amrinone has been researched along with Shock, Septic in 15 studies
Amrinone: A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
amrinone : A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study explored the hemodynamic effects of amrinone, a phosphodiesterase inhibitor, in association with intravenous fluids, in the treatment of endotoxin shock." | 7.67 | Amrinone administration in endotoxin shock. ( Cantraine, F; Contempré, B; de Boelpaepe, C; Domb, M; Motte, S; Van der Linden, P; Vincent, JL, 1988) |
| "The endotoxin shock was induced by intravenously injecting LPS (400 micro g/kg)." | 5.32 | [Effect of dexamethasone, aminoguanidin, amrinone on oxygen utilization in endotoxin shock rabbits]. ( Fan, XM; Tang, HX, 2003) |
| "This study explored the hemodynamic effects of amrinone, a phosphodiesterase inhibitor, in association with intravenous fluids, in the treatment of endotoxin shock." | 3.67 | Amrinone administration in endotoxin shock. ( Cantraine, F; Contempré, B; de Boelpaepe, C; Domb, M; Motte, S; Van der Linden, P; Vincent, JL, 1988) |
| "Septic shock is a common clinical problem in the intensive care setting." | 2.38 | The pharmacotherapy of septic shock. ( Boyd, JL; Chernow, B; Stanford, GG, 1989) |
| "The endotoxin shock was induced by intravenously injecting LPS (400 micro g/kg)." | 1.32 | [Effect of dexamethasone, aminoguanidin, amrinone on oxygen utilization in endotoxin shock rabbits]. ( Fan, XM; Tang, HX, 2003) |
| "Effects of amrinone (AMR), a phosphodiesterase inhibitor, alone and in combination with dobutamine (DOB), on hemodynamics and O2 delivery were studied during porcine endotoxemia." | 1.29 | Amrinone combined with dobutamine improves hemodynamics and oxygen delivery without down-regulation of cardiac beta-adrenergic receptor density in porcine endotoxemia. ( Dodam, JR; Gengo, PJ; Hellyer, PW; Jones, JL, 1995) |
| "Amrinone was more effective than ouabain at all left atrial filling pressures tested." | 1.27 | Inotropic interactions of dichloroacetate with amrinone and ouabain in isolated hearts from endotoxin-shocked rats. ( Burns, AH; Burns, LA; Shepherd, RE; Summer, WR, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (40.00) | 18.7374 |
| 1990's | 8 (53.33) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, HX | 1 |
| Fan, XM | 1 |
| Werner, HA | 1 |
| Herbertson, MJ | 1 |
| Walley, KR | 1 |
| Jones, JL | 1 |
| Gengo, PJ | 1 |
| Dodam, JR | 1 |
| Hellyer, PW | 1 |
| Ryding, J | 1 |
| Heslet, L | 1 |
| Hartvig, T | 1 |
| Jønsson, V | 1 |
| Ishiki, J | 1 |
| Carpati, CM | 1 |
| Astiz, ME | 1 |
| Rackow, EC | 1 |
| Hernández, G | 1 |
| Gigoux, J | 1 |
| Bugedo, G | 1 |
| Castillo, L | 1 |
| Bruhn, A | 1 |
| Tomicic, V | 1 |
| Dagnino, J | 1 |
| González, F | 1 |
| Giroir, BP | 1 |
| Beutler, B | 1 |
| Burns, AH | 1 |
| Summer, WR | 1 |
| Burns, LA | 1 |
| Shepherd, RE | 1 |
| Boyd, JL | 1 |
| Stanford, GG | 1 |
| Chernow, B | 1 |
| Vincent, JL | 2 |
| Domb, M | 2 |
| Van der Linden, P | 1 |
| Motte, S | 1 |
| de Boelpaepe, C | 2 |
| Contempré, B | 1 |
| Cantraine, F | 1 |
| Kosugi, I | 1 |
| Tajimi, K | 1 |
| Gonda, T | 1 |
| Fukatsu, O | 1 |
| Ueda, S | 1 |
| Hoffmann, P | 1 |
| Schockenhoff, B | 1 |
3 reviews available for amrinone and Shock, Septic
| Article | Year |
|---|---|
[Perioperative management of renal circulation].
Topics: Amrinone; Anesthesia; Animals; Glycoproteins; Hemodynamics; Humans; Intraoperative Period; Kidney Tr | 1997 |
Mechanisms and management of myocardial dysfunction in septic shock.
Topics: Amrinone; Animals; Cardiotonic Agents; Epinephrine; Heart; Rats; Shock, Septic; Tumor Necrosis Facto | 1999 |
The pharmacotherapy of septic shock.
Topics: Adrenergic Agonists; Amrinone; Glucagon; Humans; Naloxone; Shock, Septic | 1989 |
1 trial available for amrinone and Shock, Septic
| Article | Year |
|---|---|
[Acute effect of dobutamine and amrinone on hemodynamics and splanchnic perfusion in septic shock patients].
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Amrinone; Cardiotonic Agents; Dobutamine; Female; Hemodyn | 1999 |
11 other studies available for amrinone and Shock, Septic
| Article | Year |
|---|---|
[Effect of dexamethasone, aminoguanidin, amrinone on oxygen utilization in endotoxin shock rabbits].
Topics: Amrinone; Animals; Anti-Inflammatory Agents; Dexamethasone; Enzyme Inhibitors; Female; Guanidines; M | 2003 |
Amrinone increases ventricular contractility and diastolic compliance in endotoxemia.
Topics: Amrinone; Animals; Atrial Function, Right; Blood Pressure; Cardiac Catheterization; Cardiac Output; | 1995 |
Amrinone combined with dobutamine improves hemodynamics and oxygen delivery without down-regulation of cardiac beta-adrenergic receptor density in porcine endotoxemia.
Topics: Amrinone; Animals; Disease Models, Animal; Dobutamine; Down-Regulation; Drug Therapy, Combination; H | 1995 |
Reversal of 'refractory septic shock' by infusion of amrinone and angiotensin II in an anthracycline-treated patient.
Topics: Amrinone; Angiotensin II; Doxorubicin; Escherichia coli Infections; Female; Humans; Infusions, Intra | 1995 |
[Dobutamine and amrinone in septic shock patients].
Topics: Amrinone; Cardiotonic Agents; Dobutamine; Humans; Shock, Septic | 1999 |
Effect of amrinone on tumor necrosis factor production in endotoxic shock.
Topics: Amrinone; Animals; Cell Line; Chloramphenicol O-Acetyltransferase; Chromatography; Dexamethasone; Di | 1992 |
Inotropic interactions of dichloroacetate with amrinone and ouabain in isolated hearts from endotoxin-shocked rats.
Topics: Acetates; Adenosine Triphosphate; Amrinone; Animals; Cardiac Output; Dichloroacetic Acid; Drug Inter | 1988 |
Amrinone administration in endotoxin shock.
Topics: Amrinone; Animals; Cardiac Output; Combined Modality Therapy; Dogs; Endotoxins; Escherichia coli; Fl | 1988 |
Non-adrenergic inotropic support in septic shock.
Topics: Amrinone; Animals; Disease Models, Animal; Dogs; Hemodynamics; Myocardial Contraction; Shock, Septic | 1987 |
[Effect of amrinone on hemodynamics, oxygen consumption and plasma catecholamine levels in endotoxin injected dogs].
Topics: Aminopyridines; Amrinone; Animals; Catecholamines; Coronary Circulation; Dogs; Oxygen Consumption; S | 1985 |
[Amrinone in catecholamine refractory heart failure in septic shock].
Topics: Adult; Aged; Aminopyridines; Amrinone; Cardiotonic Agents; Catecholamines; Dose-Response Relationshi | 1985 |