dantrolene has been researched along with Shock, Septic in 5 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sepsis is the systemic inflammatory response resulting from serious infection and is the most common cause of death in intensive care units." | 5.29 | Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia. ( Hotchkiss, RS; Karl, IE, 1994) |
| "Septic shock is a complex pathophysiologic state characterized by circulatory insufficiency, multiple system organ dysfunction, and frequent mortality." | 1.31 | Increased cardiomyocyte intracellular calcium during endotoxin-induced cardiac dysfunction in guinea pigs. ( Arteaga, G; Becker, L; Bryant, D; Giroir, BP; Horton, J; Kliewer, A; Maass, D; Thompson, M; White, DJ, 2000) |
| "Sepsis is the systemic inflammatory response resulting from serious infection and is the most common cause of death in intensive care units." | 1.29 | Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia. ( Hotchkiss, RS; Karl, IE, 1994) |
| " To determine if dantrolene is safe to use in sepsis, two studies were performed." | 1.28 | Is dantrolene safe to administer in sepsis? The effect of dantrolene after endotoxin administration in dogs and rats. ( Beebe, DS; Belani, KG; Gillingham, K; Komanduri, V; Palahniuk, RJ; Sweeney, MF; Tuohy, SE, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wei, H | 1 |
| Liang, G | 1 |
| Vera, RM | 1 |
| Ginz, HF | 1 |
| Levano, S | 1 |
| Girard, T | 1 |
| Urwyler, A | 1 |
| Hamel, C | 1 |
| Hotchkiss, RS | 1 |
| Karl, IE | 1 |
| Thompson, M | 1 |
| Kliewer, A | 1 |
| Maass, D | 1 |
| Becker, L | 1 |
| White, DJ | 1 |
| Bryant, D | 1 |
| Arteaga, G | 1 |
| Horton, J | 1 |
| Giroir, BP | 1 |
| Beebe, DS | 1 |
| Belani, KG | 1 |
| Tuohy, SE | 1 |
| Sweeney, MF | 1 |
| Gillingham, K | 1 |
| Komanduri, V | 1 |
| Palahniuk, RJ | 1 |
1 review available for dantrolene and Shock, Septic
| Article | Year |
|---|---|
Dantrolene repurposed to treat sepsis or septic shock and COVID-19 patients.
Topics: Calcium; Calcium Channel Blockers; COVID-19; COVID-19 Drug Treatment; Dantrolene; Drug Repositioning | 2021 |
4 other studies available for dantrolene and Shock, Septic
| Article | Year |
|---|---|
Dantrolene for severe rhabdomyolysis in Staphylococcus aureus toxic shock syndrome.
Topics: Dantrolene; Humans; Male; Middle Aged; Rhabdomyolysis; Shock, Septic; Staphylococcal Infections | 2012 |
Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia.
Topics: Animals; Calcium; Dantrolene; Female; Glucose; Mice; Proteins; Rats; Rats, Sprague-Dawley; Sepsis; S | 1994 |
Increased cardiomyocyte intracellular calcium during endotoxin-induced cardiac dysfunction in guinea pigs.
Topics: Animals; Calcium; Cardiomyopathies; Cells, Cultured; Cytoplasm; Dantrolene; Escherichia coli; Fura-2 | 2000 |
Is dantrolene safe to administer in sepsis? The effect of dantrolene after endotoxin administration in dogs and rats.
Topics: Analysis of Variance; Animals; Dantrolene; Disease Models, Animal; Dogs; Endotoxins; Escherichia col | 1991 |