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azure b

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Description

Azure B: RN given refers to chloride [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

azure B : An organic chloride salt having 3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium as the counterion. It is used in making azure eosin stains for blood smear staining and is an active metabolite of methylene blue. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID68275
CHEMBL ID3330736
CHEMBL ID1817784
CHEBI ID87639
SCHEMBL ID41927
SCHEMBL ID1814421
MeSH IDM0085639

Synonyms (75)

Synonym
azur b
wln: t c666 bn isj fn1&1 lm1 &g &12/26
azure i
3-(dimethylamino)-7-(methylimino)-3h-phenothiazine hydrochloride
azur i
azure b
nsc-9598
3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium chloride
methylene azure b
wln: t c666 bs ey inj eun1 mn1&1 &gh
trimethylthionine chloride
nsc9598
c.i. 52010
methylene azure
3h-phenothiazine, hydrochloride
531-55-5
3-methylamino-7-dimethylaminophenothiazin-5-ium chloride
einecs 208-511-2
nsc 9598
methylene azure (van)
3-(dimethylamino)-7-(methylamino)-phenothiazin-5-ium chloride
modr kresylova bb [czech]
3-methylamino-7-dimethylaminophenzathonium chloride
3h-phenothiazine, 3-(dimethylamino)-7-(methylimino)-, hydrochloride
azure b, certified by the biological stain commission
azure b, prepared by direct synthesis
chembl3330736 ,
chebi:87639 ,
bdbm50055938
n-methyl-n-[7-(methylamino)-3h-phenothiazin-3-ylidene]methanaminium chloride
AKOS005287416
CHEMBL1817784
modr kresylova bb
phenothiazin-5-ium, 3-(dimethylamino)-7-(methylamino)-, chloride
unii-7c8bel8wqv
ccris 9314
7c8bel8wqv ,
AKOS016011170
FT-0622539
n,n,n'-trimethylthionin
methylthioninium chloride hydrate impurity a [ep impurity]
methylene blue impurity a
3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium chloride (1:1)
trimethyldiaminophenazathonium chloride
azure b [usp-rs]
7-(dimethylamino)-3-(methylimino)-3h-phenothiazine hydrochloride
azure b [mi]
3-methylamino-7-dimethylaminophenazathonium chloride
SCHEMBL41927
7-(dimethylamino)-3-(methylamino)phenothiazin-5-ium chloride
KFZNPGQYVZZSNV-UHFFFAOYSA-M
DNDJEIWCTMMZBX-UHFFFAOYSA-N
SCHEMBL1814421
phenothiazin-5-ium,3-(dimethylamino)-7-(methylamino)-, chloride (1:1)
A-9990
azureb
DTXSID7040158
mfcd00011935
azure b, united states pharmacopeia (usp) reference standard
azure-b
n-methyl-n-(7-(methylamino)-3h-phenothiazin-3-ylidene)methanaminium chloride
Q4058459
azure b, tech grade
1231958-32-9
DTXSID40944111
n,n-dimethyl-7-(methylamino)-3h-phenothiazin-3-iminium chloride
AMY22372
CS-0009900
HY-D0004
azure b (chloride)
azure b chlorideazure b chloride
A870807
n,n,n' trimethylthionin
azzurro b
n-methyl-n-(7-(methylamino)-3h-phenothiazin-3-ylidene)methanaminiumchloride

Research Excerpts

Effects

ExcerptReferenceRelevance
"Azure B has been shown to be pharmacologically active and also possesses a variety of biological actions."( The interactions of azure B, a metabolite of methylene blue, with acetylcholinesterase and butyrylcholinesterase.
Harvey, BH; Petzer, A; Petzer, JP, 2014
)
1.45

Pharmacokinetics

ExcerptReferenceRelevance
" The developed analytical method was successfully applied to the pharmacokinetic study of MB and AZB in rats."( Simultaneous quantification of methylene blue and its major metabolite, azure B, in plasma by LC-MS/MS and its application for a pharmacokinetic study.
Ha, DJ; Kim, SJ; Koo, TS, 2014
)
0.63

Dosage Studied

ExcerptRelevanceReference
", reduced Feulgen-DNA reactivity), irrespective of the dosage employed and the delay prior to sacrifice."( Cytophotometric analysis of magnocellular azure B-RNA and Feulgen-DNA following chronic GABA infusion into the nucleus basalis of rats.
Anthony, A; Ballough, G; Kan, R; Majchrzak, M; Strauss, J; Will, B, 1992
)
0.55
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Amyloid-beta precursor proteinHomo sapiens (human)IC50 (µMol)3.00000.00053.889510.0000AID1186439
Microtubule-associated protein tauHomo sapiens (human)IC50 (µMol)3.00000.06901.97693.5000AID1186442
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (125)

Processvia Protein(s)Taxonomy
regulation of gene expressionAmyloid-beta precursor proteinHomo sapiens (human)
cognitionAmyloid-beta precursor proteinHomo sapiens (human)
G2/M transition of mitotic cell cycleAmyloid-beta precursor proteinHomo sapiens (human)
microglial cell activationAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of protein phosphorylationAmyloid-beta precursor proteinHomo sapiens (human)
suckling behaviorAmyloid-beta precursor proteinHomo sapiens (human)
astrocyte activation involved in immune responseAmyloid-beta precursor proteinHomo sapiens (human)
regulation of translationAmyloid-beta precursor proteinHomo sapiens (human)
protein phosphorylationAmyloid-beta precursor proteinHomo sapiens (human)
intracellular copper ion homeostasisAmyloid-beta precursor proteinHomo sapiens (human)
endocytosisAmyloid-beta precursor proteinHomo sapiens (human)
response to oxidative stressAmyloid-beta precursor proteinHomo sapiens (human)
cell adhesionAmyloid-beta precursor proteinHomo sapiens (human)
regulation of epidermal growth factor-activated receptor activityAmyloid-beta precursor proteinHomo sapiens (human)
Notch signaling pathwayAmyloid-beta precursor proteinHomo sapiens (human)
axonogenesisAmyloid-beta precursor proteinHomo sapiens (human)
learning or memoryAmyloid-beta precursor proteinHomo sapiens (human)
learningAmyloid-beta precursor proteinHomo sapiens (human)
mating behaviorAmyloid-beta precursor proteinHomo sapiens (human)
locomotory behaviorAmyloid-beta precursor proteinHomo sapiens (human)
axo-dendritic transportAmyloid-beta precursor proteinHomo sapiens (human)
cholesterol metabolic processAmyloid-beta precursor proteinHomo sapiens (human)
negative regulation of cell population proliferationAmyloid-beta precursor proteinHomo sapiens (human)
adult locomotory behaviorAmyloid-beta precursor proteinHomo sapiens (human)
visual learningAmyloid-beta precursor proteinHomo sapiens (human)
regulation of gene expressionAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of gene expressionAmyloid-beta precursor proteinHomo sapiens (human)
negative regulation of gene expressionAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of peptidyl-threonine phosphorylationAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of G2/M transition of mitotic cell cycleAmyloid-beta precursor proteinHomo sapiens (human)
microglia developmentAmyloid-beta precursor proteinHomo sapiens (human)
axon midline choice point recognitionAmyloid-beta precursor proteinHomo sapiens (human)
neuron remodelingAmyloid-beta precursor proteinHomo sapiens (human)
dendrite developmentAmyloid-beta precursor proteinHomo sapiens (human)
regulation of Wnt signaling pathwayAmyloid-beta precursor proteinHomo sapiens (human)
extracellular matrix organizationAmyloid-beta precursor proteinHomo sapiens (human)
forebrain developmentAmyloid-beta precursor proteinHomo sapiens (human)
neuron projection developmentAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of chemokine productionAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of interleukin-1 beta productionAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of interleukin-6 productionAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of tumor necrosis factor productionAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylationAmyloid-beta precursor proteinHomo sapiens (human)
ionotropic glutamate receptor signaling pathwayAmyloid-beta precursor proteinHomo sapiens (human)
regulation of multicellular organism growthAmyloid-beta precursor proteinHomo sapiens (human)
negative regulation of neuron differentiationAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of glycolytic processAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of mitotic cell cycleAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of JNK cascadeAmyloid-beta precursor proteinHomo sapiens (human)
astrocyte activationAmyloid-beta precursor proteinHomo sapiens (human)
regulation of long-term neuronal synaptic plasticityAmyloid-beta precursor proteinHomo sapiens (human)
collateral sprouting in absence of injuryAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of inflammatory responseAmyloid-beta precursor proteinHomo sapiens (human)
regulation of peptidyl-tyrosine phosphorylationAmyloid-beta precursor proteinHomo sapiens (human)
regulation of synapse structure or activityAmyloid-beta precursor proteinHomo sapiens (human)
synapse organizationAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of calcium-mediated signalingAmyloid-beta precursor proteinHomo sapiens (human)
neuromuscular process controlling balanceAmyloid-beta precursor proteinHomo sapiens (human)
synaptic assembly at neuromuscular junctionAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of protein metabolic processAmyloid-beta precursor proteinHomo sapiens (human)
neuron apoptotic processAmyloid-beta precursor proteinHomo sapiens (human)
smooth endoplasmic reticulum calcium ion homeostasisAmyloid-beta precursor proteinHomo sapiens (human)
neuron cellular homeostasisAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeAmyloid-beta precursor proteinHomo sapiens (human)
response to interleukin-1Amyloid-beta precursor proteinHomo sapiens (human)
modulation of excitatory postsynaptic potentialAmyloid-beta precursor proteinHomo sapiens (human)
NMDA selective glutamate receptor signaling pathwayAmyloid-beta precursor proteinHomo sapiens (human)
regulation of spontaneous synaptic transmissionAmyloid-beta precursor proteinHomo sapiens (human)
cytosolic mRNA polyadenylationAmyloid-beta precursor proteinHomo sapiens (human)
negative regulation of long-term synaptic potentiationAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of long-term synaptic potentiationAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transductionAmyloid-beta precursor proteinHomo sapiens (human)
cellular response to amyloid-betaAmyloid-beta precursor proteinHomo sapiens (human)
regulation of presynapse assemblyAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of amyloid fibril formationAmyloid-beta precursor proteinHomo sapiens (human)
amyloid fibril formationAmyloid-beta precursor proteinHomo sapiens (human)
neuron projection maintenanceAmyloid-beta precursor proteinHomo sapiens (human)
positive regulation of T cell migrationAmyloid-beta precursor proteinHomo sapiens (human)
central nervous system developmentAmyloid-beta precursor proteinHomo sapiens (human)
regulation of autophagyMicrotubule-associated protein tauHomo sapiens (human)
microtubule cytoskeleton organizationMicrotubule-associated protein tauHomo sapiens (human)
microglial cell activationMicrotubule-associated protein tauHomo sapiens (human)
internal protein amino acid acetylationMicrotubule-associated protein tauHomo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic processMicrotubule-associated protein tauHomo sapiens (human)
DNA damage responseMicrotubule-associated protein tauHomo sapiens (human)
cell-cell signalingMicrotubule-associated protein tauHomo sapiens (human)
memoryMicrotubule-associated protein tauHomo sapiens (human)
response to lead ionMicrotubule-associated protein tauHomo sapiens (human)
negative regulation of gene expressionMicrotubule-associated protein tauHomo sapiens (human)
negative regulation of mitochondrial membrane potentialMicrotubule-associated protein tauHomo sapiens (human)
rRNA metabolic processMicrotubule-associated protein tauHomo sapiens (human)
axonal transport of mitochondrionMicrotubule-associated protein tauHomo sapiens (human)
central nervous system neuron developmentMicrotubule-associated protein tauHomo sapiens (human)
regulation of microtubule polymerization or depolymerizationMicrotubule-associated protein tauHomo sapiens (human)
regulation of microtubule polymerizationMicrotubule-associated protein tauHomo sapiens (human)
positive regulation of microtubule polymerizationMicrotubule-associated protein tauHomo sapiens (human)
cytoplasmic microtubule organizationMicrotubule-associated protein tauHomo sapiens (human)
neuron projection developmentMicrotubule-associated protein tauHomo sapiens (human)
positive regulation of superoxide anion generationMicrotubule-associated protein tauHomo sapiens (human)
regulation of chromosome organizationMicrotubule-associated protein tauHomo sapiens (human)
negative regulation of kinase activityMicrotubule-associated protein tauHomo sapiens (human)
stress granule assemblyMicrotubule-associated protein tauHomo sapiens (human)
cellular response to heatMicrotubule-associated protein tauHomo sapiens (human)
cellular response to reactive oxygen speciesMicrotubule-associated protein tauHomo sapiens (human)
positive regulation of axon extensionMicrotubule-associated protein tauHomo sapiens (human)
microtubule polymerizationMicrotubule-associated protein tauHomo sapiens (human)
astrocyte activationMicrotubule-associated protein tauHomo sapiens (human)
regulation of synaptic plasticityMicrotubule-associated protein tauHomo sapiens (human)
intracellular distribution of mitochondriaMicrotubule-associated protein tauHomo sapiens (human)
generation of neuronsMicrotubule-associated protein tauHomo sapiens (human)
synapse organizationMicrotubule-associated protein tauHomo sapiens (human)
regulation of calcium-mediated signalingMicrotubule-associated protein tauHomo sapiens (human)
protein polymerizationMicrotubule-associated protein tauHomo sapiens (human)
axon developmentMicrotubule-associated protein tauHomo sapiens (human)
regulation of microtubule cytoskeleton organizationMicrotubule-associated protein tauHomo sapiens (human)
plus-end-directed organelle transport along microtubuleMicrotubule-associated protein tauHomo sapiens (human)
regulation of mitochondrial fissionMicrotubule-associated protein tauHomo sapiens (human)
negative regulation of mitochondrial fissionMicrotubule-associated protein tauHomo sapiens (human)
supramolecular fiber organizationMicrotubule-associated protein tauHomo sapiens (human)
axonal transportMicrotubule-associated protein tauHomo sapiens (human)
regulation of cellular response to heatMicrotubule-associated protein tauHomo sapiens (human)
regulation of long-term synaptic depressionMicrotubule-associated protein tauHomo sapiens (human)
positive regulation of protein localization to synapseMicrotubule-associated protein tauHomo sapiens (human)
neurofibrillary tangle assemblyMicrotubule-associated protein tauHomo sapiens (human)
negative regulation of establishment of protein localization to mitochondrionMicrotubule-associated protein tauHomo sapiens (human)
positive regulation of protein localizationMicrotubule-associated protein tauHomo sapiens (human)
negative regulation of tubulin deacetylationMicrotubule-associated protein tauHomo sapiens (human)
positive regulation of diacylglycerol kinase activityMicrotubule-associated protein tauHomo sapiens (human)
amyloid fibril formationMicrotubule-associated protein tauHomo sapiens (human)
cellular response to nerve growth factor stimulusMicrotubule-associated protein tauHomo sapiens (human)
cellular response to brain-derived neurotrophic factor stimulusMicrotubule-associated protein tauHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (33)

Processvia Protein(s)Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA bindingAmyloid-beta precursor proteinHomo sapiens (human)
DNA bindingAmyloid-beta precursor proteinHomo sapiens (human)
serine-type endopeptidase inhibitor activityAmyloid-beta precursor proteinHomo sapiens (human)
signaling receptor bindingAmyloid-beta precursor proteinHomo sapiens (human)
protein bindingAmyloid-beta precursor proteinHomo sapiens (human)
heparin bindingAmyloid-beta precursor proteinHomo sapiens (human)
enzyme bindingAmyloid-beta precursor proteinHomo sapiens (human)
identical protein bindingAmyloid-beta precursor proteinHomo sapiens (human)
transition metal ion bindingAmyloid-beta precursor proteinHomo sapiens (human)
receptor ligand activityAmyloid-beta precursor proteinHomo sapiens (human)
PTB domain bindingAmyloid-beta precursor proteinHomo sapiens (human)
protein serine/threonine kinase bindingAmyloid-beta precursor proteinHomo sapiens (human)
signaling receptor activator activityAmyloid-beta precursor proteinHomo sapiens (human)
DNA bindingMicrotubule-associated protein tauHomo sapiens (human)
minor groove of adenine-thymine-rich DNA bindingMicrotubule-associated protein tauHomo sapiens (human)
double-stranded DNA bindingMicrotubule-associated protein tauHomo sapiens (human)
single-stranded DNA bindingMicrotubule-associated protein tauHomo sapiens (human)
RNA bindingMicrotubule-associated protein tauHomo sapiens (human)
actin bindingMicrotubule-associated protein tauHomo sapiens (human)
protein bindingMicrotubule-associated protein tauHomo sapiens (human)
microtubule bindingMicrotubule-associated protein tauHomo sapiens (human)
SH3 domain bindingMicrotubule-associated protein tauHomo sapiens (human)
enzyme bindingMicrotubule-associated protein tauHomo sapiens (human)
protein kinase bindingMicrotubule-associated protein tauHomo sapiens (human)
protein-macromolecule adaptor activityMicrotubule-associated protein tauHomo sapiens (human)
apolipoprotein bindingMicrotubule-associated protein tauHomo sapiens (human)
dynactin bindingMicrotubule-associated protein tauHomo sapiens (human)
phosphatidylinositol bindingMicrotubule-associated protein tauHomo sapiens (human)
identical protein bindingMicrotubule-associated protein tauHomo sapiens (human)
sequence-specific DNA bindingMicrotubule-associated protein tauHomo sapiens (human)
protein-folding chaperone bindingMicrotubule-associated protein tauHomo sapiens (human)
protein phosphatase 2A bindingMicrotubule-associated protein tauHomo sapiens (human)
Hsp90 protein bindingMicrotubule-associated protein tauHomo sapiens (human)
lipoprotein particle bindingMicrotubule-associated protein tauHomo sapiens (human)
histone-dependent DNA bindingMicrotubule-associated protein tauHomo sapiens (human)
microtubule lateral bindingMicrotubule-associated protein tauHomo sapiens (human)
phosphatidylinositol bisphosphate bindingMicrotubule-associated protein tauHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (58)

Processvia Protein(s)Taxonomy
extracellular spaceAmyloid-beta precursor proteinHomo sapiens (human)
dendriteAmyloid-beta precursor proteinHomo sapiens (human)
extracellular regionAmyloid-beta precursor proteinHomo sapiens (human)
extracellular spaceAmyloid-beta precursor proteinHomo sapiens (human)
nuclear envelope lumenAmyloid-beta precursor proteinHomo sapiens (human)
cytoplasmAmyloid-beta precursor proteinHomo sapiens (human)
mitochondrial inner membraneAmyloid-beta precursor proteinHomo sapiens (human)
endosomeAmyloid-beta precursor proteinHomo sapiens (human)
early endosomeAmyloid-beta precursor proteinHomo sapiens (human)
endoplasmic reticulumAmyloid-beta precursor proteinHomo sapiens (human)
endoplasmic reticulum lumenAmyloid-beta precursor proteinHomo sapiens (human)
smooth endoplasmic reticulumAmyloid-beta precursor proteinHomo sapiens (human)
Golgi apparatusAmyloid-beta precursor proteinHomo sapiens (human)
Golgi lumenAmyloid-beta precursor proteinHomo sapiens (human)
Golgi-associated vesicleAmyloid-beta precursor proteinHomo sapiens (human)
cytosolAmyloid-beta precursor proteinHomo sapiens (human)
plasma membraneAmyloid-beta precursor proteinHomo sapiens (human)
clathrin-coated pitAmyloid-beta precursor proteinHomo sapiens (human)
cell-cell junctionAmyloid-beta precursor proteinHomo sapiens (human)
synaptic vesicleAmyloid-beta precursor proteinHomo sapiens (human)
cell surfaceAmyloid-beta precursor proteinHomo sapiens (human)
membraneAmyloid-beta precursor proteinHomo sapiens (human)
COPII-coated ER to Golgi transport vesicleAmyloid-beta precursor proteinHomo sapiens (human)
axonAmyloid-beta precursor proteinHomo sapiens (human)
growth coneAmyloid-beta precursor proteinHomo sapiens (human)
platelet alpha granule lumenAmyloid-beta precursor proteinHomo sapiens (human)
neuromuscular junctionAmyloid-beta precursor proteinHomo sapiens (human)
endosome lumenAmyloid-beta precursor proteinHomo sapiens (human)
trans-Golgi network membraneAmyloid-beta precursor proteinHomo sapiens (human)
ciliary rootletAmyloid-beta precursor proteinHomo sapiens (human)
dendritic spineAmyloid-beta precursor proteinHomo sapiens (human)
dendritic shaftAmyloid-beta precursor proteinHomo sapiens (human)
perikaryonAmyloid-beta precursor proteinHomo sapiens (human)
membrane raftAmyloid-beta precursor proteinHomo sapiens (human)
apical part of cellAmyloid-beta precursor proteinHomo sapiens (human)
synapseAmyloid-beta precursor proteinHomo sapiens (human)
perinuclear region of cytoplasmAmyloid-beta precursor proteinHomo sapiens (human)
presynaptic active zoneAmyloid-beta precursor proteinHomo sapiens (human)
spindle midzoneAmyloid-beta precursor proteinHomo sapiens (human)
recycling endosomeAmyloid-beta precursor proteinHomo sapiens (human)
extracellular exosomeAmyloid-beta precursor proteinHomo sapiens (human)
receptor complexAmyloid-beta precursor proteinHomo sapiens (human)
early endosomeAmyloid-beta precursor proteinHomo sapiens (human)
membrane raftAmyloid-beta precursor proteinHomo sapiens (human)
cell surfaceAmyloid-beta precursor proteinHomo sapiens (human)
Golgi apparatusAmyloid-beta precursor proteinHomo sapiens (human)
plasma membraneAmyloid-beta precursor proteinHomo sapiens (human)
microtubuleMicrotubule-associated protein tauHomo sapiens (human)
membraneMicrotubule-associated protein tauHomo sapiens (human)
extracellular regionMicrotubule-associated protein tauHomo sapiens (human)
nucleusMicrotubule-associated protein tauHomo sapiens (human)
cytoplasmMicrotubule-associated protein tauHomo sapiens (human)
mitochondrionMicrotubule-associated protein tauHomo sapiens (human)
cytosolMicrotubule-associated protein tauHomo sapiens (human)
plasma membraneMicrotubule-associated protein tauHomo sapiens (human)
microtubule cytoskeletonMicrotubule-associated protein tauHomo sapiens (human)
nuclear speckMicrotubule-associated protein tauHomo sapiens (human)
axonMicrotubule-associated protein tauHomo sapiens (human)
dendriteMicrotubule-associated protein tauHomo sapiens (human)
growth coneMicrotubule-associated protein tauHomo sapiens (human)
axolemmaMicrotubule-associated protein tauHomo sapiens (human)
nuclear peripheryMicrotubule-associated protein tauHomo sapiens (human)
cytoplasmic ribonucleoprotein granuleMicrotubule-associated protein tauHomo sapiens (human)
somatodendritic compartmentMicrotubule-associated protein tauHomo sapiens (human)
neuronal cell bodyMicrotubule-associated protein tauHomo sapiens (human)
dendritic spineMicrotubule-associated protein tauHomo sapiens (human)
cell bodyMicrotubule-associated protein tauHomo sapiens (human)
main axonMicrotubule-associated protein tauHomo sapiens (human)
membrane raftMicrotubule-associated protein tauHomo sapiens (human)
glial cell projectionMicrotubule-associated protein tauHomo sapiens (human)
neurofibrillary tangleMicrotubule-associated protein tauHomo sapiens (human)
axon cytoplasmMicrotubule-associated protein tauHomo sapiens (human)
tubulin complexMicrotubule-associated protein tauHomo sapiens (human)
neuron projectionMicrotubule-associated protein tauHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1186442Inhibition of His-tagged human brain tau 3R MBD aggregation after 16 hrs by thioflavin T fluorescence method2014European journal of medicinal chemistry, Oct-06, Volume: 85Development of dual targeting inhibitors against aggregations of amyloid-β and tau protein.
AID1186439Inhibition of amyloid beta (1-42) aggregation (unknown origin) after 24 hrs by thioflavin T fluorescence method2014European journal of medicinal chemistry, Oct-06, Volume: 85Development of dual targeting inhibitors against aggregations of amyloid-β and tau protein.
AID614077Displacement of Thioflavin S from synthetic Tau 2N4R aggregate by fluorescence assay at 10 uM probe concentration2011Bioorganic & medicinal chemistry, Sep-01, Volume: 19, Issue:17
Ligand polarizability contributes to tau fibril binding affinity.
AID614076Displacement of Thioflavin T from synthetic Tau 2N4R aggregate by fluorescence assay at 1 uM probe concentration2011Bioorganic & medicinal chemistry, Sep-01, Volume: 19, Issue:17
Ligand polarizability contributes to tau fibril binding affinity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (91)

TimeframeStudies, This Drug (%)All Drugs %
pre-199031 (34.07)18.7374
1990's16 (17.58)18.2507
2000's7 (7.69)29.6817
2010's32 (35.16)24.3611
2020's5 (5.49)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 42.49

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index42.49 (24.57)
Research Supply Index4.55 (2.92)
Research Growth Index5.20 (4.65)
Search Engine Demand Index59.80 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (42.49)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (2.13%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other92 (97.87%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]