aldosterone and Shock, Septic studies

Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.

Research Excerpts

Excerpt	Relevance	Reference
"Bradykinin was measured by bioassay using rat uteri."	5.26	Effects of aldosterone and dexamethasone on blood chemical mediators in endotoxin shock. ( Ebata, T; Hayasaka, H, 1979)
"One hundred patients with sepsis and septic shock."	2.71	Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: a prospective clinical trial. ( Chhibber, VL; Fernandez, F; Flores, E; Lubarsky, L; Manglik, S; Tayek, JA, 2003)
"In 27 patients with septic shock, baseline levels of aldosterone, cortisol, ACTH, renin, sodium, potassium, and lactate were measured, followed by a cortrosyn test."	1.39	Aldosterone secretion in patients with septic shock: a prospective study. ( Czepielewski, MA; Friedman, G; Moraes, RB; Saltz, H; Tonietto, T; Viana, MV, 2013)
"Acute liver failure is often accompanied by hyperdynamic circulation, which is also a characteristic of septic shock."	1.35	Hemodynamics and metabolic studies on septic shock in patients with acute liver failure. ( Chen, PC; Chen, YC; Chu, YY; Fang, JT; Lien, JM; Peng, YS; Tang, JH; Tian, YC; Tsai, MH; Wu, CS; Yang, C, 2008)
"Hyperreninemic hypoaldosteronism has been described in critically ill patients."	1.32	Hyperreninemic hypoaldosteronism: a possible etiological factor of septic shock-induced acute renal failure. ( Charbonneau, P; Daubin, C; du Cheyron, D; Lesage, A; Ramakers, M, 2003)
"Bradykinin was measured by bioassay using rat uteri."	1.26	Effects of aldosterone and dexamethasone on blood chemical mediators in endotoxin shock. ( Ebata, T; Hayasaka, H, 1979)

Research

Studies (43)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Hemodynamics as Characterized by Mean Arterial Pressure

Timeframe	Studies, this research(%)	All Research%
pre-1990	29 (67.44)	18.7374
1990's	3 (6.98)	18.2507
2000's	5 (11.63)	29.6817
2010's	3 (6.98)	24.3611
2020's	3 (6.98)	2.80

Authors	Studies
Olivier, PY	1
Moal, V	1
Saulnier, P	1
Lasocki, S	1
Radermacher, P	1
Asfar, P	1
Cohen, J	1
Bellomo, R	1
Billot, L	1
Burrell, LM	1
Evans, DM	1
Finfer, S	1
Hammond, NE	1
Li, Q	1
Liu, D	1
McArthur, C	1
McWhinney, B	1
Moore, J	1
Myburgh, J	1
Peake, S	1
Pretorius, C	1
Rajbhandari, D	1
Rhodes, A	1
Saxena, M	1
Ungerer, JPJ	1
Young, MJ	1
Venkatesh, B	1
Møller, MH	1
Shankar-Hari, M	1
Alhazzani, W	1
Fadel, F	1
André-Grégoire, G	1
Gravez, B	1
Bauvois, B	1
Bouchet, S	1
Sierra-Ramos, C	1
Polito, A	1
Mansart, A	1
Alvarez de la Rosa, D	1
Annane, D	1
Jaisser, F	1
Marshall, JC	1
Moraes, RB	1
Friedman, G	1
Viana, MV	1
Tonietto, T	1
Saltz, H	1
Czepielewski, MA	1
Tsai, MH	1
Chen, YC	1
Lien, JM	1
Tian, YC	1
Peng, YS	1
Fang, JT	1
Yang, C	1
Tang, JH	1
Chu, YY	1
Chen, PC	1
Wu, CS	1
Manglik, S	1
Flores, E	1
Lubarsky, L	1
Fernandez, F	1
Chhibber, VL	1
Tayek, JA	1
SPINK, WW	1
VICK, JA	1
MELBY, JC	1
FINSTAD, J	1
HAYASAKA, H	8
O'MALLEY, JF	1
HOWARD, JM	4
LOUBATIERES, A	1
BOUYARD, P	1
MARIANI, MM	1
KLEIN, M	1
SAMBHI, MP	1
WEIL, MH	1
UDHOJI, VN	1
SHUBIN, H	1
O'NEILL, JA	1
FOSTER, JH	1
du Cheyron, D	1
Lesage, A	1
Daubin, C	1
Ramakers, M	1
Charbonneau, P	1
den Brinker, M	1
Joosten, KF	1
Liem, O	1
de Jong, FH	1
Hop, WC	1
Hazelzet, JA	1
van Dijk, M	1
Hokken-Koelega, AC	1
Aiura, K	1
Ueda, M	1
Endo, M	1
Kitajima, M	1
Takekoshi, K	1
Kasai, K	2
Nakamura, T	2
Tsuneyoshi, I	1
Yamada, H	1
Kakihana, Y	1
Nakamura, M	1
Nakano, Y	1
Boyle, WA	1
Oyama, T	1
Toyooka, K	1
Sato, Y	1
Kondo, S	2
Kudo, T	1
Satoh, Y	1
Ichikawa, T	1
Ebata, T	4
Osanai, H	3
Totsuka, M	3
Wakayama, S	1
Sekiguchi, Y	1
Banba, N	1
Takahashi, K	1
Emoto, T	1
Hattori, Y	1
Shimoda, S	1
Dorin, RI	1
Kearns, PJ	1
Khadzhikostova, Kh	1
Petkova, M	2
Nikolov, N	2
Hadjikostova, H	1
Lundberg, D	1
Halmagyi, DF	1
Starzecki, B	1
Horner, GJ	1
White, FN	1
Gold, EM	1
Vaughn, DL	2
Bersentes, T	2
Kirschbaum, TH	2
Assali, NS	2
Rex, H	1
Meyer, W	1
Thomas, CS	1
Brockman, SK	1
Barron, S	1
Pairent, FW	1
Vaughn, D	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effect of an Anesthetic Induction Dose of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery[NCT00415701]	Phase 4	130 participants (Anticipated)	Interventional	2006-11-30	Completed
Vasopressin Plasma Concentrations in Responders and Non-responders to Exogenous Vasopressin Infusion in Patients With Septic Shock[NCT03014063]		18 participants (Actual)	Observational	2016-11-30	Completed
Use of Arginine Vasopressin in Early Postoperative Management After Fontan Palliation[NCT03088345]	Phase 2/Phase 3	20 participants (Actual)	Interventional	2017-03-06	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Organ perfusion pressure measured as Mean Arterial Pressure (MAP). It will be measured hourly for 24 postoperative hours for all subjects and compared between the two study groups over the whole time of observation as the main between-group effect in panel regression. (NCT03088345)
Timeframe: 24 hours post-operative

Hemodynamics as Characterized by Transpulmonary Pressure Gradient

Intervention	mmHg (Mean)
Vasopressin, Arginine	67
Placebo	66

The transpulmonary pressure gradient (TPG), defined as the difference between mean pulmonary arterial pressure (Ppa) and left/common atrial (common atrial) pressure (Pla) will be measured hourly for 24 postoperative hours for all subjects and compared between the two study groups over the whole time of observation as the main between-group effect in panel regression. (NCT03088345)
Timeframe: 24 hours post-operative

Hemodynamics as Characterized by Vasoactive Inotrope Score (VIS)

Intervention	mmHg (Mean)
Vasopressin, Arginine	6.4
Placebo	8.3

The vasoactive inotrope score (VIS) is a linear sum of vasoactive and inotrope durg infusion doses. It is usually reported as dimensionless but is sometimes reported as normalized to dopamine mcg/kg/min equivalents. The score starts at 0 and has no defined upper limit, with a commonly observed range 0-50. It is used as a measure of the intensity of hemodynamic support, with higher scores indicating more vasoactive drug support for patients. The relationship of VIS to other patient outcomes is not consistent. It will be calculated hourly for all subjects and compared between groups over the entire observation timeframe. (NCT03088345)
Timeframe: 48 hours post-operative

Liver Dysfunction as Characterized by Transaminase Levels

Intervention	units (Mean)
Vasopressin, Arginine	11
Placebo	11.3

Transaminase levels (alanine and aspartate, measured in IU/L ) will be tracked for all patients and changes will be compared between study groups. (NCT03088345)
Timeframe: 48 hours post-operative

Renal Dysfunction as Characterized by Change in Cystatin Level

Intervention	iU/L (Mean)
Vasopressin, Arginine	715
Placebo	522

Cystatin levels will be measured at baseline (immediately before cardiopulmonary bypass) 24 hours postoperative. The change (postoperative minus baseline) in cystatin level will be compared between groups. (NCT03088345)
Timeframe: from baseline pre-cardiopulmonary bypass to 24 hours post-operative

Resource Utilization Measured by Length of Stay (LOS)

Intervention	mg/L (Mean)
Vasopressin, Arginine	0.095
Placebo	0.017

Length of stay (LOS) measured in postoperative hours compared between groups (NCT03088345)
Timeframe: from time of operation until hospital discharge

Article	Year
[The importance of angiotensin in clinical practice]. Zeitschrift fur arztliche Fortbildung, 1966, Nov-15, Volume: 60, Issue:21 Topics: Aldosterone; Anaphylaxis; Angiotensin II; Animals; Blood Pressure; Glomerular Filtration Rate; Human	1966
[Clinical aspects, pathogenesis and therapy of shock due to sepsis caused by gram-negative organisms]. Schweizerische medizinische Wochenschrift, 1966, Feb-05, Volume: 96, Issue:5 Topics: Adult; Aldosterone; Animals; Blood; Chlorpromazine; Diarrhea; Dogs; Electrocardiography; Endotoxins;	1966
[Endotoxin shock and its countermeasures]. Shujutsu. Operation, 1967, Volume: 21, Issue:12 Topics: Aldosterone; Animals; Endotoxins; Hemodynamics; Humans; Hydrocortisone; Hyperbaric Oxygenation; Shoc	1967

Article	Year
Renin aldosterone vasopressin and copeptin kinetics in patients with septic shock, a post-hoc Hyper2S randomized trial analysis. Intensive care medicine, 2020, Volume: 46, Issue:4 Topics: Aldosterone; Glycopeptides; Humans; Kinetics; Renin; Shock, Septic; Vasopressins	2020
Plasma Cortisol, Aldosterone, and Ascorbic Acid Concentrations in Patients with Septic Shock Do Not Predict Treatment Effect of Hydrocortisone on Mortality. A Nested Cohort Study. American journal of respiratory and critical care medicine, 2020, 09-01, Volume: 202, Issue:5 Topics: Aged; Aldosterone; Anti-Inflammatory Agents; Ascorbic Acid; Australia; Biomarkers; Female; Follow-Up	2020
Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: a prospective clinical trial. Critical care medicine, 2003, Volume: 31, Issue:6 Topics: Adrenal Cortex Function Tests; Adrenal Insufficiency; Adrenocorticotropic Hormone; Aged; Aldosterone	2003
Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock. Critical care medicine, 2001, Volume: 29, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aldosterone; Angiotensin II; Atrial Natriuretic Factor;	2001
Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock. Critical care medicine, 2001, Volume: 29, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aldosterone; Angiotensin II; Atrial Natriuretic Factor;	2001
Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock. Critical care medicine, 2001, Volume: 29, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aldosterone; Angiotensin II; Atrial Natriuretic Factor;	2001
Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock. Critical care medicine, 2001, Volume: 29, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aldosterone; Angiotensin II; Atrial Natriuretic Factor;	2001

Article	Year
Use of Hydrocortisone Based on Plasma Biomarkers in Patients with Septic Shock: Another One Bites the Dust? American journal of respiratory and critical care medicine, 2020, 09-01, Volume: 202, Issue:5 Topics: Aldosterone; Ascorbic Acid; Biomarkers; Cohort Studies; Dust; Humans; Hydrocortisone; Shock, Septic	2020
Aldosterone and Vascular Mineralocorticoid Receptors in Murine Endotoxic and Human Septic Shock. Critical care medicine, 2017, Volume: 45, Issue:9 Topics: Aldosterone; Animals; Blood Pressure; Cytokines; Disease Models, Animal; Down-Regulation; Endotoxins	2017
Steroids Redux: Targeting the Mineralocorticoid Axis in Sepsis. Critical care medicine, 2017, Volume: 45, Issue:9 Topics: Aldosterone; Animals; Endotoxins; Humans; Mice; Mineralocorticoids; Receptors, Mineralocorticoid; Se	2017
Aldosterone secretion in patients with septic shock: a prospective study. Arquivos brasileiros de endocrinologia e metabologia, 2013, Volume: 57, Issue:8 Topics: Adrenocorticotropic Hormone; Adult; Aged; Aldosterone; Cosyntropin; Female; Humans; Hydrocortisone;	2013
Hemodynamics and metabolic studies on septic shock in patients with acute liver failure. Journal of critical care, 2008, Volume: 23, Issue:4 Topics: Aldosterone; APACHE; Blood Gas Analysis; Female; Hemodynamics; Hepatitis B; Hospital Mortality; Huma	2008
Influence of aldosterone and angiotensin II on endotoxin shock in the primate. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1963, Volume: 112 Topics: Aldosterone; Angiotensin II; Animals; Endotoxins; Humans; Hypertension; Primates; Shock; Shock, Sept	1963
ANTITOXIC EFFECT OF ALDOSTERONE ON CATS IN ENDOTOXIC SHOCK. FURTHER STUDIES. Archives of surgery (Chicago, Ill. : 1960), 1963, Volume: 87 Topics: Aldosterone; Cats; Hydrocortisone; Research; Shock; Shock, Septic	1963
STUDIES ON THE MECHANISM OF ACTION OF ALDOSTERONE IN ENDOTOXIC SHOCK. Surgical forum, 1963, Volume: 14 Topics: Aldosterone; Cats; Endotoxins; Pharmacology; Research; Shock; Shock, Septic	1963
MECHANISM OF ACTION OF D-ALDOSTERONE IN ENDOTOXIN SHOCK. Surgery, 1963, Volume: 54 Topics: Aldosterone; Cats; Endotoxins; Escherichia coli; Pharmacology; Polysaccharides; Polysaccharides, Bac	1963
[EFFECTS OF D-ALDOSTERONE AND HYPERTENSIN II ON CARDIOVASCULAR SHOCK INDUCED IN THE DOG BY POLYVINYLPYRROLIDONE]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1963, Volume: 157 Topics: Aldosterone; Angiotensin Amide; Angiotensins; Cardiovascular System; Dogs; Pharmacology; Povidone; R	1963
ADRENOCORTICOIDS IN THE MANAGEMENT OF SHOCK. International anesthesiology clinics, 1964, Volume: 2 Topics: Adrenal Cortex Hormones; Aldosterone; Blood Circulation; Dexamethasone; Endotoxins; Humans; Hypotens	1964
THE INFLUENCE OF LOW MOLECULAR WEIGHT DEXTRAN ON LETHAL ENDOTOXEMIA. The American surgeon, 1964, Volume: 30 Topics: Aldosterone; Dextrans; Dogs; Endotoxemia; Endotoxins; Erythrocyte Aggregation; Escherichia coli Infe	1964
Hyperreninemic hypoaldosteronism: a possible etiological factor of septic shock-induced acute renal failure. Intensive care medicine, 2003, Volume: 29, Issue:10 Topics: Acute Kidney Injury; Adrenocorticotropic Hormone; Aldosterone; Female; Humans; Hypoaldosteronism; Lo	2003
Adrenal insufficiency in meningococcal sepsis: bioavailable cortisol levels and impact of interleukin-6 levels and intubation with etomidate on adrenal function and mortality. The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:9 Topics: 17-alpha-Hydroxyprogesterone; Adrenal Glands; Adrenal Insufficiency; Adrenocorticotropic Hormone; Al	2005
Circulating concentrations and physiologic role of atrial natriuretic peptide during endotoxic shock in the rat. Critical care medicine, 1995, Volume: 23, Issue:11 Topics: Aldosterone; Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Diuresis; Hematocrit; Immune	1995
[The effect of NG-nitro-L-arginine administration on the hemodynamics and plasma hormone levels during endotoxin shock in dogs]. Nihon Naibunpi Gakkai zasshi, 1993, Mar-20, Volume: 69, Issue:3 Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Arginine; Blood Pressure; Cardiac Output; Dogs; F	1993
Effect of endotoxic shock on renal and hormonal functions. Canadian Anaesthetists' Society journal, 1978, Volume: 25, Issue:5 Topics: Aldosterone; Animals; Blood Pressure; Cardiac Output; Dexamethasone; Dogs; Epinephrine; Hormones; Hy	1978
[Effect of steroids on hormones and renal function in endotoxin shock (author's transl)]. Masui. The Japanese journal of anesthesiology, 1978, Volume: 27, Issue:9 Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Dogs; Kidney; Renin; Shock, Septic; Steroids; Vas	1978
[Effects of coenzyme Q and dibutyryl cAMP on endocrine and renal functions in endotoxin shock (author's transl)]. Masui. The Japanese journal of anesthesiology, 1979, Volume: 28, Issue:8 Topics: Aldosterone; Animals; Bucladesine; Dogs; Hormones; Kidney; Renin; Shock, Septic; Ubiquinone; Vasopre	1979
Effects of aldosterone and dexamethasone on blood chemical mediators in endotoxin shock. The Japanese journal of surgery, 1979, Volume: 9, Issue:1 Topics: Aldosterone; Animals; Blood Pressure; Bradykinin; Catecholamines; Dexamethasone; Female; Histamine;	1979
[Studies of pathogenesis in endotoxin shock (1)--effects of aldosterone and dexamethasone (author's transl)]. Masui. The Japanese journal of anesthesiology, 1978, Volume: 27, Issue:4 Topics: Aldosterone; Animals; Dexamethasone; Rabbits; Shock, Septic	1978
[Studies of pathogenesis in endotoxin shock (2) (author's transl)]. Masui. The Japanese journal of anesthesiology, 1978, Volume: 27, Issue:6 Topics: Aldosterone; Animals; Bradykinin; Dexamethasone; Rabbits; Shock, Septic	1978
[Effect of dopamine on renal and endocrine functions during canine endotoxin shock (author's transl)]. Masui. The Japanese journal of anesthesiology, 1978, Volume: 27, Issue:7 Topics: Aldosterone; Animals; Dogs; Dopamine; Hydrocortisone; Insulin; Kidney; Renin; Shock, Septic; Vasopre	1978
[Studies of pathogenesis in endotoxin shock (3), --changes of plasma catecholamine concentration (author's transl)]. Masui. The Japanese journal of anesthesiology, 1978, Volume: 27, Issue:7 Topics: Aldosterone; Animals; Catecholamines; Dexamethasone; Epinephrine; Norepinephrine; Rabbits; Shock, Se	1978
[Effects of endotoxin shock on endocrine system and renal function in dogs (author's transl)]. Masui. The Japanese journal of anesthesiology, 1978, Volume: 27, Issue:10 Topics: Aldosterone; Animals; Catecholamines; Dogs; Endocrine Glands; Kidney; Renin; Shock, Septic; Vasopres	1978
Elevation of plasma endothelin concentrations during endotoxin shock in dogs. European journal of pharmacology, 1991, Dec-03, Volume: 205, Issue:3 Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Arginine Vasopressin; Cattle; Cells, Cultured; Do	1991
High output circulatory failure in acute adrenal insufficiency. Critical care medicine, 1988, Volume: 16, Issue:3 Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aldosterone; Cardiac Output; Diagnosis, D	1988
[Level of plasma ACTH and aldosterone in endotoxic shock in rats]. Khirurgiia, 1985, Volume: 38, Issue:2 Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Male; Rats; Rats, Inbred Strains; Shock, Septic	1985
Plasma ACTH and aldosterone levels in endotoxin shock in rats. Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression, 1985, Volume: 26, Issue:3 Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Male; Rats; Rats, Inbred Strains; Shock, Septic	1985
The pharmacological basis of treatment with high dose corticosteroids in circulatory shock. Acta chirurgica Scandinavica. Supplementum, 1985, Volume: 526 Topics: Adrenal Cortex Hormones; Adult; Aldosterone; Animals; Dexamethasone; Drug Administration Schedule; H	1985
Mechanism and pharmacology of shock due to rattlesnake venom in sheep. Journal of applied physiology, 1965, Volume: 20, Issue:4 Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Antivenins; Atropine; Blood Pressure; Cardiac Out	1965
Renin-aldosterone system in endotoxin shock in the dog. The American journal of physiology, 1967, Volume: 212, Issue:5 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Blood Pressure; C	1967
Homeostatic role of the renal-adrenal axis in bacteremic shock. Its therapeutic implications. American journal of obstetrics and gynecology, 1967, Sep-15, Volume: 99, Issue:2 Topics: Adrenal Cortex Hormones; Aldosterone; Angiotensin II; Animals; Dogs; Endotoxins; Homeostasis; Methyl	1967
The role of adrenal corticosteroid therapy in Escherichia coli endotoxin shock. Surgery, gynecology & obstetrics, 1968, Volume: 126, Issue:1 Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Dogs; Escherichia coli; Female; Glucocorticoids; Hydr	1968
The binding of aldosterone to Escherichia coli endotoxin. Archives of surgery (Chicago, Ill. : 1960), 1971, Volume: 103, Issue:3 Topics: Aldosterone; Binding Sites; Chromatography; Chromatography, Gel; Dialysis; Endotoxins; Escherichia c	1971
Effects of corticosteroid hormones on regional circulation in endotoxin shock. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1967, Volume: 124, Issue:3 Topics: Acid-Base Equilibrium; Acidosis; Aldosterone; Animals; Blood Circulation; Blood Flow Velocity; Blood	1967

aldosterone and Shock, Septic