7-nitroindazole has been researched along with Shock, Septic in 2 studies
7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nitrite/nitrate (NOx) production in the septic shock stage was much greater than those in the corresponding sham groups, and NOx production in the cytosol by inducible NOS was greater." | 1.38 | Mitochondrial nitric oxide synthase participates in septic shock myocardial depression by nitric oxide overproduction and mitochondrial permeability transition pore opening. ( Bruce, IC; Wang, H; Xia, Q; Xu, C; Yi, C, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xia, ML | 1 |
| Zhou, XM | 1 |
| Xu, C | 2 |
| Qian, LB | 1 |
| Xia, Q | 2 |
| Yi, C | 1 |
| Wang, H | 1 |
| Bruce, IC | 1 |
2 other studies available for 7-nitroindazole and Shock, Septic
| Article | Year |
|---|---|
[Effect of nitric oxide synthase inhibitors on the changes of hemodynamic parameters and aortic tension induced by septic shock in rats].
Topics: Animals; Aorta, Thoracic; Enzyme Inhibitors; Hemodynamics; Indazoles; Male; NG-Nitroarginine Methyl | 2008 |
Mitochondrial nitric oxide synthase participates in septic shock myocardial depression by nitric oxide overproduction and mitochondrial permeability transition pore opening.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Indazol | 2012 |