Page last updated: 2024-12-09

n(6)-(1-iminoethyl)lysine

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Description

N(6)-acetimidoyl-L-lysine : An L-lysine derivative that is L-lysine in which one of the hydrogens attached to N(6) is substituted by an acetimidoyl group [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID2733506
CHEMBL ID7889
CHEBI ID63971
SCHEMBL ID322091
MeSH IDM0239547

Synonyms (44)

Synonym
lopac-i-8021
NCGC00015566-01 ,
tocris-1139
NCGC00025026-01
IEL ,
n~6~-[(1z)-ethanimidoyl]-l-lysine
n6-ethanimidoyl-l-lysine
n-(iminoethyl)-l-lysine
l-nil
n6-(1-iminoethyl)-l-lysine
chebi:63971 ,
CHEMBL7889 ,
l-n6-(1-iminoethyl)lysine
bdbm50063300
(l-n6-1-iminoethyl)lysine
(s)-6-acetimidoylamino-2-amino-hexanoic acid
6-acetimidoylamino-2-amino-hexanoic acid
(2s)-2-amino-6-(1-aminoethylideneamino)hexanoic acid
AKOS006237613
l-n(omega)-(1-iminoethyl)lysine
l-n(6)-(1-iminoethyl)lysine
n(6)-acetimidoyl-l-lysine
n(6)-acetimidoyllysine
n(6)-ethanimidoyl-l-lysine
SCHEMBL322091
CS-7870
l-lysine,n6-(1-iminoethyl)-
DTXSID9041071
53774-63-3
h-lys(acetimidoyl)-oh
mfcd00792818
HY-12116
l-lysine, n6-(1-iminoethyl)-
6-acetimidamido-2-aminohexanoic acid
n-(5-amino-5-carboxypentyl)-acetamidine
(s)-6-acetimidamido-2-aminohexanoic acid
Q27132940
MS-23013
g5qa32xvn5 ,
epsilon-acetimidoyllysine
n-iminoethyl-l-lysine
lnil
unii-g5qa32xvn5
.epsilon.-acetimidoyllysine
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
L-lysine derivativeA proteinogenic amino acid derivative resulting from reaction of L-lysine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-lysine by a heteroatom.
non-proteinogenic L-alpha-amino acidAny L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (25)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
thyroid stimulating hormone receptorHomo sapiens (human)Potency5.01190.001318.074339.8107AID926
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency1.99530.031610.279239.8107AID884; AID885
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
GABA theta subunitRattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency1.99531.000012.224831.6228AID885
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Neutrophil elastaseHomo sapiens (human)IC50 (µMol)2.40000.00632.073422.3780AID85322
Nitric oxide synthase, endothelialHomo sapiens (human)IC50 (µMol)40.69090.07202.58738.7000AID241071; AID241215; AID316793; AID607321; AID67995; AID68131; AID68135; AID68136; AID68141; AID68162; AID85322
Nitric oxide synthase, brainHomo sapiens (human)IC50 (µMol)28.11590.03502.711910.0000AID146105; AID146109; AID146115; AID146117; AID146120; AID146414; AID240945; AID241124; AID316794; AID607322
Nitric oxide synthase, inducibleMus musculus (house mouse)IC50 (µMol)3.30000.00103.39119.6000AID92167
Nitric oxide synthase, inducibleMus musculus (house mouse)Ki2.16000.00522.01424.2800AID147247
Nitric oxide synthase, inducibleHomo sapiens (human)IC50 (µMol)36,158.18590.00022.319010.0000AID240996; AID241153; AID316792; AID316797; AID53921; AID53933; AID607320; AID91992; AID92001; AID92004; AID92005; AID92009; AID92304
Collagenase 3Homo sapiens (human)IC50 (µMol)2.40000.00000.767510.0000AID85322
Nitric oxide synthase, inducibleRattus norvegicus (Norway rat)IC50 (µMol)92.00002.20002.20002.2000AID92181
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Nitric oxide synthase, endothelialHomo sapiens (human)Ratio3.70001.20002.45003.7000AID243012
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (118)

Processvia Protein(s)Taxonomy
proteolysisNeutrophil elastaseHomo sapiens (human)
negative regulation of transcription by RNA polymerase IINeutrophil elastaseHomo sapiens (human)
response to yeastNeutrophil elastaseHomo sapiens (human)
leukocyte migration involved in inflammatory responseNeutrophil elastaseHomo sapiens (human)
biosynthetic process of antibacterial peptides active against Gram-negative bacteriaNeutrophil elastaseHomo sapiens (human)
proteolysisNeutrophil elastaseHomo sapiens (human)
intracellular calcium ion homeostasisNeutrophil elastaseHomo sapiens (human)
response to UVNeutrophil elastaseHomo sapiens (human)
extracellular matrix disassemblyNeutrophil elastaseHomo sapiens (human)
protein catabolic processNeutrophil elastaseHomo sapiens (human)
response to lipopolysaccharideNeutrophil elastaseHomo sapiens (human)
negative regulation of chemokine productionNeutrophil elastaseHomo sapiens (human)
negative regulation of interleukin-8 productionNeutrophil elastaseHomo sapiens (human)
positive regulation of interleukin-8 productionNeutrophil elastaseHomo sapiens (human)
defense response to bacteriumNeutrophil elastaseHomo sapiens (human)
positive regulation of MAP kinase activityNeutrophil elastaseHomo sapiens (human)
positive regulation of smooth muscle cell proliferationNeutrophil elastaseHomo sapiens (human)
negative regulation of inflammatory responseNeutrophil elastaseHomo sapiens (human)
positive regulation of immune responseNeutrophil elastaseHomo sapiens (human)
negative regulation of chemotaxisNeutrophil elastaseHomo sapiens (human)
pyroptosisNeutrophil elastaseHomo sapiens (human)
neutrophil-mediated killing of gram-negative bacteriumNeutrophil elastaseHomo sapiens (human)
neutrophil-mediated killing of fungusNeutrophil elastaseHomo sapiens (human)
positive regulation of leukocyte tethering or rollingNeutrophil elastaseHomo sapiens (human)
phagocytosisNeutrophil elastaseHomo sapiens (human)
acute inflammatory response to antigenic stimulusNeutrophil elastaseHomo sapiens (human)
positive regulation of gene expressionNitric oxide synthase, endothelialHomo sapiens (human)
angiogenesisNitric oxide synthase, endothelialHomo sapiens (human)
ovulation from ovarian follicleNitric oxide synthase, endothelialHomo sapiens (human)
in utero embryonic developmentNitric oxide synthase, endothelialHomo sapiens (human)
blood vessel remodelingNitric oxide synthase, endothelialHomo sapiens (human)
regulation of sodium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
regulation of the force of heart contraction by chemical signalNitric oxide synthase, endothelialHomo sapiens (human)
regulation of systemic arterial blood pressure by endothelinNitric oxide synthase, endothelialHomo sapiens (human)
aortic valve morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
pulmonary valve morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
endocardial cushion morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
arginine catabolic processNitric oxide synthase, endothelialHomo sapiens (human)
nitric oxide biosynthetic processNitric oxide synthase, endothelialHomo sapiens (human)
potassium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
calcium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
mitochondrion organizationNitric oxide synthase, endothelialHomo sapiens (human)
regulation of blood pressureNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of cell population proliferationNitric oxide synthase, endothelialHomo sapiens (human)
response to heatNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of platelet activationNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of muscle hyperplasiaNitric oxide synthase, endothelialHomo sapiens (human)
smooth muscle hyperplasiaNitric oxide synthase, endothelialHomo sapiens (human)
removal of superoxide radicalsNitric oxide synthase, endothelialHomo sapiens (human)
lung developmentNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of guanylate cyclase activityNitric oxide synthase, endothelialHomo sapiens (human)
regulation of nervous system processNitric oxide synthase, endothelialHomo sapiens (human)
lipopolysaccharide-mediated signaling pathwayNitric oxide synthase, endothelialHomo sapiens (human)
response to fluid shear stressNitric oxide synthase, endothelialHomo sapiens (human)
vasodilationNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of potassium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of blood vessel endothelial cell migrationNitric oxide synthase, endothelialHomo sapiens (human)
endothelial cell migrationNitric oxide synthase, endothelialHomo sapiens (human)
cell redox homeostasisNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of Notch signaling pathwayNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of angiogenesisNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of smooth muscle cell proliferationNitric oxide synthase, endothelialHomo sapiens (human)
homeostasis of number of cells within a tissueNitric oxide synthase, endothelialHomo sapiens (human)
establishment of localization in cellNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of calcium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
ventricular septum morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of biomineral tissue developmentNitric oxide synthase, endothelialHomo sapiens (human)
blood vessel diameter maintenanceNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsNitric oxide synthase, endothelialHomo sapiens (human)
nitric oxide mediated signal transductionNitric oxide synthase, endothelialHomo sapiens (human)
response to hormoneNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of blood pressureNitric oxide synthase, endothelialHomo sapiens (human)
response to lipopolysaccharideNitric oxide synthase, endothelialHomo sapiens (human)
response to hypoxiaNitric oxide synthase, brainHomo sapiens (human)
regulation of sodium ion transportNitric oxide synthase, brainHomo sapiens (human)
arginine catabolic processNitric oxide synthase, brainHomo sapiens (human)
nitric oxide biosynthetic processNitric oxide synthase, brainHomo sapiens (human)
striated muscle contractionNitric oxide synthase, brainHomo sapiens (human)
myoblast fusionNitric oxide synthase, brainHomo sapiens (human)
response to heatNitric oxide synthase, brainHomo sapiens (human)
negative regulation of calcium ion transport into cytosolNitric oxide synthase, brainHomo sapiens (human)
regulation of cardiac muscle contraction by calcium ion signalingNitric oxide synthase, brainHomo sapiens (human)
peptidyl-cysteine S-nitrosylationNitric oxide synthase, brainHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylationNitric oxide synthase, brainHomo sapiens (human)
multicellular organismal response to stressNitric oxide synthase, brainHomo sapiens (human)
xenobiotic catabolic processNitric oxide synthase, brainHomo sapiens (human)
vasodilationNitric oxide synthase, brainHomo sapiens (human)
negative regulation of potassium ion transportNitric oxide synthase, brainHomo sapiens (human)
cell redox homeostasisNitric oxide synthase, brainHomo sapiens (human)
positive regulation of DNA-templated transcriptionNitric oxide synthase, brainHomo sapiens (human)
positive regulation of transcription by RNA polymerase IINitric oxide synthase, brainHomo sapiens (human)
negative regulation of hydrolase activityNitric oxide synthase, brainHomo sapiens (human)
negative regulation of serotonin uptakeNitric oxide synthase, brainHomo sapiens (human)
negative regulation of calcium ion transportNitric oxide synthase, brainHomo sapiens (human)
regulation of cardiac muscle contractionNitric oxide synthase, brainHomo sapiens (human)
regulation of ryanodine-sensitive calcium-release channel activityNitric oxide synthase, brainHomo sapiens (human)
cellular response to growth factor stimulusNitric oxide synthase, brainHomo sapiens (human)
positive regulation of the force of heart contractionNitric oxide synthase, brainHomo sapiens (human)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayNitric oxide synthase, brainHomo sapiens (human)
positive regulation of sodium ion transmembrane transportNitric oxide synthase, brainHomo sapiens (human)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channelNitric oxide synthase, brainHomo sapiens (human)
positive regulation of membrane repolarization during ventricular cardiac muscle cell action potentialNitric oxide synthase, brainHomo sapiens (human)
positive regulation of guanylate cyclase activityNitric oxide synthase, brainHomo sapiens (human)
nitric oxide mediated signal transductionNitric oxide synthase, brainHomo sapiens (human)
response to hormoneNitric oxide synthase, brainHomo sapiens (human)
negative regulation of blood pressureNitric oxide synthase, brainHomo sapiens (human)
response to lipopolysaccharideNitric oxide synthase, brainHomo sapiens (human)
response to hypoxiaNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of leukocyte mediated cytotoxicityNitric oxide synthase, inducibleHomo sapiens (human)
innate immune response in mucosaNitric oxide synthase, inducibleHomo sapiens (human)
arginine catabolic processNitric oxide synthase, inducibleHomo sapiens (human)
superoxide metabolic processNitric oxide synthase, inducibleHomo sapiens (human)
nitric oxide biosynthetic processNitric oxide synthase, inducibleHomo sapiens (human)
circadian rhythmNitric oxide synthase, inducibleHomo sapiens (human)
response to bacteriumNitric oxide synthase, inducibleHomo sapiens (human)
negative regulation of gene expressionNitric oxide synthase, inducibleHomo sapiens (human)
peptidyl-cysteine S-nitrosylationNitric oxide synthase, inducibleHomo sapiens (human)
prostaglandin secretionNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of interleukin-6 productionNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of interleukin-8 productionNitric oxide synthase, inducibleHomo sapiens (human)
regulation of cell population proliferationNitric oxide synthase, inducibleHomo sapiens (human)
negative regulation of protein catabolic processNitric oxide synthase, inducibleHomo sapiens (human)
defense response to bacteriumNitric oxide synthase, inducibleHomo sapiens (human)
regulation of cellular respirationNitric oxide synthase, inducibleHomo sapiens (human)
cell redox homeostasisNitric oxide synthase, inducibleHomo sapiens (human)
regulation of insulin secretionNitric oxide synthase, inducibleHomo sapiens (human)
defense response to Gram-negative bacteriumNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of killing of cells of another organismNitric oxide synthase, inducibleHomo sapiens (human)
cellular response to lipopolysaccharideNitric oxide synthase, inducibleHomo sapiens (human)
cellular response to type II interferonNitric oxide synthase, inducibleHomo sapiens (human)
cellular response to xenobiotic stimulusNitric oxide synthase, inducibleHomo sapiens (human)
regulation of cytokine production involved in inflammatory responseNitric oxide synthase, inducibleHomo sapiens (human)
negative regulation of blood pressureNitric oxide synthase, inducibleHomo sapiens (human)
response to hormoneNitric oxide synthase, inducibleHomo sapiens (human)
nitric oxide mediated signal transductionNitric oxide synthase, inducibleHomo sapiens (human)
response to lipopolysaccharideNitric oxide synthase, inducibleHomo sapiens (human)
inflammatory responseNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of guanylate cyclase activityNitric oxide synthase, inducibleHomo sapiens (human)
endochondral ossificationCollagenase 3Homo sapiens (human)
growth plate cartilage developmentCollagenase 3Homo sapiens (human)
proteolysisCollagenase 3Homo sapiens (human)
extracellular matrix disassemblyCollagenase 3Homo sapiens (human)
bone mineralizationCollagenase 3Homo sapiens (human)
collagen catabolic processCollagenase 3Homo sapiens (human)
bone morphogenesisCollagenase 3Homo sapiens (human)
response to amyloid-betaCollagenase 3Homo sapiens (human)
extracellular matrix organizationCollagenase 3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (29)

Processvia Protein(s)Taxonomy
protease bindingNeutrophil elastaseHomo sapiens (human)
transcription corepressor activityNeutrophil elastaseHomo sapiens (human)
endopeptidase activityNeutrophil elastaseHomo sapiens (human)
serine-type endopeptidase activityNeutrophil elastaseHomo sapiens (human)
protein bindingNeutrophil elastaseHomo sapiens (human)
heparin bindingNeutrophil elastaseHomo sapiens (human)
peptidase activityNeutrophil elastaseHomo sapiens (human)
cytokine bindingNeutrophil elastaseHomo sapiens (human)
actin monomer bindingNitric oxide synthase, endothelialHomo sapiens (human)
nitric-oxide synthase activityNitric oxide synthase, endothelialHomo sapiens (human)
protein bindingNitric oxide synthase, endothelialHomo sapiens (human)
calmodulin bindingNitric oxide synthase, endothelialHomo sapiens (human)
FMN bindingNitric oxide synthase, endothelialHomo sapiens (human)
heme bindingNitric oxide synthase, endothelialHomo sapiens (human)
tetrahydrobiopterin bindingNitric oxide synthase, endothelialHomo sapiens (human)
arginine bindingNitric oxide synthase, endothelialHomo sapiens (human)
cadmium ion bindingNitric oxide synthase, endothelialHomo sapiens (human)
flavin adenine dinucleotide bindingNitric oxide synthase, endothelialHomo sapiens (human)
NADP bindingNitric oxide synthase, endothelialHomo sapiens (human)
scaffold protein bindingNitric oxide synthase, endothelialHomo sapiens (human)
nitric-oxide synthase activityNitric oxide synthase, brainHomo sapiens (human)
calcium channel regulator activityNitric oxide synthase, brainHomo sapiens (human)
protein bindingNitric oxide synthase, brainHomo sapiens (human)
calmodulin bindingNitric oxide synthase, brainHomo sapiens (human)
FMN bindingNitric oxide synthase, brainHomo sapiens (human)
sodium channel regulator activityNitric oxide synthase, brainHomo sapiens (human)
heme bindingNitric oxide synthase, brainHomo sapiens (human)
tetrahydrobiopterin bindingNitric oxide synthase, brainHomo sapiens (human)
arginine bindingNitric oxide synthase, brainHomo sapiens (human)
transmembrane transporter bindingNitric oxide synthase, brainHomo sapiens (human)
cadmium ion bindingNitric oxide synthase, brainHomo sapiens (human)
calcium-dependent protein bindingNitric oxide synthase, brainHomo sapiens (human)
flavin adenine dinucleotide bindingNitric oxide synthase, brainHomo sapiens (human)
NADP bindingNitric oxide synthase, brainHomo sapiens (human)
scaffold protein bindingNitric oxide synthase, brainHomo sapiens (human)
nitric-oxide synthase activityNitric oxide synthase, inducibleHomo sapiens (human)
protein bindingNitric oxide synthase, inducibleHomo sapiens (human)
calmodulin bindingNitric oxide synthase, inducibleHomo sapiens (human)
FMN bindingNitric oxide synthase, inducibleHomo sapiens (human)
heme bindingNitric oxide synthase, inducibleHomo sapiens (human)
tetrahydrobiopterin bindingNitric oxide synthase, inducibleHomo sapiens (human)
arginine bindingNitric oxide synthase, inducibleHomo sapiens (human)
protein homodimerization activityNitric oxide synthase, inducibleHomo sapiens (human)
metal ion bindingNitric oxide synthase, inducibleHomo sapiens (human)
flavin adenine dinucleotide bindingNitric oxide synthase, inducibleHomo sapiens (human)
NADP bindingNitric oxide synthase, inducibleHomo sapiens (human)
endopeptidase activityCollagenase 3Homo sapiens (human)
metalloendopeptidase activityCollagenase 3Homo sapiens (human)
serine-type endopeptidase activityCollagenase 3Homo sapiens (human)
calcium ion bindingCollagenase 3Homo sapiens (human)
collagen bindingCollagenase 3Homo sapiens (human)
zinc ion bindingCollagenase 3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (35)

Processvia Protein(s)Taxonomy
extracellular regionNeutrophil elastaseHomo sapiens (human)
extracellular spaceNeutrophil elastaseHomo sapiens (human)
cytoplasmNeutrophil elastaseHomo sapiens (human)
cytosolNeutrophil elastaseHomo sapiens (human)
cell surfaceNeutrophil elastaseHomo sapiens (human)
secretory granuleNeutrophil elastaseHomo sapiens (human)
azurophil granule lumenNeutrophil elastaseHomo sapiens (human)
specific granule lumenNeutrophil elastaseHomo sapiens (human)
phagocytic vesicleNeutrophil elastaseHomo sapiens (human)
collagen-containing extracellular matrixNeutrophil elastaseHomo sapiens (human)
extracellular exosomeNeutrophil elastaseHomo sapiens (human)
transcription repressor complexNeutrophil elastaseHomo sapiens (human)
extracellular spaceNeutrophil elastaseHomo sapiens (human)
plasma membraneGamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)
Golgi membraneNitric oxide synthase, endothelialHomo sapiens (human)
nucleusNitric oxide synthase, endothelialHomo sapiens (human)
cytoplasmNitric oxide synthase, endothelialHomo sapiens (human)
Golgi apparatusNitric oxide synthase, endothelialHomo sapiens (human)
cytosolNitric oxide synthase, endothelialHomo sapiens (human)
cytoskeletonNitric oxide synthase, endothelialHomo sapiens (human)
plasma membraneNitric oxide synthase, endothelialHomo sapiens (human)
caveolaNitric oxide synthase, endothelialHomo sapiens (human)
endocytic vesicle membraneNitric oxide synthase, endothelialHomo sapiens (human)
nucleusNitric oxide synthase, endothelialHomo sapiens (human)
plasma membraneNitric oxide synthase, endothelialHomo sapiens (human)
cytosolNitric oxide synthase, endothelialHomo sapiens (human)
photoreceptor inner segmentNitric oxide synthase, brainHomo sapiens (human)
nucleoplasmNitric oxide synthase, brainHomo sapiens (human)
cytoplasmNitric oxide synthase, brainHomo sapiens (human)
mitochondrionNitric oxide synthase, brainHomo sapiens (human)
cytosolNitric oxide synthase, brainHomo sapiens (human)
cytoskeletonNitric oxide synthase, brainHomo sapiens (human)
plasma membraneNitric oxide synthase, brainHomo sapiens (human)
sarcoplasmic reticulumNitric oxide synthase, brainHomo sapiens (human)
sarcolemmaNitric oxide synthase, brainHomo sapiens (human)
dendritic spineNitric oxide synthase, brainHomo sapiens (human)
membrane raftNitric oxide synthase, brainHomo sapiens (human)
synapseNitric oxide synthase, brainHomo sapiens (human)
perinuclear region of cytoplasmNitric oxide synthase, brainHomo sapiens (human)
cell peripheryNitric oxide synthase, brainHomo sapiens (human)
protein-containing complexNitric oxide synthase, brainHomo sapiens (human)
plasma membraneNitric oxide synthase, brainHomo sapiens (human)
postsynaptic densityNitric oxide synthase, brainHomo sapiens (human)
cytosolNitric oxide synthase, brainHomo sapiens (human)
nucleusNitric oxide synthase, brainHomo sapiens (human)
nucleusNitric oxide synthase, inducibleHomo sapiens (human)
nucleoplasmNitric oxide synthase, inducibleHomo sapiens (human)
cytoplasmNitric oxide synthase, inducibleHomo sapiens (human)
peroxisomeNitric oxide synthase, inducibleHomo sapiens (human)
peroxisomal matrixNitric oxide synthase, inducibleHomo sapiens (human)
cytosolNitric oxide synthase, inducibleHomo sapiens (human)
cortical cytoskeletonNitric oxide synthase, inducibleHomo sapiens (human)
perinuclear region of cytoplasmNitric oxide synthase, inducibleHomo sapiens (human)
plasma membraneNitric oxide synthase, inducibleHomo sapiens (human)
nucleusNitric oxide synthase, inducibleHomo sapiens (human)
cytosolNitric oxide synthase, inducibleHomo sapiens (human)
extracellular regionCollagenase 3Homo sapiens (human)
extracellular matrixCollagenase 3Homo sapiens (human)
extracellular spaceCollagenase 3Homo sapiens (human)
plasma membraneGamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)
plasma membraneGamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (78)

Assay IDTitleYearJournalArticle
AID146414Inhibition concentration against Neuronal nitric oxide synthase (nNOS) at 10 uM concentration2004Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4
5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.
AID92005Inhibitory activity against human inducible nitric oxide synthase1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.
AID92009In vitro inhibition of human Inducible nitric oxide synthase.2004Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.
AID67995Compound was evaluated for the Inhibition of endothelial isoform of Endothelial nitric oxide synthase (eNOS)enzyme1998Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
Acetamidine lysine derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide dihydrochloride: a highly selective inhibitor of human inducible nitric oxide synthase.
AID243012Ratio between Endothelial nitric oxide synthase and Inducible nitric oxide synthase2004Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17
Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.
AID147247The compound was tested for competitive antagonist of Nitric oxide synthase2000Bioorganic & medicinal chemistry letters, May-15, Volume: 10, Issue:10
Examination of N-hydroxylation as a prerequisite mechanism of nitric oxide synthase inactivation.
AID243005Ratio between Neuronal nitric oxide synthase and Inducible nitric oxide synthase2004Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17
Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.
AID146115Inhibitory activity against human neuronal nitric oxide synthase2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.
AID92304Inhibition concentration against Inducible nitric oxide synthase (iNOS) at 10 uM concentration2004Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4
5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.
AID1063490Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 5 uM after 24 hrs by Griess assay2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophages.
AID240945Inhibitory activity against Neuronal nitric oxide synthase2004Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17
Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.
AID240996Inhibitory activity against Inducible nitric oxide synthase2004Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17
Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.
AID234295Selectivity is the ratio of IC50 of mouse inducible NOS and Rat brain constitutive NOS1994Journal of medicinal chemistry, Nov-11, Volume: 37, Issue:23
L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.
AID181503Inhibition of conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellum2001Bioorganic & medicinal chemistry letters, Apr-23, Volume: 11, Issue:8
3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.
AID427901Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as NO production at 10 uM treated 1 hr before LPS challenge measured after 24 hrs by Griess reagent assay (RVb= 28.72 +/- 1.31 uM)2009Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
Phenolic glycosides from Alangium salviifolium leaves with inhibitory activity on LPS-induced NO, PGE(2), and TNF-alpha production.
AID356479Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess method2003Journal of natural products, Sep, Volume: 66, Issue:9
Saponins from Cussonia bancoensis and their inhibitory effects on nitric oxide production.
AID68164Selectivity for endothelial nitric oxide synthase over inducible nitric oxide synthase2004Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4
5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.
AID1650939Antiinflammatory activity against murine RAW264.7 cells assessed as inhibition of LPS-induced NO production at 40 uM preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess assay relative to control2020Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4
Inhibitory effects of triarylpyrazole derivatives on LPS-induced nitric oxide and PGE
AID513346Inhibition of wild-type Bacillus subtilis 168 1A1 lysine riboswitch 179 lysc assessed as reduction of beta-galactosidase activity at 5 mM after 3 hrs by lacZ reporter gene assay2007Nature chemical biology, Jan, Volume: 3, Issue:1
Antibacterial lysine analogs that target lysine riboswitches.
AID241124Inhibitory concentration against Neuronal nitric oxide synthase2004Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.
AID146416Selectivity for Neuronal nitric oxide synthase over inducible nitric oxide synthase2004Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4
5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.
AID68135Inhibitory activity against human endothelial nitric oxide synthase2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.
AID1688220Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction in LPS-induced NO level at 40 uM incubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay2020European journal of medicinal chemistry, Feb-15, Volume: 188Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents.
AID1564031Anti-inflammatory activity in mouse RAW264.7 cells assessed as remaining LPS-induced NO production at 40 uM preincubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent-based assay relative to control2019European journal of medicinal chemistry, Oct-15, Volume: 180Repurposing mosloflavone/5,6,7-trimethoxyflavone-resveratrol hybrids: Discovery of novel p38-α MAPK inhibitors as potent interceptors of macrophage-dependent production of proinflammatory mediators.
AID234272Selectivity is defined as the ratio of the IC50(hncNOS) to IC50(hiNOS)1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.
AID235902Selectivity index determined by the ratio of IC50 of eNOS to the iNOS1998Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
Acetamidine lysine derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide dihydrochloride: a highly selective inhibitor of human inducible nitric oxide synthase.
AID607321Inhibition of human eNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting2011Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.
AID182968Inhibition of LPS induced nitrite production in rat following 4 hr of oral administration2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.
AID356480Cytotoxicity against LPS-stimulated mouse RAW264.7 cells by Griess method2003Journal of natural products, Sep, Volume: 66, Issue:9
Saponins from Cussonia bancoensis and their inhibitory effects on nitric oxide production.
AID1537347Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by Griess reagent based colorimetric method2019Journal of natural products, 02-22, Volume: 82, Issue:2
Chloraserrtone A, a Sesquiterpenoid Dimer from Chloranthus serratus.
AID513344Antibacterial activity against Bacillus subtilis 168 1A1 at 100 uM after 24 hrs by by CLSI method2007Nature chemical biology, Jan, Volume: 3, Issue:1
Antibacterial lysine analogs that target lysine riboswitches.
AID1367568Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess assay2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Inhibitory effect of moschamine isolated from Carthamus tinctorius on LPS-induced inflammatory mediators via AP-1 and STAT1/3 inactivation in RAW 264.7 macrophages.
AID234085Selectivity for inhibition of neuronal nitric oxide synthases to that of inhibition of inducible nitric oxide synthases2000Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
AID53933Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cells2001Bioorganic & medicinal chemistry letters, Apr-23, Volume: 11, Issue:8
3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.
AID235903Selectivity index determined by the ratio of IC50 of nNOS to the iNOS1998Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
Acetamidine lysine derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide dihydrochloride: a highly selective inhibitor of human inducible nitric oxide synthase.
AID1329427Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins followed by LPS stimulation for 24 hrs by Griess assay2016Journal of natural products, 09-23, Volume: 79, Issue:9
Chlojaponilactone B from Chloranthus japonicus: Suppression of Inflammatory Responses via Inhibition of the NF-κB Signaling Pathway.
AID1063492Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophages.
AID68141In vitro inhibition of human endothelial nitric oxide synthase.2004Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.
AID244220Ratio of inhibitory concentration against Endothelial nitric oxide synthase to Neuronal nitric oxide synthase2004Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.
AID1063489Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 20 uM after 24 hrs by Griess assay2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophages.
AID1192870Antiinflammatory activity in mouse RAW264.7 cells assessed as decrease in LPS-induced NO production after 24 hrs by Griess assay2015Bioorganic & medicinal chemistry letters, Mar-01, Volume: 25, Issue:5
Constituents of the stem barks of Ailanthus altissima and their potential to inhibit LPS-induced nitric oxide production.
AID146117Inhibitory activity against human Neuronal nitric oxide synthase1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.
AID513343Binding affinity to Bacillus subtilis 168 1A1 lysine riboswitch 179 lysc by in-line probing assay2007Nature chemical biology, Jan, Volume: 3, Issue:1
Antibacterial lysine analogs that target lysine riboswitches.
AID92004Inhibitory activity of compound against human inducible nitric oxide synthase2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.
AID68136Inhibitory activity against human Endothelial nitric oxide synthase1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.
AID1355607Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pretreated for 1 hr followed by LPS-stimulation and measured after 24 hrs by Griess assay2018Journal of natural products, 07-27, Volume: 81, Issue:7
Chemical Constituents of Apios americana Tubers and Their Inhibitory Activities on Nitric Oxide Production in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.
AID91992Compound was evaluated for the Inhibition of induced isoform of Inducible nitric oxide synthase1998Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
Acetamidine lysine derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide dihydrochloride: a highly selective inhibitor of human inducible nitric oxide synthase.
AID146120In vitro inhibition of human neuronal nitric oxide synthase.2004Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.
AID68131Inhibitory activity against endothelial nitric oxide synthase (eNOS)2000Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
AID234271Selectivity is defined as the ratio of the IC50(hecNOS) to IC50(hiNOS)1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.
AID92167Tested for inhibition of mouse inducible nitric oxide synthase1994Journal of medicinal chemistry, Nov-11, Volume: 37, Issue:23
L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.
AID85322Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells2001Bioorganic & medicinal chemistry letters, Apr-23, Volume: 11, Issue:8
3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.
AID146109Inhibitory activity against neuronal nitric oxide synthase2000Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
AID316792Inhibition of human iNOS expressed in human DLD1 cells after 1 hr2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Discovery of a series of aminopiperidines as novel iNOS inhibitors.
AID53921Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells2001Bioorganic & medicinal chemistry letters, Apr-23, Volume: 11, Issue:8
3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.
AID92181Tested for inhibition of rat brain inducible nitric oxide synthase1994Journal of medicinal chemistry, Nov-11, Volume: 37, Issue:23
L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.
AID1355117Inhibition of LPS-stimulated nitric oxide production in rat RAW264.7 cells after 24 hrs by Griess assay2018Journal of natural products, 06-22, Volume: 81, Issue:6
Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production.
AID68162Inhibition concentration against Endothelial nitric oxide synthase (eNOS) at 10 uM concentration2004Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4
5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.
AID53793Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.
AID241153Inhibitory concentration against Inducible nitric oxide synthase2004Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.
AID92001Inhibitory activity against inducible nitric oxide synthase (iNOS)2000Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
AID241071Inhibitory activity against Endothelial nitric oxide synthase2004Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17
Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.
AID316796Selectivity for human nNOS to human iNOS2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Discovery of a series of aminopiperidines as novel iNOS inhibitors.
AID1537348Cytotoxicity against mouse RAW264.7 cells assessed as cellular metabolic activity at 50 uM after 48 hrs by MTT assay relative to control2019Journal of natural products, 02-22, Volume: 82, Issue:2
Chloraserrtone A, a Sesquiterpenoid Dimer from Chloranthus serratus.
AID316797Inhibition of cytokine-induced iNOS activity in human DLD1 cells after 24 hrs2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Discovery of a series of aminopiperidines as novel iNOS inhibitors.
AID241215Inhibitory concentration against Endothelial nitric oxide synthase2004Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.
AID316794Inhibition of human nNOS expressed in insect SF9 cells after 1 hr2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Discovery of a series of aminopiperidines as novel iNOS inhibitors.
AID147245Pseudo-first order inactivation rate constant against nitric oxide synthase was determined2000Bioorganic & medicinal chemistry letters, May-15, Volume: 10, Issue:10
Examination of N-hydroxylation as a prerequisite mechanism of nitric oxide synthase inactivation.
AID316795Selectivity for human eNOS to human iNOS2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Discovery of a series of aminopiperidines as novel iNOS inhibitors.
AID513357Antibacterial activity against Bacillus subtilis 168 1A1 after 24 hrs by CLSI method2007Nature chemical biology, Jan, Volume: 3, Issue:1
Antibacterial lysine analogs that target lysine riboswitches.
AID244221Ratio of inhibitory concentration against Endothelial nitric oxide synthase to Inducible nitric oxide synthase2004Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.
AID146105Compound was evaluated for the Inhibition of Neuronal nitric oxide synthase1998Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
Acetamidine lysine derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide dihydrochloride: a highly selective inhibitor of human inducible nitric oxide synthase.
AID316793Inhibition of human eNOS expressed in insect SF9 cells after 1 hr2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Discovery of a series of aminopiperidines as novel iNOS inhibitors.
AID234083Selectivity for inhibition of inducible nitric oxide synthases to that of inhibition of endothelial cell nitric oxide synthases2000Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
AID607320Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting2011Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.
AID607322Inhibition of human nNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting2011Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14
Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (28)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (10.71)18.2507
2000's12 (42.86)29.6817
2010's9 (32.14)24.3611
2020's4 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.36 (24.57)
Research Supply Index3.37 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.36)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other28 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]