glucosaminylmuramyl-2-alanine-d-isoglutamine and Shock--Septic

glucosaminylmuramyl-2-alanine-d-isoglutamine has been researched along with Shock--Septic* in 2 studies

Other Studies

2 other study(ies) available for glucosaminylmuramyl-2-alanine-d-isoglutamine and Shock--Septic

Article	Year
Prevention of experimental septic shock by pretreatment of mice with muramyl peptides. International immunopharmacology, 2001, Volume: 1, Issue:9-10 Muramyl peptides, immunostimulators with macrophage as a main target cell, are used for protecting mice from LPS-lethality (the experimental model of septic shock). Different protocols of pretreatment mice by muramyl peptides lead to opposite results. LPS and glycopeptides act synergistically in the induction of lethal shock, when mice receive peptides 1 day prior to lethal dose of LPS. However, extension of the period between the peptide and LPS injections to 6 days cancels the effect of synergism. Moreover, a 14-day interval between the same injections leads to protection of 70-90% animals from the toxic effect of LPS. Lipophilic analogs require 10-100 lower concentrations to protect the animals than the parent highly hydrophilic glycopeptides. Production of TNF, IL-1 and phagocytosis by macrophages was studied within the periods corresponding to "synergism" and LPS-resistance. High level of macrophage activity was observed during the "synergism" period. Low TNF production and reduced macrophage phagocyte activity corresponded to LPS-resistant state. These results partly explain the LPS-unresponsiveness in mice after their pretreatment by muramyl peptides. Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Endotoxins; Female; Glycopeptides; Interleukin-1; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Phagocytosis; Shock, Septic; Stereoisomerism; Survival Analysis; Tumor Necrosis Factor-alpha	2001
[Increase of the production of tumor necrosis factor in endotoxin shock in mice presensitized with sera of tumor-bearing mice or tumor cell factor]. Biulleten' eksperimental'noi biologii i meditsiny, 1991, Volume: 112, Issue:7 We investigated the phenomenon of increased sensitivity of tumor-bearing mice to endotoxin shock. I/V administration of sera from tumor (EL-4, B16, R815, MOPC-315) bearers or tumoral culture media into intact mice caused the increased sensitivity to lethal action of LPS plus GMDP. Production of TNF in above mice was also significantly increased under the influence of LPS plus GMDP. Sensitivity induced factors in tumor bearing mice sera have mol. weight more than 50 kDa. This action was partially abolished by indomethacin. Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Indomethacin; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Shock, Septic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	1991

Article

Year

Prevention of experimental septic shock by pretreatment of mice with muramyl peptides.

International immunopharmacology, 2001, Volume: 1, Issue:9-10

Muramyl peptides, immunostimulators with macrophage as a main target cell, are used for protecting mice from LPS-lethality (the experimental model of septic shock). Different protocols of pretreatment mice by muramyl peptides lead to opposite results. LPS and glycopeptides act synergistically in the induction of lethal shock, when mice receive peptides 1 day prior to lethal dose of LPS. However, extension of the period between the peptide and LPS injections to 6 days cancels the effect of synergism. Moreover, a 14-day interval between the same injections leads to protection of 70-90% animals from the toxic effect of LPS. Lipophilic analogs require 10-100 lower concentrations to protect the animals than the parent highly hydrophilic glycopeptides. Production of TNF, IL-1 and phagocytosis by macrophages was studied within the periods corresponding to "synergism" and LPS-resistance. High level of macrophage activity was observed during the "synergism" period. Low TNF production and reduced macrophage phagocyte activity corresponded to LPS-resistant state. These results partly explain the LPS-unresponsiveness in mice after their pretreatment by muramyl peptides.

Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Endotoxins; Female; Glycopeptides; Interleukin-1; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Phagocytosis; Shock, Septic; Stereoisomerism; Survival Analysis; Tumor Necrosis Factor-alpha

2001

[Increase of the production of tumor necrosis factor in endotoxin shock in mice presensitized with sera of tumor-bearing mice or tumor cell factor].

Biulleten' eksperimental'noi biologii i meditsiny, 1991, Volume: 112, Issue:7

We investigated the phenomenon of increased sensitivity of tumor-bearing mice to endotoxin shock. I/V administration of sera from tumor (EL-4, B16, R815, MOPC-315) bearers or tumoral culture media into intact mice caused the increased sensitivity to lethal action of LPS plus GMDP. Production of TNF in above mice was also significantly increased under the influence of LPS plus GMDP. Sensitivity induced factors in tumor bearing mice sera have mol. weight more than 50 kDa. This action was partially abolished by indomethacin.

Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Indomethacin; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Shock, Septic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1991