methyl 2,4-dihydroxy-3,6-dimethyl benzoate profile

atraric acid: structure in first source; from the stem barks of Newbouldia laevis [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	78435
CHEMBL ID	508287
CHEBI ID	144127
SCHEMBL ID	113732
MeSH ID	M0447649

Synonym
HMS1579G21
CBDIVE_016254
MLS000517295
2,4-dihydroxy-3,6-dimethyl-benzoic acid methyl ester
smr000127412
12yh9t04qe ,
methyl beta-resorcinolcarboxylate
methyl 3-methylorsellinate
unii-12yh9t04qe
beta-resorcylic acid, 3,6-dimethyl-, methyl ester
methyl 3,6-dimethylresorcylate
beta-resorcyclic acid, 3,6-dimethyl-, methyl ester
einecs 225-193-0
benzoic acid, 2,4-dihydroxy-3,6-dimethyl-, methyl ester
.beta.-resorcylic acid, 3,6-dimethyl-, methyl ester
methyl 2,4-dihydroxy-3,6-dimethylbenzoate
4707-47-5
methyl 2,4-dihydroxy-3,6-dimethyl-benzoate
methyl beta-orcinolcarboxylate
methyl atratate, >=98%
STK021597
atraric acid
methyl-beta-orcinol carboxylate
CHEMBL508287
CHEBI:144127
NCGC00247061-01
dtxcid7021653
dtxsid9041653 ,
NCGC00255527-01
cas-4707-47-5
tox21_301667
methyl-2,4-dihydroxy-3,6-dimethylbenzoate
A827149
HMS2267P05
AKOS005379221
methyl2,4-dihydroxy-3,6-dimethylbenzoate
FT-0628828
91061-32-4
SCHEMBL113732
BBL028296
2,4-dihydroxy-3,6-dimethylbenzoic acid, methyl ester
UUQHKWMIDYRWHH-UHFFFAOYSA-N
moss synth
methyl atrarate
methyl .beta.-orsellinate
methyl 3,6-dimethyl-2,4-dihydroxybenzoate
methyl 3,6-dimethyl-.beta.-resorcylate
veramoss
evernyl
methyl .beta.-orcinolcarboxylate
oakmoss synthetic
everniate
lrg-201
mousse cristal
W-109992
methyl 2,4-dioh-3,6-dimethylbenzoate
mfcd00157202
E75862
VS-08714
Q15634313
thiazolidine,3-[(2s,3s)-2-amino-3-methyl-1-thioxopentyl]- (9ci)
atraric acid-methyl ester
HY-N2908
CS-0023504

Class	Description
4-hydroxybenzoate ester	A benzoate ester that is an ester of 4-hydroxybenzoic acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
GLI family zinc finger 3	Homo sapiens (human)	Potency	45.9174	0.0007	14.5928	83.7951	AID1259369; AID1259392
AR protein	Homo sapiens (human)	Potency	22.1358	0.0002	21.2231	8,912.5098	AID1259243; AID1259247; AID743035
Smad3	Homo sapiens (human)	Potency	12.5893	0.0052	7.8098	29.0929	AID588855
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	36.8031	0.0010	22.6508	76.6163	AID1224838; AID1224839; AID1224893
progesterone receptor	Homo sapiens (human)	Potency	19.3312	0.0004	17.9460	75.1148	AID1346795
pregnane X nuclear receptor	Homo sapiens (human)	Potency	61.1306	0.0054	28.0263	1,258.9301	AID1346982
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	49.9144	0.0002	29.3054	16,493.5996	AID743069; AID743075; AID743079
chromobox protein homolog 1	Homo sapiens (human)	Potency	89.1251	0.0060	26.1688	89.1251	AID540317
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	0.3162	1.7783	16.2081	35.4813	AID652104
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
negative regulation of protein phosphorylation	TAR DNA-binding protein 43	Homo sapiens (human)
mRNA processing	TAR DNA-binding protein 43	Homo sapiens (human)
RNA splicing	TAR DNA-binding protein 43	Homo sapiens (human)
negative regulation of gene expression	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of protein stability	TAR DNA-binding protein 43	Homo sapiens (human)
positive regulation of insulin secretion	TAR DNA-binding protein 43	Homo sapiens (human)
response to endoplasmic reticulum stress	TAR DNA-binding protein 43	Homo sapiens (human)
positive regulation of protein import into nucleus	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of circadian rhythm	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of apoptotic process	TAR DNA-binding protein 43	Homo sapiens (human)
negative regulation by host of viral transcription	TAR DNA-binding protein 43	Homo sapiens (human)
rhythmic process	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of cell cycle	TAR DNA-binding protein 43	Homo sapiens (human)
3'-UTR-mediated mRNA destabilization	TAR DNA-binding protein 43	Homo sapiens (human)
3'-UTR-mediated mRNA stabilization	TAR DNA-binding protein 43	Homo sapiens (human)
nuclear inner membrane organization	TAR DNA-binding protein 43	Homo sapiens (human)
amyloid fibril formation	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of gene expression	TAR DNA-binding protein 43	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
double-stranded DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
RNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
mRNA 3'-UTR binding	TAR DNA-binding protein 43	Homo sapiens (human)
protein binding	TAR DNA-binding protein 43	Homo sapiens (human)
lipid binding	TAR DNA-binding protein 43	Homo sapiens (human)
identical protein binding	TAR DNA-binding protein 43	Homo sapiens (human)
pre-mRNA intronic binding	TAR DNA-binding protein 43	Homo sapiens (human)
molecular condensate scaffold activity	TAR DNA-binding protein 43	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
intracellular non-membrane-bounded organelle	TAR DNA-binding protein 43	Homo sapiens (human)
nucleus	TAR DNA-binding protein 43	Homo sapiens (human)
nucleoplasm	TAR DNA-binding protein 43	Homo sapiens (human)
perichromatin fibrils	TAR DNA-binding protein 43	Homo sapiens (human)
mitochondrion	TAR DNA-binding protein 43	Homo sapiens (human)
cytoplasmic stress granule	TAR DNA-binding protein 43	Homo sapiens (human)
nuclear speck	TAR DNA-binding protein 43	Homo sapiens (human)
interchromatin granule	TAR DNA-binding protein 43	Homo sapiens (human)
nucleoplasm	TAR DNA-binding protein 43	Homo sapiens (human)
chromatin	TAR DNA-binding protein 43	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (70)

Assay ID	Title	Year	Journal	Article
AID1347082	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347083	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347086	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID1081980	Antifungal activity against Athelia rolfsii assessed as growth inhibition at 62.5 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081961	Antifungal activity against Pythium debaryanum assessed as growth inhibition at 125 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081969	Antifungal activity against Fusarium udum assessed as growth inhibition at 125 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081967	Antifungal activity against Fusarium udum assessed as growth inhibition by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081970	Antifungal activity against Fusarium udum assessed as growth inhibition at 250 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1419106	Binding affinity to recombinant human PPARgamma LBD at 40 uM by TR-FRET based green polar-screen PPAR competitor assay	2018	Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22	Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ.
AID377856	Phytogrowth-inhibitory activity against Echinochloa crusgalli assessed as inhibition of seedling growth	2000	Journal of natural products, Oct, Volume: 63, Issue:10	Effect of lichen metabolites on thylakoid electron transport and photophosphorylation in isolated spinach chloroplasts.
AID1081962	Antifungal activity against Pythium debaryanum assessed as growth inhibition at 250 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1419085	Inhibition of TLR4 in human U937-3xkappaB-LUC cells assessed as inhibition of Aggregatibacter actinomycetemcomitans LPS-induced NF-kappaB activation at 20 uM preincubated for 30 mins followed by LPS stimulation and measured after 6 hrs post LPS challenge	2018	Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22	Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ.
AID1419081	Cytotoxicity against PMA-differentiated human U937 macrophages assessed as cell viability at 40 uM after 24 hrs by MTT assay relative to untreated control	2018	Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22	Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ.
AID1081959	Antifungal activity against Pythium debaryanum assessed as growth inhibition by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1437932	Antifungal activity against Candida albicans ATCC 28366 assessed as growth inhibition at 80 uM after 24 hrs	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Dibenzofurans and Pseudodepsidones from the Lichen Stereocaulon paschale Collected in Northern Quebec.
AID1081972	Antifungal activity against Rhizoctonia bataticola assessed as growth inhibition at 62.5 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081977	Antifungal activity against Rhizoctonia solani assessed as growth inhibition at 125 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID377854	Phytogrowth-inhibitory activity against Echinochloa crusgalli assessed as inhibition of seedling germination	2000	Journal of natural products, Oct, Volume: 63, Issue:10	Effect of lichen metabolites on thylakoid electron transport and photophosphorylation in isolated spinach chloroplasts.
AID377855	Phytogrowth-inhibitory activity against Amaranthus hypochondriacus assessed as inhibition of seedling germination	2000	Journal of natural products, Oct, Volume: 63, Issue:10	Effect of lichen metabolites on thylakoid electron transport and photophosphorylation in isolated spinach chloroplasts.
AID1081973	Antifungal activity against Rhizoctonia bataticola assessed as growth inhibition at 125 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1419087	Inhibition of TLR4 in human U937-3xkappaB-LUC cells assessed as inhibition of Aggregatibacter actinomycetemcomitans LPS-induced NF-kappaB activation at 5 uM preincubated for 30 mins followed by LPS stimulation and measured after 6 hrs post LPS challenge b	2018	Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22	Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ.
AID1419092	Antiinflammatory activity in PMA-differentiated human U937 cells assessed as inhibition of LPS-induced TNFalpha secretion at 10 uM preincubated for 2 hrs followed by LPS stimulation and measured after 24 hrs post LPS challenge by ELISA relative to control	2018	Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22	Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ.
AID1419089	Antiinflammatory activity in PMA-differentiated human U937 cells assessed as inhibition of LPS-induced TNFalpha secretion at 80 uM preincubated for 2 hrs followed by LPS stimulation and measured after 24 hrs post LPS challenge by ELISA relative to control	2018	Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22	Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ.
AID1081966	Antifungal activity against Pythium aphanidermatum assessed as growth inhibition at 250 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1419086	Inhibition of TLR4 in human U937-3xkappaB-LUC cells assessed as inhibition of Aggregatibacter actinomycetemcomitans LPS-induced NF-kappaB activation at 10 uM preincubated for 30 mins followed by LPS stimulation and measured after 6 hrs post LPS challenge	2018	Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22	Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ.
AID1419090	Antiinflammatory activity in PMA-differentiated human U937 cells assessed as inhibition of LPS-induced TNFalpha secretion at 40 uM preincubated for 2 hrs followed by LPS stimulation and measured after 24 hrs post LPS challenge by ELISA relative to control	2018	Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22	Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ.
AID1419091	Antiinflammatory activity in PMA-differentiated human U937 cells assessed as inhibition of LPS-induced TNFalpha secretion at 20 uM preincubated for 2 hrs followed by LPS stimulation and measured after 24 hrs post LPS challenge by ELISA relative to control	2018	Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22	Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ.
AID1437929	Antibacterial activity against Streptococcus mutans ATCC 25175 after 24 hrs	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Dibenzofurans and Pseudodepsidones from the Lichen Stereocaulon paschale Collected in Northern Quebec.
AID1081982	Antifungal activity against Athelia rolfsii assessed as growth inhibition at 250 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1419084	Inhibition of TLR4 in human U937-3xkappaB-LUC cells assessed as inhibition of Aggregatibacter actinomycetemcomitans LPS-induced NF-kappaB activation at 50 uM preincubated for 30 mins followed by LPS stimulation and measured after 6 hrs post LPS challenge	2018	Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22	Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ.
AID379832	Inhibition of AAPH-induced lipid peroxidation in bovine brain phospholipid liposome	1999	Journal of natural products, Jun, Volume: 62, Issue:6	Lichen metabolites. 1. Inhibitory action against leukotriene B4 biosynthesis by a non-redox mechanism.
AID377853	Phytogrowth-inhibitory activity against Amaranthus hypochondriacus assessed as inhibition of seedling growth	2000	Journal of natural products, Oct, Volume: 63, Issue:10	Effect of lichen metabolites on thylakoid electron transport and photophosphorylation in isolated spinach chloroplasts.
AID1081978	Antifungal activity against Rhizoctonia solani assessed as growth inhibition at 250 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1419080	Cytotoxicity against PMA-differentiated human U937 macrophages assessed as cell viability at 80 uM after 24 hrs by MTT assay relative to untreated control	2018	Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22	Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ.
AID1090826	Antifeedant activity against Hylobius abietis (pine weevil ) in compound pre-treated Scots pine twig at 50 mM measured after 24 hr by two-choice laboratory bioassay	2007	Journal of agricultural and food chemistry, Nov-14, Volume: 55, Issue:23	Quantitative structure-activity relationships of pine weevil antifeedants, a multivariate approach.
AID1081971	Antifungal activity against Rhizoctonia bataticola assessed as growth inhibition by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081976	Antifungal activity against Rhizoctonia solani assessed as growth inhibition at 62.5 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081964	Antifungal activity against Pythium aphanidermatum assessed as growth inhibition at 62.5 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081968	Antifungal activity against Fusarium udum assessed as growth inhibition at 62.5 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1419082	Cytotoxicity against PMA-differentiated human U937 macrophages assessed as cell viability at 20 uM after 24 hrs by MTT assay relative to untreated control	2018	Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22	Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ.
AID1437928	Antibacterial activity against Porphyromonas gingivalis ATCC 33277 after 24 hrs	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Dibenzofurans and Pseudodepsidones from the Lichen Stereocaulon paschale Collected in Northern Quebec.
AID1081965	Antifungal activity against Pythium aphanidermatum assessed as growth inhibition at 125 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID379834	Antioxidant activity assessed as DPPH radical scavenging activity at equimolar amount of compound	1999	Journal of natural products, Jun, Volume: 62, Issue:6	Lichen metabolites. 1. Inhibitory action against leukotriene B4 biosynthesis by a non-redox mechanism.
AID1437930	Bactericidal activity against Porphyromonas gingivalis ATCC 33277 after 24 hrs	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Dibenzofurans and Pseudodepsidones from the Lichen Stereocaulon paschale Collected in Northern Quebec.
AID1081974	Antifungal activity against Rhizoctonia bataticola assessed as growth inhibition at 250 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081979	Antifungal activity against Athelia rolfsii assessed as growth inhibition by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1437931	Bactericidal activity against Streptococcus mutans ATCC 25175 after 24 hrs	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Dibenzofurans and Pseudodepsidones from the Lichen Stereocaulon paschale Collected in Northern Quebec.
AID1081975	Antifungal activity against Rhizoctonia solani assessed as growth inhibition by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1081960	Antifungal activity against Pythium debaryanum assessed as growth inhibition at 62.5 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID1419083	Cytotoxicity against PMA-differentiated human U937 macrophages assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to untreated control	2018	Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22	Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ.
AID515865	Cytotoxicity against human LNCAP cells at 10 uM after 2 days	2010	Bioorganic & medicinal chemistry, Oct-01, Volume: 18, Issue:19	20-Aminosteroids as a novel class of selective and complete androgen receptor antagonists and inhibitors of prostate cancer cell growth.
AID379837	Growth inhibition of human HaCaT cells assessed as lactate dehydrogenase release at 2 uM after 4 hrs by UV method	1999	Journal of natural products, Jun, Volume: 62, Issue:6	Lichen metabolites. 2. Antiproliferative and cytotoxic activity of gyrophoric, usnic, and diffractaic acid on human keratinocyte growth.
AID379836	Antiproliferative activity against human HaCaT cells	1999	Journal of natural products, Jun, Volume: 62, Issue:6	Lichen metabolites. 2. Antiproliferative and cytotoxic activity of gyrophoric, usnic, and diffractaic acid on human keratinocyte growth.
AID1081981	Antifungal activity against Athelia rolfsii assessed as growth inhibition at 125 ug/ml by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID379833	Inhibition of LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells	1999	Journal of natural products, Jun, Volume: 62, Issue:6	Lichen metabolites. 1. Inhibitory action against leukotriene B4 biosynthesis by a non-redox mechanism.
AID1081963	Antifungal activity against Pythium aphanidermatum assessed as growth inhibition by poisoned food technique	2011	Journal of agricultural and food chemistry, Mar-23, Volume: 59, Issue:6	Isolation, characterization and antifungal activity of major constituents of the Himalayan lichen Parmelia reticulata Tayl.
AID379835	Prooxidant activity assessed as hydroxyl radical formation at 75 uM measured as malondialdehyde per mmol of deoxyribose by deoxyribose assay	1999	Journal of natural products, Jun, Volume: 62, Issue:6	Lichen metabolites. 1. Inhibitory action against leukotriene B4 biosynthesis by a non-redox mechanism.
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299	A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis	2010	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21	Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (8.00)	18.2507
2000's	6 (24.00)	29.6817
2010's	10 (40.00)	24.3611
2020's	7 (28.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (8.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	23 (92.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
4-hydroxybenzoic acid 4-hydroxybenzoic acid : A monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring.	2.03	1	monohydroxybenzoic acid	algal metabolite; plant metabolite
salicylic acid Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).	2.03	1	monohydroxybenzoic acid	algal metabolite; antifungal agent; antiinfective agent; EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor; keratolytic drug; plant hormone; plant metabolite
2,4-dichlorophenoxyacetic acid 2,4-Dichlorophenoxyacetic Acid: An herbicide with irritant effects on the eye and the gastrointestinal system.. 2,4-D : A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.	2	1	chlorophenoxyacetic acid; dichlorobenzene	agrochemical; defoliant; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; environmental contaminant; phenoxy herbicide; synthetic auxin
anthralin Anthralin: An anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.. anthralin : An anthracene compound derived by the substitution of -OH groups for hydrogen at C-1 and C-8, and with an oxo group at C-9.	2.4	2	anthracenes	antipsoriatic
bicalutamide bicalutamide: approved for treatment of advanced prostate cancer. N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide : A member of the class of (trifluoromethyl)benzenes that is 4-amino-2-(trifluoromethyl)benzonitrile in which one of the amino hydrogens is substituted by a 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanoyl group.. bicalutamide : A racemate comprising of equal amounts of (R)-bicalutamide and (S)-bicalutamide. It is an oral non-steroidal antiandrogen used in the treatment of prostate cancer and hirsutism.	2.05	1	(trifluoromethyl)benzenes; monocarboxylic acid amide; monofluorobenzenes; nitrile; sulfone; tertiary alcohol
diuron Diuron: A pre-emergent herbicide.. diuron : A member of the class of 3-(3,4-substituted-phenyl)-1,1-dimethylureas that is urea in which both of the hydrogens attached to one nitrogen are substituted by methyl groups, and one of the hydrogens attached to the other nitrogen is substituted by a 3,4-dichlorophenyl group.	2	1	3-(3,4-substituted-phenyl)-1,1-dimethylurea; dichlorobenzene	environmental contaminant; mitochondrial respiratory-chain inhibitor; photosystem-II inhibitor; urea herbicide; xenobiotic
flutamide Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.	2.05	1	(trifluoromethyl)benzenes; monocarboxylic acid amide	androgen antagonist; antineoplastic agent
masoprocol nordihydroguaretic acid: antioxidant compound found in the creosote bush (Larrea tridentata)	2	1	catechols; lignan; tetrol	antioxidant; ferroptosis inhibitor; geroprotector; plant metabolite
penicillin g Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.	2.15	1	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
veratric acid veratric acid: RN given refers to parent cpd; structure. 3,4-dimethoxybenzoic acid : A member of the class of benzoic acids that is benzoic acid substituted by methoxy groups at positions 2 and 3.	2.03	1	benzoic acids	allergen; plant metabolite
piperonylic acid piperonylic acid: RN given refers to parent cpd; structure. piperonylic acid : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a carboxy group at position 5. It is a natural product isolated from several plant species. It is a selective mechanism-based inactivator of the trans-cinnamate 4-hydroxylase enzyme and exhibits antifungal and skin wound healing properties.	2.03	1	aromatic carboxylic acid; benzodioxoles; monocarboxylic acid	antifungal agent; EC 1.14.14.91 ( trans-cinnamate 4-monooxygenase) inhibitor; plant metabolite; vulnerary
alpha-resorcylic acid alpha-resorcylic acid: RN given refers to parent cpd. 3,5-dihydroxybenzoic acid : A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 5.	2.03	1	dihydroxybenzoic acid; resorcinols	metabolite
methyl gallate methyl gallate: has both immunosuppressive and phytogenic antineoplastic activities; isolated from Acer saccharinum. methyl 3,4,5-trihydroxybenzoate : A gallate ester obtained by the formal condensation of gallic acid with methanol. It exhibits anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory properties.	2.03	1	gallate ester	anti-inflammatory agent; antioxidant; plant metabolite
methylparaben methylparaben: used as a preservative in cosmetics but potentiates UV-induced damage of skin; RN given refers to parent cpd. methylparaben : A 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. It is the most frequently used antimicrobial preservative in cosmetics. It occurs naturally in several fruits, particularly in blueberries.	2.03	1	paraben	antifungal agent; antimicrobial food preservative; neuroprotective agent; plant metabolite
vanillic acid Vanillic Acid: A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).. vanillic acid : A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3.	2.03	1	methoxybenzoic acid; monohydroxybenzoic acid	plant metabolite
methyl 4-anisate methyl 4-anisate: volatile biomarker of Mycobacterium tuberculosis; structure in first source. methyl p-anisate : A benzoate ester obtained by the formal condensation of the carboxy group of 4-methoxybenzoic acid with methanol.	2.03	1	benzoate ester; monomethoxybenzene
orcinol orcinol: used as reagent for pentoses, lignin, beet sugar, saccharoses, arabinose & diastase; RN given refers to parent cpd; structure. orcinol : A 5-alkylresorcinol in which the alkyl group is specified as methyl.	2	1	5-alkylresorcinol; dihydroxytoluene	Aspergillus metabolite
syringic acid syringic acid: RN given refers to parent cpd; structure in third source. syringic acid : A dimethoxybenzene that is 3,5-dimethyl ether derivative of gallic acid.	2.03	1	benzoic acids; dimethoxybenzene; phenols	plant metabolite
isovanillic acid 3-hydroxy-4-methoxybenzoic acid : A methoxybenzoic acid that is 4-methoxybenzoic acid bearing a hydroxy substituent at position 3.	2.03	1	methoxybenzoic acid; monohydroxybenzoic acid	antibacterial agent; plant metabolite
3,4,5-trimethoxybenzamide [no description available]	2.03	1
n-butylbenzenesulfonamide N-butylbenzenesulfonamide: a neurotoxic plasticising agent. N-butylbenzenesulfonamide : A sulfonamide that is benzenesulfonamide substituted by a butyl group at the nitrogen atom. It has been isolated from the plant Prunus africana and has been shown to exhibit antiandrogenic activity.	3.16	1	sulfonamide	neurotoxin; plant metabolite
methyl vanillate methyl vanillate: isolated from Hovenia dulcis. methyl vanillate : A benzoate ester that is the methyl ester of vanillic acid.	2.03	1	aromatic ether; benzoate ester; phenols	antioxidant; plant metabolite
hexaconazole 2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol : A member of the class of triazoles that is 1-hexyl-1H-1,2,4-triazole in which the hydrogens at position 2 of the hexyl chain are replaced by hydroxy and 2,4-dichlorophenyl groups.. hexaconazole : A racemate comprising equimolar amounts of (R)- and (S)-hexaconazole. An agricultural fungicide introduced in the 1980s, it is not approved for use within the European Union.	2.06	1	dichlorobenzene; tertiary alcohol; triazoles	chelator
atranorin atranorin: RN given refers to parent cpd; structure given in first source	2.71	3	carbonyl compound
3-methoxysalicylic acid 2-hydroxy-3-methoxybenzoic acid: structure in first source	2.03	1	methoxysalicylic acid	metabolite
methyl syringate methyl syringate : A benzoate ester obtained by the formal condensation of carboxy group of syringic acid with methanol.	2.03	1	benzoate ester; dimethoxybenzene; phenols	plant metabolite
lobaric acid lobaric acid: inhibits formation of leukotrienes C4, D4, and E4; also reduces muscle contraction; structure in first source	2.57	2	carbonyl compound
2-hydroxy-4-methoxy benzoic acid [no description available]	2.03	1	methoxybenzoic acid
2,4-dihydroxy-6-methylbenzoic acid ethyl ester [no description available]	2.06	1	4-hydroxybenzoate ester
5-methoxysalicylic acid 5-methoxysalicylic acid: enhances intestinal absorption of insulin in rats; RN given refers to parent cpd. 5-methoxysalicylic acid : A methoxysalicylic acid that is salicylic acid which is carrying a methoxy group at position 5.	2.03	1	methoxysalicylic acid	bacterial metabolite; human urinary metabolite
methyl orsellinate methyl orsellinate: orcinol derivative from the lichen Peltigera leucophlebia (Peltigeraceae); structure in first source	2	1	hydroxybenzoic acid	metabolite
rosiglitazone [no description available]	2.17	1	aminopyridine; thiazolidinediones	EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; insulin-sensitizing drug
methyl 3-(4-hydroxyphenyl)propionate methyl 3-(4-hydroxyphenyl)propionate: a root-exuded compound responsible for biological nitrification inhibition by sorghum (Sorghum bicolor); structure in first source. methyl 3-(4-hydroxyphenyl)propionate : A methyl ester resulting from the formal condensation of the carboxy group of phloretic acid with methanol. It is a nitrification inhibitor and a plant growth regulator.	2.03	1	methyl ester; phenols	nitrification inhibitor; plant growth regulator
diffractaic acid difractaic acid: from Lichen, Usnea steineri; active against Gram-positive, multidrug-resistant bacteria; structure in first source	2.4	2	carbonyl compound
gyrophoric acid gyrophoric acid: a tridepside isolated from Parmelia nepalensis	2.69	3	carbonyl compound
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.01	1
methyl 3,4-dihydroxybenzoate [no description available]	2.03	1	catechols; methyl ester	antioxidant; neuroprotective agent; plant metabolite
(+)-usnic acid [no description available]	2.4	2	usnic acid
Methyl Haematommate [no description available]	2.98	4	4-hydroxybenzoate ester
ethyl cinnamate ethyl cinnamate: a pine weevil antifeedant; structure in first source	2.03	1	alkyl cinnamate; ethyl ester
phenylalanine methyl ester phenylalanine methyl ester: RN given refers to (L)-isomer. methyl L-phenylalaninate : An alpha-amino acid ester that is the methyl ester of L-phenylalanine.	2.03	1	alpha-amino acid ester; L-phenylalanine derivative
naphthoquinones Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.	2.01	1
salazinic acid salazinic acid: lichen metabolite; structure in first source	2.06	1
baeomycesic acid baeomycesic acid: structure in first source	2.06	1	carbonyl compound
bay 11-7082 (E)-3-tosylacrylonitrile : A nitrile that is acrylonitrile in which the hydrogen located beta,trans to the cyano group is replaced by a tosyl group. It is an inhibitor of cytokine-induced IkappaB-alpha phosphorylation in cells.	2.17	1	nitrile; sulfone	apoptosis inducer; EC 2.7.11.10 (IkappaB kinase) inhibitor; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor; non-steroidal anti-inflammatory drug; platelet aggregation inhibitor
lichexanthone lichexanthone: a dihydropyranexanthone derived from the natural xanthone; structure in first source. lichexanthone : A member of the class of xanthones that is 9H-xanthen-9-one substituted by a hydroxy group at position 1, a methyl group at position 8 and methoxy groups at positions 3 and 6. It has been isolated from the bark of Cupania cinerea.	2.43	2	aromatic ether; phenols; xanthones	plant metabolite

Condition	Relationship Strength	Studies
Cancer of Prostate [description not available]	4.54	5
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	4.54	5
Innate Inflammatory Response [description not available]	2.05	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.05	1
Encephalitis, Polio [description not available]	2.06	1
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	2.06	1
Androgen-Independent Prostatic Cancer [description not available]	4.12	10
Prostatic Neoplasms, Castration-Resistant Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE.	4.12	10
Hypermelanosis [description not available]	2.41	1
Hyperpigmentation Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.	2.41	1
Endotoxin Shock [description not available]	2.25	1
Shock, Septic Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.	2.25	1
Invasiveness, Neoplasm [description not available]	2.05	1
Adenoma, Prostatic [description not available]	2.98	1
Prostatic Hyperplasia Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.	2.98	1

methyl 2,4-dihydroxy-3,6-dimethyl benzoate

Description

Cross-References

Synonyms (64)

Drug Classes (1)

Protein Targets (9)

Potency Measurements

Biological Processes (18)

Molecular Functions (10)

Ceullar Components (9)

Bioassays (70)

Research

Studies (25)

Market Indicators

Research Demand Index: 11.62

Study Types

methyl 2,4-dihydroxy-3,6-dimethyl benzoate

Description

Cross-References

Synonyms (64)

Drug Classes (1)

Protein Targets (9)

Potency Measurements

Biological Processes (18)

Molecular Functions (10)

Ceullar Components (9)

Bioassays (70)

Research

Studies (25)

Market Indicators

Research Demand Index: 11.62

Study Types

Related Drugs (46)

Related Conditions (15)