Compounds > anisodine
Page last updated: 2024-09-25

anisodine

Description

anisodine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID123673
MeSH IDM0059074

Synonyms (2)

Synonym
anisodine
[(1r,2s,4r,5s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl] (2s)-2,3-dihydroxy-2-phenylpropanoate

Effects

ExcerptReference
"Anisodine has been reported to exert neuroprotective effects in cerebral ischemia/reperfusion (I/R) animal model."( Ao, H; Chen, D; Chen, Q; Liu, H; Peng, C; Wan, F; Xie, X; Zhang, S, 2017)

Research

Studies (51)

TimeframeStudies, This Drug (%)All Drugs %
pre-199020 (39.22)18.7374
1990's17 (33.33)18.2507
2000's6 (11.76)29.6817
2010's7 (13.73)24.3611
2020's1 (1.96)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (3.92%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other49 (96.08%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study To Evaluate The Efficacy, Safety, And Tolerability Of Anisodine Hydrobromide For The Preventive Treatment Of Episodic Migraine[NCT05416476]Phase 3288 participants (Anticipated)Interventional2023-09-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
aspartic acid[no description available]medium10aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
tiotropium bromide[no description available]medium10
anisodamine[no description available]medium140
scopolamine hydrobromide[no description available]medium140
atropine[no description available]medium100
endothelin-1[no description available]medium10
mannitol[no description available]medium10mannitolallergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent
cytidine diphosphate choline[no description available]medium10nucleotide-(amino alcohol)s;
phosphocholines		human metabolite;
mouse metabolite;
neuroprotective agent;
psychotropic drug;
Saccharomyces cerevisiae metabolite
cycloheximide[no description available]medium10antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
physostigmine[no description available]medium30carbamate ester;
indole alkaloid		antidote to curare poisoning;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic
arecoline[no description available]medium10enoate ester;
methyl ester;
pyridine alkaloid;
tetrahydropyridine		metabolite;
muscarinic agonist
chlorpromazine[no description available]medium20organochlorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug
hemicholinium 3[no description available]medium10
chloramphenicol[no description available]medium10C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
oxotremorine[no description available]medium10N-alkylpyrrolidine
morphine[no description available]medium10morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
hyaluronoglucosaminidase[no description available]medium10
lignans[no description available]medium20
clausenamide[no description available]medium20
tacrine[no description available]medium10acridines;
aromatic amine		EC 3.1.1.7 (acetylcholinesterase) inhibitor
clonidine[no description available]medium10clonidine;
imidazoline
phenylephrine[no description available]medium10phenols;
phenylethanolamines;
secondary amino compound		alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent
wb 4101[no description available]medium10aromatic ether;
benzodioxine;
secondary amino compound		alpha-adrenergic antagonist
dipalmitoylphosphatidic acid[no description available]medium10phosphatidic acid
sodium nitrite[no description available]medium10inorganic sodium salt;
nitrite salt		antidote to cyanide poisoning;
antihypertensive agent;
antimicrobial food preservative;
food antioxidant;
poison
nifedipine[no description available]medium10C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
vincamine[no description available]medium10alkaloid ester;
hemiaminal;
methyl ester;
organic heteropentacyclic compound;
vinca alkaloid		antihypertensive agent;
metabolite;
vasodilator agent
nimodipine[no description available]medium102-methoxyethyl ester;
C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
isopropyl ester		antihypertensive agent;
calcium channel blocker;
cardiovascular drug;
vasodilator agent
huperzine a[no description available]medium10quinolone
ConditionIndicatedRelationship StrengthStudiesTrials
Academic Disorder, Developmental0low10
Adult Learning Disabilities0low10
Adult Learning Disorders0low10
Age-Related Memory Disorders0medium41
Aging0low10
Amentia0low10
Amnesia0low30
Amnesia-Memory Loss0low30
Amnesia, Dissociative0low30
Amnesia, Global0low30
Amnesia, Hysterical0low30
Amnesia, Tactile0low30
Amnesia, Temporary0low30
Amnestic State0low30
Anoxemia0low10
Anoxia0low10
Anterior Choroidal Artery Infarction0low10
Anterior Circulation Transient Ischemic Attack0low20
Anterior Ischemic Optic Neuropathy0low10
Brain Embolism and Thrombosis0low10
Brain Ischemia0low10
Brain Stem Ischemia, Transient0low20
Brain Stem Transient Ischemic Attack0low20
Brain TIA0low20
Brainstem Ischemia, Transient0low20
Brainstem Transient Ischemic Attack0low20
Bruise0low30
Burns, Chemical0low10
Carotid Circulation Transient Ischemic Attack0low20
Cerebral Arteriosclerosis0low10
Cerebral Atherosclerosis0low10
Cerebral Embolism and Thrombosis0low10
Cerebral Infarct0low10
Cerebral Infarction0low10
Cerebral Infarction, Left Hemisphere0low10
Cerebral Infarction, Right Hemisphere0low10
Cerebral Ischemia0low10
Cerebral Ischemia, Transient0low20
Cerebral, Left Hemisphere, Infarction0low10
Cerebral, Right Hemisphere, Infarction0low10
Chemical Burns0low10
Chronic Primary Open Angle Glaucoma0medium11
Cicatrix0low10
Cicatrization0low10
Cognition Disorders0low10
Contusions0low30
Cranial Nerve II Injuries0low10
Crescendo Transient Ischemic Attacks0low20
Deficiency, Mental0medium11
Deficiency, Oxygen0low10
Dementia0low10
Developmental Academic Disability0low10
Developmental Academic Disorder0low10
Developmental Disabilities of Scholastic Skills0low10
Developmental Disorders of Scholastic Skills0low10
Disability, Intellectual0medium11
Disease Models, Animal0low10
Embolism and Thrombosis, Brain0low10
Encephalopathy, Ischemic0low10
Endotoxin Shock0low10
Eye Injuries0low30
Familial Dementia0low10
Gastric Ulcer0low10
Glaucoma Simplex0medium11
Glaucoma, Compensated0medium11
Glaucoma, Compensative0medium11
Glaucoma, Open Angle0medium11
Glaucoma, Open-Angle0medium11
Glaucoma, Pigmentary0medium11
Glaucoma, Primary Open Angle0medium11
Glaucoma, Secondary Open Angle0medium11
Glaucoma, Simple0medium11
Glaucoma, Suspect0low10
Hypertension, Ocular0low10
Hypoxemia0low10
Hypoxia0low10
Idiocy0medium11
Infarction, Cerebral0low10
Infarction, Cerebral, Left Hemisphere0low10
Infarction, Cerebral, Right Hemisphere0low10
Infarction, Left Hemisphere, Cerebral0low10
Infarction, Right Hemisphere, Cerebral0low10
Injuries, Eye0low30
Injury, Ischemia-Reperfusion0low10
Injury, Reperfusion0low10
Intellectual Development Disorder0medium11
Intellectual Disability0medium11
Intracranial Arteriosclerosis0low10
Intracranial Atherosclerosis0low10
Intracranial Embolism and Thrombosis0low10
Intraocular Pressure0low10
Ischemia-Reperfusion Injury0low10
Ischemia, Cerebral0low10
Ischemic Attack, Transient0low20
Ischemic Encephalopathy0low10
Ischemic Optic Neuropathy0low10
Learning Disabilities0low10
Learning Disorders0low10
Learning Disorders, Adult0low10
Learning Disturbance0low10
Left Hemisphere, Cerebral Infarction0low10
Left Hemisphere, Infarction, Cerebral0low10
Memory Deficits0medium41
Memory Disorder, Semantic0medium41
Memory Disorder, Spatial0medium41
Memory Disorders0medium41
Memory Disorders, Age-Related0medium41
Memory Loss0medium41
Mental Deficiency0medium11
Mental Retardation0medium11
Mental Retardation, Psychosocial0medium11
NAION0low10
Nonarteritic Anterior Ischemic Optic Neuropathy0low10
Ocular Hypertension0low10
Open-Angle Glaucoma0medium11
Optic Ischaemic Neuropathy0low10
Optic Ischemic Neuropathy0low10
Optic Nerve Avulsion0low10
Optic Nerve Contusion0low10
Optic Nerve Injuries0low10
Optic Nerve Ischemia0low10
Optic Nerve Transection0low10
Optic Nerve Trauma0low10
Optic Neuropathy, Anterior Ischemic0low10
Optic Neuropathy, Ischemic0low10
Optic Neuropathy, Posterior Ischemic0low10
Optic Neuropathy, Traumatic0low10
Overinclusion0low10
Oxygen Deficiency0low10
Posterior Choroidal Artery Infarction0low10
Posterior Circulation Transient Ischemic Attack0low20
Posterior Ischemic Optic Neuropathy0low10
Primary Open Angle Glaucoma0medium11
Reperfusion Damage0low10
Reperfusion Injury0low10
Retardation, Mental0medium11
Retention Disorders, Cognitive0medium41
Right Hemisphere, Cerebral Infarction0low10
Right Hemisphere, Infarction, Cerebral0low10
Scar0low10
Scarring0low10
Scars0low10
Scholastic Skills Development Disorders0low10
Second Cranial Nerve Injuries0low10
Second Cranial Nerve Trauma0low10
Secondary Open Angle Glaucoma0medium11
Semantic Memory Disorder0medium41
Senile Paranoid Dementia0low10
Sensitivity and Specificity0low30
Septic Shock0low10
Shock, Endotoxic0low10
Shock, Septic0low10
Shock, Toxic0low10
Spatial Memory Disorder0medium41
Stomach Ulcer0low10
Subcortical Infarction0low10
TIA (Transient Ischemic Attack)0low20
Toxic Shock0low10
Toxic Shock Syndrome0low10
Transient Ischemic Attack0low20
Transient Ischemic Attack, Anterior Circulation0low20
Transient Ischemic Attack, Brain Stem0low20
Transient Ischemic Attack, Brainstem0low20
Transient Ischemic Attack, Carotid Circulation0low20
Transient Ischemic Attack, Posterior Circulation0low20
Transient Ischemic Attack, Vertebrobasilar Circulation0low20
Transient Ischemic Attacks, Crescendo0low20
Trauma, Second Cranial Nerve0low10
Vertebrobasilar Circulation Transient Ischemic Attack0low20

Research Highlights

Pharmacokinetics (1)

ArticleYear
Comparative study on pharmacokinetics of a series of anticholinergics, atropine, anisodamine, anisodine, scopolamine and tiotropium in rats.
European journal of drug metabolism and pharmacokinetics, Volume: 40, Issue: 3		2015
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (1)

ArticleYear
Comparative study on pharmacokinetics of a series of anticholinergics, atropine, anisodamine, anisodine, scopolamine and tiotropium in rats.
European journal of drug metabolism and pharmacokinetics, Volume: 40, Issue: 3		2015
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (1)

ArticleYear
[Improving memory effects of eel oil capsule on memory obstruction of mice hurt by anisodine].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, Volume: 23, Issue: 4		2000
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (1)

ArticleYear
Efficacy of cytidine-5'-diphosp-bocholine combined with compound anisodine in the treatment of early optic nerve contusion.
Eye science, Volume: 27, Issue: 1		2012
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]