gw9662 and Shock--Septic

gw9662 has been researched along with Shock--Septic* in 1 studies

Other Studies

1 other study(ies) available for gw9662 and Shock--Septic

Article	Year
Endogenous ligands of PPAR-gamma reduce the liver injury in haemorrhagic shock. European journal of pharmacology, 2004, Feb-20, Volume: 486, Issue:2 We demonstrate here for the first time that the novel, potent peroxisome proliferator-activated receptor (PPAR)-gamma antagonist GW9662 (2-chloro-5-nitrobenzanilide) augments the degree of liver injury associated with haemorrhagic (haemorrhage for 90 min and resuscitation for 4 h), but not endotoxic (6 mg/kg E. coli endotoxin i.v. for 6 h) shock in the anaesthetised rat. Thus, endogenous ligands for PPAR-gamma are released in haemorrhagic, but not endotoxic, shock in sufficient amounts to protect against injury. Topics: Anilides; Animals; Endotoxins; Escherichia coli; Ligands; Liver Diseases; Male; PPAR gamma; Rats; Rats, Wistar; Shock, Hemorrhagic; Shock, Septic	2004

Article

Year

Endogenous ligands of PPAR-gamma reduce the liver injury in haemorrhagic shock.

European journal of pharmacology, 2004, Feb-20, Volume: 486, Issue:2

We demonstrate here for the first time that the novel, potent peroxisome proliferator-activated receptor (PPAR)-gamma antagonist GW9662 (2-chloro-5-nitrobenzanilide) augments the degree of liver injury associated with haemorrhagic (haemorrhage for 90 min and resuscitation for 4 h), but not endotoxic (6 mg/kg E. coli endotoxin i.v. for 6 h) shock in the anaesthetised rat. Thus, endogenous ligands for PPAR-gamma are released in haemorrhagic, but not endotoxic, shock in sufficient amounts to protect against injury.

Topics: Anilides; Animals; Endotoxins; Escherichia coli; Ligands; Liver Diseases; Male; PPAR gamma; Rats; Rats, Wistar; Shock, Hemorrhagic; Shock, Septic

2004