ritonavir and Shock--Septic

ritonavir has been researched along with Shock--Septic* in 2 studies

Other Studies

2 other study(ies) available for ritonavir and Shock--Septic

Article	Year
A case of COVID-19 Convalescent Plasma Donation in Greece: Directed donation for compassionate use in the donor's critically ill father. Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine, 2020, Volume: 27, Issue:4 Topics: Adrenal Cortex Hormones; Aged; Anti-Bacterial Agents; Antifungal Agents; Antiviral Agents; Cardiotonic Agents; Combined Modality Therapy; Compassionate Use Trials; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Directed Tissue Donation; Drug Resistance, Multiple; Drug Substitution; Drug Therapy, Combination; Fatal Outcome; Greece; Humans; Hydroxychloroquine; Immunization, Passive; Lopinavir; Male; Respiration, Artificial; Ritonavir; Shock, Septic; Superinfection; Time-to-Treatment	2020
Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor. The Journal of clinical investigation, 2005, Volume: 115, Issue:7 Inhibitors of HIV protease have been shown to have antiapoptotic effects in vitro, yet whether these effects are seen in vivo remains controversial. In this study, we have evaluated the impact of the HIV protease inhibitor (PI) nelfinavir, boosted with ritonavir, in models of nonviral disease associated with excessive apoptosis. In mice with Fas-induced fatal hepatitis, Staphylococcal enterotoxin B-induced shock, and middle cerebral artery occlusion-induced stroke, we demonstrate that PIs significantly reduce apoptosis and improve histology, function, and/or behavioral recovery in each of these models. Further, we demonstrate that both in vitro and in vivo, PIs block apoptosis through the preservation of mitochondrial integrity and that in vitro PIs act to prevent pore function of the adenine nucleotide translocator (ANT) subunit of the mitochondrial permeability transition pore complex. Topics: Animals; Antibodies; Apoptosis; Disease Models, Animal; Female; Hepatitis; HIV Protease Inhibitors; Humans; Jurkat Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitochondrial ADP, ATP Translocases; Models, Molecular; Nelfinavir; Ritonavir; Shock, Septic; Signal Transduction; Stroke	2005

Article

Year

A case of COVID-19 Convalescent Plasma Donation in Greece: Directed donation for compassionate use in the donor's critically ill father.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine, 2020, Volume: 27, Issue:4

Topics: Adrenal Cortex Hormones; Aged; Anti-Bacterial Agents; Antifungal Agents; Antiviral Agents; Cardiotonic Agents; Combined Modality Therapy; Compassionate Use Trials; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Directed Tissue Donation; Drug Resistance, Multiple; Drug Substitution; Drug Therapy, Combination; Fatal Outcome; Greece; Humans; Hydroxychloroquine; Immunization, Passive; Lopinavir; Male; Respiration, Artificial; Ritonavir; Shock, Septic; Superinfection; Time-to-Treatment

2020

Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor.

The Journal of clinical investigation, 2005, Volume: 115, Issue:7

Inhibitors of HIV protease have been shown to have antiapoptotic effects in vitro, yet whether these effects are seen in vivo remains controversial. In this study, we have evaluated the impact of the HIV protease inhibitor (PI) nelfinavir, boosted with ritonavir, in models of nonviral disease associated with excessive apoptosis. In mice with Fas-induced fatal hepatitis, Staphylococcal enterotoxin B-induced shock, and middle cerebral artery occlusion-induced stroke, we demonstrate that PIs significantly reduce apoptosis and improve histology, function, and/or behavioral recovery in each of these models. Further, we demonstrate that both in vitro and in vivo, PIs block apoptosis through the preservation of mitochondrial integrity and that in vitro PIs act to prevent pore function of the adenine nucleotide translocator (ANT) subunit of the mitochondrial permeability transition pore complex.

Topics: Animals; Antibodies; Apoptosis; Disease Models, Animal; Female; Hepatitis; HIV Protease Inhibitors; Humans; Jurkat Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitochondrial ADP, ATP Translocases; Models, Molecular; Nelfinavir; Ritonavir; Shock, Septic; Signal Transduction; Stroke

2005