gw9662 has been researched along with Shock--Septic* in 1 studies
1 other study(ies) available for gw9662 and Shock--Septic
Article | Year |
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Endogenous ligands of PPAR-gamma reduce the liver injury in haemorrhagic shock.
We demonstrate here for the first time that the novel, potent peroxisome proliferator-activated receptor (PPAR)-gamma antagonist GW9662 (2-chloro-5-nitrobenzanilide) augments the degree of liver injury associated with haemorrhagic (haemorrhage for 90 min and resuscitation for 4 h), but not endotoxic (6 mg/kg E. coli endotoxin i.v. for 6 h) shock in the anaesthetised rat. Thus, endogenous ligands for PPAR-gamma are released in haemorrhagic, but not endotoxic, shock in sufficient amounts to protect against injury. Topics: Anilides; Animals; Endotoxins; Escherichia coli; Ligands; Liver Diseases; Male; PPAR gamma; Rats; Rats, Wistar; Shock, Hemorrhagic; Shock, Septic | 2004 |