gentamicin has been researched along with Shock, Septic in 87 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Short-course empirical gentamicin use in patients with sepsis was associated with an increased incidence of renal failure but not with faster reversal of shock or improved survival in a setting with low prevalence of antimicrobial resistance." | 7.85 | Short-Course Adjunctive Gentamicin as Empirical Therapy in Patients With Severe Sepsis and Septic Shock: A Prospective Observational Cohort Study. ( Bonten, MJM; Cremer, OL; Frencken, JF; Juffermans, N; Klein Klouwenberg, PMC; Ong, DSY; van der Poll, T, 2017) |
| "Previous studies have shown that the high dose of gentamicin (8 mg/kg) rarely achieves the desired peak plasma concentration (Cmax) of ≥30 mg/l in patients with severe sepsis or septic shock." | 7.83 | A study to evaluate the first dose of gentamicin needed to achieve a peak plasma concentration of 30 mg/l in patients hospitalized for severe sepsis. ( Allou, N; Allyn, J; Augustin, P; Charifou, Y; Corradi, L; Galas, T; Martinet, O; Valance, D; Vandroux, D, 2016) |
| "Sepsis and septic shock are common cause of hospitalisation in intensive care unit." | 6.48 | [An effect of continuous and intermittent renal replacement therapy on antibiotic treatment in critically ill patients with sepsis - a practice-based perspective of vancomycin and gentamycin therapies]. ( Duricová, J; Grundmann, M; Kacířová, I; Martínek, A; Petejová, N; Plášek, J; Valkovský, I; Zahálková, J, 2012) |
| "Mean gentamicin dose was 4." | 5.43 | No increased risk of acute kidney injury after a single dose of gentamicin in patients with sepsis. ( Cobussen, M; de Kort, JM; Dennert, RM; Lowe, SH; Stassen, PM, 2016) |
| "Short-course empirical gentamicin use in patients with sepsis was associated with an increased incidence of renal failure but not with faster reversal of shock or improved survival in a setting with low prevalence of antimicrobial resistance." | 3.85 | Short-Course Adjunctive Gentamicin as Empirical Therapy in Patients With Severe Sepsis and Septic Shock: A Prospective Observational Cohort Study. ( Bonten, MJM; Cremer, OL; Frencken, JF; Juffermans, N; Klein Klouwenberg, PMC; Ong, DSY; van der Poll, T, 2017) |
| "Previous studies have shown that the high dose of gentamicin (8 mg/kg) rarely achieves the desired peak plasma concentration (Cmax) of ≥30 mg/l in patients with severe sepsis or septic shock." | 3.83 | A study to evaluate the first dose of gentamicin needed to achieve a peak plasma concentration of 30 mg/l in patients hospitalized for severe sepsis. ( Allou, N; Allyn, J; Augustin, P; Charifou, Y; Corradi, L; Galas, T; Martinet, O; Valance, D; Vandroux, D, 2016) |
| " For each syndrome 17-27% of participants had etiologic diagnoses that would be non-responsive to ceftriaxone, but responsive to other available antimicrobial regimens including amphotericin for cryptococcosis and histoplasmosis; anti-tuberculosis therapy for bacteremic disseminated tuberculosis; or tetracycline therapy for rickettsioses and Q fever." | 3.81 | Etiologies of illness among patients meeting integrated management of adolescent and adult illness district clinician manual criteria for severe infections in northern Tanzania: implications for empiric antimicrobial therapy. ( Bartlett, JA; Crump, JA; Maro, VP; Rubach, MP, 2015) |
| " Treatment with gentamicin (5 mg/kg every 12 h for five doses) was instituted 4 h after induction of peritonitis." | 3.70 | Delayed treatment with recombinant human tissue factor pathway inhibitor improves survival in rabbits with gram-negative peritonitis. ( Camerota, AJ; Creasey, AA; Fink, MP; Larkin, VA; Patla, V, 1998) |
| " The effects of ibuprofen, methylprednisolone-sodium succinate, and gentamicin alone, or in combination on survival time and, TxA2 and PGI2 production in rats in a LD100 fecal peritonitis shock model were assessed." | 3.67 | Ibuprofen, methylprednisolone, and gentamicin as conjoint therapy in septic shock. ( Cook, JA; Halushka, PV; Knapp, RG; Wise, WC, 1985) |
| "5 mM), gentamicin (4 mM), and hypoxia; altered inotropic reactivity to these interventions followed similar temporal development as the postendotoxin changes in basal contractile parameters." | 3.67 | Development of myocardial dysfunction in endotoxin shock. ( Adams, HR; Parker, JL, 1985) |
| "We investigated the effects of the thromboxane synthetase inhibitor 7-(1-imidazolyl)heptanoic acid (7-IHA) and the fatty acid cyclooxygenase inhibitors indomethacin or ibuprofen in the treatment of fecal peritonitis in the rat." | 3.66 | Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production. ( Butler, RR; Cook, JA; Halushka, PV; Wise, WC, 1983) |
| " in cases of abdominal and puerperal sepsis necessitates addition of a lincomycin or metronidazole." | 3.65 | Septicaemia. ( , 1975) |
| "Gentamicin (2 mg/kg) was administered at 6, 12, and 18 h after injury." | 2.71 | Gentamicin improves hemodynamics in ovine septic shock after smoke inhalation injury. ( Enkhbaatar, P; Heggers, JP; Herndon, DN; Jodoin, JM; Maybauer, DM; Maybauer, MO; Morita, N; Traber, DL; Traber, LD; Westphal, M, 2005) |
| "Eleven post-operative septic shock patients were grouped into (i) a control group (n=7) who received the conventional gentamicin or tobramycin dosing regimen of 2 mg/kg loading dose followed by a maintenance dose of approximately 1." | 2.69 | Appropriateness of a 4 mg/kg gentamicin or tobramycin loading dose in post-operative septic shock patients. ( Cornwell, EE; Mezghebe, HM; Oparaoji, EC; Shoheiber, O; Siram, S, 1998) |
| "Sepsis and septic shock are common cause of hospitalisation in intensive care unit." | 2.48 | [An effect of continuous and intermittent renal replacement therapy on antibiotic treatment in critically ill patients with sepsis - a practice-based perspective of vancomycin and gentamycin therapies]. ( Duricová, J; Grundmann, M; Kacířová, I; Martínek, A; Petejová, N; Plášek, J; Valkovský, I; Zahálková, J, 2012) |
| "Mean gentamicin dose was 4." | 1.43 | No increased risk of acute kidney injury after a single dose of gentamicin in patients with sepsis. ( Cobussen, M; de Kort, JM; Dennert, RM; Lowe, SH; Stassen, PM, 2016) |
| "One patient died of septic shock." | 1.37 | Management of septic complications following modular endoprosthetic reconstruction of the proximal femur. ( Dominkus, M; Funovics, PT; Hipfl, C; Hofstaetter, JG; Kotz, RI; Puchner, S, 2011) |
| " Gentamicin-resistant infections are a serious complication of the long-term use of GHLs." | 1.36 | Emergence of gentamicin-resistant bacteremia in hemodialysis patients receiving gentamicin lock catheter prophylaxis. ( Braden, GL; Gobeille, SL; Haessler, SD; Landry, DL; Sweet, SJ; Vaidya, CK, 2010) |
| "In 1998, a signal was generated for endotoxic shock with PRRs but not with MGPS, based on one case." | 1.33 | Endotoxin-like reactions with intravenous gentamicin: results from pharmacovigilance tools under investigation. ( Hauben, M; Reich, L, 2005) |
| " The recommended dosing interval based on the Hartford Hospital nomogram and one-serum concentration at 6 h was correct in only 62% of all cases." | 1.31 | Experience with a once-daily dosing program of aminoglycosides in critically ill patients. ( Bruining, HA; Buijk, SE; Gyssens, IC; Mouton, JW; Verbrugh, HA, 2002) |
| "A recent increase in reports of necrotizing fasciitis resulting from group B streptococcus has alerted physicians to a possible concomitant increase of toxic shock-like syndrome." | 1.31 | Necrotizing fasciitis and toxic shock-like syndrome caused by group B streptococcus. ( Grimsley, EW; Holmström, B, 2000) |
| "Necrotizing fasciitis is a potentially fatal, acute bacterial infection characterized by extensive fascial and subcutaneous tissue necrosis." | 1.28 | Fatal necrotizing fasciitis of dental origin. ( Beecroft, WA; Cogan, AG; Stoykewych, AA, 1992) |
| "Maxillary sinusitis was discovered incidentally on a CT scan four days after the onset of symptoms." | 1.28 | Septic shock and death due to occult sinusitis. ( Hariri, MA; Vice, PA, 1990) |
| "A newborn with fatal neonatal listeriosis developed septic shock, neutropenia, thrombocytopenia and profound hypoxaemia due to severe pulmonary hypertension." | 1.28 | Tumour necrosis factor in neonatal listeriosis: a case report. ( Berner, M; Dayer, JM; Girardin, E; Grau, GE; Roux-Lombard, P; Suter, S, 1989) |
| "Early endotoxic shock in the rat is associated with marked elevations of plasma TxB2 (the stable metabolite of TxA2) and lesser increases in plasma 6-keto-PGF1 alpha (the stable metabolite of PGI2)." | 1.27 | The potential role of thromboxane and prostacyclin in endotoxic and septic shock. ( Butler, RR; Cook, JA; Halushka, PV; Rambo, W; Reines, HD; Wise, WC, 1984) |
| "Cardiac effects of endotoxin shock were compared in left atrial preparations isolated from guinea pigs and rats injected with 4 or 8 mg/kg E coli endotoxin." | 1.27 | Contractile function of heart muscle isolated from endotoxin-shocked guinea pigs and rats. ( Parker, JL, 1983) |
| "Neonatal meningitis is characterized by unusual clinical manifestations caused by unusual organisms (with a marked predominance of gram-negative organisms), a poor prognosis due to the failure of antibiotics to penetrate the blood-brain barrier, and frequent complications (ventriculitis, hydrocephalus, and brain damage)." | 1.27 | Purulent meningitis in the newborn. ( Karan, S, 1986) |
| "In conclusion, primates in septic shock are clearly protected with delayed steroid/antibiotic therapy." | 1.26 | Survival of primates in lethal septic shock following delayed treatment with steroid. ( Archer, LT; Beller-Todd, BK; Benjamin, B; Flournoy, DJ; Hinshaw, LB; Passey, R, 1981) |
| "A study of 113 patients with septic shock admitted to an intensive therapy unit (I." | 1.26 | Prospective study of the treatment of septic shock. ( Ledingham, IM; McArdle, CS, 1978) |
| "During endotoxin shock, the cardiovascular effects of gentamicin and tobramycin were relatively more pronounced (sometimes more than doubled) than effects observed during the control state." | 1.26 | Cardiovascular manifestations of acute antibiotic toxicity during E coli endotoxin shock in anesthetized dogs. ( Adams, HR; Mathew, BP; Parker, JL, 1979) |
| " The biological half-life of tobramycin doubled." | 1.26 | Pharmacokinetics of tobramycin in rats with reduced renal parenchyma and in experimental shock. ( Hatala, M; Konícková, Z; Liska, M; Morávek, J; Prát, V; Schück, O, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (60.92) | 18.7374 |
| 1990's | 10 (11.49) | 18.2507 |
| 2000's | 6 (6.90) | 29.6817 |
| 2010's | 16 (18.39) | 24.3611 |
| 2020's | 2 (2.30) | 2.80 |
| Authors | Studies |
|---|---|
| Tsao, N | 1 |
| Chang, YC | 1 |
| Hsieh, SY | 1 |
| Li, TC | 1 |
| Chiu, CC | 1 |
| Yu, HH | 1 |
| Hsu, TC | 1 |
| Kuo, CF | 1 |
| Driessen, RGH | 1 |
| Groven, RVM | 1 |
| van Koll, J | 1 |
| Oudhuis, GJ | 1 |
| Posthouwer, D | 2 |
| van der Horst, ICC | 1 |
| Bergmans, DCJJ | 1 |
| Schnabel, RM | 1 |
| Ong, DSY | 3 |
| Frencken, JF | 1 |
| Klein Klouwenberg, PMC | 1 |
| Juffermans, N | 1 |
| van der Poll, T | 1 |
| Bonten, MJM | 3 |
| Cremer, OL | 3 |
| Cobussen, M | 2 |
| Havenith, T | 1 |
| van Tiel, FH | 1 |
| Stassen, PM | 2 |
| Haeseker, MB | 1 |
| Lipcsey, M | 1 |
| Castegren, M | 1 |
| Furebring, M | 1 |
| Sjölin, J | 1 |
| Rubach, MP | 1 |
| Maro, VP | 1 |
| Bartlett, JA | 1 |
| Crump, JA | 1 |
| de Kort, JM | 1 |
| Dennert, RM | 1 |
| Lowe, SH | 1 |
| Allou, N | 2 |
| Allyn, J | 2 |
| Levy, Y | 1 |
| Bouteau, A | 1 |
| Caujolle, M | 1 |
| Delmas, B | 1 |
| Valance, D | 2 |
| Brulliard, C | 1 |
| Martinet, O | 2 |
| Vandroux, D | 2 |
| Montravers, P | 1 |
| Augustin, P | 2 |
| Charifou, Y | 1 |
| Galas, T | 1 |
| Corradi, L | 1 |
| Tabah, A | 1 |
| Lipman, J | 1 |
| Roberts, JA | 1 |
| Landry, DL | 1 |
| Braden, GL | 1 |
| Gobeille, SL | 1 |
| Haessler, SD | 1 |
| Vaidya, CK | 1 |
| Sweet, SJ | 1 |
| González Robledo, J | 1 |
| Pérez Losada, ME | 1 |
| Ballesteros Herráez, JC | 1 |
| Rodríguez Encinas, A | 1 |
| Funovics, PT | 1 |
| Hipfl, C | 1 |
| Hofstaetter, JG | 1 |
| Puchner, S | 1 |
| Kotz, RI | 1 |
| Dominkus, M | 1 |
| Uddin, MN | 1 |
| Siddiq, A | 1 |
| Oettinger, CW | 1 |
| D'Souza, MJ | 1 |
| Petejová, N | 1 |
| Martínek, A | 1 |
| Zahálková, J | 1 |
| Duricová, J | 1 |
| Plášek, J | 1 |
| Valkovský, I | 1 |
| Grundmann, M | 1 |
| Kacířová, I | 1 |
| Radej, J | 1 |
| Matejovic, M | 1 |
| Buijk, SE | 1 |
| Mouton, JW | 1 |
| Gyssens, IC | 1 |
| Verbrugh, HA | 1 |
| Bruining, HA | 1 |
| Hauben, M | 1 |
| Reich, L | 1 |
| Mellerup, MT | 1 |
| Bruun, NE | 1 |
| Nielsen, JD | 1 |
| Maybauer, MO | 1 |
| Maybauer, DM | 1 |
| Traber, LD | 1 |
| Westphal, M | 1 |
| Enkhbaatar, P | 1 |
| Morita, N | 1 |
| Jodoin, JM | 1 |
| Heggers, JP | 1 |
| Herndon, DN | 1 |
| Traber, DL | 1 |
| Manrique-González, E | 1 |
| Carranza-González, R | 1 |
| Tena-Gómez, D | 1 |
| Serrano-Castañeda, J | 1 |
| Butler, RR | 2 |
| Wise, WC | 3 |
| Halushka, PV | 3 |
| Cook, JA | 3 |
| Archer, LT | 11 |
| Kosanke, SD | 1 |
| Beller, BK | 5 |
| Passey, RB | 4 |
| Hinshaw, LB | 10 |
| McCafferty, MH | 1 |
| Saba, TM | 1 |
| Flournoy, DJ | 7 |
| Chang, AC | 2 |
| Lahti, RA | 1 |
| Reines, HD | 1 |
| Rambo, W | 1 |
| Vallent, K | 1 |
| Bodnár, A | 1 |
| Weltner, J | 1 |
| Arnow, PM | 1 |
| Chou, T | 1 |
| Weil, D | 1 |
| Crass, BA | 1 |
| Bergdoll, MS | 1 |
| Wilson, MF | 2 |
| Brackett, DJ | 1 |
| Beller-Todd, BK | 5 |
| Tompkins, P | 1 |
| Fabian, TC | 1 |
| Patterson, R | 1 |
| Coalson, JJ | 1 |
| Passey, R | 4 |
| Benjamin, B | 3 |
| White, GL | 2 |
| Vogel, F | 1 |
| Parker, JL | 3 |
| Stalder, H | 1 |
| Kaufmann, B | 1 |
| Wiest, RH | 1 |
| Stern, M | 1 |
| Fischer, M | 1 |
| Althoff, PH | 1 |
| Le Lann, AD | 1 |
| Bret, LC | 1 |
| Delverdier, ME | 1 |
| Amardeilh, MF | 1 |
| Alary, C | 1 |
| Fournié, GJ | 1 |
| He, S | 1 |
| Hinshaw, L | 1 |
| Emerson, T | 1 |
| Kosanke, S | 1 |
| White, G | 1 |
| Randolph, MM | 1 |
| Chang, AK | 1 |
| Duerr, M | 1 |
| Peer, G | 1 |
| van Langevelde, P | 1 |
| van Dissel, JT | 1 |
| Meurs, CJ | 1 |
| Renz, J | 1 |
| Groeneveld, PH | 1 |
| Camerota, AJ | 1 |
| Creasey, AA | 1 |
| Patla, V | 1 |
| Larkin, VA | 1 |
| Fink, MP | 1 |
| Ashhurst-Smith, C | 1 |
| Norton, R | 1 |
| Thoreau, W | 1 |
| Peel, MM | 1 |
| Oparaoji, EC | 1 |
| Siram, S | 1 |
| Shoheiber, O | 1 |
| Cornwell, EE | 1 |
| Mezghebe, HM | 1 |
| Haziot, A | 1 |
| Hijiya, N | 1 |
| Schultz, K | 1 |
| Zhang, F | 1 |
| Gangloff, SC | 1 |
| Goyert, SM | 1 |
| Holmström, B | 1 |
| Grimsley, EW | 1 |
| Phillips, RW | 2 |
| Hopkin, DA | 2 |
| Ledingham, IM | 1 |
| McArdle, CS | 1 |
| Benini, G | 1 |
| Grilli, M | 1 |
| Gentile, C | 1 |
| Amigoni, A | 1 |
| Balis, JU | 1 |
| Paterson, JF | 1 |
| Shelley, SA | 1 |
| Larson, CH | 1 |
| Fareed, J | 1 |
| Gerber, LI | 1 |
| Adams, HR | 2 |
| Mathew, BP | 1 |
| Six, P | 1 |
| Schuppler, J | 1 |
| Schärer, HU | 1 |
| Mihatsch, MJ | 1 |
| Noone, P | 1 |
| Abeysundere, RL | 1 |
| Bradley, JM | 1 |
| Mimuth, JN | 1 |
| Morávek, J | 1 |
| Hatala, M | 1 |
| Schück, O | 1 |
| Prát, V | 1 |
| Liska, M | 1 |
| Konícková, Z | 1 |
| Pitcairn, M | 1 |
| Schuler, J | 1 |
| Erve, PR | 1 |
| Holtzman, S | 1 |
| Schumer, W | 1 |
| Seneca, H | 1 |
| Grant, JP | 1 |
| Stoykewych, AA | 1 |
| Beecroft, WA | 1 |
| Cogan, AG | 1 |
| Hariri, MA | 1 |
| Vice, PA | 1 |
| Girardin, E | 1 |
| Berner, M | 1 |
| Grau, GE | 1 |
| Dayer, JM | 1 |
| Roux-Lombard, P | 1 |
| Suter, S | 1 |
| Ispahani, P | 1 |
| Donald, FE | 1 |
| Aveline, AJ | 1 |
| Fettman, MJ | 1 |
| Hand, MS | 1 |
| Chandrasena, LG | 1 |
| Cleek, JL | 1 |
| Mason, RA | 1 |
| Brooks, PA | 1 |
| Karan, S | 1 |
| Knapp, RG | 1 |
| Ho, CH | 1 |
| Chiang, YM | 1 |
| Chong, LL | 1 |
| Lin, HY | 1 |
| Hwang, TS | 1 |
| Murray, CK | 1 |
| Hellman, A | 1 |
| Alestig, K | 1 |
| Gikonyo, BM | 1 |
| Dunnigan, A | 1 |
| Benson, DW | 1 |
| McHenry, MC | 3 |
| Hawk, WA | 1 |
| Lambert, HP | 1 |
| Wittels, W | 1 |
| Murray, JD | 1 |
| Fleming, PC | 1 |
| Anglin, CS | 1 |
| Steele, JC | 1 |
| Fujiwara, MW | 1 |
| Turgeon, PL | 1 |
| Mokgokong, ET | 1 |
| Zuckerman, JE | 1 |
| Stubblefield, PG | 1 |
| Ridley, M | 1 |
| Phillips, I | 1 |
| Eykyn, S | 1 |
| Müller, FE | 1 |
4 reviews available for gentamicin and Shock, Septic
| Article | Year |
|---|---|
[An effect of continuous and intermittent renal replacement therapy on antibiotic treatment in critically ill patients with sepsis - a practice-based perspective of vancomycin and gentamycin therapies].
Topics: Acute Kidney Injury; Anti-Bacterial Agents; Critical Illness; Gentamicins; Humans; Renal Dialysis; S | 2012 |
Myocardial dysfunction in endotoxin- and E. coli-induced shock: pathophysiological mechanisms.
Topics: Animals; Cardiac Output; Coronary Circulation; Electrolytes; Energy Metabolism; Escherichia coli Inf | 1985 |
Bacteremic shock due to gram-negative bacilli. Some concepts of pathogenesis and management based on recent developments.
Topics: Animals; Bacteroides Infections; Chloramphenicol; Enterobacter; Escherichia coli Infections; Gentami | 1969 |
The management of bacteremic shock.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Burns; Catheterization; Cephaloridine; Cephalot | 1969 |
5 trials available for gentamicin and Shock, Septic
| Article | Year |
|---|---|
Gentamicin improves hemodynamics in ovine septic shock after smoke inhalation injury.
Topics: Animals; Arteries; Blood Pressure; Female; Gentamicins; Hemodynamics; Lung; Nitrates; Nitric Oxide; | 2005 |
[Experience with intravenous metronidazole administration in the preoperative care of surgery of the large intestine].
Topics: Colon; Drug Therapy, Combination; Gentamicins; Humans; Infusions, Parenteral; Metronidazole; Premedi | 1983 |
[Prevention and therapy of infections in intensive internal medicine].
Topics: Aged; Aminoglycosides; Anti-Bacterial Agents; Critical Care; Cross Infection; Female; Gentamicins; H | 1983 |
Appropriateness of a 4 mg/kg gentamicin or tobramycin loading dose in post-operative septic shock patients.
Topics: Adult; Aged; Anti-Bacterial Agents; Female; Gentamicins; Humans; Male; Middle Aged; Postoperative Co | 1998 |
High doses of corticosteroids in the treatment of septic shock.
Topics: Adrenal Cortex Hormones; Animals; Clinical Trials as Topic; Dexamethasone; Drug Therapy, Combination | 1985 |
78 other studies available for gentamicin and Shock, Septic
| Article | Year |
|---|---|
AR-12 Has a Bactericidal Activity and a Synergistic Effect with Gentamicin against Group A
Topics: A549 Cells; Animals; Anti-Bacterial Agents; Cell Line; Cell Line, Tumor; Gentamicins; Humans; Male; | 2021 |
Appropriateness of empirical antibiotic therapy and added value of adjunctive gentamicin in patients with septic shock: a prospective cohort study in the ICU.
Topics: Anti-Bacterial Agents; Gentamicins; Humans; Intensive Care Units; Prospective Studies; Sepsis; Shock | 2021 |
Short-Course Adjunctive Gentamicin as Empirical Therapy in Patients With Severe Sepsis and Septic Shock: A Prospective Observational Cohort Study.
Topics: Aged; Anti-Bacterial Agents; Cohort Studies; Drug Resistance, Multiple, Bacterial; Female; Gentamici | 2017 |
Reply to Cobussen et al.
Topics: Cohort Studies; Gentamicins; Humans; Prospective Studies; Sepsis; Shock, Septic | 2017 |
Short Course of Empirical Gentamicin in Patients With Severe Sepsis and Septic Shock in the ICU: A Benefit or a Burden?
Topics: Cohort Studies; Gentamicins; Humans; Intensive Care Units; Prospective Studies; Sepsis; Shock, Septi | 2017 |
Should the Aminoglycoside β-Lactam Combination Be Abandoned in All Severely Ill Patients With Presumed Gram-Negative Infection?
Topics: Aminoglycosides; Anti-Bacterial Agents; beta-Lactams; Cohort Studies; Gentamicins; Humans; Prospecti | 2018 |
Reply to Lipcsey.
Topics: Cohort Studies; Gentamicins; Humans; Prospective Studies; Sepsis; Shock, Septic | 2018 |
Etiologies of illness among patients meeting integrated management of adolescent and adult illness district clinician manual criteria for severe infections in northern Tanzania: implications for empiric antimicrobial therapy.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Amphotericin B; Ampicillin; Anti-Infectiv | 2015 |
No increased risk of acute kidney injury after a single dose of gentamicin in patients with sepsis.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Drug Combina | 2016 |
Assessment of the National French recommendations regarding the dosing regimen of 8mg/kg of gentamicin in patients hospitalised in intensive care units.
Topics: Aged; Algorithms; Anti-Bacterial Agents; APACHE; Cohort Studies; Critical Care; Enterobacteriaceae; | 2016 |
A study to evaluate the first dose of gentamicin needed to achieve a peak plasma concentration of 30 mg/l in patients hospitalized for severe sepsis.
Topics: Aged; Anti-Bacterial Agents; Comorbidity; Drug Monitoring; Female; Gentamicins; Hospitalization; Hum | 2016 |
Are new gentamicin dosing guidelines suitable for achieving target concentrations in patients with sepsis and septic shock?
Topics: Anti-Bacterial Agents; France; Gentamicins; Guidelines as Topic; Humans; Sepsis; Shock, Septic | 2016 |
Emergence of gentamicin-resistant bacteremia in hemodialysis patients receiving gentamicin lock catheter prophylaxis.
Topics: Ambulatory Care; Anti-Bacterial Agents; Antibiotic Prophylaxis; Anticoagulants; Catheter-Related Inf | 2010 |
[Septic shock due to primary myonecrosis of psoas].
Topics: Alcoholism; Anti-Bacterial Agents; Bacteremia; Cerebrovascular Disorders; Cloxacillin; Combined Moda | 2011 |
Management of septic complications following modular endoprosthetic reconstruction of the proximal femur.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Arthroplasty, Replacement, Hip; Bone Cements; Bone N | 2011 |
Potentiation of pro-inflammatory cytokine suppression and survival by microencapsulated dexamethasone in the treatment of experimental sepsis.
Topics: Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Dose-Response Relationship | 2011 |
[Antimicrobial dosing in critically ill patients requiring renal replacement therapy - maximize efficacy and minimize toxicity!].
Topics: Acute Kidney Injury; Anti-Bacterial Agents; Critical Illness; Gentamicins; Humans; Renal Dialysis; S | 2012 |
Experience with a once-daily dosing program of aminoglycosides in critically ill patients.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Creatine; Critical Care | 2002 |
Endotoxin-like reactions with intravenous gentamicin: results from pharmacovigilance tools under investigation.
Topics: Adverse Drug Reaction Reporting Systems; Algorithms; Antineoplastic Agents; Bayes Theorem; Gentamici | 2005 |
[Increased bleeding tendency induced by beta-lactam antibiotics].
Topics: Aged; Anti-Bacterial Agents; beta-Lactams; Endocarditis, Bacterial; Gentamicins; Hemorrhage; Humans; | 2005 |
[Perineal erythema, distal cyanosis and sepsis in an adult woman].
Topics: Acute Kidney Injury; Adult; Bacteremia; Cefotaxime; Cellulitis; Clindamycin; Combined Modality Thera | 2006 |
Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production.
Topics: Animals; Epoprostenol; Fatty Acids, Essential; Female; Fibrin Fibrinogen Degradation Products; Genta | 1983 |
Prevention or amelioration of morphologic lesions in LD100 E coli-shocked baboons with steroid/antibiotic therapy.
Topics: Adrenal Glands; Animals; Digestive System; Drug Therapy, Combination; Gentamicins; Kidney; Liver; Lu | 1983 |
Influence of septic peritonitis on circulating fibronectin, immunoglobulin, and complement: relationship to reticuloendothelial phagocytic function.
Topics: Animals; Complement C3; Escherichia coli Infections; Fibronectins; Gentamicins; Immunoglobulin G; Ma | 1983 |
Effectiveness of modified steroid-antibiotic therapies for lethal sepsis in the dog.
Topics: Animals; Blood Pressure; Dogs; Drug Evaluation; Drug Therapy, Combination; Escherichia coli Infectio | 1983 |
Evaluation of naloxone for therapy of Escherichia coli shock. Species differences.
Topics: Animals; Blood Pressure; Body Temperature; Dogs; Drug Therapy, Combination; Epinephrine; Escherichia | 1984 |
The potential role of thromboxane and prostacyclin in endotoxic and septic shock.
Topics: Animals; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Epoprostenol; Fatty Acids; Gentamici | 1984 |
Spread of a toxic-shock syndrome-associated strain of Staphylococcus aureus and measurement of antibodies to staphylococcal enterotoxin F.
Topics: Adult; Antibodies, Bacterial; Bacterial Toxins; Burn Units; Burns; Drug Resistance, Microbial; Enter | 1984 |
Survival characteristics during septic shock in 39 baboons.
Topics: Animals; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Escherichia coli Infections; Female; Ge | 1982 |
Current management of the septic shock patient: experimental basis for treatment.
Topics: Animals; Blood Glucose; Dogs; Drug Therapy, Combination; Endotoxins; Escherichia coli; Gentamicins; | 1982 |
Steroid therapy in septic shock. Survival studies in a laboratory model.
Topics: Animals; Cecum; Clindamycin; Disease Models, Animal; Female; Gentamicins; Glucocorticoids; Male; Met | 1982 |
Survival of primates in LD100 septic shock following steroid/antibiotic therapy.
Topics: Acid-Base Equilibrium; Animals; Anuria; Blood Cell Count; Blood Glucose; Blood Urea Nitrogen; Bone M | 1980 |
Contractile function of heart muscle isolated from endotoxin-shocked guinea pigs and rats.
Topics: Animals; Calcium; Gentamicins; Guinea Pigs; Heart Atria; Hypoxia; Male; Myocardial Contraction; Rats | 1983 |
Effectiveness of steroid/antibiotic treatment in primates administered LD100 Escherichia coli.
Topics: Animals; Drug Evaluation, Preclinical; Escherichia coli Infections; Gentamicins; Hypotension; Methyl | 1981 |
Survival of primates in lethal septic shock following delayed treatment with steroid.
Topics: Animals; Drug Therapy, Combination; Female; Gentamicins; Male; Methylprednisolone; Methylprednisolon | 1981 |
[Toxic shock syndrome].
Topics: Adult; Ampicillin; Anuria; Diarrhea; Female; Gentamicins; Humans; Hypotension; Menstrual Hygiene Pro | 1981 |
Toxic shock syndrome in a middle-aged male.
Topics: Adolescent; Adult; Ampicillin; Child; Drug Therapy, Combination; Gentamicins; Hernia, Inguinal; Huma | 1981 |
[Severe infection by methicillin-resistant staphylococci after insertion of PEG].
Topics: Aged; Aged, 80 and over; Enteral Nutrition; Female; Gastrostomy; Gentamicins; Humans; Injections, In | 1995 |
Urinary DNA as an indicator of nephrotoxicity caused by endotoxin and gentamicin in mice.
Topics: Animals; Biomarkers; Cell Death; DNA; Endotoxins; Female; Gentamicins; Kidney; Lipopolysaccharides; | 1994 |
Retrospective study comparing the pathophysiology of antibiotic-treated and untreated Escherichia coli- and Staphylococcus aureus-infused baboons.
Topics: Animals; Ceftriaxone; Disease Models, Animal; Escherichia coli Infections; Gentamicins; Hemodynamics | 1993 |
Combination of flucloxacillin and gentamicin inhibits toxic shock syndrome toxin 1 production by Staphylococcus aureus in both logarithmic and stationary phases of growth.
Topics: Anti-Bacterial Agents; Bacterial Toxins; Colony Count, Microbial; Drug Therapy, Combination; Enterot | 1997 |
Delayed treatment with recombinant human tissue factor pathway inhibitor improves survival in rabbits with gram-negative peritonitis.
Topics: Animals; Anti-Bacterial Agents; Anticoagulants; Blood Coagulation; Blood Pressure; Dose-Response Rel | 1998 |
Actinobacillus equuli septicemia: an unusual zoonotic infection.
Topics: Actinobacillus; Actinobacillus Infections; Animals; Bacteremia; Drug Therapy, Combination; Floxacill | 1998 |
CD14 plays no major role in shock induced by Staphylococcus aureus but down-regulates TNF-alpha production.
Topics: Animals; Bacterial Capsules; Cytokines; Down-Regulation; Gentamicins; Lipopolysaccharide Receptors; | 1999 |
Necrotizing fasciitis and toxic shock-like syndrome caused by group B streptococcus.
Topics: Anti-Bacterial Agents; Clindamycin; Combined Modality Therapy; Debridement; Diabetes Complications; | 2000 |
Recovery from lethal Escherichia coli shock in dogs.
Topics: Animals; Blood Glucose; Carbon Dioxide; Dogs; Drug Therapy, Combination; Escherichia coli Infections | 1979 |
Too rapid destruction of gram-negative organisms.
Topics: Chloramphenicol; Gentamicins; Humans; Salmonella typhi; Sepsis; Shock, Septic | 1977 |
Prospective study of the treatment of septic shock.
Topics: Adult; Aged; Bacteroides Infections; Blood Transfusion; Electrolytes; Gentamicins; Humans; Intermitt | 1978 |
[Resuscitation and intensive therapy in Lyell's syndrome].
Topics: Adrenal Cortex Hormones; Aged; Aprotinin; Female; Gentamicins; Histamine H1 Antagonists; Humans; Pro | 1975 |
Glucocorticoid and antibiotic effects on hepatic microcirculation and associated host responses in lethal gram-negative bacteremia.
Topics: Animals; Anti-Bacterial Agents; Bilirubin; Disseminated Intravascular Coagulation; Drug Therapy, Com | 1979 |
Cardiovascular manifestations of acute antibiotic toxicity during E coli endotoxin shock in anesthetized dogs.
Topics: Animals; Anti-Bacterial Agents; Cephalothin; Depression, Chemical; Dogs; Dose-Response Relationship, | 1979 |
[Intracranial mycotic aneurysm in staphylococcal endocarditis (authors transl)].
Topics: Adult; Aneurysm, Infected; Cerebral Arteries; Endocarditis, Bacterial; Epilepsy; Gentamicins; Humans | 1977 |
Anaphylaxis and tetracycline.
Topics: Anaphylaxis; Gentamicins; Humans; Shock, Septic; Tetracycline | 1978 |
Bacteraemia.
Topics: Adult; Anti-Bacterial Agents; Digestive System Surgical Procedures; Female; Gentamicins; Humans; Liv | 1978 |
Letter: Management of bacterial shock.
Topics: Gentamicins; Humans; Shock, Septic | 1976 |
Pharmacokinetics of tobramycin in rats with reduced renal parenchyma and in experimental shock.
Topics: Animals; Anti-Bacterial Agents; Burns; Gentamicins; Half-Life; Kidney; Kinetics; Nephrectomy; Rats; | 1976 |
Glucocorticoid and antibiotic effect on experimental gram-negative bacteremic shock.
Topics: Ampicillin; Animals; Chloramphenicol; Dexamethasone; Escherichia coli; Gentamicins; Humans; Male; Pe | 1975 |
Septicaemia.
Topics: Cefazolin; Cephaloridine; Cephalothin; Cephradine; Clindamycin; Drug Resistance, Microbial; Flucytos | 1975 |
Glucocorticoid therapy in sepsis/shock caused by gram-negative microorganisms.
Topics: Ampicillin; Carbenicillin; Cefazolin; Cephalothin; Dexamethasone; Endotoxins; Gentamicins; Glucocort | 1975 |
Fatal necrotizing fasciitis of dental origin.
Topics: Adult; Bacteroides Infections; Candidiasis; Cefotaxime; Clindamycin; Cloxacillin; Fasciitis; Female; | 1992 |
Septic shock and death due to occult sinusitis.
Topics: Aged; Ampicillin; Gentamicins; Humans; Male; Maxillary Sinusitis; Pneumococcal Infections; Shock, Se | 1990 |
Tumour necrosis factor in neonatal listeriosis: a case report.
Topics: Amoxicillin; Gentamicins; Humans; Hypertension, Pulmonary; Infant, Newborn; Listeriosis; Male; Shock | 1989 |
Streptococcus pyogenes bacteraemia: an old enemy subdued, but not defeated.
Topics: Adolescent; Adult; Aged; Ampicillin; Child; Child, Preschool; England; Female; Fever; Floxacillin; G | 1988 |
Methylprednisolone and gentamicin effects on hepatosplanchnic blood flow and carbohydrate metabolism in endotoxemic Yucatan miniature pigs.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Drug Therapy, Combination; Female; Gentamicins; Glucos | 1986 |
Purulent meningitis in the newborn.
Topics: Ampicillin; Anti-Bacterial Agents; Chloramphenicol; Gentamicins; Humans; Infant, Newborn; Injections | 1986 |
Ibuprofen, methylprednisolone, and gentamicin as conjoint therapy in septic shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Disease Models, Animal; Drug Therapy, Combination; Female; Ge | 1985 |
Development of chronic lymphocytic leukaemia in a case of Sjögren's syndrome with systemic lupus erythematosus.
Topics: Aged; B-Lymphocytes; Cephalosporins; Female; Gentamicins; Humans; Leukemia, Lymphoid; Lupus Erythema | 1985 |
Corticosteroid/antibiotic treatment of adrenalectomized dogs challenged with lethal E. coli.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Animals; Anti-Bacterial Agents; Blood Pressure; Dogs; Escher | 1985 |
Development of myocardial dysfunction in endotoxin shock.
Topics: Animals; Calcium; Gentamicins; Guinea Pigs; Heart; Hypoxia; Male; Muscle Contraction; Myocardial Con | 1985 |
Cardiovascular collapse in infants: association with paroxysmal atrial tachycardia.
Topics: Ampicillin; Echocardiography; Electrocardiography; Emergencies; Female; Gentamicins; Heart Rate; Hum | 1985 |
Bacteremia caused by gram-negative bacilli.
Topics: Bacteria; Chronic Disease; Endotoxins; Enterobacteriaceae Infections; Erwinia; Escherichia coli; Gen | 1974 |
[Antibiotics and corticosteroids in the corticosteroids in the treatment of burns].
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Burns; Chloramphenicol; Dexamethasone; Gentamicins; | 1971 |
Acute bacterial meningitis in childhood: an outline of management.
Topics: Adrenal Cortex Hormones; Age Factors; Ampicillin; Anti-Bacterial Agents; Anticonvulsants; Blood Tran | 1972 |
Managing medical emergencies caused by bacterial infections.
Topics: Acute Disease; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Bacteroides Infections; Blood | 1973 |
Treatment of septicaemic shock in gynaecology and obstetrics.
Topics: Abortion, Septic; Adrenal Cortex Hormones; Bicarbonates; Blood Transfusion; Chloramphenicol; Digoxin | 1973 |
E. coli septicemia in pregnancy associated with the shield intrauterine contraceptive device.
Topics: Abortion, Therapeutic; Adult; Ampicillin; Escherichia coli Infections; Female; Gentamicins; Humans; | 1974 |
Septic shock.
Topics: Ampicillin; Cephaloridine; Gentamicins; Humans; Kanamycin; Penicillin Resistance; Shock, Septic | 1970 |
[Chemotherapy of Pseudomonas infections in severely burned patients. 2-year experience with gentamycin].
Topics: Bicarbonates; Burns; Dextrans; Drug Resistance, Microbial; Gentamicins; Humans; Pseudomonas Infectio | 1968 |