysaccharide-induced septic shock. ( Erol, K; Kilic, FS; Sirmagul, B; Tunc, O; Yildirim, E, 2006) |
| "Treatment with verapamil (30 microM) markedly inhibited endotoxin (1 microg/ml)-induced TNFalpha production in these cells." | 1.31 | Preventive effects of a verapamil against tumor necrosis factor-alpha-induced shock symptoms: approached from lipoprotein metabolic disorders. ( Furusawa, S; Iizuka, Y; Sakaguchi, S; Satoh, S; Takayanagi, M, 2002) |
| "Pretreatment with indomethacin (5 mg/kg iv." | 1.27 | [The effects of indomethacin and verapamil on dextran-induced shock in rats]. ( Ishizaki, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (54.55) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wyska, E | 1 |
| Sakaguchi, S | 1 |
| Iizuka, Y | 1 |
| Furusawa, S | 1 |
| Takayanagi, M | 1 |
| Satoh, S | 1 |
| Zhao, KS | 1 |
| Jin, C | 1 |
| Huang, X | 1 |
| Liu, J | 1 |
| Yan, WS | 1 |
| Huang, Q | 1 |
| Kan, W | 1 |
| Sirmagul, B | 1 |
| Kilic, FS | 1 |
| Tunc, O | 1 |
| Yildirim, E | 1 |
| Erol, K | 1 |
| Bowles, HF | 1 |
| Thangathurai, D | 1 |
| Morgan, GE | 1 |
| Mikhail, M | 1 |
| Ishizaki, M | 1 |
| Lee, HC | 1 |
| Lum, BK | 1 |
| Liu, MS | 1 |
| Ghosh, S | 1 |
| Shenkman, BZ | 1 |
| Bosson, S | 1 |
| Kuenzig, M | 1 |
| Schwartz, SI | 1 |
| Mayer, U | 1 |
| Buhl, N | 1 |
| Sachs, H | 1 |
| Sigel, H | 1 |
11 other studies available for verapamil and Shock, Septic
| Article | Year |
|---|---|
Pretreatment with R(+)-verapamil significantly reduces mortality and cytokine expression in murine model of septic shock.
Topics: Animals; Anti-Inflammatory Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytokine | 2009 |
Preventive effects of a verapamil against tumor necrosis factor-alpha-induced shock symptoms: approached from lipoprotein metabolic disorders.
Topics: Animals; Cell Line; Hyperlipoproteinemias; Lipoprotein Lipase; Lipoproteins; Male; Mice; Shock, Sept | 2002 |
The mechanism of Polydatin in shock treatment.
Topics: Animals; Calcium Channel Blockers; Calcium Signaling; Cell Adhesion; Cells, Cultured; Drug Evaluatio | 2003 |
Effects of verapamil and nifedipine on different parameters in lipopolysaccharide-induced septic shock.
Topics: Animals; Calcium Channel Blockers; Carotid Arteries; Catalase; Disease Models, Animal; Interleukin-1 | 2006 |
Management of supraventricular tachycardia in septic patients.
Topics: Drug Therapy, Combination; Humans; Phenylephrine; Shock, Septic; Tachycardia, Supraventricular; Vera | 1990 |
[The effects of indomethacin and verapamil on dextran-induced shock in rats].
Topics: Animals; Dextrans; Indomethacin; Male; Rats; Rats, Inbred Strains; Shock, Septic; Verapamil | 1985 |
Protective action of calcium entry blockers in endotoxin shock.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Escherichia coli; Heart Rate; Male; Nifedipine; N | 1986 |
Myocardial sodium pump activity in endotoxin shock.
Topics: Animals; Calcium; Dogs; Female; Male; Myocardium; Ouabain; Phosphorylation; Rubidium; Shock, Septic; | 1986 |
[Effect of verapamil, cromoglycate and dimedrol on the survivability of mice in endotoxic shock].
Topics: Animals; Cromolyn Sodium; Diphenhydramine; Dose-Response Relationship, Drug; Drug Evaluation, Precli | 1987 |
Verapamil improves cardiac function and increases survival in canine E. coli endotoxin shock.
Topics: Acid Phosphatase; Animals; Blood Glucose; Blood Pressure; Calcium; Dogs; Escherichia coli; Heart; He | 1985 |
[Fatal poisoning by the retard form of verapamil. Therapeutic considerations].
Topics: Coma; Delayed-Action Preparations; Female; Humans; Intestinal Absorption; Intestine, Small; Middle A | 1985 |