bmap-28 profile

BMAP-28: C-terminal domain of a cathelicidin, a myeloid antimicrobial peptide precursor; BMAP-28 stands for bovine myeloid antimicrobial peptide of 28 residues; amino acid sequence in first source; GenBank X97609 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	16131512
MeSH ID	M0268057

Synonym
bmap-28

Excerpt	Reference
" Furthermore, while D BMAP28 maintains the same cytotoxicity profile against epithelial cells and monocytes as the natural peptide, RI BMAP28 is markedly less toxic against these cell types."	( Stability, toxicity, and biological activity of host defense peptide BMAP28 and its inversed and retro-inversed isomers. Attah-Poku, S; Babiuk, LA; Bell, K; Griebel, PJ; Kindrachuk, J; Napper, S; Potter, A; Scruten, E, 2011)

Excerpt	Reference
"A mouse model of staphylococcal sepsis was used to evaluate the efficacy of RNAIII-inhibiting peptide (RIP) combined with the cathelicidin BMAP-28."	( RNAIII-inhibiting peptide in combination with the cathelicidin BMAP-28 reduces lethality in mouse models of staphylococcal sepsis. Balaban, N; Bergnach, C; Cirioni, O; Dell'Acqua, G; Ghiselli, R; Giacometti, A; Licci, A; Mocchegiani, F; Orlando, F; Saba, V; Scalise, G; Silvestri, C; Skerlavaj, B; Zanetti, M, 2006)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (6.06)	18.2507
2000's	13 (39.39)	29.6817
2010's	17 (51.52)	24.3611
2020's	1 (3.03)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (6.06%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	1 (3.03%)	0.25%
Other	30 (90.91%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
palmitic acid Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.	2.1	1	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor; plant metabolite
erythrosine Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.	2.01	1
vancomycin Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.	7.04	1	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
tobramycin Tobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.. tobramycin : A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.	2.06	1	amino cyclitol glycoside	antibacterial agent; antimicrobial agent; toxin
fluorexon fluorexon: structure	2.01	1	xanthene dye	fluorochrome
bactenecin bactenecin: from bovine neutrophils	2.02	1
n-acetylneuraminic acid N-Acetylneuraminic Acid: An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518). N-acetylneuraminic acid : An N-acylneuraminic acid where the N-acyl group is specified as acetyl.	2.08	1	N-acetylneuraminic acids	antioxidant; bacterial metabolite; EC 3.2.1.18 (exo-alpha-sialidase) inhibitor; human metabolite; mouse metabolite
1-(1-naphthylmethyl)piperazine [no description available]	2.15	1
sodium dodecyl sulfate Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.	2.17	1	organic sodium salt	detergent; protein denaturant
magainin 2 peptide, xenopus magainin 2 peptide, Xenopus: from skin of Xenopus laevis; 23-amino acid sequence given in first source; differs from magainin 1 by substitution of Lys instead of Gly at position 10 & Asn instead of Lys at position 22; also used to prevent development of malarial oocysts in mosquito vector; Z-12 is magainin 2 with Lys and Phe residues replaced with their respective D-isomers; homologue of the Xenopus laevis cement; GenBank AF004262 (mouse), AF007791, AF038451-2 (human)	3.13	1
bmap-27 BMAP-27: C-terminal domain of a cathelicidin, a myeloid antimicrobial peptide precursor; BMAP-27 stands for bovine myeloid antimicrobial peptide of 27 residues; amino acid sequence in first source; GenBank X97608	3.65	9
protegrin-1 protegrin-1: GenBank X84094	2.42	2
ceca1 protein, drosophila [no description available]	3.13	1
indolicidin [no description available]	2.06	1
cyclosporine Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).	2.01	1
lactoferrin Lactoferrin: An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion.	3.13	1
lipoteichoic acid lipoteichoic acid: lipopolysaccharides with an acyl group anchored to the cell membrane of gram-positive bacteria; functions as an adhesion molecule to facilitate the binding of bacteria to cells, colonization, and invasion; interacts with CD14 to induce NF-κB activation and inflammatory cytokine production; can function as surface antigen; inhibits remineraliztion of artificial lesions and surface-softened enamels;. lipoteichoic acid : A teichoic acid which is covalently bound to a lipid.	2.03	1

Condition	Relationship Strength	Studies
Mastitis, Bovine INFLAMMATION of the UDDER in cows.	2.51	2
Breast Cancer [description not available]	2.08	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.08	1
Diathesis [description not available]	2.15	1
Infections, Staphylococcal [description not available]	3.43	7
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	3.43	7
Cystic Fibrosis of Pancreas [description not available]	2.49	2
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	3.42	7
Infections, Pseudomonas [description not available]	2.13	1
Staphylococcal Pneumonia [description not available]	2.13	1
Cystic Fibrosis An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.	2.49	2
Pneumonia, Staphylococcal Pneumonia caused by infections with bacteria of the genus STAPHYLOCOCCUS, usually with STAPHYLOCOCCUS AUREUS.	2.13	1
Pseudomonas Infections Infections with bacteria of the genus PSEUDOMONAS.	2.13	1
Extravascular Hemolysis [description not available]	2.46	2
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	2.46	2
Bacterial Disease [description not available]	2.06	1
Bacterial Infections Infections by bacteria, general or unspecified.	2.06	1
Bacterial Infections, Gram-Negative [description not available]	2.06	1
Gram-Negative Bacterial Infections Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.	2.06	1
Innate Inflammatory Response [description not available]	2.07	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.07	1
Primary Peritonitis [description not available]	2.01	1
Peritonitis INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.	2.01	1
Endotoxin Shock [description not available]	2.02	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.42	2
Shock, Septic Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.	2.02	1
Bacteremia The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.	2.02	1
Benign Neoplasms [description not available]	2.94	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.94	1
Bovine Diseases [description not available]	2.03	1
Infections, Pasteurella [description not available]	2.03	1
Ovine Diseases [description not available]	2.03	1
Swine Diseases Diseases of domestic swine and of the wild boar of the genus Sus.	2.03	1

bmap-28

Description

Cross-References

Synonyms (1)

Toxicity

Compound-Compound Interactions

Research

Studies (33)

Study Types