Page last updated: 2024-12-09

xc 386

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

XC 386: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID705850
CHEMBL ID3622459
MeSH IDM0128176

Synonyms (24)

Synonym
3,4-dimethylpyrano(3,2-c)pyrazol-6-one
pyrano(2,3-c)pyrazol-6(1h)-one, 3,4-dimethyl-
xc386
xc-386
3,4-dimethyl-1h-pyrano[2,3-c]pyrazol-6-one
MAYBRIDGE1_001391
AKOS000291369
xc 386
HMS545H05
5203-98-5
3,4-dimethylpyrano[2,3-c]pyrazol-6(1h)-one
FT-0691992
3,4-dimethyl-2h-pyrano[2,3-c]pyrazol-6-one
STK328210
3,4-dimethyl-1,6-dihydropyrano[2,3-c]pyrazol-6-one
3,4-dimethyl-1h,6h-pyrano[2,3-c]pyrazol-6-one
TS-02188
CHEMBL3622459
J-511222
DTXSID20200000
mfcd00104457
3,4-di-methylpyrano[2,3-c]pyrazol-6(1h)-one
3,4-dimethylpyrano[2,3-c]pyrazol-6-one
Z57063951
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Polymerase acidic proteinInfluenza A virus (A/X-31(H3N2))IC50 (µMol)500.00003.20003.20003.2000AID1249917
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID1249917Inhibition of recombinant Influenza virus A/X-31 N-terminal RdRp PA subunit (1 to 217) expressed in Escherichia coli using single-stranded circular DNA plasmid M13mp18 as substrate after 2 hrs by agarose gel electrophoresis2015ACS medicinal chemistry letters, Aug-13, Volume: 6, Issue:8
Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.38 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]