suramin has been researched along with Shock, Septic in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sakaki, H | 1 |
| Tsukimoto, M | 1 |
| Harada, H | 1 |
| Moriyama, Y | 1 |
| Kojima, S | 1 |
| Estrov, Z | 1 |
| Kurzrock, R | 1 |
| Talpaz, M | 1 |
1 review available for suramin and Shock, Septic
| Article | Year |
|---|---|
Interleukin-1 and its inhibitors: implications for disease biology and therapy.
Topics: Animals; Antineoplastic Agents; Bone Marrow Diseases; Caspase 1; Cysteine Endopeptidases; Gene Expre | 1995 |
1 trial available for suramin and Shock, Septic
| Article | Year |
|---|---|
Interleukin-1 and its inhibitors: implications for disease biology and therapy.
Topics: Animals; Antineoplastic Agents; Bone Marrow Diseases; Caspase 1; Cysteine Endopeptidases; Gene Expre | 1995 |
1 other study available for suramin and Shock, Septic
| Article | Year |
|---|---|
Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor.
Topics: Adenosine Triphosphate; Animals; Ascitic Fluid; Autocrine Communication; Cell Line, Tumor; Exocytosi | 2013 |