Page last updated: 2024-12-07
mci 154
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
MCI 154: structure given in UD 38:41n [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 123941 |
| CHEMBL ID | 543966 |
| MeSH ID | M0148314 |
Synonyms (24)
| Synonym |
|---|
| mci-154 |
| senazodan hydrochloride |
| 6-(4-(4'-pyridyl)aminophenyl)-4,5-dihydro-3(2h)-pyridazinone hydrochloride |
| mci 154 |
| 3(2h)-pyridazinone, 4,5-dihydro-6-(4-(4-pyridinylamino)phenyl)-, monohydrochloride |
| 4,5-dihydro-6-(4-(4-pyridinylamino)phenyl)-3(2h)-pyridazinone monohydrochloride |
| CHEMBL543966 |
| 98326-33-1 |
| unii-8aqj5mim3p |
| 8aqj5mim3p , |
| 3(2h)-pyridazinone, 4,5-dihydro-6-(4-(4-pyridinylamino)phenyl)-, hydrochloride (1:1) |
| AKOS030558030 |
| 6-{4-[(pyridin-4(1h)-ylidene)amino]phenyl}-4,5-dihydropyridazin-3-ol--hydrogen chloride (1/1) |
| DTXSID00913328 |
| senazodan hcl |
| 3-[4-(pyridin-4-ylamino)phenyl]-4,5-dihydro-1h-pyridazin-6-one;hydrochloride |
| Q27270120 |
| MS-24374 |
| 6-(4-(pyridin-4-ylamino)phenyl)-4,5-dihydropyridazin-3(2h)-one hydrochloride |
| HY-101693A |
| senazodan (hydrochloride) |
| CS-0033842 |
| 3(2h)-pyridazinone, 4,5-dihydro-6-[4-(4-pyridinylamino)phenyl]-, monohydrochloride |
| mci 154 (hydrochloride) |
Research Excerpts
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| "Compared with the normal control group, the cumulative dose-response curve of SMA to Ca2+ in shock group was shifted to the right, the maximal contraction to Ca2+ was decreased significantly (P<0." | ( [Effect of MCI-154 on calcium sensitivity of vascular smooth muscle and its mechanism in hemorrhagic shock in rats]. Liu, LM; Yang, GM, 2005) | 0.33 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (20)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID60280 | Inotropic activity determined by evaluating the % change in Diastolic Blood Pressure (DBP) at a dose of 3 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID59137 | Positive inotropic in the isolated papillary muscle of the dog. | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID60150 | Inotropic activity determined by evaluating the % change in contractile force (CF) of right ventricle at a dose of 3 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID60153 | Inotropic activity determined by evaluating the % change in Cardiac out put (CO)at a dose of 10 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID60149 | Inotropic activity determined by evaluating the % change in contractile force (CF) of right ventricle at a dose of 30 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID61605 | Inotropic activity determined by evaluating the maximum rate of rise in left ventricular pressure at a dose of 10 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID61742 | Inotropic activity determined by evaluating the maximum rate of rise in left ventricular pressure at a dose of 3 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID60291 | Inotropic activity determined by evaluating the % change in Systolic Blood Pressure (SBP) at a dose of 10 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID60287 | Inotropic activity determined by evaluating the % change in Heart Rate (HR) at a dose of 3 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID60279 | Inotropic activity determined by evaluating the % change in Diastolic Blood Pressure (DBP) at a dose of 30 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID60294 | Inotropic activity determined by evaluating the % change in Systolic Blood Pressure (SBP) at a dose of 30 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID61741 | Inotropic activity determined by evaluating the maximum rate of rise in left ventricular pressure at a dose of 30 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID60146 | Inotropic activity determined by evaluating the % change in contractile force (CF) of right ventricle at a dose of 10 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID59298 | Positive inotropic activity determined in the isolated papillary muscle of the dog(that produced 30% increase in dose- response curves [dP/dt(max)]) | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID60286 | Inotropic activity determined by evaluating the % change in Heart Rate (HR) at a dose of 30 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID60156 | Inotropic activity determined by evaluating the % change in Cardiac out put (CO)at a dose of 30 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID60157 | Inotropic activity determined by evaluating the % change in Cardiac out put (CO)at a dose of 3 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID60295 | Inotropic activity determined by evaluating the % change in Systolic Blood Pressure (SBP) at a dose of 3 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID60160 | Inotropic activity determined by evaluating the % change in Diastolic Blood Pressure (DBP) at a dose of 10 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| AID60283 | Inotropic activity determined by evaluating the % change in Heart Rate (HR) at a dose of 10 ug/kg administered intravenously in isolated papillary muscle of the dog | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7 | A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (65)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 17 (26.15) | 18.7374 |
| 1990's | 35 (53.85) | 18.2507 |
| 2000's | 13 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 10.25
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (10.25) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (1.54%) | 5.53% |
| Reviews | 6 (9.23%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 58 (89.23%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||