gabexate has been researched along with Shock, Septic in 10 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experimental disseminated intravascular coagulation (DIC) can be induced by 4 h sustained infusion of endotoxin at a dose of 100 mg/kg in rats." | 5.27 | Protective effect of gabexate mesilate against experimental disseminated intravascular coagulation in rats. ( Furukawa, Y; Kondo, M; Murakami, M; Takemura, S; Yoshikawa, T, 1983) |
| "Circulatory shock, especially endotoxin shock, is characterized by the release of a large number of mediators, among which proteases play a key role." | 1.29 | [Antioxidant action of gabexate mesilate (Foy) in an experimental model of endotoxic shock]. ( Bonizzoli, M; Casali, R; Giorgi, L; Lemma, M; Novelli, GP; Piscitelli, P, 1995) |
| "Endotoxic shock was induced in rabbits of either sex by IV injection of 50 micrograms/kg endotoxin (ET) extracted from E coli O-55 by Boivin's method." | 1.27 | Effects of gabexate mesilate on the reactions of lipid metabolism in endotoxic shock. ( Drysch, K; Poetter, E; Richardt, G; Rox, G; Schmahl, FW; Wabnitz, RW, 1983) |
| "Experimental disseminated intravascular coagulation (DIC) can be induced by 4 h sustained infusion of endotoxin at a dose of 100 mg/kg in rats." | 1.27 | Protective effect of gabexate mesilate against experimental disseminated intravascular coagulation in rats. ( Furukawa, Y; Kondo, M; Murakami, M; Takemura, S; Yoshikawa, T, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (80.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tumurkhuu, G | 1 |
| Koide, N | 1 |
| Hiwasa, T | 1 |
| Ookoshi, M | 1 |
| Dagvadorj, J | 1 |
| Iftakhar-E-Khuda, I | 1 |
| Naiki, Y | 1 |
| Komatsu, T | 1 |
| Yoshida, T | 1 |
| Yokochi, T | 1 |
| Stemberger, A | 1 |
| Strasser, F | 1 |
| Blümel, G | 1 |
| von Hundelshausen, B | 1 |
| Jelen, S | 1 |
| Schmidt, O | 1 |
| Tempel, G | 1 |
| Schmahl, FW | 2 |
| Wabnitz, RW | 1 |
| Rox, G | 1 |
| Drysch, K | 1 |
| Richardt, G | 1 |
| Poetter, E | 1 |
| Yoshikawa, T | 1 |
| Furukawa, Y | 1 |
| Murakami, M | 1 |
| Takemura, S | 1 |
| Kondo, M | 1 |
| Miyazaki, M | 1 |
| Yoda, K | 1 |
| Ogli, K | 1 |
| Yokono, S | 1 |
| Novelli, GP | 1 |
| Casali, R | 1 |
| Bonizzoli, M | 1 |
| Giorgi, L | 1 |
| Lemma, M | 1 |
| Piscitelli, P | 1 |
| Tanaka, K | 1 |
| Metzler, B | 1 |
| Rettenmeier, AW | 1 |
| Wodarz, I | 1 |
| Traber, DL | 1 |
| Adams, T | 1 |
| Sziebert, L | 1 |
| Traber, LD | 1 |
| Takeda, S | 1 |
| Kume, M | 1 |
| Takechi, K | 1 |
| Kasamatsu, T | 1 |
| Yoshida, K | 1 |
| Kinoshita, K | 1 |
| Mizuno, M | 1 |
| Sakamoto, S | 1 |
10 other studies available for gabexate and Shock, Septic
| Article | Year |
|---|---|
ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock.
Topics: Allylglycine; Animals; Benzamidines; Cell Line, Tumor; Culture Media, Conditioned; Esters; Female; G | 2011 |
Endotoxins and coagulation parameters in patients with traumatic haemorrhagic- and bacteriotoxic shock.
Topics: Aprotinin; Blood Coagulation; Endotoxins; Gabexate; Guanidines; Humans; Peptide Hydrolases; Protease | 1984 |
Effects of gabexate mesilate on the reactions of lipid metabolism in endotoxic shock.
Topics: Animals; Arrhythmias, Cardiac; Endotoxins; Fatty Acids, Nonesterified; Female; Gabexate; Glycerol; G | 1983 |
Protective effect of gabexate mesilate against experimental disseminated intravascular coagulation in rats.
Topics: Animals; Blood Coagulation Tests; Disseminated Intravascular Coagulation; Female; Fibrin Fibrinogen | 1983 |
[Problems in the use of newly introduced anti-shock agents].
Topics: Adrenal Cortex Hormones; Animals; Benzamidines; Complement Inactivator Proteins; Gabexate; Guanidine | 1983 |
[Antioxidant action of gabexate mesilate (Foy) in an experimental model of endotoxic shock].
Topics: Animals; Antioxidants; Capillary Permeability; Gabexate; Male; Microcirculation; Rats; Rats, Wistar; | 1995 |
[The anti-shock effects of several drugs, with special reference to the effect of lidocaine].
Topics: Animals; Aprotinin; Fibrin; Gabexate; Guanidines; Lidocaine; Methylprednisolone; Rabbits; Shock, Sep | 1985 |
Changes of serum amino acid concentrations in experimentally induced endotoxic shock. The significance of hyperalaninemia in the prediction of lethality.
Topics: Alanine; Amino Acids; Animals; Gabexate; Guanidines; Male; Prognosis; Protease Inhibitors; Rabbits; | 1989 |
Effect of a proteolytic enzyme inhibitor on the cardiopulmonary response to endotoxin.
Topics: Animals; Blood Proteins; Cardiac Output; Endotoxins; Female; Gabexate; Guanidines; Hemodynamics; Lun | 1986 |
The effect of a serine proteinase inhibitor on DIC in septic abortion.
Topics: Abortion, Septic; Adult; Anticoagulants; Disseminated Intravascular Coagulation; Female; Gabexate; G | 1987 |