dehydroepiandrosterone has been researched along with Shock, Septic in 6 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The protective effects of the hormones androstenediol (androstene-3beta, 17beta,-diol; AED) and dehydroepiandrosterone (5-androsten-3beta-ol-17-one; DHEA) on the pathophysiology of two lethal bacterial infections and endotoxin shock were examined." | 3.70 | Androstenediol and dehydroepiandrosterone protect mice against lethal bacterial infections and lipopolysaccharide toxicity. ( Ben-Nathan, D; Loria, RM; Padgett, DA, 1999) |
| "Adrenal insufficiency is a rare disease, but its prevalence is increasing." | 2.43 | Management of adrenal insufficiency in different clinical settings. ( Allolio, B; Hahner, S, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Angele, MK | 2 |
| Pratschke, S | 1 |
| Hubbard, WJ | 1 |
| Chaudry, IH | 2 |
| Auci, DL | 1 |
| Reading, CL | 1 |
| Frincke, JM | 1 |
| Hahner, S | 1 |
| Allolio, B | 2 |
| Arlt, W | 1 |
| Hammer, F | 1 |
| Sanning, P | 1 |
| Butcher, SK | 1 |
| Lord, JM | 1 |
| Annane, D | 1 |
| Stewart, PM | 1 |
| Ben-Nathan, D | 1 |
| Padgett, DA | 1 |
| Loria, RM | 1 |
| Schwacha, MG | 1 |
| Ayala, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of the Sex Differences in Inflammatory Diseases in Children[NCT04815811] | 160 participants (Anticipated) | Interventional | 2019-08-17 | Recruiting | |||
| Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis (Steroids in Paediatric Sepsis, StePS) - a Randomised Pilot Study[NCT00732277] | Phase 2 | 21 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for dehydroepiandrosterone and Shock, Septic
| Article | Year |
|---|---|
Gender differences in sepsis: cardiovascular and immunological aspects.
Topics: Androgen Receptor Antagonists; Androgens; Animals; Cardiovascular System; Dehydroepiandrosterone; Es | 2014 |
7-Hydroxy androstene steroids and a novel synthetic analogue with reduced side effects as a potential agent to treat autoimmune diseases.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Clinical Trials as Topic; Colitis; Dehyd | 2009 |
Management of adrenal insufficiency in different clinical settings.
Topics: Acute Disease; Adrenal Insufficiency; Clinical Trials as Topic; Dehydroepiandrosterone; Drug Adminis | 2005 |
Effect of gender and sex hormones on immune responses following shock.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Animals, Congenic; Antibody Formation; | 2000 |
2 other studies available for dehydroepiandrosterone and Shock, Septic
| Article | Year |
|---|---|
Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Dehydroepiandr | 2006 |
Androstenediol and dehydroepiandrosterone protect mice against lethal bacterial infections and lipopolysaccharide toxicity.
Topics: Androstenediol; Animals; Dehydroepiandrosterone; Enterococcus faecalis; Female; Gram-Positive Bacter | 1999 |