losartan has been researched along with Shock, Septic in 2 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of the present study was to elucidate the capability of losartan, a nonpeptide angiotensin II type 1 (AT1) receptor antagonist, to attenuate splanchnic blood flow disturbances and counteract intestinal mucosal acidosis in endotoxin shock." | 3.70 | Angiotensin II receptor antagonism increases gut oxygen delivery but fails to improve intestinal mucosal acidosis in porcine endotoxin shock. ( Alving, K; Oldner, A; Rudehill, A; Rundgren, M; Ullman, J; Wanecek, M; Weitzberg, E, 1999) |
| "Treatment with LOS improved lung injury in an endotoxin shock model system by an anti-inflammatory action that inhibits reduction of ACE2." | 1.35 | Antagonist of the type-1 ANG II receptor prevents against LPS-induced septic shock in rats. ( Hagiwara, S; Hasegawa, A; Hidaka, S; Iwasaka, H; Koga, H; Noguchi, T, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hagiwara, S | 1 |
| Iwasaka, H | 1 |
| Hidaka, S | 1 |
| Hasegawa, A | 1 |
| Koga, H | 1 |
| Noguchi, T | 1 |
| Oldner, A | 1 |
| Wanecek, M | 1 |
| Weitzberg, E | 1 |
| Rundgren, M | 1 |
| Alving, K | 1 |
| Ullman, J | 1 |
| Rudehill, A | 1 |
2 other studies available for losartan and Shock, Septic
| Article | Year |
|---|---|
Antagonist of the type-1 ANG II receptor prevents against LPS-induced septic shock in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cytokines; Enzyme-Linked Immunosorbent Assay; HMGB | 2009 |
Angiotensin II receptor antagonism increases gut oxygen delivery but fails to improve intestinal mucosal acidosis in porcine endotoxin shock.
Topics: Acidosis; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Dose-Response Relation | 1999 |