spironolactone has been researched along with Shock, Septic in 5 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In part 1 the endotoxic shock model showed a significant reduction in TNF levels in the spironolactone-treated group compared to the non-treated group, suggesting that spironolactone acts as a TNF inhibitor." | 5.33 | The effect of spironolactone on experimental periodontitis in rats. ( Bendtzen, K; Bentzen, BH; Björnsson, M; Grauballe, MC; Holmstrup, P; Jonassen, TE; Moe, D; Stoltze, K, 2005) |
| "In part 1 the endotoxic shock model showed a significant reduction in TNF levels in the spironolactone-treated group compared to the non-treated group, suggesting that spironolactone acts as a TNF inhibitor." | 1.33 | The effect of spironolactone on experimental periodontitis in rats. ( Bendtzen, K; Bentzen, BH; Björnsson, M; Grauballe, MC; Holmstrup, P; Jonassen, TE; Moe, D; Stoltze, K, 2005) |
| "Shock is to define by clinical symptoms, measurable haemodynamic and metabolic changes, clotting failure and disorders of fluid, electrolyte and acid-base balance." | 1.26 | [Drug therapy of shock]. ( Bartels, O; Junge, O; Topf, G, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| PATRINI, G | 1 |
| Grauballe, MC | 1 |
| Bentzen, BH | 1 |
| Björnsson, M | 1 |
| Moe, D | 1 |
| Jonassen, TE | 1 |
| Bendtzen, K | 1 |
| Stoltze, K | 1 |
| Holmstrup, P | 1 |
| Bartels, O | 2 |
| Junge, O | 1 |
| Topf, G | 1 |
| Sawyer, RB | 1 |
| Spencer, JR | 1 |
| Dudzinski, PJ | 1 |
| Enis, JE | 1 |
5 other studies available for spironolactone and Shock, Septic
| Article | Year |
|---|---|
[APROPOS OF BACTEREMIC SHOCK IN OBSTETRICS].
Topics: Abortion, Induced; Anti-Bacterial Agents; Central Nervous System Stimulants; Communicable Diseases; | 1963 |
The effect of spironolactone on experimental periodontitis in rats.
Topics: Administration, Oral; Alveolar Bone Loss; Animals; Lipopolysaccharides; Male; Maxillary Diseases; Pe | 2005 |
[Drug therapy of shock].
Topics: Bicarbonates; Dehydration; Dihydroergotoxine; Furosemide; Glucagon; Humans; Methylprednisolone; Peri | 1978 |
[Emergency therapy in manifested shock].
Topics: Acidosis; Adrenal Cortex Hormones; Bicarbonates; Capillary Permeability; Emergencies; Heart Massage; | 1973 |
Hypernatremia with pharmacologic doses of steroids.
Topics: Aged; Female; Humans; Hydrocortisone; Hypernatremia; Male; Methylprednisolone; Middle Aged; Pituitar | 1967 |