molsidomine has been researched along with Shock, Septic in 11 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (81.82) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stahl, W | 1 |
| Matejovic, M | 1 |
| Radermacher, P | 1 |
| Takakura, K | 1 |
| Xiaohong, W | 1 |
| Takeuchi, K | 1 |
| Yasuda, Y | 1 |
| Fukuda, S | 1 |
| Pastor, CM | 2 |
| Losser, MR | 1 |
| Payen, D | 1 |
| Payen, DM | 1 |
| Horton, RA | 1 |
| Ceppi, ED | 1 |
| Knowles, RG | 1 |
| Titheradge, MA | 1 |
| Zhang, H | 2 |
| Rogiers, P | 2 |
| Friedman, G | 1 |
| Preiser, JC | 2 |
| Spapen, H | 1 |
| Buurman, WA | 1 |
| Vincent, JL | 2 |
| Avila, MA | 1 |
| Mingorance, J | 1 |
| Martínez-Chantar, ML | 1 |
| Casado, M | 1 |
| Martin-Sanz, P | 1 |
| Boscá, L | 1 |
| Mato, JM | 1 |
| Kumins, NH | 1 |
| Hunt, J | 1 |
| Gamelli, RL | 1 |
| Filkins, JP | 1 |
| Smail, N | 1 |
| Cabral, A | 1 |
| Peny, MO | 1 |
| Wolkow, PP | 1 |
| Cochran, JB | 1 |
| Genovese, F | 1 |
| Ogura, S | 1 |
| Teti, G | 1 |
| Cook, JA | 1 |
1 review available for molsidomine and Shock, Septic
| Article | Year |
|---|---|
Involvement and dual effects of nitric oxide in septic shock.
Topics: Animals; Electrochemistry; Electron Spin Resonance Spectroscopy; Enzyme Induction; Enzyme Inhibitors | 1998 |
10 other studies available for molsidomine and Shock, Septic
| Article | Year |
|---|---|
Inhibition of nitric oxide synthase during sepsis: revival because of isoform selectivity?
Topics: Acidosis; Animals; Blood Circulation; Clinical Trials, Phase II as Topic; Early Termination of Clini | 2010 |
Deactivation of norepinephrine by peroxynitrite as a new pathogenesis in the hypotension of septic shock.
Topics: Anesthesia; Animals; Aorta, Thoracic; Binding, Competitive; Blood Pressure; Hydrogen-Ion Concentrati | 2003 |
Nitric oxide donor prevents hepatic and systemic perfusion decrease induced by endotoxin in anesthetized rabbits.
Topics: Animals; Aorta; Blood Flow Velocity; Blood Pressure; Endotoxins; Liver; Male; Molsidomine; Nitric Ox | 1995 |
Effect of modifying nitric oxide pathway on liver circulation in a rabbit endotoxin shock model.
Topics: Animals; Arginine; Blood Flow Velocity; Blood Pressure; Hepatic Artery; Liver Circulation; Male; Mes | 1994 |
Inhibition of hepatic gluconeogenesis by nitric oxide: a comparison with endotoxic shock.
Topics: Animals; Dihydroxyacetone; Endotoxins; Fructose; Gluconeogenesis; Glycerol; Lactates; Liver; Male; M | 1994 |
Effects of nitric oxide donor SIN-1 on oxygen availability and regional blood flow during endotoxic shock.
Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Female; Hemodynamics; Male; Molsidomine; Nitric Oxide | 1996 |
Regulation of rat liver S-adenosylmethionine synthetase during septic shock: role of nitric oxide.
Topics: Animals; Lipopolysaccharides; Liver; Methionine Adenosyltransferase; Molsidomine; Nitric Oxide; Rats | 1997 |
Molsidomine increases endotoxic survival and decreases cytokine production.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytokines; Dose-Response Relationship, Drug; Endoto | 1997 |
Effects of nitric oxide on blood flow distribution and O2 extraction capabilities during endotoxic shock.
Topics: Animals; Blood Pressure; Cardiac Output; Cardiac Tamponade; Dogs; Endotoxins; Enzyme Inhibitors; Mol | 1997 |
Effect of nitric oxide donors and nitric oxide synthase inhibitors in neonatal rat endotoxic shock.
Topics: Animals; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Female; Molsidomine; NG-Nitroarginine | 1999 |