mdl-201112

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-(6-amino-9H-purin-9-yl)-cyclopentanol: structure given in first source; a synthetic carbocyclic adenosine analog; RN given refers to (1R-cis)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	132408
CHEMBL ID	316207
SCHEMBL ID	4351091
MeSH ID	M0218975

Synonyms (14)

Synonym
cyclopentanol, 3-(6-amino-9h-purin-9-yl)-, (1r-cis)-
9-(cis-cyclopentan-3-ol)adenine
142130-73-2
3-(6-amino-9h-purin-9-yl)-cyclopentanol
mdl-201112
mdl 201449a
SCHEMBL4351091
(1r,3s)-3-(6-aminopurin-9-yl)cyclopentan-1-ol
CHEMBL316207
(1r,3s)-3-(6-amino-9h-purin-9-yl)cyclopentan-1-ol
mdl201112
DTXSID80931363
3-(6-amino-9h-purin-9-yl)cyclopentan-1-ol
(1r,3s)-3-(6-amino-9h-purin-9-yl)cyclopentanol

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay ID	Title	Year	Journal	Article
AID90492	in vitro inhibitory activity was measured against interleukin-1-beta (IL1-beta) production	1996	Journal of medicinal chemistry, Jun-21, Volume: 39, Issue:13	Carbocyclic nucleosides as inhibitors of human tumor necrosis factor-alpha production: effects of the stereoisomers of (3-hydroxycyclopentyl)adenines.
AID90493	in vitro inhibitory activity was measured against interleukin-6 (IL-6) production	1996	Journal of medicinal chemistry, Jun-21, Volume: 39, Issue:13	Carbocyclic nucleosides as inhibitors of human tumor necrosis factor-alpha production: effects of the stereoisomers of (3-hydroxycyclopentyl)adenines.
AID124148	Protective effects against lethal injections of D-galactosamine sensitized Lipopolysaccharide challenged (LD100) CF1 mice (100 mg/kg IP in PBS)	1996	Journal of medicinal chemistry, Jun-21, Volume: 39, Issue:13	Carbocyclic nucleosides as inhibitors of human tumor necrosis factor-alpha production: effects of the stereoisomers of (3-hydroxycyclopentyl)adenines.
AID90490	In vitro inhibitory activity was measured against tumor necrosis factor-alpha production	1996	Journal of medicinal chemistry, Jun-21, Volume: 39, Issue:13	Carbocyclic nucleosides as inhibitors of human tumor necrosis factor-alpha production: effects of the stereoisomers of (3-hydroxycyclopentyl)adenines.
AID123988	D-galactosamine sensitized mice were given 3 times the LD100 dose of LPS (100 mg/kg IP in PBS)	1996	Journal of medicinal chemistry, Jun-21, Volume: 39, Issue:13	Carbocyclic nucleosides as inhibitors of human tumor necrosis factor-alpha production: effects of the stereoisomers of (3-hydroxycyclopentyl)adenines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	6 (60.00)	18.2507
2000's	4 (40.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.80 (24.57)
Research Supply Index	2.40 (2.92)
Research Growth Index	4.20 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.80)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
adenine [no description available]	3.6	9	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
dipyridamole Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752). dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.	1.98	1	piperidines; pyrimidopyrimidine; tertiary amino compound; tetrol	adenosine phosphodiesterase inhibitor; EC 3.5.4.4 (adenosine deaminase) inhibitor; platelet aggregation inhibitor; vasodilator agent
pentoxifylline [no description available]	2.4	2	oxopurine
adenosine quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit	2.68	3	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	1.98	1	D-glucopyranose	epitope; mouse metabolite
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	1.99	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
interleukin-8 Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.	1.99	1
cyclosporine Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).	2.4	2
orabase Orabase: used in therapy of oral mucosal ulcers	2.01	1
concanavalin a Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.	2.01	1

Condition	Relationship Strength	Studies
Alloxan Diabetes [description not available]	2.41	2
Endotoxin Shock [description not available]	1.98	1
Shock, Septic Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.	1.98	1
Delayed Hypersensitivity [description not available]	2	1

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