cyproheptadine has been researched along with Shock, Septic in 7 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| " By these criteria, we have observed a different degree of anaphylactic reaction depending on the genetic background of the hosts as well as a protection against anaphylactic shock using the antiserotoninic cyproheptadine and, to a lesser extent, by the platelet antiaggregant ticlopidine." | 3.67 | [Quantification (by nomograms) of physiopathological parameters in an experimental model of passive anaphylaxis caused by immune complexes]. ( Díaz, R; Portolés, A; Rojo, JM, 1984) |
| "Cyp exerts an anti-endotoxic shock effect by inhibiting TNF(alpha) gene expression, enhancing SOD activity, reducing lipid peroxidation, and preventing [Ca(2+)](i) overload." | 1.31 | Anti-endotoxic shock effects of cyproheptadine in rats. ( Hu, X; Lun, N; Wang, B; Wang, L; Zhang, Q; Zhu, F, 2002) |
| "Dogs treated with cyproheptadine both prior to and after induction of endotoxin shock were compared with the standard endotoxin shock model." | 1.27 | Effect of cyproheptadine on endotoxin-induced pulmonary platelet trapping. ( Almqvist, P; Kuenzig, M; Schwartz, SI; Skudder, P, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| KALAS, JP | 1 |
| JACOBSON, ED | 1 |
| Portolés, A | 1 |
| Rojo, JM | 1 |
| Díaz, R | 1 |
| Almqvist, P | 1 |
| Skudder, P | 1 |
| Kuenzig, M | 1 |
| Schwartz, SI | 1 |
| Wang, LZ | 1 |
| Liu, YQ | 1 |
| Cui, YH | 1 |
| Zhu, FH | 1 |
| Wang, BS | 1 |
| Lun, N | 2 |
| Wang, L | 1 |
| Zhang, Q | 1 |
| Hu, X | 1 |
| Wang, B | 1 |
| Zhu, F | 1 |
| Agarwal, MK | 1 |
| Martin, DS | 1 |
| Kurzweg, FT | 1 |
| Amor, RL | 1 |
| Harvey, R | 1 |
| Daigle, L | 1 |
7 other studies available for cyproheptadine and Shock, Septic
| Article | Year |
|---|---|
THE EFFECT OF VASOACTIVE ANTAGONISTS IN ENDOTOXIN SHOCK.
Topics: Animals; Atropine; Blood Circulation; Blood Pressure; Blood Pressure Determination; Chloralose; Cypr | 1964 |
[Quantification (by nomograms) of physiopathological parameters in an experimental model of passive anaphylaxis caused by immune complexes].
Topics: Anaphylaxis; Animals; Cyproheptadine; Immune Complex Diseases; Mathematics; Mice; Mice, Inbred Strai | 1984 |
Effect of cyproheptadine on endotoxin-induced pulmonary platelet trapping.
Topics: Animals; Blood Pressure; Cyproheptadine; Dogs; Female; Male; Organ Size; Platelet Aggregation; Pulmo | 1984 |
Effects of dexamethasone, cyproheptadine, anisodamine, and dinoprostone on TNF alpha production in endotoxic shock.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyproheptadine; Dexamethasone; Dinoprostone; Gluco | 1999 |
Anti-endotoxic shock effects of cyproheptadine in rats.
Topics: Animals; Cyproheptadine; Histamine H1 Antagonists; Malondialdehyde; Rats; Rats, Wistar; Shock, Septi | 2002 |
Neurotransmitting substances and endotoxin respone in relation to hepatic enzyme induction.
Topics: Aminobutyrates; Animals; Chloromercuribenzoates; Cortisone; Cyproheptadine; Dihydroxyphenylalanine; | 1974 |
Multiantagonist and volume therapy for late endotoxin shock.
Topics: Acidosis; Aminocaproates; Animals; Aprotinin; Bicarbonates; Cyproheptadine; Diphenhydramine; Dogs; E | 1966 |