phentolamine has been researched along with Shock, Septic in 29 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Subdiaphragmatic vagotomy and abdominal perivagal lidocaine administration, or lidocaine injection into the nucleus tractus solitarius (NTS) prevented LPS hypotension." | 3.74 | Lipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area. ( Cutrera, RA; Feleder, C; Goktalay, G; Millington, WR; Myer, BS; Yilmaz, MS, 2008) |
| " The keys to successful therapy are time, antibiotics, vasopressors, cortisone and correction of acidosis." | 3.64 | SEPTIC SHOCK. ( LANSING, AM, 1963) |
| " Following control measurements of Pm and arteriolar and venular dimensions, dose-response curves of arteriolar and venular dimensions to topical norepinephrine (10(-10) M to 10(-3) M) was obtained." | 1.27 | Microvascular responses to E. coli endotoxin with altered adrenergic activity. ( Baker, CH; Wilmoth, FR, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (75.86) | 18.7374 |
| 1990's | 5 (17.24) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brosnahan, AJ | 1 |
| Vulchanova, L | 1 |
| Witta, SR | 1 |
| Dai, Y | 1 |
| Jones, BJ | 1 |
| Brown, DR | 1 |
| Yilmaz, MS | 1 |
| Goktalay, G | 1 |
| Millington, WR | 1 |
| Myer, BS | 1 |
| Cutrera, RA | 1 |
| Feleder, C | 1 |
| LANSING, AM | 1 |
| SCHAPOSNIK, F | 1 |
| VICK, JA | 1 |
| JACOBSON, ED | 1 |
| Ick, JA | 1 |
| Dietzman, RH | 2 |
| Manax, WG | 1 |
| Lillehei, RC | 2 |
| Baker, CH | 1 |
| Wilmoth, FR | 1 |
| Filkins, JP | 2 |
| Hauser, GJ | 1 |
| Myers, AK | 1 |
| Dayao, EK | 1 |
| Zukowska-Grojec, Z | 1 |
| Law, WR | 1 |
| Mourelatos, MG | 1 |
| Krahmer, R | 1 |
| Dziki, AJ | 1 |
| Lynch, WH | 1 |
| Ferguson, JL | 1 |
| Maitra, SR | 1 |
| Sayeed, MM | 1 |
| Ruffolo, RR | 1 |
| Gonzalez, C | 1 |
| Fernandez, A | 1 |
| Martin, C | 1 |
| Moncada, S | 1 |
| Estrada, C | 1 |
| Wei, ZY | 1 |
| Wang, JQ | 1 |
| Pan, XJ | 1 |
| Nelson, NC | 1 |
| Nelson, JL | 1 |
| Weldon, WE | 1 |
| Vela, AR | 1 |
| García Barreno, P | 1 |
| Jacob, E | 1 |
| Gassner, S | 1 |
| Shapira, Z | 1 |
| Weil, MH | 1 |
| Shubin, H | 1 |
| Motsay, GJ | 1 |
| Hopkins, RW | 1 |
| Dmochowski, JR | 1 |
| Couch, NP | 1 |
| Sasaki, Y | 1 |
| Wilson, RF | 1 |
| Sarver, EJ | 1 |
| Rizzo, J | 1 |
| Shoemaker, WC | 1 |
| Brown, RS | 1 |
| Schröder, R | 1 |
| Torsti, P | 1 |
1 review available for phentolamine and Shock, Septic
| Article | Year |
|---|---|
Fundamentals of receptor theory: basics for shock research.
Topics: Binding, Competitive; Drug Design; Naphazoline; Oxymetazoline; Phentolamine; Phenylephrine; Receptor | 1992 |
28 other studies available for phentolamine and Shock, Septic
| Article | Year |
|---|---|
Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Cell Line, Tra | 2013 |
Lipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area.
Topics: Acute Disease; Adrenergic alpha-Antagonists; Anesthetics, Local; Animals; Hypotension; Lidocaine; Li | 2008 |
SEPTIC SHOCK.
Topics: Acidosis; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antibiotics, Antitubercular; Anuria; Bicar | 1963 |
[SHOCK IN OBSTETRICS].
Topics: Abortion, Induced; Abortion, Spontaneous; Abruptio Placentae; Anti-Bacterial Agents; Blood Transfusi | 1964 |
TRIGGER MECHANISM OF ENDOTOXIN SHOCK.
Topics: Atropine; Blood; Blood Platelets; Cerebrospinal Fluid; Dextrans; Diphenhydramine; Dogs; Endotoxins; | 1964 |
IS HISTAMINE THE "TRIGGER MECHANISM" OF ENDOTOXIN SHOCK?
Topics: Endotoxins; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; p-Methoxy-N-methylphenet | 1964 |
BIOASSAY OF THE PROMINENT HUMORAL AGENTS INVOLVED IN ENDOTOXIN SHOCK.
Topics: Adrenalectomy; Biological Assay; Blood Pressure; Blood Pressure Determination; Diphenhydramine; Dogs | 1965 |
Shock: mechanisms and therapy.
Topics: Animals; Chlorpromazine; Digitalis Glycosides; Dogs; Endotoxins; Epinephrine; Equipment and Supplies | 1967 |
Microvascular responses to E. coli endotoxin with altered adrenergic activity.
Topics: Animals; Arterioles; Endotoxins; Escherichia coli; Male; Metiamide; Microcirculation; Muscles; Norep | 1984 |
Effect of phentolamine on insulin levels and insulin responsiveness in endotoxicosis.
Topics: Animals; Blood Glucose; Endotoxins; Glucose; Hyperinsulinism; Hypoglycemia; In Vitro Techniques; Ins | 1982 |
Neuropeptide Y infusion improves hemodynamics and survival in rat endotoxic shock.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Endotoxins; Hemodynamics; Infusions, Intraven | 1993 |
Effects of phentolamine or yohimbine on naloxone's actions during endotoxin shock in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Flow Velocity; Blood Pressure; Cardiac Output; Endotoxi | 1997 |
Adrenergic blockade and glucoregulation in endotoxin shock.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Gluconeogenesis; | 1979 |
Effect of alpha-adrenergic blockage on cellular Ca2+ during endotoxic shock.
Topics: Animals; Calcium; Cells, Cultured; Endotoxins; Epinephrine; Liver; Male; Phentolamine; Prazosin; Rat | 1992 |
Nitric oxide from endothelium and smooth muscle modulates responses to sympathetic nerve stimulation: implications for endotoxin shock.
Topics: Acetylcholine; Animals; Arginine; Cycloheximide; Dexamethasone; Dinoprost; Endothelium, Vascular; En | 1992 |
[The pressor effect of naloxone phentolamine or cinanserine injected into the lateral cerebroventricle of rabbit with haemorrhagic or endotoxic shock].
Topics: Animals; Blood Pressure; Cinanserin; Cinnamates; Female; Injections, Intraventricular; Male; Naloxon | 1988 |
Mechanisms of change in thoracic duct lymph flow during hypotensive states.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Aspirin; Capillary Permeability; | 1970 |
[Results of the administration of large doses of corticoids to patients in endotoxic shock].
Topics: Drug Evaluation; Glucosephosphate Dehydrogenase; Humans; Injections, Intravenous; Isoproterenol; Met | 1974 |
[Phentolamine in the treatment of septic shock].
Topics: Adolescent; Adult; Female; Humans; Male; Middle Aged; Phentolamine; Sepsis; Shock, Septic | 1972 |
Treatment of shock caused by bacterial infections.
Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; Bicarbonates; Glucocorticoids; Heparin; Human | 1973 |
[Drugs in shock treatment].
Topics: Adrenal Cortex Hormones; Cardiac Output; Chlorpromazine; Digitalis Glycosides; Humans; Isoproterenol | 1971 |
Septic shock: hemodynamic cost of inflammation.
Topics: Animals; Arteries; Calcium Chloride; Dogs; Hemodynamics; Hindlimb; Hyperemia; Inflammation; Methylpr | 1970 |
Skeletal muscle hydrogen ion activity in endotoxin shock.
Topics: Acidosis; Animals; Blood; Blood Pressure; Dogs; Endotoxins; Hematocrit; Hydrogen-Ion Concentration; | 1970 |
[Renal blood flow in endotoxin shock].
Topics: Animals; Dogs; Hydrocortisone; Isoproterenol; Kidney; Norepinephrine; Phentolamine; Propranolol; Reg | 1970 |
Hemodynamic changes, treatment, and prognosis in clinical shock.
Topics: Blood Pressure; Cardiac Output; Heart; Hemodynamics; Humans; Liver Cirrhosis; Phenoxybenzamine; Phen | 1971 |
The dilemma of vasopressors and vasodilators in the therapy of shock.
Topics: Blood Pressure; Cardiac Output; Central Venous Pressure; Chlorpromazine; Heart Rate; Hemodynamics; H | 1971 |
[Basic principles of shock therapy].
Topics: Blood Transfusion; Digitalis Glycosides; Dopamine; Glucagon; Humans; Isoproterenol; Metaproterenol; | 1971 |
[The use of sympathomimetics and sympatholytics in shock].
Topics: Chlorpromazine; Dopamine; Humans; Isoproterenol; Metaraminol; Norepinephrine; Phenoxybenzamine; Phen | 1971 |