kynurenine has been researched along with Shock, Septic in 10 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients (n = 16) with septic shock had indoleamine 2,3-dioxygenase activity assessed as the kynurenine-to-tryptophan ratio, and the severity of hypotension was determined by their inotrope requirements." | 7.77 | Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. ( Celermajer, DS; Changsirivathanathamrong, D; dos Remedios, CG; Duflou, J; Gebski, V; Maghzal, GJ; Mak, WM; Rajbhandari, D; Stocker, R; Wang, Y; Woolfe, C, 2011) |
| "Thirty-six patients with severe sepsis/septic shock and sepsis-associated immunosuppression (assessed using monocytic human leukocyte antigen-DR (mHLA-DR) expression) were assessed in a controlled trial of GM-CSF or placebo treatment for 8 days." | 6.75 | Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock. ( Fotopoulou, C; Fusch, G; Hammoud, B; Hasper, D; Meisel, C; Pschowski, R; Reinke, P; Schefold, JC; Schütt, C; Volk, HD; Von Haehling, S; Zeden, JP, 2010) |
| "Patients (n = 16) with septic shock had indoleamine 2,3-dioxygenase activity assessed as the kynurenine-to-tryptophan ratio, and the severity of hypotension was determined by their inotrope requirements." | 3.77 | Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. ( Celermajer, DS; Changsirivathanathamrong, D; dos Remedios, CG; Duflou, J; Gebski, V; Maghzal, GJ; Mak, WM; Rajbhandari, D; Stocker, R; Wang, Y; Woolfe, C, 2011) |
| "Thirty-six patients with severe sepsis/septic shock and sepsis-associated immunosuppression (assessed using monocytic human leukocyte antigen-DR (mHLA-DR) expression) were assessed in a controlled trial of GM-CSF or placebo treatment for 8 days." | 2.75 | Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock. ( Fotopoulou, C; Fusch, G; Hammoud, B; Hasper, D; Meisel, C; Pschowski, R; Reinke, P; Schefold, JC; Schütt, C; Volk, HD; Von Haehling, S; Zeden, JP, 2010) |
| "Despite advances in our understanding of endotoxic shock, novel therapeutic interventions that can reduce the burden of sepsis remain elusive." | 1.62 | 3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice. ( Ando, T; Hoshi, M; Kubo, H; Nakamoto, K; Saito, K; Tashita, C; Tezuka, H; Yamamoto, Y, 2021) |
| "Septic shock is associated with a strong inflammatory response that induces vasodilation and vascular hyporeactivity." | 1.56 | Tryptophan pathway catabolites (serotonin, 5-hydroxyindolacetic acid, kynurenine) and enzymes (monoamine oxidase and indole amine 2,3 dioxygenase) in patients with septic shock: A prospective observational study versus healthy controls. ( Bédos, JP; Bruneel, F; Henry-Lagarrigue, M; Legriel, S; Soppelsa, F; Spreux-Varoquaux, O; Troché, G; Yehia, A, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Troché, G | 1 |
| Henry-Lagarrigue, M | 1 |
| Soppelsa, F | 1 |
| Legriel, S | 1 |
| Yehia, A | 1 |
| Bruneel, F | 1 |
| Bédos, JP | 1 |
| Spreux-Varoquaux, O | 1 |
| Hoshi, M | 2 |
| Kubo, H | 1 |
| Ando, T | 1 |
| Tashita, C | 1 |
| Nakamoto, K | 1 |
| Yamamoto, Y | 2 |
| Tezuka, H | 1 |
| Saito, K | 2 |
| Yamasuge, W | 1 |
| Imai, S | 1 |
| Kunisawa, K | 1 |
| Fujigaki, H | 1 |
| Mouri, A | 1 |
| Nabeshima, T | 1 |
| Ferrario, M | 1 |
| Cambiaghi, A | 1 |
| Brunelli, L | 1 |
| Giordano, S | 1 |
| Caironi, P | 1 |
| Guatteri, L | 1 |
| Raimondi, F | 1 |
| Gattinoni, L | 1 |
| Latini, R | 1 |
| Masson, S | 1 |
| Ristagno, G | 1 |
| Pastorelli, R | 1 |
| Schefold, JC | 1 |
| Zeden, JP | 1 |
| Pschowski, R | 1 |
| Hammoud, B | 1 |
| Fotopoulou, C | 1 |
| Hasper, D | 1 |
| Fusch, G | 1 |
| Von Haehling, S | 1 |
| Volk, HD | 1 |
| Meisel, C | 1 |
| Schütt, C | 1 |
| Reinke, P | 1 |
| Changsirivathanathamrong, D | 1 |
| Wang, Y | 1 |
| Rajbhandari, D | 1 |
| Maghzal, GJ | 1 |
| Mak, WM | 1 |
| Woolfe, C | 1 |
| Duflou, J | 1 |
| Gebski, V | 1 |
| dos Remedios, CG | 1 |
| Celermajer, DS | 1 |
| Stocker, R | 1 |
| Eiserich, JP | 1 |
| Hayakawa, KA | 1 |
| Cross, CE | 1 |
| Oxenkrug, GF | 1 |
| Morris, KM | 1 |
| Moon, RJ | 1 |
| Boruchow, IB | 1 |
| Ludwig, GD | 1 |
| Wontorsky, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Tryptophan, Serotonin and Kynurenine in Septic Shock[NCT00684736] | 30 participants (Actual) | Observational | 2004-06-30 | Completed | |||
| Efficacy of Albumin Administration for Volume Replacement in Patients With Severe Sepsis or Septic Shock - the ALBumin Italian Outcome Sepsis (ALBIOS) Study[NCT00707122] | Phase 3 | 1,818 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for kynurenine and Shock, Septic
| Article | Year |
|---|---|
Mortality prediction in patients with severe septic shock: a pilot study using a target metabolomics approach.
Topics: Aged; Aged, 80 and over; Amino Acids; Carnitine; Cohort Studies; Female; Glycerophospholipids; Gram- | 2016 |
Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock.
Topics: Aged; Calcitonin; Calcitonin Gene-Related Peptide; Granulocyte-Macrophage Colony-Stimulating Factor; | 2010 |
8 other studies available for kynurenine and Shock, Septic
| Article | Year |
|---|---|
Tryptophan pathway catabolites (serotonin, 5-hydroxyindolacetic acid, kynurenine) and enzymes (monoamine oxidase and indole amine 2,3 dioxygenase) in patients with septic shock: A prospective observational study versus healthy controls.
Topics: Aged; Case-Control Studies; Female; Humans; Hydroxyindoleacetic Acid; Indoleamine-Pyrrole 2,3,-Dioxy | 2020 |
3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice.
Topics: Activating Transcription Factor 4; Animals; Disease Models, Animal; Humans; Interleukin-6; Kynurenin | 2021 |
Lipopolysaccharide shock reveals the immune function of indoleamine 2,3-dioxygenase 2 through the regulation of IL-6/stat3 signalling.
Topics: Animals; Cytokines; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-6; Kaplan-Meier Estimate; Kynu | 2018 |
Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypotension; Indoleamine-Pyrrole 2,3,-Dioxygenase; I | 2011 |
Sepsis and hypotension: enter kynurenine, move over nitric oxide.
Topics: Female; Humans; Hypotension; Kynurenine; Male; Shock, Septic; Tryptophan | 2011 |
Kynurenine and hypotension: historic perspectives.
Topics: Female; Humans; Hypotension; Kynurenine; Male; Shock, Septic; Tryptophan | 2012 |
Quantitative analysis of serotonin biosynthesis in endotoxemia.
Topics: Animals; Carbon Radioisotopes; Female; Injections, Intraperitoneal; Kynurenine; Mice; Salmonella typ | 1974 |
Potentiation of endotoxin shock by oral L-tryptophan.
Topics: Ammonia; Animals; Chromatography, Paper; Dogs; Endotoxins; Glucuronates; Hydrocortisone; Indoles; Ky | 1968 |