metformin has been researched along with Shock, Septic in 8 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In our data, preadmission metformin use is associated with a significantly larger decrease in lactate after admission with sepsis or septic shock and with reduced mortality in septic shock." | 8.31 | New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study. ( De Decker, K; De Neve, N; Tackaert, T; Van Moorter, N; Van Vlem, B, 2023) |
| "We aimed to evaluate the impact of metformin use on lactate kinetics in patients with severe sepsis and septic shock." | 7.85 | Impact of Metformin Use on Lactate Kinetics in Patients with Severe Sepsis and Septic Shock. ( Carriere, KC; Cha, WC; Hwang, SY; Jeon, K; Jo, IJ; Lee, TR; Park, J; Shin, TG; Sim, MS; Suh, GY; Yeon, S; Yoon, H, 2017) |
| "Metformin users were similar to nonusers with respect to levels of lactate, HCO3, and blood pH; however, they were older and had higher incidence rates of cardiovascular disease and acute kidney injury at admission, compared to nonusers." | 5.43 | Lactic acidosis and severe septic shock in metformin users: a cohort study. ( Beberashvili, I; Doenyas-Barak, K; Efrati, S; Marcus, R, 2016) |
| "In our data, preadmission metformin use is associated with a significantly larger decrease in lactate after admission with sepsis or septic shock and with reduced mortality in septic shock." | 4.31 | New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study. ( De Decker, K; De Neve, N; Tackaert, T; Van Moorter, N; Van Vlem, B, 2023) |
| "We aimed to evaluate the impact of metformin use on lactate kinetics in patients with severe sepsis and septic shock." | 3.85 | Impact of Metformin Use on Lactate Kinetics in Patients with Severe Sepsis and Septic Shock. ( Carriere, KC; Cha, WC; Hwang, SY; Jeon, K; Jo, IJ; Lee, TR; Park, J; Shin, TG; Sim, MS; Suh, GY; Yeon, S; Yoon, H, 2017) |
| "Metformin users were similar to nonusers with respect to levels of lactate, HCO3, and blood pH; however, they were older and had higher incidence rates of cardiovascular disease and acute kidney injury at admission, compared to nonusers." | 1.43 | Lactic acidosis and severe septic shock in metformin users: a cohort study. ( Beberashvili, I; Doenyas-Barak, K; Efrati, S; Marcus, R, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (87.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Van Moorter, N | 3 |
| Tackaert, T | 3 |
| De Decker, K | 3 |
| Van Vlem, B | 3 |
| De Neve, N | 3 |
| Hall, DT | 1 |
| Griss, T | 1 |
| Ma, JF | 1 |
| Sanchez, BJ | 1 |
| Sadek, J | 1 |
| Tremblay, AMK | 1 |
| Mubaid, S | 1 |
| Omer, A | 1 |
| Ford, RJ | 1 |
| Bedard, N | 1 |
| Pause, A | 1 |
| Wing, SS | 1 |
| Di Marco, S | 1 |
| Steinberg, GR | 1 |
| Jones, RG | 1 |
| Gallouzi, IE | 1 |
| Makehei, S | 1 |
| Sam, R | 1 |
| Doenyas-Barak, K | 1 |
| Beberashvili, I | 1 |
| Marcus, R | 1 |
| Efrati, S | 1 |
| Honore, PM | 1 |
| Spapen, HD | 1 |
| Posma, RA | 1 |
| Absalom, AR | 1 |
| Touw, DJ | 1 |
| van der Horst, IC | 1 |
| Nijsten, MW | 1 |
| Park, J | 1 |
| Hwang, SY | 1 |
| Jo, IJ | 1 |
| Jeon, K | 1 |
| Suh, GY | 1 |
| Lee, TR | 1 |
| Yoon, H | 1 |
| Cha, WC | 1 |
| Sim, MS | 1 |
| Carriere, KC | 1 |
| Yeon, S | 1 |
| Shin, TG | 1 |
| Kjelland, CB | 1 |
| Djogovic, D | 1 |
1 review available for metformin and Shock, Septic
| Article | Year |
|---|---|
The role of serum lactate in the acute care setting.
Topics: Acidosis, Lactic; Adult; Aged; Antiretroviral Therapy, Highly Active; Biomarkers; Critical Care; Dru | 2010 |
7 other studies available for metformin and Shock, Septic
| Article | Year |
|---|---|
New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study.
Topics: Acute Kidney Injury; Humans; Kidney; Lactic Acid; Metformin; Retrospective Studies; Sepsis; Shock, S | 2023 |
New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study.
Topics: Acute Kidney Injury; Humans; Kidney; Lactic Acid; Metformin; Retrospective Studies; Sepsis; Shock, S | 2023 |
New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study.
Topics: Acute Kidney Injury; Humans; Kidney; Lactic Acid; Metformin; Retrospective Studies; Sepsis; Shock, S | 2023 |
New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study.
Topics: Acute Kidney Injury; Humans; Kidney; Lactic Acid; Metformin; Retrospective Studies; Sepsis; Shock, S | 2023 |
The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Animals; Cachexia; Cell Line; Enzy | 2018 |
Does lactate account for all of the increase in anion gap in cases of metformin-induced lactic acidosis?
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Shock, | 2015 |
Lactic acidosis and severe septic shock in metformin users: a cohort study.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Cohort Studies; Female; Hospital Mortality; Humans; Hypog | 2016 |
Prognosis of extremely severe lactic acidosis in metformin-treated patients with septic shock: continuous (?) renal replacement therapy in the spotlight!
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Prognosis; Rena | 2016 |
Metformin and lactic acidosis during shock: just the tip of the iceberg?
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Shock, Septic | 2016 |
Impact of Metformin Use on Lactate Kinetics in Patients with Severe Sepsis and Septic Shock.
Topics: Aged; Emergency Service, Hospital; Female; Hospital Mortality; Humans; Lactic Acid; Male; Metformin; | 2017 |