indomethacin has been researched along with Shock, Septic in 96 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To elucidate the effect of arachidonic acid metabolite inhibitors on liver injury in endotoxin shock with special reference to the role of polymorphonuclear leukocytes (PMNs), we pretreated rats with three kinds of arachidonic acid metabolite inhibitors (hydrocortisone, Hy; AA-861, AA; indomethacin, In) in our rat model of endotoxin shock." | 7.69 | [The effect of arachidonic acid metabolite inhibitors on liver injury in endotoxin shock, with special reference to the role of polymorphonuclear leukocytes (PMNs)]. ( Furukawa, K; Kobayashi, T; Onda, M, 1994) |
| "The effects of indomethacin administration on hemodynamics were investigated in canine acute hemorrhagic pancreatitis (AHP)." | 7.67 | Indomethacin in canine acute hemorrhagic pancreatitis. ( Kairaluoma, MI; Kiviniemi, H; Rämö, OJ; Ståhlberg, M, 1988) |
| "The effects of single and multiple doses of indomethacin and multiple doses of nicotinic acid upon Escherichia coli endotoxin shock were studied in mongrel dogs anesthetized with sodium pentobarbital." | 7.65 | Effects of indomethacin and nicotinic acid on E. coli endotoxin shock in anesthetized dogs. ( Hilton, JG; Wells, CH, 1976) |
| "This indomethacin treatment immediately reversed the hypotension, restored the organ perfusion, delayed the haemoconcentration and thrombocytopenia and prevented death." | 5.28 | Sequential release of tumour necrosis factor, platelet activating factor and eicosanoids during endotoxin shock in anaesthetized pigs: protective effects of indomethacin. ( Ben-Efraim, S; Bonta, IL; Heiligers, JP; Mózes, T; Saxena, PR; Tak, CJ; Zijlstra, FJ, 1991) |
| " Contractility was examined in a randomized dose-response manner to both norepinephrine and the prostaglandin endoperoxide analog U-46619." | 5.26 | Vascular reactivity in endotoxin shock: effect of lidocaine or indomethacin pretreatment. ( Casey, L; Fletcher, JR; Pomerantz, K; Ramwell, PW, 1982) |
| "To elucidate the effect of arachidonic acid metabolite inhibitors on liver injury in endotoxin shock with special reference to the role of polymorphonuclear leukocytes (PMNs), we pretreated rats with three kinds of arachidonic acid metabolite inhibitors (hydrocortisone, Hy; AA-861, AA; indomethacin, In) in our rat model of endotoxin shock." | 3.69 | [The effect of arachidonic acid metabolite inhibitors on liver injury in endotoxin shock, with special reference to the role of polymorphonuclear leukocytes (PMNs)]. ( Furukawa, K; Kobayashi, T; Onda, M, 1994) |
| "In the present study, we observed the effects of indomethacin, ibuprofen, naloxone and morphine on plasma CGRP concentration 3 h after endotoxin shock in conscious rats." | 3.68 | [Antiinflammatory drugs inhibit the elevation of plasma CGRP concentration in endotoxin shock in rats]. ( Chen, MZ; Han, QD; Wang, XA; Yang, LH, 1991) |
| " We studied the effects of anti-inflammatory drugs, indomethacin (IND) and dexamethasone (DX), on glucoregulation, body weight, and mortality in 10-day-old suckling rats administered Salmonella enteritidis lipopolysaccharide (LPS)." | 3.68 | Dexamethasone and indomethacin treatment during endotoxicosis in the suckling rat. ( Goto, M; Hurley, RM; Zeller, WP, 1990) |
| "The effects of indomethacin administration on hemodynamics were investigated in canine acute hemorrhagic pancreatitis (AHP)." | 3.67 | Indomethacin in canine acute hemorrhagic pancreatitis. ( Kairaluoma, MI; Kiviniemi, H; Rämö, OJ; Ståhlberg, M, 1988) |
| " The effect of the inhibition of endogenous prostaglandin generation by indomethacin on these parameters was also investigated in this model of endotoxin shock." | 3.67 | Indomethacin potentiates endotoxin-induced blood flow reduction and histological injury in rat gastric mucosa. ( Guth, PH; Leung, FW; Piqué, JM; Whittle, BJ; Yonei, Y, 1988) |
| " The effects of ibuprofen, methylprednisolone-sodium succinate, and gentamicin alone, or in combination on survival time and, TxA2 and PGI2 production in rats in a LD100 fecal peritonitis shock model were assessed." | 3.67 | Ibuprofen, methylprednisolone, and gentamicin as conjoint therapy in septic shock. ( Cook, JA; Halushka, PV; Knapp, RG; Wise, WC, 1985) |
| "We investigated the effects of the thromboxane synthetase inhibitor 7-(1-imidazolyl)heptanoic acid (7-IHA) and the fatty acid cyclooxygenase inhibitors indomethacin or ibuprofen in the treatment of fecal peritonitis in the rat." | 3.66 | Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production. ( Butler, RR; Cook, JA; Halushka, PV; Wise, WC, 1983) |
| "The effects of single and multiple doses of indomethacin and multiple doses of nicotinic acid upon Escherichia coli endotoxin shock were studied in mongrel dogs anesthetized with sodium pentobarbital." | 3.65 | Effects of indomethacin and nicotinic acid on E. coli endotoxin shock in anesthetized dogs. ( Hilton, JG; Wells, CH, 1976) |
| "We have developed a septic shock model in mice by sequential administration of beta-glucan, a biological response modifier, and indomethacin (IND), a nonsteroidal anti-inflammatory drug." | 1.34 | Lincomycin protects mice from septic shock in beta-glucan-indomethacin model. ( Adachi, Y; Miura, NN; Nameda, S; Ohno, N, 2007) |
| "Taking into consideration the effect of septic shock on releasing various mediators, the present study was undertaken in an attempt to elucidate the effect of endotoxin on naloxone-induced withdrawal contractions in the guinea-pig isolated ileum." | 1.31 | Effects of endotoxin-induced shock on withdrawal contractions in the Guinea-pig isolated ileum. ( Fatehi, M; Fatehi-Hassanabad, Z; Tanomand, A, 2002) |
| "Gram-negative sepsis/septic shock in the newborn continues to be a major medical problem, causing high mortality." | 1.29 | Lipopolysaccharide alters suckling rat liver glycogenolysis. ( Goto, M; Goto, MP; Hurley, RM; Picken, M; Zeller, WP, 1993) |
| "Indomethacin or captopril was given by oral gavage 30-35 min before endotoxin." | 1.29 | Role of angiotensin II in neonatal sepsis. ( Dunn, CW; Horton, JW, 1993) |
| "Endotoxic shock was induced in newborn dogs (2 to 10 days old; 300 to 800 g) by Escherichia coli lipopolysaccharide (LPS; 1." | 1.28 | Adjuvant effects of beta-adrenergic drugs on indomethacin treatment of newborn canine endotoxic shock. ( Goto, M; Griffin, A, 1991) |
| "This indomethacin treatment immediately reversed the hypotension, restored the organ perfusion, delayed the haemoconcentration and thrombocytopenia and prevented death." | 1.28 | Sequential release of tumour necrosis factor, platelet activating factor and eicosanoids during endotoxin shock in anaesthetized pigs: protective effects of indomethacin. ( Ben-Efraim, S; Bonta, IL; Heiligers, JP; Mózes, T; Saxena, PR; Tak, CJ; Zijlstra, FJ, 1991) |
| "The mechanisms of vasodilation in septic shock have not been well elucidated." | 1.28 | The effect of tumor necrosis factor on vascular smooth muscle. In vitro studies using rat aortic rings. ( Cunnion, RE; Hollenberg, SM; Parrillo, JE, 1991) |
| "Indomethacin treatment 20 min prior to LPS injection attenuated the hypotension (50 +/- 3 mmHg at 120 min, p less than 0." | 1.28 | Indomethacin treatment in newborn canine endotoxic shock. ( Goto, M; Griffin, AJ, 1991) |
| "Pretreatment with indomethacin, or BM 13505, a specific thromboxane A2 receptor blocker, ameliorated the development of metabolic acidosis in N-6 fatty acid-fed animals, demonstrating a role for prostanoids in the sequelae of endotoxemia." | 1.28 | Diets enriched with N-3 fatty acids ameliorate lactic acidosis by improving endotoxin-induced tissue hypoperfusion in guinea pigs. ( Bistrian, BR; Blackburn, GL; Flores, EA; Pomposelli, JJ; Zeisel, SH, 1991) |
| "Pretreatment with indomethacin (5 mg/kg iv." | 1.27 | [The effects of indomethacin and verapamil on dextran-induced shock in rats]. ( Ishizaki, M, 1985) |
| "Pretreatment with indomethacin alone blunted the endotoxin- (8 mg/kg) induced hypoglycemia." | 1.27 | The effects of alpha adrenergic blockade on arachidonic acid metabolism and shock sequelae in endotoxemia. ( Armstrong, J; Cook, JA; Halushka, PV; Tempel, GE; Wise, WC, 1986) |
| " In this model no effect of the receptor site antagonist was noted, but due to the short half-life of this compound, a different dosing schedule may be needed before its efficacy can be determined." | 1.27 | Group B streptococcal (GBSS) newborn septic shock model: the role of prostaglandins. ( Miller, MK; Pan, J; Short, BL, 1988) |
| "A rabbit model of septic shock was used to determine if myocardial dysfunction is a common component of shock due to diverse neonatal pathogens, and prostaglandins modulate septic myocardial dysfunction." | 1.27 | The comparison of myocardial dysfunction in three forms of experimental septic shock. ( Boerth, RC; Chartrand, SA; Olson, RD; Peevy, KJ; Reed, T, 1986) |
| "Indomethacin pretreatment (10 mg kg-1 i." | 1.26 | Effect of indomethacin on the blood pressure and plasma catecholamine responses to acute endotoxaemia. ( Dimicco, JA; Feuerstein, G; Kopin, IJ; Ramu, A, 1981) |
| "Indomethacin post-treatment significantly elevated aortic pressure, cardiac output, and left ventricular isometric tension elevated aortic pressure, cardiac output, and left ventricular isometric tension rise (LVP dp/dt max) following endotoxin administration in the dog." | 1.26 | The effect of indomethacin and adrenergic receptor blocking agents on rats and canine responses to endotoxin. ( Fujita, T; Goto, F; Otani, E; Yamamuro, M, 1980) |
| " Contractility was examined in a randomized dose-response manner to both norepinephrine and the prostaglandin endoperoxide analog U-46619." | 1.26 | Vascular reactivity in endotoxin shock: effect of lidocaine or indomethacin pretreatment. ( Casey, L; Fletcher, JR; Pomerantz, K; Ramwell, PW, 1982) |
| "Pretreatment with indomethacin markedly attenuated both the hemodynamic changes and the rise in plasma renin activity caused by endotoxin administration." | 1.26 | Prostaglandins and the renin-angiotensin system in canine endotoxemia. ( Feldhaus, RA; Isakson, PC; McKnight, RC; Needleman, P; Raz, A; Shofer, F, 1977) |
| "Systemic hypotension was not observed and the blood pressure in the indomethacintreated cats 1, 2 and 4 h after endotoxin was 30 mmHg higher than in those cats administered endotoxin alone." | 1.25 | The effect of indomethacin on the cardiovascular and metabolic responses to E. coli endotoxin in the cat. ( Parratt, JR; Sturgess, RM, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 59 (61.46) | 18.7374 |
| 1990's | 31 (32.29) | 18.2507 |
| 2000's | 6 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tunctan, B | 1 |
| Yaghini, FA | 1 |
| Estes, A | 1 |
| Malik, KU | 1 |
| Erdös, EG | 3 |
| Hinshaw, LB | 1 |
| Gill, CC | 1 |
| Nameda, S | 4 |
| Saito, M | 2 |
| Miura, NN | 4 |
| Adachi, Y | 4 |
| Ohno, N | 4 |
| Hagmann, W | 1 |
| Denzlinger, C | 1 |
| Keppler, D | 1 |
| Feuerstein, G | 1 |
| Dimicco, JA | 1 |
| Ramu, A | 1 |
| Kopin, IJ | 1 |
| Goto, F | 3 |
| Fujita, T | 2 |
| Otani, E | 2 |
| Yamamuro, M | 3 |
| Butler, RR | 2 |
| Wise, WC | 6 |
| Halushka, PV | 6 |
| Cook, JA | 6 |
| Carli, A | 2 |
| Auclair, MC | 2 |
| Vernimmen, C | 1 |
| Fink, MP | 2 |
| MacVittie, TJ | 1 |
| Casey, LC | 2 |
| Short, BL | 3 |
| Gardiner, WM | 2 |
| Mishik, AN | 1 |
| Ramwell, PW | 10 |
| Walker, D | 1 |
| Fletcher, JR | 13 |
| Pomerantz, K | 1 |
| Casey, L | 1 |
| Tempel, GE | 2 |
| Gardiner, M | 1 |
| Walker, RI | 1 |
| Jones, SR | 1 |
| Harris, RH | 1 |
| Zmudka, M | 1 |
| Maddox, Y | 1 |
| Makabali, GL | 1 |
| Mandal, AK | 1 |
| Morris, JA | 1 |
| Ishihara, Y | 1 |
| Kitamura, S | 1 |
| Kosaka, K | 1 |
| Ohtsu, A | 1 |
| Oba, T | 1 |
| Kamimoto, F | 1 |
| Wada, H | 1 |
| Hoshina, K | 1 |
| Saitoh, N | 1 |
| Okada, N | 1 |
| Yamazaki, N | 1 |
| Kurozumi, S | 1 |
| Naruchi, T | 1 |
| Ramwell, PC | 1 |
| Hom, GJ | 1 |
| Grant, SK | 1 |
| Wolfe, G | 1 |
| Bach, TJ | 1 |
| MacIntyre, DE | 1 |
| Hutchinson, NI | 1 |
| Ashorobi, RB | 1 |
| Williams, PA | 1 |
| Szabó, C | 2 |
| Thiemermann, C | 2 |
| Vane, JR | 2 |
| Gan, H | 1 |
| Newman, GW | 1 |
| Remold, HG | 1 |
| Pettipher, ER | 1 |
| Wimberly, DJ | 1 |
| Wang, X | 2 |
| Han, C | 2 |
| Jones, SB | 1 |
| Yang, L | 2 |
| Fiscus, RR | 2 |
| Wu, CC | 1 |
| Chen, SJ | 1 |
| Kobayashi, T | 1 |
| Furukawa, K | 1 |
| Onda, M | 1 |
| Lindahl, M | 1 |
| Tagesson, C | 1 |
| Goto, M | 5 |
| Zeller, WP | 2 |
| Picken, M | 1 |
| Goto, MP | 1 |
| Hurley, RM | 2 |
| Dunn, CW | 1 |
| Horton, JW | 1 |
| Campanile, F | 1 |
| Giampietri, A | 1 |
| Grohmann, U | 1 |
| Belladonna, ML | 1 |
| Fioretti, MC | 1 |
| Puccetti, P | 1 |
| Shindo, M | 1 |
| Majima, M | 1 |
| Ohno, T | 1 |
| Sugimoto, K | 1 |
| Ohwada, T | 1 |
| Yamamoto, S | 1 |
| Burman, HP | 1 |
| O'Donnell, CP | 1 |
| Cahill, PA | 1 |
| Robotham, JL | 1 |
| Tambourgi, DV | 1 |
| Petricevich, VL | 1 |
| Magnoli, FC | 1 |
| Assaf, SL | 1 |
| Jancar, S | 1 |
| Dias Da Silva, W | 1 |
| Grief, WM | 1 |
| Forse, RA | 1 |
| Fatehi, M | 1 |
| Tanomand, A | 1 |
| Fatehi-Hassanabad, Z | 1 |
| Parratt, JR | 3 |
| Sturgess, RM | 2 |
| Brotzu, G | 1 |
| Dazzi, E | 1 |
| Savona, G | 1 |
| Pinna, M | 1 |
| Spada, MC | 1 |
| Hilton, JG | 1 |
| Wells, CH | 1 |
| Schimmel, D | 1 |
| Schimmel, I | 1 |
| Lutter, K | 1 |
| Putsche, R | 1 |
| Herman, CM | 2 |
| Isakson, PC | 1 |
| Shofer, F | 1 |
| McKnight, RC | 1 |
| Feldhaus, RA | 1 |
| Raz, A | 1 |
| Needleman, P | 1 |
| Anderson, FL | 1 |
| Jubiz, W | 1 |
| Tsagaris, TJ | 1 |
| Kuida, H | 1 |
| Mozes, T | 2 |
| Ben-Efraim, S | 2 |
| Bonta, IL | 2 |
| Taylor, DJ | 1 |
| Faragher, EB | 1 |
| Evanson, JM | 1 |
| Chen, M | 1 |
| Wang, XA | 1 |
| Han, QD | 1 |
| Yang, LH | 1 |
| Chen, MZ | 1 |
| Griffin, A | 1 |
| Fuks, BB | 1 |
| Shapoval, AI | 1 |
| Grzhebin IM, I | 1 |
| Zijlstra, FJ | 1 |
| Heiligers, JP | 1 |
| Tak, CJ | 1 |
| Saxena, PR | 1 |
| Pons, L | 1 |
| Droy-Lefaix, MT | 1 |
| Braquet, P | 1 |
| Buéno, L | 1 |
| Hollenberg, SM | 1 |
| Cunnion, RE | 1 |
| Parrillo, JE | 1 |
| Griffin, AJ | 2 |
| Pomposelli, JJ | 1 |
| Flores, EA | 1 |
| Blackburn, GL | 1 |
| Zeisel, SH | 1 |
| Bistrian, BR | 1 |
| Myers, AK | 1 |
| Robey, JW | 1 |
| Price, RM | 1 |
| Ferguson-Chanowitz, KM | 1 |
| Katocs, AS | 1 |
| Pickett, WC | 1 |
| Kaplan, JB | 1 |
| Sass, PM | 1 |
| Oronsky, AL | 1 |
| Kerwar, SS | 1 |
| Miller-Graziano, CL | 1 |
| Szabo, G | 1 |
| Kodys, K | 1 |
| Griffey, K | 1 |
| Ishizaki, M | 1 |
| Boughton-Smith, NK | 1 |
| Hutcheson, I | 1 |
| Whittle, BJ | 2 |
| Schade, UF | 1 |
| von der Bosch, J | 1 |
| Schönharting, M | 1 |
| McKenna, TM | 1 |
| Titius, WA | 1 |
| Peevy, KJ | 2 |
| Panus, P | 1 |
| Longenecker, GL | 1 |
| Chartrand, SA | 2 |
| Wiseman, HJ | 1 |
| Boerth, RC | 2 |
| Olson, RD | 2 |
| Armstrong, J | 1 |
| Miller, MK | 1 |
| Pan, J | 1 |
| Morrissey, PE | 1 |
| Stein, KL | 1 |
| Clement, RE | 1 |
| Fiallo, V | 1 |
| Deng, XF | 1 |
| Goran, MI | 1 |
| Little, RA | 1 |
| Frayn, KN | 1 |
| Jones, R | 1 |
| Fozzard, G | 1 |
| Bone, RC | 1 |
| Jacobs, ER | 1 |
| Wilson, FJ | 1 |
| Nunez, EA | 1 |
| Christeff, N | 1 |
| Benassayag, C | 1 |
| Schützer, KM | 1 |
| Haglund, U | 1 |
| Falk, A | 1 |
| Kiviniemi, H | 1 |
| Rämö, OJ | 1 |
| Ståhlberg, M | 1 |
| Kairaluoma, MI | 1 |
| Piqué, JM | 1 |
| Yonei, Y | 1 |
| Leung, FW | 1 |
| Guth, PH | 1 |
| Choudhary, G | 1 |
| Sharma, MP | 1 |
| Reed, T | 1 |
| Hall-Angerås, M | 1 |
| Säljö, A | 1 |
| Hasselgren, PO | 1 |
| Knapp, RG | 1 |
| Wang, JP | 1 |
| Hsu, MF | 1 |
| Huang, LJ | 1 |
| Sturgess, R | 1 |
| Culp, JR | 1 |
| Hinshaw, IB | 1 |
| Holmes, DD | 1 |
96 other studies available for indomethacin and Shock, Septic
| Article | Year |
|---|---|
Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production.
Topics: Amitrole; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Blotting, Western; Cytoc | 2008 |
Effect of indomethacin in endotoxin shock in the dog.
Topics: Animals; Blood Pressure; Body Temperature; Disease Models, Animal; Dogs; Hematocrit; Indomethacin; P | 1967 |
Effect of nitric oxide on beta-glucan/indomethacin-induced septic shock.
Topics: Animals; beta-Glucans; Enzyme-Linked Immunosorbent Assay; Indomethacin; Interleukin-6; Liver; Male; | 2005 |
Antibiotics protect against septic shock in mice administered beta-glucan and indomethacin.
Topics: Animals; Anti-Bacterial Agents; Bacterial Translocation; beta-Glucans; Body Weight; Colon; Cytokines | 2007 |
Lincomycin protects mice from septic shock in beta-glucan-indomethacin model.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; beta-Glucans; Blood Glucose | 2007 |
SPG/IND-induced septic shock in a LPS-low responder strain, C3H/HeJ mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Temperature; Body Weight; Gastroint | 2008 |
Role of peptide leukotrienes and their hepatobiliary elimination in endotoxin action.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Bile; Chromones; Dexamethason | 1984 |
Effect of indomethacin on the blood pressure and plasma catecholamine responses to acute endotoxaemia.
Topics: Animals; Blood Pressure; Catecholamines; Cats; Escherichia coli; Female; Indomethacin; Male; Shock, | 1981 |
The effect of indomethacin and adrenergic receptor blocking agents on rats and canine responses to endotoxin.
Topics: Animals; Cyclic AMP; Dogs; Endotoxins; Female; Hemodynamics; Indomethacin; Male; Phenoxybenzamine; P | 1980 |
Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production.
Topics: Animals; Epoprostenol; Fatty Acids, Essential; Female; Fibrin Fibrinogen Degradation Products; Genta | 1983 |
Indomethacin suppresses the early cardiodepressant factor released by endotoxin in the rat: possible involvement of a prostacyclin-related material.
Topics: Animals; Caffeine; Cells, Cultured; Depression, Chemical; Epoprostenol; Imidazoles; Indomethacin; Ma | 1983 |
Inhibition of prostaglandin synthesis restores normal hemodynamics in canine hyperdynamic sepsis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Disease Models, Animal; Dogs; Escherichia coli Infections; Fe | 1984 |
Thromboxane synthetase inhibitors in septic shock.
Topics: Animals; Depression, Chemical; Imidazoles; Indomethacin; Male; Oxidoreductases; Prostaglandins F; Ra | 1983 |
Thromboxane and prostacyclin production during septic shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Epoprostenol; Fatty Acids, Essential; Female; Fibrin Fibrinog | 1982 |
Vascular reactivity in endotoxin shock: effect of lidocaine or indomethacin pretreatment.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta, Thoracic; Dose-R | 1982 |
The improvement in endotoxin-induced redistribution of organ blood flow by inhibition of thromboxane and prostaglandin synthesis.
Topics: Animals; Arachidonic Acids; Blood Circulation; Cardiac Output; Cerebrovascular Circulation; Coronary | 1982 |
Indomethacin improves survival in gram-negative sepsis.
Topics: Animals; Blood Pressure; Disease Models, Animal; Escherichia coli Infections; Indomethacin; Leukocyt | 1981 |
Relationship of TXB2 and 6-keto PGF1 alpha to the hemodynamic changes during baboon endotoxic shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arteries; Blood Pressure; Haplorhini; Indomethacin; Lidocaine | 1980 |
An assessment of the participatory role of prostaglandins and serotonin in the pathophysiology of endotoxic shock.
Topics: Animals; Dogs; Hemodynamics; Indomethacin; Ketanserin; Oxygen; Piperidines; Prostaglandins; Pulmonar | 1983 |
[Experimental investigation on the pathogenesis of endotoxin shock--the change of plasma serotonin, histamine, thromboxane B2 and 6-keto PGF1 alpha levels and modulation by indomethacin (author's transl)].
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dogs; Histamine; Indomethacin; Serotonin; Shock, Septic; Thro | 1982 |
Implications for thromboxane A2 in the pathogenesis of endotoxic shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprost; Disseminated Intravascular Coagulation; Fibrin Fib | 1981 |
Prostaglandins in shock: to give or to block?
Topics: Animals; Arachidonic Acids; Aspirin; Dogs; Epoprostenol; Hemodynamics; Indomethacin; Papio; Prostagl | 1980 |
Indomethacin treatment following baboon endotoxin shock improves survival.
Topics: Animals; Endotoxins; Escherichia coli; Hemodynamics; Indomethacin; Male; Papio; Shock, Septic | 1980 |
Effects of a novel acylindole derivative on experimental thrombotic models, ulceration of the gastric mucosa and prostacyclin production in the aorta.
Topics: Animals; Aorta; Arteriovenous Shunt, Surgical; Blood Platelets; Epoprostenol; Fibrinolytic Agents; G | 1981 |
The role of prostaglandins in sepsis.
Topics: Animals; Escherichia coli Infections; Indomethacin; Male; Prostaglandin Antagonists; Prostaglandins; | 1982 |
The protective effect of lidocaine on arachidonate metabolism in septic shock.
Topics: Animals; Arachidonic Acids; Dogs; Humans; Indomethacin; Lidocaine; Papio; Prostaglandins; Rats; Shoc | 1981 |
Lipopolysaccharide-induced hypotension and vascular hyporeactivity in the rat: tissue analysis of nitric oxide synthase mRNA and protein expression in the presence and absence of dexamethasone, NG-monomethyl-L-arginine or indomethacin.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Dexamethasone; Female; Gene Expressio | 1995 |
Indomethacin and alpha-tocopheral enhanced survival in endotoxic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation, Preclinical; Drug Therapy, Combin | 1995 |
Inhibition of the production of nitric oxide and vasodilator prostaglandins attenuates the cardiovascular response to bacterial endotoxin in adrenalectomized rats.
Topics: Adrenalectomy; Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Calcium; Dexamethasone | 1993 |
Human macrophages acquire a hyporesponsive state of tumor necrosis factor alpha production in response to successive Mycobacterium avium serovar 4 stimulation.
Topics: Dinoprostone; Humans; Indomethacin; Macrophages; Mycobacterium avium; RNA, Messenger; Serotyping; Sh | 1995 |
Cyclooxygenase inhibitors enhance tumour necrosis factor production and mortality in murine endotoxic shock.
Topics: Animals; Cyclooxygenase Inhibitors; Death; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Ibup | 1994 |
Calcitonin gene-related peptide release in endotoxicosis may be mediated by prostaglandins.
Topics: Animals; Aspirin; Blood Glucose; Blood Pressure; Calcitonin Gene-Related Peptide; Cyclooxygenase Inh | 1995 |
Activation of soluble guanylyl cyclase by a factor other than nitric oxide or carbon monoxide contributes to the vascular hyporeactivity to vasoconstrictor agents in the aorta of rats treated with endotoxin.
Topics: Animals; Aorta; Carbon Monoxide; Endotoxins; Enzyme Activation; Guanylate Cyclase; In Vitro Techniqu | 1994 |
[The effect of arachidonic acid metabolite inhibitors on liver injury in endotoxin shock, with special reference to the role of polymorphonuclear leukocytes (PMNs)].
Topics: Animals; Arachidonic Acid; Benzoquinones; Hydrocortisone; Indomethacin; Liver Diseases; Male; Neutro | 1994 |
Selective inhibition of group II phospholipase A2 by quercetin.
Topics: Animals; Aristolochic Acids; Chlorpromazine; Humans; Indomethacin; Pancreas; Phenanthrenes; Phosphol | 1993 |
Lipopolysaccharide alters suckling rat liver glycogenolysis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Cytarabine; Disease Models | 1993 |
Role of angiotensin II in neonatal sepsis.
Topics: Angiotensin II; Animals; Animals, Newborn; Captopril; Dogs; Epoprostenol; Escherichia coli; Hemodyna | 1993 |
Evidence for tumor necrosis factor alpha as a mediator of the toxicity of a cyclooxygenase inhibitor in Gram-negative sepsis.
Topics: Animals; Cyclooxygenase Inhibitors; Female; Gene Amplification; Gene Expression; Indomethacin; Male; | 1996 |
Induction mechanism of small intestinal lesions caused by intravenous injection of endotoxin in rats.
Topics: Animals; Capillary Leak Syndrome; Cyclooxygenase Inhibitors; Endotoxins; Enzyme Inhibitors; Epoprost | 1996 |
Endothelin causes portal and pulmonary hypertension in porcine endotoxemic shock.
Topics: Analysis of Variance; Animals; Bosentan; Cyclooxygenase Inhibitors; Endothelin Receptor Antagonists; | 1997 |
Endotoxemic-like shock induced by Loxosceles spider venoms: pathological changes and putative cytokine mediators.
Topics: Animals; Antibodies, Monoclonal; Antivenins; Cyclooxygenase Inhibitors; Cytokines; Enzyme-Linked Imm | 1998 |
Interventions to improve cardiopulmonary hemodynamics during laparoscopy in a porcine sepsis model.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Cardiovascular Agents; Disease Models, Anima | 1999 |
Effects of endotoxin-induced shock on withdrawal contractions in the Guinea-pig isolated ileum.
Topics: Animals; Endotoxins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Male; Morphine; | 2002 |
E. coli endotoxin shock in the cat; treatment with indomethacin.
Topics: Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Cardiac Output; Cats; Endotoxins; Escherichi | 1975 |
Modification of surfactants in rat in septic shock.
Topics: Animals; Aprotinin; Fatty Acids; Hydrocortisone; Indomethacin; Lipids; Phosphatidylcholines; Pulmona | 1979 |
E. coli endotoxin shock in the dog; treatment with lidocaine or indomethacin.
Topics: Animals; Blood Cell Count; Blood Coagulation; Dogs; Endotoxins; Escherichia coli; Hemodynamics; Indo | 1978 |
Lidocaine or indomethacin improves survival in baboon endotoxin shock.
Topics: Animals; Dogs; Haplorhini; Hemodynamics; Indomethacin; Lidocaine; Male; Papio; Prostaglandins F; Sho | 1978 |
E. coli endotoxin shock in the baboon: treatment with lidocaine or indomethacin.
Topics: Animals; Blood Pressure; Cardiac Output; Escherichia coli; Haplorhini; Heart Rate; Indomethacin; Lid | 1978 |
[The effect of indomethacin on rat and canine responses to endotoxin (author's transl)].
Topics: Animals; Dogs; Hemodynamics; Indomethacin; Phenoxybenzamine; Prostaglandins; Rats; Shock, Septic | 1979 |
[The effects of indomethacin on rat and canine responses to endotoxin (author's transl)].
Topics: Animals; Dogs; Indomethacin; Male; Phenoxybenzamine; Rats; Shock, Septic | 1978 |
Effects of indomethacin and nicotinic acid on E. coli endotoxin shock in anesthetized dogs.
Topics: Animals; Blood Pressure; Cardiac Output; Disease Models, Animal; Dogs; Endotoxins; Escherichia coli; | 1976 |
[Effect of acetylsalicylic acid on experimentally induced endotoxin reactions in swine].
Topics: Animals; Aspirin; Drug Interactions; Endotoxins; Escherichia coli; Indomethacin; Shock, Septic; Swin | 1976 |
Prostaglandins and the hemodynamic course of endotoxin shock.
Topics: Animals; Aspirin; Blood Pressure; Cardiac Output; Disease Models, Animal; Haplorhini; Hemodynamics; | 1976 |
Prostaglandins and the renin-angiotensin system in canine endotoxemia.
Topics: Angiotensin II; Animals; Disease Models, Animal; Dogs; Female; Hemodynamics; Indomethacin; Kidney; M | 1977 |
Improved survival in endotoxemia with aspirin and indomethacin pretreatment.
Topics: Animals; Aspirin; Dogs; Endotoxins; Hemodynamics; Indomethacin; Male; Shock, Septic | 1976 |
Endotoxin-induced prostaglandin E and F release in dogs.
Topics: Animals; Aorta; Aspirin; Blood Pressure; Cardiac Output; Dogs; Indomethacin; Portal Vein; Prostaglan | 1975 |
Lethal and non-lethal course of endotoxic shock is determined by interactions between tumor necrosis factor, platelet activating factor and eicosanoids.
Topics: Animals; Blood Pressure; Diterpenes; Eicosanoids; Endotoxins; Escherichia coli; Ginkgolides; Indomet | 1992 |
Inflammatory cytokines stimulate glucose uptake and glycolysis but reduce glucose oxidation in human dermal fibroblasts in vitro.
Topics: Biological Transport; Cells, Cultured; Citric Acid Cycle; Dexamethasone; Fibroblasts; Glucose; Glyco | 1992 |
Ibuprofen, indomethacin, and high-dose aspirin, but not low-dose aspirin or imidazole, inhibit CGRP elevations in plasma during endotoxicosis.
Topics: Animals; Aspirin; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Endotoxins; Ibu | 1992 |
[Antiinflammatory drugs inhibit the elevation of plasma CGRP concentration in endotoxin shock in rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Ibuprofen; Indome | 1991 |
Adjuvant effects of beta-adrenergic drugs on indomethacin treatment of newborn canine endotoxic shock.
Topics: Adjuvants, Pharmaceutic; Animals; Animals, Newborn; Dobutamine; Dogs; Dopamine; Drug Therapy, Combin | 1991 |
[Increase of the production of tumor necrosis factor in endotoxin shock in mice presensitized with sera of tumor-bearing mice or tumor cell factor].
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Indomethacin; Lipopolysaccharide | 1991 |
Sequential release of tumour necrosis factor, platelet activating factor and eicosanoids during endotoxin shock in anaesthetized pigs: protective effects of indomethacin.
Topics: Anesthesia; Animals; Blood Chemical Analysis; Blood Glucose; Eicosanoids; Escherichia coli; Female; | 1991 |
Myoelectric intestinal disturbances in Escherichia coli endotoxic shock in rats. Involvement of platelet-activating factor.
Topics: Animals; Diterpenes; Duodenum; Endotoxins; Escherichia coli; Ginkgolides; Indomethacin; Jejunum; Lac | 1991 |
The effect of tumor necrosis factor on vascular smooth muscle. In vitro studies using rat aortic rings.
Topics: Animals; Aorta, Thoracic; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Interleukin-1; I | 1991 |
Indomethacin treatment in newborn canine endotoxic shock.
Topics: Animals; Animals, Newborn; Blood Pressure; Cardiac Output; Dogs; Heart Rate; Hemodynamics; Indometha | 1991 |
Diets enriched with N-3 fatty acids ameliorate lactic acidosis by improving endotoxin-induced tissue hypoperfusion in guinea pigs.
Topics: Acidosis, Lactic; Animals; Dietary Fats; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Fish Oils; | 1991 |
Relationships between tumour necrosis factor, eicosanoids and platelet-activating factor as mediators of endotoxin-induced shock in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Capillary Permeability; Diter | 1990 |
Platelet-activating factor or a platelet-activating factor antagonist decreases tumor necrosis factor-alpha in the plasma of mice treated with endotoxin.
Topics: Alprazolam; Animals; Cell Line; Endotoxins; Enzyme-Linked Immunosorbent Assay; Indomethacin; Kidney; | 1990 |
Dexamethasone and indomethacin treatment during endotoxicosis in the suckling rat.
Topics: Animals; Animals, Suckling; Blood Glucose; Body Weight; Dexamethasone; Indomethacin; Lactates; Lacti | 1990 |
Aberrations in post-trauma monocyte (MO) subpopulation: role in septic shock syndrome.
Topics: Adult; Aged; Burns; Cell Separation; Humans; Immune Tolerance; Indomethacin; Middle Aged; Monocytes; | 1990 |
[The effects of indomethacin and verapamil on dextran-induced shock in rats].
Topics: Animals; Dextrans; Indomethacin; Male; Rats; Rats, Inbred Strains; Shock, Septic; Verapamil | 1985 |
Relationship between PAF-acether and thromboxane A2 biosynthesis in endotoxin-induced intestinal damage in the rat.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non | 1989 |
Pentoxifylline increases survival of mice in endotoxic shock.
Topics: Animals; Epoprostenol; Female; Indomethacin; Leukopenia; Lipopolysaccharides; Mice; Pentoxifylline; | 1989 |
Role of monokines in altering receptor and non-receptor mediated vascular contraction in sepsis.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Endothelium, Vascular; In Vitro Techniques; Indomethacin; I | 1989 |
Prostaglandin synthetase inhibition in group B streptococcal shock: hematologic and hemodynamic effects.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Bicarbonates; Blood Gas Analysis; Blood Platelets; Blood Pres | 1986 |
The effects of alpha adrenergic blockade on arachidonic acid metabolism and shock sequelae in endotoxemia.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Indomethacin; Male; Phen | 1986 |
Group B streptococcal (GBSS) newborn septic shock model: the role of prostaglandins.
Topics: Animals; Animals, Newborn; Blood Glucose; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, | 1988 |
Systemic and regional hemodynamic effects of cyclo-oxygenase and thromboxane synthetase inhibition in normal and hyperdynamic endotoxemic rabbits.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Endotoxins | 1988 |
Adjuvant effects of beta-adrenergic drugs in the indomethacin treatment of highly lethal endotoxic shock.
Topics: Animals; Dobutamine; Dopamine; Drug Synergism; Drug Therapy, Combination; Indomethacin; Isoprotereno | 1988 |
[Effect of indomethacin on septic shock experimental and preliminary clinical trials].
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Child; Child, Preschool; Female; Humans; Indomethacin; Infant | 1988 |
Effects of chronic endotoxaemia on oxygen consumption at different ambient temperatures in the unanaesthetised rat.
Topics: Animals; Body Temperature Regulation; Body Weight; Chronic Disease; Consciousness; Disease Models, A | 1988 |
Increased hemodynamic and survival with endotoxin and septic shock with ibuprofen treatment.
Topics: Animals; Anti-Bacterial Agents; Escherichia coli Infections; Hemodynamics; Ibuprofen; Indomethacin; | 1987 |
Influence of indomethacin on the endotoxin-induced cardiodepressant effect of serum and steroid hormone changes in male rats.
Topics: Animals; Dose-Response Relationship, Drug; Endotoxins; Escherichia coli; Estrogens; Hormones; In Vit | 1987 |
The role of prostanoids in the feline intestinal vascular and central haemodynamic responses to i.v. infusion of live E. coli.
Topics: Animals; Cats; Escherichia coli; Hemodynamics; Imidazoles; Indomethacin; Intestines; Shock, Septic; | 1987 |
Indomethacin in canine acute hemorrhagic pancreatitis.
Topics: Acute Disease; Animals; Blood Pressure; Dogs; Hemodynamics; Hemorrhage; Indomethacin; Pancreatitis; | 1988 |
Indomethacin potentiates endotoxin-induced blood flow reduction and histological injury in rat gastric mucosa.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Drug Synergism; Endotoxins; Gastric Mucos | 1988 |
Septicaemia: newer mode of therapy.
Topics: Adrenal Cortex Hormones; Blood Transfusion; Humans; Immunization, Passive; Indomethacin; Naloxone; S | 1987 |
The comparison of myocardial dysfunction in three forms of experimental septic shock.
Topics: Animals; Disease Models, Animal; Escherichia coli Infections; Haemophilus Infections; Haemophilus in | 1986 |
Effect of methylprednisolone, indomethacin, and diethylcarbamazine on survival rate following trauma and sepsis in rats.
Topics: Animals; Diethylcarbamazine; Escherichia coli Infections; Indomethacin; Male; Methylprednisolone; Ra | 1986 |
Ibuprofen, methylprednisolone, and gentamicin as conjoint therapy in septic shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Disease Models, Animal; Drug Therapy, Combination; Female; Ge | 1985 |
Antihemostatic and antithrombotic effects of XC386.
Topics: Animals; Aspirin; Blood Coagulation; Hematocrit; Heparin; Indomethacin; Mice; Platelet Aggregation; | 1985 |
Proceedings: The effect of indomethacin on the cardiovascular responses of cats to E. coli endotoxin.
Topics: Animals; Cats; Endotoxins; Escherichia coli; Hemodynamics; Indomethacin; Shock, Septic | 1973 |
The effect of indomethacin on the cardiovascular and metabolic responses to E. coli endotoxin in the cat.
Topics: Acidosis; Animals; Arteries; Blood; Blood Glucose; Cardiac Output; Cats; Central Venous Pressure; En | 1974 |
Effect of nonsteroidal anti-inflammatory drugs in endotoxin shock.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Blood Pressure; Depression, Chemical; Dogs; Endotoxins; | 1968 |
Effects of anti-inflammatory drugs in shock caused by injection of living E. coli cells.
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents; Arteries; Blood Pressure; Dogs; Escherichia coli; Fl | 1971 |