Compounds > 4-methoxyindole-3-acetonitrile
Page last updated: 2024-11-07

4-methoxyindole-3-acetonitrile

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-methoxyindole-3-acetonitrile: precursor of mutagens in Chinese cabbage [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID119406
CHEMBL ID2063293
SCHEMBL ID2725123
MeSH IDM0159870

Synonyms (28)

Synonym
1h-indole-3-acetonitrile, 4-methoxy-
4837-74-5
2-(4-methoxy-1h-indol-3-yl)acetonitrile
A827522
2-(4-methoxy-1h-indol-3-yl)ethanenitrile
4-methoxyindole-3-acetonitrile
AKOS006326907
arvelexin
CHEMBL2063293
FT-0648592
1h-indole-3-acetonitrile,4-methoxy-
SCHEMBL2725123
(4-methoxy-1h-indol-3-yl)-acetonitrile
(4-methoxy-1h-indol-3-yl)acetonitrile
A1-00707
1h-indole, 4-methoxy-3-cyanomethyl-
(4-methoxy-1h-indol-3-yl)acetonitrile #
(1h)indole, 4-methoxy-3-cynanomethyl-
DTXSID90197498
4-methoxy-indole-3-acetonitrile
Z1198222836
mfcd09751226
AS-41706
AMY15254
EN300-127765
SB15220
4-methoxy-1h-indole-3-acetonitrile
CS-0308695
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID674375Cytotoxicity against human Bel7402 cells at 10 uM after 96 hrs by MTT assay2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Alkaloids from the root of Isatis indigotica.
AID674371Antiviral activity against Herpes simplex virus 1 at 10 uM2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Alkaloids from the root of Isatis indigotica.
AID744721Cytotoxicity against mouse RAW264.7 cells assessed as cell viability after 24 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Synthesis of indolyl-3-acetonitrile derivatives and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells.
AID674367Antiviral activity against influenza A virus A/Hanfang/359/95 (H3N2) assessed as inhibition of virus-induced cytopathic effect in cell-based assay2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Alkaloids from the root of Isatis indigotica.
AID674377Cytotoxicity against human HCT8 cells at 10 uM after 96 hrs by MTT assay2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Alkaloids from the root of Isatis indigotica.
AID744720Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite production after 24 hrs by Griess assay2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Synthesis of indolyl-3-acetonitrile derivatives and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells.
AID674373Cytotoxicity against human BGC823 cells at 10 uM after 96 hrs by MTT assay2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Alkaloids from the root of Isatis indigotica.
AID674370Antiviral activity against HIV1 infected in 293T cells cotransfected with VSV-G at 10 uM after 48 hrs by ELISA2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Alkaloids from the root of Isatis indigotica.
AID674374Cytotoxicity against human MCF7 cells at 10 uM after 96 hrs by MTT assay2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Alkaloids from the root of Isatis indigotica.
AID674372Cytotoxicity against human A549 cells at 10 uM after 96 hrs by MTT assay2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Alkaloids from the root of Isatis indigotica.
AID744719Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production incubated for 1 hr prior to LPS challenge measured after 24 hrs by EIA2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Synthesis of indolyl-3-acetonitrile derivatives and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells.
AID674376Cytotoxicity against human Ketr3 cells at 10 uM after 96 hrs by MTT assay2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Alkaloids from the root of Isatis indigotica.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.03

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.03 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.97 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.03)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pleconaril
WIN 63843: structure given in first source		2.0710
thiazoles
[no description available]		2.02101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
indirubin
[no description available]		2.0710
indigo
[no description available]		2.0710hydroxyindoles
indole-3-carbaldehyde
indole-3-carbaldehyde: metabolite of tryptophan; structure. indole-3-carbaldehyde : A heteroarenecarbaldehyde that is indole in which the hydrogen at position 3 has been replaced by a formyl group.		2.0710heteroarenecarbaldehyde;
indole alkaloid;
indoles		bacterial metabolite;
human xenobiotic metabolite;
marine metabolite;
plant metabolite
oseltamivir
Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.. oseltamivir : A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.		2.0710acetamides;
amino acid ester;
cyclohexenecarboxylate ester;
primary amino compound		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
environmental contaminant;
prodrug;
xenobiotic
tryptanthrine
tryptanthrine: minor constituent of traditional Chinese medicine qing dai		2.0710alkaloid antibiotic;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound
indole-3-acetonitrile
indole-3-acetonitrile: occurs in edible cruciferous vegetables. indole-3-acetonitrile : A nitrile that is acetonitrile where one of the methyl hydrogens is substituted by a 1H-indol-3-yl group.		2.4420indoles;
nitrile		auxin;
human xenobiotic metabolite;
plant hormone;
plant metabolite
indican
[no description available]		2.0710beta-D-glucoside;
exopolysaccharide;
indolyl carbohydrate
oleic acid
Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.		2.0210octadec-9-enoic acidantioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent
sesquiterpenes
[no description available]		2.0210
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.4820prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
bicyclol
bicyclol: an antihepatitis drug, on the metabolism and hepatotoxicity of aflatoxin B1 (AFB1) in rats.		2.0710
sodium nitrite
Sodium Nitrite: Nitrous acid sodium salt. Used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in ANALYTICAL CHEMISTRY TECHNIQUES. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.. sodium nitrite : An inorganic sodium salt having nitrite as the counterion. Used as a food preservative and antidote to cyanide poisoning.		1.9610inorganic sodium salt;
nitrite salt		antidote to cyanide poisoning;
antihypertensive agent;
antimicrobial food preservative;
food antioxidant;
poison
interleukin-8
Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.		2.0710
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.4720
Endotoxin Shock
[description not available]		02.0610
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.4720
Shock, Septic
Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.		02.0610
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0710
Colitis
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.		02.0710