ly 171883 has been researched along with Shock, Septic in 7 studies
LY 171883: structure in first source; leukotriene receptor antagonist
tomelukast : A member of the class of acetophenones that is 1-phenylethanone substituted at position 2 by a hydroxy group, a propyl group at position 3 and a 4-(1H-tetrazol-5-yl)butoxy group at position 4. A leukotriene antagonist, it exhibits anti-asthmatic activity.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ibuprofen-treated dogs required less NaHCO3 for acid-base maintenance than did dual-blocked animals." | 1.28 | Hemodynamic and renal advantages of dual cyclooxygenase and leukotriene blockade during canine endotoxic shock. ( Passmore, JC; Young, JS, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cohn, SM | 1 |
| Fink, MP | 1 |
| Lee, PC | 1 |
| Wang, H | 1 |
| Rothschild, HR | 1 |
| Deniz, YF | 1 |
| Baum, T | 1 |
| Cook, JA | 3 |
| Li, EJ | 1 |
| Spicer, KM | 1 |
| Wise, WC | 3 |
| Halushka, PV | 3 |
| Young, JS | 1 |
| Passmore, JC | 1 |
| Krausz, MM | 1 |
| Dahan, JB | 1 |
| Gross, D | 1 |
| Etemadi, AR | 1 |
| Tempel, GE | 1 |
| Farah, BA | 1 |
| Puranapanda, V | 1 |
| Hinshaw, LB | 1 |
| O'Rear, EA | 1 |
| Chang, AC | 1 |
| Whitsett, TL | 1 |
7 other studies available for ly 171883 and Shock, Septic
| Article | Year |
|---|---|
LY171883 preserves mesenteric perfusion in porcine endotoxic shock.
Topics: Acetophenones; Animals; Autacoids; Azoles; Escherichia coli; Hydrogen-Ion Concentration; Oxygen Cons | 1990 |
Effect of leukotriene receptor antagonists on vascular permeability during endotoxic shock.
Topics: Acetophenones; Animals; Capillary Permeability; Dicarboxylic Acids; Endotoxins; Erythrocytes; Indium | 1990 |
Hemodynamic and renal advantages of dual cyclooxygenase and leukotriene blockade during canine endotoxic shock.
Topics: Acetophenones; Animals; Bicarbonates; Blood Pressure; Cardiac Output; Cyclooxygenase Inhibitors; Diu | 1990 |
Effect of the leukotriene receptor antagonist LY-171883 on endotoxemia in awake sheep.
Topics: 6-Ketoprostaglandin F1 alpha; Acetophenones; Animals; Azoles; Blood Pressure; Cardiac Output; Leukoc | 1988 |
Protective effect of a selective leukotriene antagonist in endotoxemia in the rat.
Topics: Acetophenones; Analysis of Variance; Animals; Azoles; Bacterial Toxins; Blood Pressure; Endotoxins; | 1985 |
Beneficial effects of a leukotriene antagonist on endotoxin-induced acute hemodynamic alterations.
Topics: Acetophenones; Animals; Azoles; Blood Circulation; Endotoxins; Hemodynamics; Leukotriene E4; Male; R | 1987 |
Erythrocyte deformability in canine septic shock and the efficacy of pentoxifylline and a leukotriene antagonist.
Topics: Acetophenones; Animals; Azoles; Dogs; Erythrocyte Deformability; Escherichia coli Infections; Female | 1987 |