Sphingomyelin phosphodiesterase 3

A sphingomyelin phosphodiesterase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY59]

Synonyms

EC 3.1.4.12;
Neutral sphingomyelinase 2;
nSMase-2;
nSMase2;
Neutral sphingomyelinase II

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	1 (50.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cambinol	Homo sapiens (human)	IC50	3.0000	2	2

Enables

This protein enables 8 target(s):

Target	Category	Definition
phosphatidylserine binding	molecular function	Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. [ISBN:0198506732, PMID:12000961]
sphingomyelin phosphodiesterase activity	molecular function	Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+. [EC:3.1.4.12, RHEA:19253]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
phosphoric diester hydrolase activity	molecular function	Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. [EC:3.1.4.-]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
neutral sphingomyelin phosphodiesterase activity	molecular function	Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in a neutral environment. [GOC:dph, PMID:26493087]
phosphatidic acid binding	molecular function	Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. [CHEBI:16337, GOC:jp, ISBN:0198506732]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
Golgi cis cisterna	cellular component	The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER. [ISBN:0815316194]
Golgi membrane	cellular component	The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 35 target(s):

Target	Category	Definition
regulation of protein phosphorylation	biological process	Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. [GOC:hjd]
endochondral ossification	biological process	Replacement ossification wherein bone tissue replaces cartilage. [GO_REF:0000034, ISBN:0878932437]
hematopoietic progenitor cell differentiation	biological process	The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251]
regulation of leukocyte migration	biological process	Any process that modulates the frequency, rate, or extent of leukocyte migration. [GOC:add]
chondrocyte development involved in endochondral bone morphogenesis	biological process	The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. [GOC:ascb_2009, GOC:dph, GOC:tb]
ceramide metabolic process	biological process	The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. [ISBN:0198547684]
sphingomyelin metabolic process	biological process	The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine. [ISBN:0198506732]
sphingomyelin catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. [ISBN:0198506732]
polysaccharide transport	biological process	The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [GOC:ai]
peptide hormone secretion	biological process	The regulated release of a peptide hormone from a cell. [GOC:mah]
bone mineralization	biological process	The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. [GOC:mah, PMID:22936354]
BMP signaling pathway	biological process	The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, ISBN:0878932437, PMID:17428827]
collagen metabolic process	biological process	The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). [GOC:mah, ISBN:0198506732]
multicellular organism growth	biological process	The increase in size or mass of an entire multicellular organism, as opposed to cell growth. [GOC:bf, GOC:curators, GOC:dph, GOC:tb]
positive regulation of mitotic nuclear division	biological process	Any process that activates or increases the frequency, rate or extent of mitosis. [GOC:go_curators]
platelet-derived growth factor receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]
lung alveolus development	biological process	The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. [GOC:mtg_lung, PMID:9751757]
positive regulation of smooth muscle cell proliferation	biological process	Any process that activates or increases the rate or extent of smooth muscle cell proliferation. [CL:0000192, GOC:ebc]
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
regulation of cartilage development	biological process	Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. [GOC:dph]
cellular response to hydrogen peroxide	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. [CHEBI:16240, GOC:mah]
G1 to G0 transition	biological process	A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence. [GOC:mah, GOC:mtg_cell_cycle, ISBN:0815316194]
cellular response to magnesium ion	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. [GOC:mah]
cellular response to tumor necrosis factor	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. [GOC:mah]
cellular response to redox state	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. [GOC:mah]
DNA biosynthetic process	biological process	The biosynthetic process resulting in the formation of DNA. [GOC:mah]
extracellular matrix assembly	biological process	The aggregation, arrangement and bonding together of the extracellular matrix. [GOC:jl]
sphingolipid mediated signaling pathway	biological process	The series of molecular signals mediated by a sphingolipid. [PMID:9525917]
dentinogenesis	biological process	The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin. [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346]
bone growth	biological process	The increase in size or mass of a bone that contributes to the shaping of that bone. [GOC:dos]
mitotic nuclear division	biological process	A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. [ISBN:0198547684]
cellular response to oxidised low-density lipoprotein particle stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus. [GOC:aruk, GOC:BHF, PMID:20037584, PMID:27607416]
negative regulation of hyaluronan biosynthetic process	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process. [GOC:TermGenie, GOC:yaf]
cellular response to peptide	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. [GOC:pr, GOC:TermGenie]
positive regulation of exosomal secretion	biological process	Any process that activates or increases the frequency, rate or extent of exosomal secretion. [GO_REF:0000058, GOC:TermGenie, PMID:24105262]