clonidine has been researched along with Shock, Septic in 13 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Presently, the most robust clinical evidence involves the use of the cardioselective β-blocker esmolol in patients with septic shock with persistent tachycardia secondary to catecholamine use." | 4.98 | Misdirected Sympathy: The Role of Sympatholysis in Sepsis and Septic Shock. ( Bissell, BD; Ferreira, JA, 2018) |
| "Nevertheless, refractory septic shock still carries a mortality close to 100%." | 2.52 | Pressor Response to Noradrenaline in the Setting of Septic Shock: Anything New under the Sun-Dexmedetomidine, Clonidine? A Minireview. ( Géloën, A; Ghignone, M; Julien, C; Leroy, S; May, CN; Pichot, C; Quintin, L, 2015) |
| "During septic shock, vasopressors are a cornerstone of therapy." | 1.39 | Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study. ( Chapelier, K; Cividjian, A; Dantony, E; Geloen, A; May, CN; Quintin, L; Rabilloud, M, 2013) |
| " However, vasoconstriction due to clonidine post-ENDT even at maximal dosage (10(-3) M), was greatly attenuated in all four branching orders as in group II." | 1.29 | Attenuation of arteriolar alpha 2-adrenoceptor sensitivity during endotoxemia. ( Baker, CH; Nessellroth, S; Ortiz-Tweed, M; Price, JM; Sutton, ET, 1994) |
| "Alinidine is a recently developed antiarrhythmic medication that acts directly on the cardiac pacemaker cells to reduce heart rate (HR)." | 1.28 | Addition of alinidine, a specific bradycardic agent, to dobutamine in a canine model of endotoxic shock. ( Moulart, D; Preiser, JC; Vincent, JL, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferreira, J | 1 |
| Geloen, A | 3 |
| Chapelier, K | 1 |
| Cividjian, A | 1 |
| Dantony, E | 1 |
| Rabilloud, M | 1 |
| May, CN | 2 |
| Quintin, L | 4 |
| Dünser, MW | 1 |
| Gradwohl-Matis, I | 1 |
| Pichot, C | 2 |
| Leroy, S | 2 |
| Julien, C | 1 |
| Ghignone, M | 2 |
| Aladin, L | 1 |
| Laplace, C | 1 |
| Jalem, S | 1 |
| Rosenthal, JM | 1 |
| Abrial, A | 1 |
| Ferreira, JA | 1 |
| Bissell, BD | 1 |
| Mathern, P | 1 |
| Khettab, F | 1 |
| Cheng, ZQ | 1 |
| Bose, D | 1 |
| Jacobs, H | 1 |
| Light, RB | 1 |
| Mink, SN | 1 |
| Zaloga, GP | 1 |
| Hostinsky, C | 1 |
| Chernow, B | 1 |
| Baker, CH | 1 |
| Sutton, ET | 1 |
| Price, JM | 1 |
| Ortiz-Tweed, M | 1 |
| Nessellroth, S | 1 |
| Dodd-o, JM | 1 |
| Breslow, MJ | 1 |
| Dorman, T | 1 |
| Rosenfeld, BA | 1 |
| Hikasa, Y | 1 |
| Fukui, H | 1 |
| Sato, Y | 1 |
| Ogasawara, S | 1 |
| Matsuda, H | 1 |
| Preiser, JC | 1 |
| Moulart, D | 1 |
| Vincent, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dexmedetomidine Improve Microcirculatory Alterations in Initial Resuscitated Septic Shock Patients[NCT02270281] | Phase 4 | 44 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| Low-Dose Dexmedetomidine for Delirium Prevention in Mechanically Ventilated Septic Patients in Intensive Care Unit: a Multi-Center, Randomized, Double-Blind, Placebo-Controlled Trial[NCT04876937] | 116 participants (Anticipated) | Interventional | 2021-05-28 | Recruiting | |||
| A Pilot Study to Quantify the Autonomic Nervous System Balance in Healthy, Able-Bodied Individuals[NCT04100486] | 48 participants (Anticipated) | Observational | 2019-08-29 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for clonidine and Shock, Septic
| Article | Year |
|---|---|
The Theory is Out There: The Use of ALPHA-2 Agonists in Treatment of Septic Shock.
Topics: Adrenergic alpha-2 Receptor Agonists; Clonidine; Dexmedetomidine; Humans; Shock, Septic | 2018 |
Pressor Response to Noradrenaline in the Setting of Septic Shock: Anything New under the Sun-Dexmedetomidine, Clonidine? A Minireview.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Dexmedetomidine; Humans; Inflammation; Mul | 2015 |
Misdirected Sympathy: The Role of Sympatholysis in Sepsis and Septic Shock.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Animals; Catecholamine | 2018 |
Endogenous opioid peptides: critical care implications.
Topics: Animals; Body Temperature Regulation; Cardiovascular System; Clonidine; Endorphins; Halothane; Human | 1984 |
9 other studies available for clonidine and Shock, Septic
| Article | Year |
|---|---|
Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arterial Pressure; Clonidine; Dexmedetomidine; Hypote | 2013 |
Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arterial Pressure; Clonidine; Dexmedetomidine; Hypote | 2013 |
Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arterial Pressure; Clonidine; Dexmedetomidine; Hypote | 2013 |
Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arterial Pressure; Clonidine; Dexmedetomidine; Hypote | 2013 |
α(2)-agonists to restore adrenergic vasoconstrictor responsiveness in septic shock: thinking outside of the box or fishing in the wrong pond?
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arterial Pressure; Clonidine; Dexmedetomidine; Hypote | 2013 |
Introduction of a centrally anti-hypertensive, clonidine, reduces noradrenaline requirements in septic shock caused by necrotizing enterocolitis.
Topics: Antihypertensive Agents; Clonidine; Enterocolitis, Necrotizing; Female; Humans; Infant, Newborn; Inf | 2017 |
Increased pressor response to noradrenaline during septic shock following clonidine?
Topics: Adrenergic alpha-Agonists; Blood Pressure; Clonidine; Drug Interactions; Humans; Male; Middle Aged; | 2010 |
Sepsis causes presynaptic histamine H3 and alpha2-adrenergic dysfunction in canine myocardium.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Clonidine; Culture Techniques; Dogs; GT | 2002 |
Attenuation of arteriolar alpha 2-adrenoceptor sensitivity during endotoxemia.
Topics: Animals; Arterioles; Clonidine; Dioxanes; Endotoxins; Escherichia coli; Idazoxan; Male; Muscles; Phe | 1994 |
Preserved sympathetic response to hypotension despite perioperative alpha2 agonist administration.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Clonidine; Epinephrine; Humans; Hypotension; Intra | 1997 |
Platelet and brain alpha 2-adrenoceptors and cardiovascular sensitivity to agonists in dogs suffering from endotoxic shock.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; An | 1998 |
Addition of alinidine, a specific bradycardic agent, to dobutamine in a canine model of endotoxic shock.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Clonidine; Disease Models, Animal; Dobutamine | 1992 |