ketanserin has been researched along with Shock, Septic in 12 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketanserin could ameliorate endotoxic shock by restoring baroreflex function." | 1.37 | Effects of ketanserin on endotoxic shock and baroreflex function in rodents. ( Cai, GJ; Liu, C; Liu, WH; Miao, CY; Song, SW; Su, DF; Zhang, GF, 2011) |
| "Ketanserin pretreatment had no effect on the pulmonary vascular reactions, the tracheal pressure difference or the number of circulating platelets or white blood cells." | 1.27 | The role of 5-hydroxytryptamine in the feline response to intravenous infusion of live E. coli. ( Arvidsson, S; Falk, A; Haglind, E; Haglund, U, 1983) |
| "Septic shock was induced by i." | 1.27 | Pulmonary vascular response to live Escherichia coli: influences of different antiplatelet substances. ( Bergqvist, D; Haglund, U; Lindblad, B; Ljungberg, J; Svartholm, E, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, C | 2 |
| Zhang, X | 1 |
| Zhou, JX | 1 |
| Wei, W | 1 |
| Liu, DH | 1 |
| Ke, P | 1 |
| Zhang, GF | 2 |
| Cai, GJ | 2 |
| Su, DF | 2 |
| Vellinga, NA | 1 |
| Veenstra, G | 1 |
| Scorcella, C | 1 |
| Koopmans, M | 1 |
| van Roon, EN | 1 |
| Ince, C | 1 |
| Boerma, EC | 1 |
| Song, SW | 1 |
| Liu, WH | 1 |
| Miao, CY | 1 |
| Arvidsson, S | 2 |
| Falk, A | 1 |
| Haglind, E | 1 |
| Haglund, U | 3 |
| Lindblad, B | 2 |
| Esquivel, C | 1 |
| Fält, K | 1 |
| Lindström, C | 1 |
| Bergqvist, D | 2 |
| Makabali, GL | 1 |
| Mandal, AK | 1 |
| Morris, JA | 1 |
| Meuleman, TR | 1 |
| Hill, DC | 1 |
| Port, JD | 1 |
| Stanley, TH | 1 |
| Pace, NL | 1 |
| Mohammad, SF | 1 |
| Naess, F | 1 |
| Waage, A | 1 |
| Roeise, O | 1 |
| Stadaas, JO | 3 |
| Aasen, AO | 3 |
| Schrauwen, E | 1 |
| Houvenaghel, A | 1 |
| Svartholm, E | 1 |
| Ljungberg, J | 1 |
| Ruud, TE | 2 |
| Pillgram-Larsen, J | 2 |
1 trial available for ketanserin and Shock, Septic
| Article | Year |
|---|---|
Effects of ketanserin on microcirculatory alterations in septic shock: An open-label pilot study.
Topics: Adult; Aged; Capillaries; Female; Hemodynamics; Humans; Hypotension; Inflammation; Ketanserin; Male; | 2015 |
11 other studies available for ketanserin and Shock, Septic
| Article | Year |
|---|---|
The protective action of ketanserin against lipopolysaccharide-induced shock in mice is mediated by inhibiting inducible NO synthase expression via the MEK/ERK pathway.
Topics: Animals; Antihypertensive Agents; Blotting, Western; Disease Models, Animal; Electrophoretic Mobilit | 2013 |
Effects of ketanserin on endotoxic shock and baroreflex function in rodents.
Topics: Animals; Baroreflex; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Interleukin-10; I | 2011 |
The role of 5-hydroxytryptamine in the feline response to intravenous infusion of live E. coli.
Topics: Animals; Blood Pressure; Cats; Escherichia coli Infections; Hemodynamics; Intestines; Ketanserin; Lu | 1983 |
Effects of dihydroergotamine on the feline cardiovascular response to intravenous infusion of live Escherichia coli bacteria.
Topics: Animals; Blood Pressure; Cardiovascular System; Cats; Dihydroergotamine; Escherichia coli Infections | 1984 |
An assessment of the participatory role of prostaglandins and serotonin in the pathophysiology of endotoxic shock.
Topics: Animals; Dogs; Hemodynamics; Indomethacin; Ketanserin; Oxygen; Piperidines; Prostaglandins; Pulmonar | 1983 |
Ketanserin prevents platelet aggregation and endotoxin-induced pulmonary vasoconstriction.
Topics: Animals; Dogs; Epinephrine; Hemodynamics; Hypertension, Pulmonary; Ketanserin; Male; Oxygen; Piperid | 1983 |
Effects of a combined drug regimen on tumour necrosis factor and plasma kallikrein activity in experimental endotoxaemia.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Escherichia coli Infections; Hemodynamic | 1994 |
Hemodynamic evaluation of endotoxic shock in anesthetized piglets: antagonism of endogenous vasoactive substances.
Topics: Adrenal Cortex Hormones; Anesthesia; Animals; Bacterial Toxins; Blood Pressure; Cardiac Output; Ente | 1985 |
Pulmonary vascular response to live Escherichia coli: influences of different antiplatelet substances.
Topics: Animals; Blood Platelets; Dipyridamole; Escherichia coli Infections; Female; Imidazoles; Ketanserin; | 1987 |
Multitherapy: a new treatment regimen in endotoxemia.
Topics: Animals; Drug Therapy, Combination; Endotoxins; Escherichia coli; Hemodynamics; Kallikreins; Ketanse | 1987 |
Hemodynamic consequences of multitherapy pretreatment in experimental endotoxemia.
Topics: Animals; Drug Therapy, Combination; Endotoxins; Escherichia coli; Hemodynamics; Ketanserin; Lipopoly | 1987 |