Compounds > 15-deoxy-delta(12-14)-prostaglandin-j2

15-deoxy-delta(12-14)-prostaglandin-j2 and Shock--Septic

15-deoxy-delta(12-14)-prostaglandin-j2 has been researched along with Shock--Septic* in 1 studies

Other Studies

1 other study(ies) available for 15-deoxy-delta(12-14)-prostaglandin-j2 and Shock--Septic

Article	Year
The PPAR-gamma ligand 15-deoxy(delta12,14) prostaglandin J2 reduces the liver injury in endotoxic shock. European journal of pharmacology, 2003, Aug-29, Volume: 476, Issue:3 We demonstrate here for the first time that the endogenous cyclopentenone prostaglandin 15-deoxy-Delta12,14-prostaglandin J2 (15d-prostaglandin J2) reduces the liver injury (rise in serum transaminases) caused by severe endotoxaemia (6 mg/kg Escherichia coli endotoxin i.v. for 6 h) in the anaesthetised rat. The protection of the liver afforded by this potent agonist of PPAR-gamma was not secondary to a haemodynamic effect. Thus, 15d-prostaglandin J2 and other PPAR-gamma agonists may be useful in the therapy of septic shock. Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Endotoxins; Escherichia coli; Ligands; Liver Diseases; Male; Prostaglandin D2; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Shock, Septic; Transcription Factors	2003

Article

Year

The PPAR-gamma ligand 15-deoxy(delta12,14) prostaglandin J2 reduces the liver injury in endotoxic shock.

European journal of pharmacology, 2003, Aug-29, Volume: 476, Issue:3

We demonstrate here for the first time that the endogenous cyclopentenone prostaglandin 15-deoxy-Delta12,14-prostaglandin J2 (15d-prostaglandin J2) reduces the liver injury (rise in serum transaminases) caused by severe endotoxaemia (6 mg/kg Escherichia coli endotoxin i.v. for 6 h) in the anaesthetised rat. The protection of the liver afforded by this potent agonist of PPAR-gamma was not secondary to a haemodynamic effect. Thus, 15d-prostaglandin J2 and other PPAR-gamma agonists may be useful in the therapy of septic shock.

Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Endotoxins; Escherichia coli; Ligands; Liver Diseases; Male; Prostaglandin D2; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Shock, Septic; Transcription Factors

2003